Sandra India Aldana

• MPH MPhil PhD
• Postdoctoral Fellow at Icahn School of Medicine at Mount Sinai

Epidemiological evidence supports an association between exposure to air pollution during pregnancy and birth and child health outcomes. Typically, such associations are estimated by regressing an outcome on daily or weekly measures of exposure during pregnancy using a distributed lag model. However, these associations may be modified by multiple f...

Pregnancy is a critical window for long-term metabolic programming of fetal effects stemming from exposure to airborne particulate matter below 2.5 (PM2.5). Yet, little is known about long-term metabolic effects of PM2.5 exposure during and surrounding pregnancy in mothers. We assessed potential critical windows of PM2.5 exposure during and surroun...

Background and Aims Scarce knowledge about the impact of metabolism-disrupting chemicals (MDCs) on liver injury limits opportunities for intervention. We evaluated pregnancy MDC-mixture associations with liver injury and effect modification by folic acid (FA) supplementation in mother-child pairs. Methods We studied ~200 mother-child pairs from the...

Background/Aim Fluoride is a natural mineral present in food, water, and dental products, constituting ubiquitous long-term exposure in early childhood and across the lifespan. Experimental evidence shows fluoride-induced lipid disturbances with potential implications for cardiometabolic health. However, epidemiological studies are scarce. For the...

INTRODUCTION Evidence is limited on the role of mid‐life Dietary Approaches to Stop Hypertension (DASH) diet in late‐life subjective cognitive complaints (SCCs). METHODS We included 5116 women (mean age in 1985–1991: 46 years) from the New York University Women's Health Study. SCCs were assessed from 2018 to 2020 (mean age: 79 years) by a 6‐item q...

Disclosure: N.J. Cohen: None. M. Yao: None. V. Midya: None. S. India-Aldana: None. S.S. Andra: None. S. Narasimhan: None. A.K. Meher: None. M. Arora: None. J.K. Chan: None. S.Y. Chan: None. Y. Kway: None. N. Michael: None. S.A. Sadanathan: None. J.G. Eriksson: None. S.S. Velan: None. T.K. Hian: None. Y. Oulhote: None. J. Huang: None. D. Valvi: None...

Background: Living in neighborhoods with higher levels of walkability has been associated with a reduced risk of obesity and higher levels of physical activity. Obesity has been linked to increased risk of 13 cancers in women. However, long-term prospective studies of neighborhood walkability and risk for obesity-related cancer are scarce. Object...

Context Obesity surveillance is scarce in adolescents and little is known on whether salivary metabolomics data, emerging minimally invasive biomarkers, can characterize metabolic patterns associated with overweight or obesity in adolescents. Objective This pilot study aims to identify the salivary molecular signatures associated with body mass in...

Purpose of Review There is a growing interest in understanding the health effects of exposure to per- and polyfluoroalkyl substances (PFAS) through the study of the human metabolome. In this systematic review, we aimed to identify consistent findings between PFAS and metabolomic signatures. We conducted a search matching specific keywords that was...

Objectives: Experimental models have demonstrated a link between exposure to perfluoroalkyl substances (PFAS) and decreased fertility and fecundability; however, human studies are scarce. We assessed the associations between preconception plasma PFAS concentrations and fertility outcomes in women. Methods: In a case-control study nested within t...

Background Neighborhood walkability (NW) has been linked to increased physical activity, which in turn is associated with lower concentrations of sex hormones and higher concentration of SHBG in women. However, no study has directly examined the association of NW with female sex hormone levels. Objective We conducted a cross-sectional study to eva...

Background Large-scale longitudinal studies evaluating influences of the built environment on risk for type 2 diabetes (T2D) are scarce, and findings have been inconsistent. Objective To evaluate whether land use environment (LUE), a proxy of neighborhood walkability, is associated with T2D risk across different US community types, and to assess w...

Objective: Little is known about psychiatric symptoms among patients with migraine and newly diagnosed focal epilepsy. The investigators compared symptoms of depression, anxiety, and suicidality among people with newly diagnosed focal epilepsy with migraine versus without migraine. Methods: The Human Epilepsy Project is a prospective multicenter...

Background: There is a paucity of prospective cohort studies evaluating neighborhood walkability in relation to the risk of death. Methods: We geocoded baseline residential addresses of 13,832 women in the New York University Women's Health Study (NYUWHS) and estimated the Built Environment and Health Neighborhood Walkability Index (BEH-NWI) for...

Abstract Health-related quality of life (QOL) may impact life expectancy, chronic disease, and productivity. Evidence suggests the gut microbiome may contribute to QOL, but few studies have evaluated this association. We newly assessed cross-sectionally gut microbiome and QOL in the multi-ethnic FAMiLI sample of adults recruited between 2016-2018 (...

The goal of this study was to assess biomarkers of exposure to glyphosate and assess potential associations with renal function in children. Glyphosate is used ubiquitously in agriculture worldwide. While previous studies have indicated that glyphosate may have nephrotoxic effects, few have examined potential effects on kidney function in children....

Human Epilepsy Project www.aesnet.org/meetings_events/annual_meeting_abstracts/view/506540

Abstract Background: Dietary vitamins B9 (folate) and B12 (cobalamin) have been previously linked to both risk and prevention of cancer and other chronic diseases. Folate and vitamin B12 can be synthesized by bacteria in the gut, and we hypothesized that the intake of these vitamins may have an influence on the gut microbiome. For the first time,...