Sandrine De Ribaupierre

Sandrine De Ribaupierre
The University of Western Ontario | UWO · Department of Clinical Neurological Sciences

MD, MSc

About

194
Publications
27,876
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2,646
Citations
Citations since 2017
71 Research Items
1636 Citations
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2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300

Publications

Publications (194)
Article
OBJECTIVE Some neonates born prematurely with intraventricular hemorrhage develop posthemorrhagic hydrocephalus and require lifelong treatment to divert the flow of CSF. Early prediction of the eventual need for a ventriculoperitoneal shunt (VPS) is difficult, and early discussions with families are based on statistics and the grade of hemorrhage....
Preprint
Full-text available
Background: Hypoxic ischemic encephalopathy (HIE) is a severe brain injury impacting term-born neonates. Despite treatment with therapeutic hypothermia (TH), HIE is associated with myriad adverse developmental outcomes suggesting the involvement of subcortical structures, including the thalamus and basal ganglia, which may be vulnerable to perinata...
Preprint
Objective: To appraise blood oxygen level-dependent (BOLD) signal variability metrics uses in pediatric populations with a focus on evaluating their clinical applicability in pediatric neurological diseases. Methods: A systematic review of the literature was conducted on five databases: Psychinfo, Healthstar, Medline, Embase, and Scopus. Inclusion...
Preprint
Full-text available
Purpose Infantile hydrocephalus causes diffuse neuronal injury and periventricular white matter damage and is a common neurosurgical indication to limit adverse neurodevelopmental outcomes. Higher-order executive functions which develop throughout childhood and adolescence are not currently well characterized in surgically managed patients. Method...
Article
Full-text available
Background Volumetric measurements of fetal brain maturation in the third trimester of pregnancy are key predictors of developmental outcomes. Improved understanding of fetal brain development trajectories may aid in identifying and clinically managing at-risk fetuses. Currently, fetal brain structures in magnetic resonance images (MRI) are often m...
Preprint
Full-text available
Germinal Matrix-Intraventricular hemorrhage (GMH-IVH) remains a significant cause of adverse neurodevelopment in preterm infants. Current management relies on 2-dimensional cranial ultrasound (2D cUS) ventricular measurements. Reliable biomarkers are needed to aid in the early detection of posthemorrhagic ventricular dilatation (PHVD) and subsequen...
Preprint
Full-text available
Fetal functional magnetic resonance imaging (fMRI) offers critical insight into the developing brain and could aid in predicting developmental outcomes. As the fetal brain is surrounded by heterogeneous tissue, it is not possible to use adult- or child-based segmentation toolboxes. Manually-segmented masks can be used to extract the fetal brain; ho...
Preprint
Full-text available
Purpose: Registration and segmentation of magnetic resonance (MR) and ultrasound (US) images play an essential role in surgical planning and resection of brain tumors. However, validating these techniques is challenging due to the scarcity of publicly accessible sources with high-quality ground truth information. To this end, we propose a unique an...
Preprint
Full-text available
We develop a hybrid model-based data-driven seizure detection algorithm called Mutual Information-based CNNAided Learned factor graphs (MICAL) for detection of eclectic seizures from EEG signals. Our proposed method contains three main components: a neural mutual information (MI) estimator, 1D convolutional neural network (CNN), and factor graph in...
Article
Background: Greater variability of neuronal signalling, measured as the standard deviation of the blood oxygen dependent signal (BOLD SD ), relates to information processing capacity. Resting-state functional magnetic resonance imaging was used to determine differences in BOLD SD between children with and without epilepsy. Methods: We studied 24 co...
Article
Full-text available
The relationship between age-related changes in brain structural connectivity (SC) and functional connectivity (FC) with cognition is not well understood. Furthermore, it is not clear whether cognition is represented via a similar spatial pattern of FC and SC or instead is mapped by distinct sets of distributed connectivity patterns. To this end, w...
Article
Introduction: Infantile hydrocephalus is a condition in which there is an abnormal build-up of cerebrospinal fluid in the ventricles within the first few months of life, which puts pressure on surrounding brain tissues. Compression of the developing brain increases the risk of secondary brain injury and cognitive disabilities. Methods: In this s...
Preprint
Full-text available
Template-based segmentation techniques have been used for targeting deep brain structures in fetal MR images. In this study, two registration algorithms were compared to determine the optimal strategy of segmenting subcortical structures in T2-weighted images acquired during the third trimester of pregnancy. Adult women with singleton pregnancies (...
Preprint
Full-text available
We propose a convolutional neural network (CNN) aided factor graphs assisted by mutual information features estimated by a neural network for seizure detection. Specifically, we use neural mutual information estimation to evaluate the correlation between different electroencephalogram (EEG) channels as features. We then use a 1D-CNN to extract extr...
Chapter
As with any new surgical technique, robotic surgery in particular involves a significant training curve. Given sufficient training, surgeons can become adept at performing robotic procedures, entailing reduction of the associated costs and maximization of patient safety. In this chapter, we propose that augmented or virtual reality training systems...
Article
Background Electrical stimulation mapping (ESM) is an important tool for the localization of the seizure onset zone (SOZ) in patients with medically resistant epilepsy (MRE). ESM is the gold standard for the identification of eloquent cortex in epilepsy surgery candidates. However, there is no standard protocol outlining how to perform ESM, to obta...
Article
Full-text available
A major concern with preterm birth is the risk of neurodevelopmental disability. Poor cerebral circulation leading to periods of hypoxia is believed to play a significant role in the etiology of preterm brain injury, with the first three days of life considered the period when the brain is most vulnerable. This study focused on monitoring cerebral...
Article
Background: Intraventricular hemorrhaging (IVH) within cerebral lateral ventricles affects 20-30% of very low birth weight infants (<1500g). As the ventricles increase in size, the intracranial pressure increases leading to post-hemorrhagic ventricle dilatation (PHVD), an abnormal enlargement of the head. The most widely used imaging tool for meas...
Article
Hand telerehabilitation currently has limitations for accurate and remote assessment of range of motion (ROM) in small finger joints. ‘DIGITS’ application utilises the front smartphone camera to measure finger ROM in a reliable and rapid assessment protocol. Our initial beta-phase testing examined the consistency of our software measurements to in-...
Conference Paper
We propose a computationally efficient algorithm for seizure detection. Instead of using a purely data-driven approach, we develop a hybrid model-based/data-driven method, combining convolutional neural networks with factor graph inference. On the CHB-MIT dataset, we demonstrate that the proposed method can generalize well in a 6 fold leave-4-patie...
Article
Full-text available
Background: For patients with generalized epilepsy who do not respond to anti-seizure medications, the therapeutic options are limited. Vagus nerve stimulation (VNS) is a treatment mainly approved for therapy resistant focal epilepsy. There is limited information on the use of VNS on generalized epilepsies, including Lennox Gastaut Syndrome(LGS) an...
Preprint
Full-text available
We propose a computationally efficient algorithm for seizure detection. Instead of using a purely data-driven approach, we develop a hybrid model-based/data-driven method, combining convolutional neural networks with factor graph inference. On the CHB-MIT dataset, we demonstrate that the proposed method can generalize well in a 6 fold leave-4-patie...
Conference Paper
The premature brain embodies an underdeveloped vascular system, which can lead to poor cerebral blood flow (CBF), impaired metabolism, and subsequent brain injury. NNeMo (Neonatal NeuroMonitor) is an in-house built brain monitor that provides continuous and simultaneous measurements of CBF, tissue saturation (StO2), and metabolism. Nine premature i...
Article
Full-text available
Background: Despite its many advantages, experience with fetal magnetic resonance imaging (MRI) is limited, as is knowledge of how fetal tissue relaxation times change with gestational age (GA). Quantification of fetal tissue relaxation times as a function of GA provides insight into tissue changes during fetal development and facilitates comparis...
Article
OBJECTIVE Epilepsy affects neural processing and often causes intra- or interhemispheric language reorganization, rendering localization solely based on anatomical landmarks (e.g., Broca’s area) unreliable. Preoperative brain mapping is necessary to weigh the risk of resection with the risk of postoperative deficit. However, the use of conventional...
Article
Objective This study aimed to determine whether there are differences in the lateral ventricular volumes, measured by three-dimensional ultrasound (3D US) depending on the posture of the neonate (right and left lateral decubitus). Study Design This was a prospective analysis of the lateral ventricular volumes of preterm neonates recruited from Vict...
Article
Full-text available
Introduction: Increasing head circumference is a common presentation of hydrocephalus within the first 2 years of life but is extremely rare in older children or adults. Here, we present a rare case of rapidly increasing head circumference, as the sole symptom, as a new diagnosis of hydrocephalus in a 7-year-old boy, who then re-presented with an i...
Article
Background For patients with generalized epilepsy who do not respond to antiseizure medications, the therapeutic options are limited. Vagus nerve stimulation (VNS) is a treatment mainly approved for therapy-resistant focal epilepsy. There is limited information on the use of VNS on generalized epilepsies, including Lennox–Gastaut Syndrome (LGS) and...
Article
Full-text available
Post-hemorrhagic ventricular dilatation (PHVD) is characterized by a build-up of cerebral spinal fluid (CSF) in the ventricles, which increases intracranial pressure and compresses brain tissue. Clinical interventions (i.e., ventricular taps, VT) work to mitigate these complications through CSF drainage; however, the timing of these procedures rema...
Article
Full-text available
Purpose: The craniometrics of head circumference (HC) and ventricular size are part of the clinical assessment of infants with hydrocephalus and are often utilized in conjunction with other clinical and radiological parameters to determine the success of treatment. We aimed to assess the effect of endoscopic third ventriculostomy (ETV) and shuntin...
Article
Full-text available
Background: Simulation-based medical education (SBME) is growing as a powerful aid in delivering proficient skills training in many specialties. Cerebral angiography (CA), a spatially and navigationally challenging endovascular procedure, can benefit from SBME by training targetable skills outside of the Angiosuite. In order to standardize and spe...
Article
Full-text available
Objective The aim of this study is to investigate whether ventricular volume in posthemorrhagic ventricle dilatation impacts neurodevelopmental outcome. Infants were scanned with 3D cranial ultrasound in the first few months of life, and their neurodevelopmental outcome at 4, 8, 12, and 24 months corrected age (CA) was examined. Methods Forty-nine...
Article
Background: Functional MRI (fMRI) is a noninvasive method to investigate the neural correlates of brain development. Insight into the rapidly developing brain in utero is limited, and fetal fMRI can be used to gain a greater understanding of the developmental process. Fetal brain fMRI is typically limited to resting-state fMRI due to the difficult...
Article
Full-text available
The time course of neuroanatomical structural and functional measures across the lifespan is commonly reported in association with aging. Blood oxygen-level dependent signal variability, estimated using the standard deviation of the signal, or “BOLDSD,” is an emerging metric of variability in neural processing, and has been shown to be positively c...
Article
Advances in mobile technology have enabled virtual reality (VR) and augmented reality (AR) systems to become more accessible and affordable. There are several devices that can be integrated with the mobile platform to make the applications more interactive, such as Leap Motion (LM). In this article, an AR environment has been designed that uses an...
Article
Pediatric neuroendovascular procedures are increasingly performed as several studies have shown the safety of these interventions. In the literature, an upper limit of 4 French catheter size is conventionally used for femoral access in neuroangiography of very young infants. However, this constraint in luminal size may not allow for more complex pr...
Book
This book constitutes the refereed joint proceedings of the First International Workshop on OR 2.0 Context-Aware Operating Theaters, OR 2.0 2018, 5th International Workshop on Computer Assisted Robotic Endoscopy, CARE 2018, 7th International Workshop on Clinical Image-Based Procedures, CLIP 2018, and the First International Workshop on Skin Image A...
Article
Full-text available
R1 Simulation training in stroke thrombolysis: reducing door to needle times to less than 15 minutes R2 Sequential Simulation (SqS): an empirical and theoretical model R3 Debriefing with team deliberate practice: an instructional design to enhance the performance of undergraduate nursing students in recognising the deteriorating patient R4 Behavior...
Article
Dilatation of the cerebral ventricles is a common condition in preterm neonates with intraventricular hemorrhage. This posthemorrhagic ventricle dilatation (PHVD) can lead to lifelong neurological impairment through ischemic injury due to increased intracranial pressure, and without treatment can lead to death. Two-dimensional ultrasound (US) throu...
Article
Background Connectivity studies targeting the thalamus have revealed patterns of atrophy and deafferentiation in temporal lobe epilepsy (TLE). The thalamus can be parcellated using probabilistic tractography to demonstrate regions of cortical connectivity; however, sensitivity to smaller or less connected regions is low. Purpose/Hypothesis To inve...
Conference Paper
A validation study was conducted to show that broadband NIRS could measure similar changes in cerebral oxygen saturation as time-resolved NIRS. Experiments were conducted in piglets in which inhaled oxygen was progressively decreased.
Article
Full-text available
Purpose: The purpose of this study was to determine whether drainage and revision are an effective treatment for abdominal pseudocyst associated ventriculoperitoneal (VP) shunt failure by estimating the total rate of secondary shunt failure. Methods: We performed a retrospective review of children with hydrocephalus diagnosed with and treated fo...
Article
Full-text available
There are a number of challenges that must be faced when trying to develop AR and VR-based Neurosurgical simulators, Surgical Navigation Platforms, and "Smart OR" systems. Trying to simulate an operating room environment and surgical tasks in Augmented and Virtual Reality is a challenge many are attempting to solve, in order to train surgeons or he...
Article
Full-text available
Non-invasive assessment of cognitive importance has been a major challenge for planning of neurosurgical procedures. In the past decade, in vivo brain imaging modalities have been considered for estimating the ‘eloquence’ of brain areas. In order to estimate the impact of damage caused by an access path towards a target region inside of the skull,...
Article
Full-text available
Advances in virtual and augmented reality (AR) are having an impact on the medical field in areas such as surgical simulation. Improvements to surgical simulation will provide students and residents with additional training and evaluation methods. This is particularly important for procedures such as the endoscopic third ventriculostomy (ETV), whic...
Conference Paper
Full-text available
Neurosurgical interventions require preoperative planning and precise navigation and manipulation of medical instruments since the workspace involves healthy brain tissues and eloquent brain structures. Computer-assisted surgery research is gaining more interest in medical disciplines such as neurosurgery. Visualization and rendering of three-dimen...
Article
Background: Construction of brain functional and structural networks by neuroimaging methods facilitates inter-modal studies. These type of studies often demand exploration tools to carry out functional-structural discoveries and answer questions regarding the anatomical basis of brain networks. New method: This paper describes the design and de...
Article
Background: Morphometry and connectivity studies targeting the thalamus have revealed specific patterns of atrophy and deafferentiation in patients with temporal lobe epilepsy (TLE). We used probabilistic tractography to investigate thalamic connectivity with respect to duration of epilepsy and surgical outcomes in TLE. Methods: Patients (N=20) wit...
Article
Background: Post-hemorrhagic ventricular dilatation (PHVD) is predictive of mortality and morbidity among very low birth-weight preterm infants. Impaired cerebral blood flow (CBF) due to elevated intracranial pressure (ICP) is believed to be a contributing factor. Methods: A hyperspectral near-infrared spectroscopy (NIRS) method of measuring CBF...
Conference Paper
Full-text available
Neurosurgical procedures are complicated pro- cesses, providing challenges and demands ranging from medical knowledge and judgment to the neurosurgeon's dexterity and perceptual capacities. Deliberate training of common neurosurgical procedures and underlying tasks is extremely important. One effective method of the training is to enhance the requi...
Article
Full-text available
Preterm neonates with a very low birth weight of less than 1,500 grams are at increased risk for developing intraventricular hemorrhage (IVH), which is a major cause of brain injury in preterm neonates. Quantitative measurements of ventricular dilatation or shrinkage play an important role in monitoring patients and evaluating treatment options. 3D...
Poster
Full-text available
The ability to minimize damage to healthy tissues and eloquent brain structures when navigating toward a specific target is a priority in any neurosurgery. The aim of the work is to objectively evaluate fourteen novice participants during their neurosurgical targeting tasks with a variety of targets settings and to investigate the participants’ per...
Article
The aim of this study is to compare longitudinal two-dimensional (2-D) and three-dimensional (3-D) ultrasound (US) estimates of ventricle size in preterm neonates with posthemorrhagic ventricular dilatation (PHVD) using quantitative measurements of the lateral ventricles. Cranial 2-D US and 3-D US images were acquired from neonatal patients with di...
Article
Full-text available
Neuroimaging is a valuable diagnostic tool for the early detection of neonatal brain injury, but equipment and radiologic staff are expensive and unavailable to most hospitals in developing countries. We evaluated an affordable, portable ultrasound machine as a quantitative and qualitative diagnostic tool and to establish whether a novice sonograph...
Article
Context: Fidelity is widely viewed as an important element of simulation instructional design based on its purported relationship with transfer of learning. However, higher levels of fidelity may increase task complexity to a point at which novices' cognitive resources become overloaded. Objectives: In this experiment, we investigate the effects...
Conference Paper
Numerous augmented reality image guidance tools have been evaluated under specific clinical criteria, but there is a lack of investigation into the broad effect on targeting ability and perception. In this paper, we evaluated performance of 18 subjects on a targeting task modeling ventriculostomy trajectory planning. Users targeted ellipsoids withi...
Article
Purpose: To provide a more detailed investigation of hippocampal subfields using 7T magnetic resonance imaging (MRI) for the identification of hippocampal sclerosis in temporal lobe epilepsy (TLE). Materials and methods: Patients (n = 13) with drug-resistant TLE previously identified by conventional imaging as having hippocampal sclerosis (HS) o...
Article
The clinical identification of hippocampal sclerosis (HS) is important in predicting surgical outcomes in patients with temporal lobe epilepsy (TLE). In cases where gross hippocampal sclerosis is not identifiable clinically, a more detailed analysis of hippocampal subfields using ultra-high-field magnetic resonance imaging (MRI) may reveal areas of...