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My current research interests focus on structural biology, protein engineering and virology using X-ray crystallography, electron microscopy and atomic force microscopy.
July 2020 - present
June 2020 - October 2020
- Volunteer for the Bibliovid project - Translation and International Relations unit
- This project is an initiative from researchers that aims at centralizing the latest scientific literature on COVID-19 on a free dedicated website called “BiblioVid” (https://bibliovid.org).
March 2020 - April 2021
- An initiative from the scientific community to put all available resources at the service of the fight against COVID-19. https://blog.crowdfightcovid19.org/blog/
Vitamin B1 is essential for all organisms being well recognized as a necessary cofactor for key metabolic pathways such as glycolysis, and was more recently implicated in DNA damage responses. Little is known about the enzyme responsible for the formation of the pyrimidine moiety (4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) synthas...
Pentatricopeptide repeat (PPR) proteins control diverse aspects of RNA metabolism in eukaryotic cells. Although recent computational and structural studies have provided insights into RNA recognition by PPR proteins, their highly insoluble nature and inconsistencies between predicted and observed modes of RNA binding have restricted our understandi...
Crystallography by X-ray diffraction is a powerful method to determine the structure of proteins or macromolecular complexes in biology, and to get some insights into their reaction mechanisms and functions. This thesis deals with the use of X-ray crystallography in different areas of biology, ranging from reaction mechanisms in vitamin B1 biosynth...
Mitochondria are essential organelles carrying their own genetic information which require specific gene expression processes. The leucine rich pentatricopeptide protein (LRPPRC) and its partner the SRA stem-loop interacting RNA binding protein (SLIRP) form a stable complex implicated in mRNA stability and polyadenylation. LRPPRC/SLIRP complex form...
Pentatricopeptide repeat (PPR) proteins are RNA binding proteins with pre-determined RNA binding specificity, which are involved in multiple aspects of organelle RNA metabolism such as splicing, editing, degradation and translation. Computational and structural studies have allowed to elucidate the RNA-binding code of PPR proteins. However, their h...
In eukaryotes, mRNA polyadenylation is a well-known modification that is essential for many aspects of the protein-coding RNAs life cycle. However, modification of the 3' terminal nucleotide within various RNA molecules is a general and conserved process that broadly modulates RNA function in all kingdoms of life. Numerous types of modifications ha...
Targeting nucleic acid polymers to modulate gene expression is a booming field of research for the last decade largely due to the discovery of the miRNA pathways in higher eukaryotes. Numerous efforts to directly correct the genomic sequences were undertaken. Zinc finger nucleases, transcription activator-like effectors (TALEs) fused to endonucleas...
This study has for objective to obtain, on the one hand, the tri-dimensional structure of proteins belonging to the pentatricopeptide repeat (PPR) family by bioinformatics and crystallographic methods. On the other hand, the same techniques are used for determining the atomic model of enzymes implicated in the biosynthesis of vitamin B1 (or thiamin...
Cette présente étude propose un état de la recherche documenté sur la phylogénie d'un groupe particulier de Plathelminthes parasites, les cestodes, et plus spécifiquement l'ordre des Proteocephalidea. Dans la section introductive, nous exposons les caractéristiques morphologiques et écologiques de ce clade ainsi que les différentes représentations...
Testudotaenia testudo (Magath, 1924) is redescribed from the intestine of the softshell turtle Apalone spinifera (Le Sueur) (Trionychidae) and the bowfin Amia calva Linnaeus (Amiidae) from Reelfoot Lake, Tennessee, United States. A new subfamily, the Testudotaeniinae, is erected. The new taxon differs from all proteocephalidean subfamilies in the p...
Cairaella henrii gen. n., sp. n. (Proteocephalidea: Proteocephalinae) is described from the intestine of Norops trachyderma (Cope) (Polychrotidae) from San Pablo de Kantesiya in Ecuador. The new genus differs from the 12 other known genera of the Proteocephalinae (and all other proteocephalidean genera) by the presence of a dense network of osmoreg...
Ophiotaenia bonneti sp. n. is described from the intestine of the frog Rana vaillanti Brocchi, 1877 (Anura: Ranidae) from San Gerardo, Guanacaste, Costa Rica. The new species is characterized by the testes 100-177 in number, the genital pores situated anteriorly, the osmoregulatory canals overlapping the testis field, the cirrus pouch length as 15-...
Bibliovid.org is a tool gathering more than 800 articles on COVID-19, analyzed and summarized by physicians, researchers and public health specialists in order to provide caregivers with an enlightened view of the COVID-19 situation. Each article is associated with a gradation according to its quality (low, medium or high quality) and sorted according to the research specialties around COVID-19. Bibliovid.org is a free international initiative supported by the efforts of qualified volunteers for this task. With the progress of the situation, the quantity of articles to be analyzed is now phenomenal and therefore Bibliovid.org needs you to help us to keep this platform alive, which promotes quality in science and medical decisions supported by scientific evidence!
Help us support caregivers and promote quality science and visit https://lnkd.in/dR2PxEX now to contribute to Bibliovid.org and review articles on COVID-19!
We are building the future together!
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The CoronaSurveys project (https://coronasurveys.org/) is a collaborative endeavour from several universities and research institutions. Data about COVID-19 cases is collected via anonymous open surveys (all the data collected is openly available). You can help by regularly completing the anonymous survey. If you would like to join as ambassadors for the project to promote it, please feel free to contact me. Thank you in advance for your help !
I am looking for references from immunology studies which provide an estimation of the death rate of T cells targeting specifically melanoma-related antigen gp100.
This project is focused on the structural characterization using X-ray crystallography of two enzymes, THI5 and THIC, involved in vitamin B1 biosynthesis in yeast and plants respectively.