Sandra Wagner

Sandra Wagner
French Institute of Health and Medical Research | Inserm

PhD

About

62
Publications
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Skills and Expertise

Publications

Publications (62)
Article
Full-text available
Background Hyperuricemia is associated with poor cardiovascular outcomes, although it is uncertain whether this relationship is causal in nature. This study aimed to: (1) assess the heritability of serum uric acid (SUA) levels, (2) conduct a genome‐wide association study on SUA levels, and (3) investigate the association between certain single‐nucl...
Article
Full-text available
Background and AimsLittle is known about the effects of probiotics on inflammation in the context of chronic kidney disease (CKD). We investigated the association between probiotic intake and inflammation in patients with moderate-to-advanced CKD.Methods We performed a cross-sectional study of 888 patients with stage 3–5 CKD and data on serum C-rea...
Article
Full-text available
Background Long-chain polyunsaturated fatty acids (PUFAs) generate diverse bioactive lipid mediators, which tightly regulate vascular inflammation. The effects of omega-3 PUFA supplementation in cardiovascular prevention however remains controversial. In addition to direct dietary intake, fatty acid desaturases (FADS) determines PUFA levels. Increa...
Article
Background and objectives Statins are less efficacious in reducing cardiovascular disease risk in patients on dialysis than in the general population. Recent experimental data showed that phosphate excess promotes cellular de novo cholesterol synthesis through 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase activation. Whether this mechanism mig...
Article
Introduction et but de l’étude L’effet de la consommation de probiotique sur l’inflammation dans la maladie rénale chronique (MRC) est mal connu. L’objectif était d’étudier l’association entre la consommation de probiotique et l’inflammation chez des patients avec une MRC modérée ou avancée. Matériel et méthodes Cette étude transversale est basée...
Article
Full-text available
Background and Aims: Beverages are an important aspect of diet, and their quality can possibly affect health. The Healthy Beverage Index (HBI) has been developed to take into account these effects. This study aimed to highlight the relationships between health and beverage quality by assessing the association of the HBI and its components with kidn...
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Aims Elevated brain natriuretic peptide (BNP) and the N-terminal fragment of its pro-hormone (NT-proBNP) have become established biomarkers for heart failure and are associated with cardiovascular morbidity and mortality. Investigating sources of inter-individual heterogeneity, particularly genetic factors, could help better identify patients at ri...
Article
Background: Optimal daily water intake to prevent chronic kidney disease (CKD) progression is unknown. Taking kidney urine-concentrating ability into account, we studied the relation of kidney outcomes in patients with CKD to total and plain water intake and urine volume. Methods: Including 1265 CKD patients (median age, 69 years; mean estimated...
Article
État de la question L’obésité est associée à un risque accru de maladie rénale chronique. On en sait peu sur l’effet des changements d’indices anthropométriques au cours de la vie et leurs associations avec la fonction rénale chez les individus en bonne santé. Le but de cette étude était d’identifier les trajectoires d’indice de masse corporelle (I...
Article
Objective: Determining the factors associated with new-onset pre-diabetes and type 2 diabetes mellitus (T2D) is important for improving the current prevention strategies and for a better understanding of the disease. Design: To study the factors (clinical, circulating protein and genetic) associated with new onset pre-diabetes and T2D in an initial...
Article
Background: Recent studies have shown that hyperuricemia may be associated with incident hypertension (HTN). We examined whether serum uric acid (SUA) is a predictor of HTN and target organ damage (TOD) 20 years later in initially healthy middle-aged individuals. Methods: Participants from the Suivi Temporaire Annuel Non-Invasif de la Santé des...
Article
Full-text available
Background The diet impact on cardiovascular diseases has been investigated widely, but the association between dietary patterns (DPs) and subclinical cardiovascular damage remains unclear. More informative DPs could be provided by considering metabolic syndrome components as intermediate markers. This study aimed to identify DPs according to gener...
Article
Introduction Une hydratation adéquate semble avoir un effet bénéfique sur la prévention de la maladie rénale chronique (MRC) en population générale. L’effet sur la progression de la maladie chez les patients avec une MRC a été peu étudié. L’objectif était d’étudier l’association entre la consommation d’eau pure et le risque d’insuffisance rénale te...
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Full-text available
Previous studies have shown a high level of noncompliance with recommendations on breastfeeding duration, especially in France. The objective was to describe the association between breastfeeding initiation and duration and the statutory duration of postnatal maternity leave, the gap between the end of legal maternity leave and the mother's return...
Article
Infants' olfactory experience begins before birth and extends after birth through milk and complementary foods. Until now, studies on the effects of chemosensory experience in utero and/or through human milk focused on experimentally controlled exposure to only one target food bearing a specific odor quality and administered in sizeable amounts. Th...
Article
Rationale & objective: Chronic kidney disease (CKD) characterized by decreased glomerular filtration rate (GFR) is often accompanied by various degrees of impaired tubular function in the cortex and medulla. Assessment of tubular function may therefore be useful in establishing the severity of kidney disease and identifying those at greater risk f...
Article
The incidence of malignant melanoma has increased over the past two decades. A combined BRAF/MEK inhibitor regimen has been shown to lead to prolonged survival and progression‐free survival in patients with metastatic BRAF V600‐mutant melanoma. Different nephrotoxic effects have been described, among them hyponatremia. The goal of the present narra...
Article
Objective: To assess the role of the mother's mother and mothers’ previous personal experiences with breastfeeding and childcare in breastfeeding practices. Design and setting: The analysis included 13,774 mother–infant dyads from the French national birth cohort ELFE. Feeding practices were assessed by face-to-face interview in maternity wards in...
Article
The objectives of this study were to estimate the age of complementary feeding introduction (CFI) and investigate the related health, demographic, and socio-economic factors. Analyses were based on 10,931 infants from the French national birth cohort ELFE, born in 2011. Health, demographic, and socio-economic data concerning infants and parents wer...
Article
Full-text available
Background A balanced diet is essential to slowing the progression of chronic kidney disease (CKD) and managing the symptoms. Currently, no tool is available to easily and quickly assess energy and macronutrient intake in patients with non end-stage CKD. We aimed to develop and evaluate the validity and reproducibility of a new short 49-item food f...
Article
Full-text available
Background: Low and high blood potassium levels are common and were both associated with poor outcomes in patients with chronic kidney disease (CKD). Whether such relationships may be altered in CKD patients receiving optimized nephrologist care is unknown. Methods: NephroTest is a hospital-based prospective cohort study that enrolled 2078 nondi...
Article
Introduction et but de l’étude L’âge de début de la diversification (introduction des aliments autres que le lait maternel ou les préparations infantiles) a récemment été décrit en France, mais peu de données sont disponibles sur le déroulement de cette diversification et les caractéristiques familiales qui y sont associées. Notre objectif était de...
Article
Aims: To document the family transmission of Type 2 diabetes to men and women. Method: The French D.E.S.I.R. cohort followed men and women over 9 years, with 3-yearly testing for incident Type 2 diabetes. First- and/or second-degree family histories of diabetes were available for 2187 men and 2282 women. Age-adjusted hazard ratios were estimated...
Article
Breastfeeding is recommended until 6 months of age, but a wide range of infant formula is available for nonbreastfed or partially breastfed infants. Our aim was to describe infant formula selection and to examine social- and health-related factors associated with this selection. Analyses were based on 13,291 infants from the French national birth c...
Article
Introduction: Over the last few decades, the prevalence of obesity has increased dramatically. This increase has been mirrored by a rise in the risk of a number of health conditions, including hypertension, diabetes and chronic kidney disease. Although the weight loss following bariatric surgery has been shown to relieve the severity of diabetes a...
Article
Introduction et but de l’etude Une large gamme de preparations pour nourrissons est disponible sur le marche. L’objectif de ce travail etait de decrire l’utilisation des differents types de preparations infantiles (hydrolysee, epaissie, enrichie en pre/probiotiques, standard) au cours de la premiere annee de vie en 2011 a partir des la cohorte nati...
Article
Évaluer l’adéquation des consommations alimentaires des femmes enceintes aux recommandations du Programme national nutrition santé (PNNS) et identifier les principaux facteurs démographiques et socioéconomiques associés.
Article
Statin treatment reduces the risk of cardiovascular mortality in the general population, but it has little or no benefit in hemodialyzed (HD) patients. This may reflect different underlying pathophysiology of cardiovascular disease (CVD) in patients treated with HD, maybe involving the oxidative stress. Our aim was to assess the association of oxid...
Article
Objectives: Chronic impaired renal function (IRC) constitutes a major risk factor of morbi-mortality during the treatment of an abdominal aortic aneurism (AAA). The inflammatory state due to the AAA could result in a reduction in the muscular mass and an over-estimation of the glomerular filtration rate (GFR) with the usual formulas. The objective...
Article
Introduction La prévalence de l’obésité et des comorbidités associées a fortement augmenté ces dernières années. La perte de poids engendrée par la chirurgie bariatrique permet une rémission du diabète ainsi qu’une amélioration du contrôle tensionnel chez certains patients. Cependant, son effet sur la fonction rénale a été peu étudié. L’objectif de...
Article
Full-text available
Previous research has identified relationships between chemosensory reactivity and food neophobia in children. However, most studies have investigated this relationship using declarative data and without separately analysing smell and taste reactivity. Our first objective was to assess the relationships between smell and taste differential reactivi...
Article
Previous research has identified relationships between chemosensory reactivity and food neophobia in children. However, most studies have investigated this relationship using declarative data and without separately analysing smell and taste reactivity. Our first objective was to assess the relationships between smell and taste differential reactivi...
Article
Full-text available
Objectives – Based on the data from the ELFE Study (French longitudinal study from infancy) and on a large sample of births in France in 2011, the first objective of this work was to describe the total breastfeeding duration (infants consuming breast-milk along with whatever others foods and drinks associated), and distinguish predominant breastfee...
Article
Objectives: Using data from the French Longitudinal Study of Children ELFE (Growing up in France), our objectives were to describe breastfeeding prevalence at maternity units and its association with both parents’ characteristics and the context of delivery.
Conference Paper
Context and objective: Research has previously identified relationships between chemosensory reactivity and food neophobia in toddlers. However, most studies have addressed this question using declarative data, and without analyzing separately smell and taste. The objective of the present study was twofold. The first objective was to assess the rel...
Article
Full-text available
Objectives –Using data from the French Longitudinal Study of Children ELFE (Growing up in France), ourobjectives were to describe breastfeeding prevalence at maternity units and its association with both parents’characteristics and the context of delivery.Methods –The Elfe survey is based on a representative sample of more than 18,000 infants born...
Article
Full-text available
Olfaction is a highly salient sensory modality in early human life. Neonates show keen olfactory sensitivity and hedonic responsiveness. However, little is known about hedonic olfactory responsiveness between the neonatal period and 2 years of age. In an attempt to fill this gap, this longitudinal follow-up study aimed at investigating hedonic resp...
Article
www.opaline-dijon.fr/ ; Equipe de recherche OPALINE : Centre des Sciences du Goût et de l'Alimentation (R. Bouhalassa, C. Chabanet, S. Crevoisier, F. Durey, V. Feyen, S. Issanchou, S. Jacob, C. Lange, C. Laval, S. Monnery Patris, S. Nicklaus, C. Pédron, J. Piérard, P. Schlich, B. Schaal, C. Schwartz, E. Szleper, M. Visali) + Faculté de Médecine de...

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