Sanghoon Lee

Sanghoon Lee
Daegu Gyeongbuk Institute of Science and Technology (DGIST) · Robotics Engineering

Ph.D.

About

42
Publications
5,448
Reads
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791
Citations
Introduction
Our mission is to develop devices and robotic systems based on the modulation of nerves for neuroprosthetics or therapeutic applications. We are welcome to discuss possible research opportunities to join our group or to collaborate together. www.nirobot.org

Publications

Publications (42)
Article
Full-text available
Neural modulation technology and the capability to affect organ function have spawned the new field of bioelectronic medicine. Therapeutic interventions depend on wireless bioelectronic neural interfaces that can conformally and easily attach to small (few hundred micrometers) nerves located deep in the body without neural damage. Besides size, fac...
Article
Flexible and stretchable electronics, also known as e-skin, have been a technology to create diversified sensors and wearable devices. Implantable bioelectronics have recently been recognized as a promising research field to modulate biological signals and treat many diseases and pathological conditions. The marriage of two technologies gives us a...
Article
Reliable neural interfaces between peripheral nerves and implantable devices are at the center of advanced neural prosthetics and bioelectronic medicine. In this paper, selective sciatic nerve recording and stimulation were investigated using flexible split ring electrodes. The design enabled easy and reliable implantation of active electrodes on t...
Article
A novel flexible neural ribbon electrode with a self-adaptive feature is successfully implemented for various small nerves recording. As a neural interface, the selective recording capability is characterized by having reliable signal acquisitions from the sciatic nerve and its branches such as the peroneal nerve, the tibial nerve, and the sural ne...
Article
Full-text available
Recently, methods for the treatment of chronic diseases and disorders through the modulation of peripheral and autonomic nerves have been proposed. To investigate various treatment methods and results, experiments are being conducted on animals such as rabbits and rat. However the diameter of the targeted nerves is small (several hundred μm) and it...
Article
Three-dimensionally (3D) structured soft electronic devices that fit the contour of target organs or tissues are preferred for the stable implantation of biomedical devices. However, the metal patterns deposited on soft materials, especially polydimethylsiloxane (PDMS), can generate microcracks or disconnections following an expansion of the substr...
Article
Neuromodulation is a multi-interdisciplinary field of neuroscience, neural engineering, and medicine in a complex, but a way of understanding. Recently, the interest and researches in this field have been attracted due to its promising applications such as bionic limbs and bioelectronic medicine. For easier entry into this field, in this review, we...
Article
Full-text available
Modulation of the peripheral nervous system (PNS) has a great potential for therapeutic intervention as well as restore bodily functions. Recent interest has focused on autonomic nerves, as they regulate extensive functions implicated in organ physiology, chronic disease state and appear tractable to targeted modulation of discrete nerve units. The...
Article
Full-text available
Electrical excitation of neural tissue has wide applications, but how electrical stimulation interacts with neural tissue remains to be elucidated. Here, we propose a new theory, named the Circuit-Probability theory, to reveal how this physical interaction happen. The relation between the electrical stimulation input and the neural response can be...
Preprint
Full-text available
Objectives The bladder becomes retentive during the early phase of spinal cord injury, and requires proper bladder management to prevent damage to the lower urinary tract and kidney. We investigated the effects of on-demand pelvic nerve stimulation on the areflexive bladder during the earliest phase of complete spinal cord injury in rats and the us...
Article
The adoption of chronic implantable peripheral nerve-based prosthetic devices is currently hampered by the lack of a highly integrated neural signal acquisition system-on-chip (SoC). We report a ten-channel peripheral nervous system (PNS) electroneurogram (ENG) signal acquisition SoC within an implantable package. Requiring only four off-chip capac...
Article
Flexible electronics technology dramatically changes the capability of sensors, which allows us to detect human biological signals not only on the skin but also inside the human body. Wearable sensors that stick to the skin surface can detect various biomechanical movements, biological signals, and byproducts such as useful elements from sweat and...
Article
Mechano-neuromodulation of autonomic pelvic nerves was demonstrated for the first time using a triboelectric neurostimulator integrated with flexible neural clip interface. The detailed stimulation parameters such as current, pulse width, and charges generated by the proposed TENG were investigated for the stimulation of autonomic pelvic nerve. In...
Article
Full-text available
The concept of converting human energy into useful power by various mechanisms has been explored as an alternative way to support the operation of implantable bioelectronics. Triboelectric nanogenerators (TENGs) have recently been proposed as a promising technology to harvest energy as an alternative power source for these implantable devices. In t...
Article
Modulation of nerve signals from the peripheral nervous system (PNS) is a growing field of neurotechnology for therapeutic effects of the human body and for interfacing with neural prostheses. For this, neural interfaces, that provide the basis for direct communication with neuron tissues and mapping neural signals, are preferentially developed. Ev...
Preprint
Full-text available
A new theory, named the Circuit-Probability theory, is proposed to unveil the secret of electrical nerve stimulation, essentially explain the nonlinear and resonant phenomena observed when neural and non-neural tissues are electrically stimulated. For the explanation of frequency dependent response, an inductor is involved in the neural circuit mod...
Article
Modulation of peripheral nerves is an emerging field for neuroprothesis and bioelectronic medicine. With developing neural interfacing technology (NIT) that directly communicates with peripheral nerves, several powering schemes have been investigated for long-term use of implantable devices such as wireless and conversion of human body energy. Rece...
Article
Artificial sensors on the skin are proposed as a way to capture information that can be used in intracortical microstimulation or peripheral intraneural stimulation to restore sensory feedback to persons with tetraplegia. However, the ability of these artificial sensors to replicate the density and complexity of the natural mechanoreceptors is limi...
Article
The alternating current (AC) magnetically-induced heating characteristics of MgFe2O4 ferrimagnetic nanoparticles (FMNPs) are investigated in both powder and ferrofluidic states for efficient hyperthermia agent applications. To obtain MgFe2O4 FMNPs with different sizes and size distributions, a ball milling process (ball diameters: 3 mm and 5 mm) is...
Article
Alternating current (AC) magnetically-induced heating characteristics of MgFe2O4 ferrimagnetic nanoparticles (FMNPs) are investigated in both powder and ferrofluidic states for efficient hyperthermia agent applications. To obtain different sizes and size distributions of MgFe2O4 FMNPs, ball milling process (ball diameters: 3 mm and 5 mm) is carried...
Article
Full-text available
There has been a lot of recent interest in using electrical impulses to interface with the nervous system to regulate organ functions in the body. In article 1500386, Shih-Cheng Yen, Chengkuo Lee, and co-workers demonstrate the ability to selectively stimulate the nerve trunk and, for the first time, record simultaneously the effect on different ne...
Article
Full-text available
Selective stimulation is delivered to the sciatic nerve using different paris of contacts on a split-ring electrode, while simulatneous recordings are acquired by the neural ribbon electrodes on three different branches. Two hook electrodes are also implanted in the muscle to monitor the activated muscle responses. It shows that the high precision...
Conference Paper
This paper demonstrates bidirectional selective recording and stimulation by using flexible and adjustable sling electrodes aiming at electroceuticals application in the future. The sling design enables helical implantations of sensing electrodes on a nerve with less pressure and tight contact. Neural signals are recorded from six sensing electrode...
Article
A ferrimagnetic nanoparticle with a smaller size, a narrower size distribution, and a higher ac heat generation ability has been still studied for intra-arterial or intra-tumoral hyperthermia. In this study, we manipulate the calcining temperature in the range of 400∼600 °C to modify MgFe2O4 ferrimagnetic nanoparticles (FMNPs) during modified sol–g...
Article
This paper demonstrates flexible epineural strip electrodes (FLESE) for recording from small nerves. Small strip-shaped FLESE enables to easily and closely stick on various sized nerves for less damage in a nerve and optimal recording quality. In addition, in order to enhance the neural interface, the gold electrode contacts were coated with carbon...
Conference Paper
Various peripheral nerve interfaces have been developed in the last decades and transferred into neuroscientific researches or clinical applications. In this study, we present a novel flexible neural ribbon electrode that can achieve self-adaption to nerves in various diameters and have three dimensional (3D) contacts. Impedance spectroscopy of the...
Conference Paper
Selective fascicle stimulation is a requirement for the neuroprosthetic treatment of peripheral nerve injuries in order to achieve a proper functional recovery. Here we show that multi-contact polyimide-based flexible split-ring electrodes can provide selective motor stimulation of the rat sciatic nerve. Considering the results, these kinds of elec...
Article
Solid-state ferrimagnetic MFe2O4 (M = Mg, Ni, Co; mean diameter size d = 30-35 nm) and superparamagnetic MFe2O4 (M = Mg, Ni, Mn0.5Zn0.5; d = 6-8 nm) nanoparticles [ferromagnetic nanoparticles (FMNPs) and superparamagnetic nanoparticles (SPNPs)] were used to explore the physical mechanisms of ac magnetically induced heating and identify what physica...
Article
Magnetic and AC magnetically induced heating characteristics of Fe3O4 nanoparticles (IONs) with different mean diameters, d, systematically controlled from 4.2 to 22.5 nm were investigated to explore the physical relationship between magnetic phase and specific loss power (SLP) for hyperthermia agent applications. It was experimentally confirmed th...
Article
Ocular neuroprotection induced by localized heat shock proteins (HSPs) has been paid considerable attention as an efficacious treatment modality for glaucoma. However, the current clinical approaches to induce HSPs in the retinal ganglion cells (RGCs) are limited due to undesirable side effects. Here, we present that the induction of HSPs by local...

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Projects

Projects (5)
Project
Development of advanced muscle-nerve interface for sensory feedback of lower prostheses.
Project
Development of bidirectional bionic interface for intuitive control of bionic limb prosthesis.
Project
Development of mechano-neurostimulator for Neurogenic Bladder; Triboelectric Neurostimulator integrated with a novel neural interface