Sandip Das

Sandip Das
University of Delhi | DU · Department of Botany (Faculty of Science)

M.Phil; Ph.D

About

153
Publications
25,087
Reads
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1,328
Citations
Citations since 2016
33 Research Items
757 Citations
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
Additional affiliations
February 2010 - April 2021
University of Delhi
Position
  • Professor
Description
  • Teaching and Research
February 2010 - present
University of Delhi
September 2002 - September 2004
Max Planck Institute for Developmental Biology
Position
  • PostDoc Position
Education
June 1992 - October 1999
University of Delhi and Hamdard University
Field of study
  • Botany

Publications

Publications (153)
Article
Full-text available
Myeloblastosis (MYB) family, the largest plant transcription factor family, has been subcategorised based on the number and type of repeats in the MYB domain. In spite of several reports, evolution of MYB genes and repeats remains enigmatic. Brassicaceae members are endowed with complex genomes, including dysploidy because of its unique history wit...
Chapter
The transformational agenda of the United Nations (UN) on Sustainable Development recognizes the crucial role of agriculture in mitigation and adaptation to climate change for safeguarding food security and alleviating hunger. Widespread crop losses are foretold in climate-change-induced disrupted agro-ecosystems meriting urgent intervention. The d...
Article
Plant-specific Ovate Family Proteins (OFP), containing OVATE domain were identified as regulators of fruit shape. OFP homologs have been detected across plant kingdom as negative regulators of growth and adaptation, albeit with fragmentary information about evolutionary history, diversification, and functional significance. Phylogenetic position, e...
Article
Full-text available
Key message Extensive regulatory divergence during development, abiotic stress and ABA regime observed amongst promoter homologs and homeologs of MIR319 from Brassica juncea. Abstract Gene duplication followed by sub-functionalization, neo-functionalization, and pseudogenization are routes to functional and adaptive diversification. The influence...
Chapter
Evolutionary history of angiosperms illustrates extensive and recurrent whole genome duplication (WGD) events. A direct consequence of WGD is establishment of multiple notional sub-genomes within the polyploid cytotypes accompanied with an overall increase in gene copies known as homeologs. Even in diploids, prevalence of multiple, redundantly func...
Conference Paper
MYB genes, characterized by the presence of a conserved N-terminal MYB domain, constitute one of the largest family of transcription factors in plants. In plants, MYB family is further categorized into four subfamilies based on the number (1-4) and type of repeats (R1, R2 and R3) in the MYB domain. Two-repeat (R2R3-MYB / 2R-MYB) containing MYBs con...
Article
Intra- and epicuticular- waxes primarily comprising of very long chain aliphatic lipid (VLCFA), terpenoids and secondary metabolites such as sterol and flavonoids played a major role in successful colonization of terrestrial ecosystem by aquatic plants and are thus considered as a key evolutionary innovation. The key rate limiting step of Fatty Aci...
Article
The relationship between evolutionary history, organisation and transcriptional regulation of genes are intrinsically linked. These have been well studied in canonically organised protein-coding genes but not of MIRNAs. In the present study, we investigated the non-canonical arrangement of MIRNAs across taxonomic boundaries from algae to angiosperm...
Chapter
Full-text available
Rapid progress in genetic engineering of plants has opened vistas for manipulation of traits to not only meet the ever-increasing need of food, feed, and fuel but also produce novel compounds in transgenic plants (genetically modified crops or GM crops). The widespread global adoption of transgenic plants has raised doubts and fears about its ill-i...
Article
Full-text available
CRABS CLAW (CRC), a member of YABBY transcription factor family, has been previously reported to be principally involved in carpel development across angiosperms, and nectary development in core eudicots. Most of the studies suggest that CRC exists as a single copy gene, except in the Solanaceae where CRC occurs as paralogous pairs—CRCa–CRCb in Sol...
Article
Full-text available
Identification and functional analysis of promoters is critical towards gaining insights into transcriptional regulation, and helps in identifying interacting trans-factors. Analysis of MIRNA promoter can differentiate the function of paralogs and homeologs where identifying the role of members of MIRNA family is difficult based on small RNA blots...
Chapter
Health, productivity, and reproductive success of plants as primary producer are dependent on soil mineral nutrients, among many other biotic and abiotic factors. Mineral nutrients have been categorized into major and minor nutrients. Both deficiency and excess of nutrient availability cause deficiency stress and nutrient toxicity, respectively; “s...
Article
Full-text available
Whole-genome and segmental duplications coupled with sequence and functional diversification are responsible for gene family expansion, and morphological and adaptive diversity. Although broad contours of such processes are understood, detailed investigations on regulatory elements, such as miRNA-transcription factor modules, especially in non-mode...
Article
Full-text available
The availability of a large number of whole-genome sequences allows comparative genomic analysis to reveal and understand evolution of regulatory regions and elements. The role played by events such as whole-genome and segmental duplications followed by genome fractionation in shaping genomic landscape and in expansion of gene families is crucial t...
Article
Full-text available
Mosses, liverworts, hornworts and lycophytes represent transition stages between the aquatic to terrestrial/land plants. Several morphological and adaptive novelties driven by genomic components including emergence and expansion of new or existing gene families have played a critical role during and after the transition, and contributed towards suc...
Article
Natural structural variants of regulatory proteins causing quantitative phenotypic consequences have not been reported in plants. Herein, we show that 28 natural structural variants of FT homeologs, isolated from 6 species of Brassica, differ with respect to amino-acid substitutions in regions critical for interactions with FD and represent two evo...
Article
Full-text available
The impact of polyploidy on functional diversification of cis-regulatory elements is poorly understood. This is primarily on account of lack of well-defined structure of cis-elements and a universal regulatory code. To the best of our knowledge, this is the first report on characterization of sequence and functional diversification of paralogous an...
Article
We present here a modified, sonication-assisted transient transformation assay for rapid analysis of cis-regulatory elements. We tested promoter elements from MIR159B locus of Brassica juncea by generating stable transgenic lines and compared the transcriptional activity of GUS reporter with that of the transient assay method. To obtain reliable an...
Article
Novel morphological structures allowed adaptation to dry conditions in early land plants. The cuticle, one such novelty, plays diverse roles in tolerance to abiotic and biotic stresses and plant development. Cuticular waxes represent a major constituent of the cuticle and are comprised of an assortment of chemicals that include, among others, very...
Chapter
The growth and development of plant are adversely affected due to various abiotic stresses such as cold, heat, drought, salinity, heavy metal, hypoxia, etc. Plant adaptation to the stress conditions is brought out by changes in its physiological parameters which have underlying molecular basis. Multiple signalling pathways are activated in response...
Chapter
Full-text available
Environmental stresses have a major influence on growth and development of plant. In order to counteract these stresses, plants have evolved various physiological and morphological adaptations. Evolution of the cuticle was one of the major adaptive morphological novelties in the transition of plants from aquatic to terrestrial habitat. One adaptive...
Conference Paper
MYB transcription factors are characterized by a conserved “MYB” domain at N-terminal. Plant MYB proteins have been classified into four groups based on number and type of imperfect repeat units in MYB domain. Of the four groups, the two repeat (R2R3) MYBs, with over 120 members in Arabidopsis thaliana, constitute the largest sub-family characteriz...
Article
Full-text available
• Reproductive success of a plant species is largely influenced by the outcomes of mating pattern in a population. It is believed that a significantly greater proportion of animal-pollinated plants have evolved a mixed-mating strategy, the extent of which may vary among species. It is thus pertinent to investigate the key contributors of mating suc...
Article
Key message Conserved genome organization and function of miR165a between Brassica juncea, Brassica rapa and Arabidopsis thaliana were revealed through synteny analysis and characterization of gain-of-function mutants. Abstract MicroRNA-mediated regulation of target genes is critical for development and adaptation. A handful of plant miRNAs along...
Article
Full-text available
Comparative genomics-based synteny analysis has proved to be an effective strategy to understand evolution of genomic regions spanning a single gene (micro-unit) to large segments encompassing hundreds of kilobases to megabases. Brassicaceae is in a unique position to contribute to understanding genome and trait evolution through comparative genomi...
Article
Full-text available
The recent availability of genome sequences together with syntenic block information for Brassicaceae offers an opportunity to study microRNA (miRNA) evolution across this family. We employed a synteny-based comparative genomics strategy to unambiguously identify miRNA homologs from the genome sequence of members of Brassicaceae. Such an analysis o...
Article
Plant genomes are characterized by the presence of large miRNA gene families which are few in number. The expansion of miRNA families is thought to be driven by gene and genome duplication. Some members of these miRNA gene families are tandemly arranged and their analysis is of interest because such organisation may indicate origin through tandem d...
Article
Full-text available
Medicinal plants have been used worldwide for centuries to maintain health and to treat diseases, more so chronic diseases. However, adulteration and use of spurious materials as substitutes have become a major concern for users and industry for reasons of safety and efficacy. Therefore, authentication of medicinal plants is of utmost importance. M...
Article
Full-text available
Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human-and machine-inter-pretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bot...
Article
Full-text available
Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bot...
Article
Full-text available
Convolvulus pluricaulis Choisy, commonly known as ''Shankhpushpi'', is an ayurvedic medicinal plant recommended as a brain tonic to promote intellect and memory, eliminate nervous disorders and to treat hyper-tension. Because of increasing demand of the drug, this plant species has been over-exploited. As a consequence, many unrelated plants are be...
Article
For conservation and genetic transformation, a successful in vitro micropropagation protocol for Ajuga bracteosa, a medicinal herb has been established for the first time. MS medium supplemented with IAA (2 mg/L) and BA (5 mg/L) induced 100 % shoot regeneration with an average of 41.4 shoots of 8.4 cm per culture. Excised in vitro shoots when trans...
Article
Full-text available
Capsella rubella is an inbreeding annual forb closely related to Arabidopsis thaliana, a model species widely used for studying natural variation in adaptive traits such as flowering time. Although mutations in dozens of genes can affect flowering of A. thaliana in the laboratory, only a handful of such genes vary in natural populations. Chief amon...
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