Sander Rozemeijer

Sander Rozemeijer
Vrije Universiteit Amsterdam | VU · Department of Adult Intensive Care

Master of Science

About

9
Publications
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67
Citations

Publications

Publications (9)
Article
Full-text available
Background Hypovitaminosis C and vitamin C deficiency are common in critically ill patients and associated with organ dysfunction. Low vitamin C status often goes unnoticed because determination is challenging. The static oxidation reduction potential (sORP) reflects the amount of oxidative stress in the blood and is a potential suitable surrogate...
Article
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2021. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2021. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from https://link.springer.com/...
Chapter
This chapter underlines the potential clinical relevance and practical difficulties of the currently available measurement of vitamin C. In recent years, there has been increasing interest in the effects of intravenous vitamin C in critically ill patients, but results of multiple clinical trials are not consistent. A possible explanation is the het...
Article
Full-text available
Background High-dose intravenous vitamin C directly scavenges and decreases the production of harmful reactive oxygen species (ROS) generated during ischemia/reperfusion after a cardiac arrest. The aim of this study is to investigate whether short-term treatment with a supplementary or very high-dose intravenous vitamin C reduces organ failure in p...
Article
Full-text available
Vitamin C deficiency is common in critically ill patients. Vitamin C, the most important antioxidant, is likely consumed during oxidative stress and deficiency is associated with organ dysfunction and mortality. Assessment of vitamin C status may be important to identify patients who might benefit from vitamin C administration. Up to now, vitamin C...
Article
Full-text available
Introduction: Shock is characterized by micro- and macrovascular flow impairment contributing to acute kidney injury (AKI). Routine monitoring of the circulation regards the macrocirculation but not the renal circulation which can be assessed with Doppler ultrasound as renal resistive index (RRI). RRI reflects resistance to flow. High RRI predicts...
Article
Full-text available
Background Acute kidney injury (AKI) complicates shock. Diagnosis is based on rising creatinine, a late phenomenon. Intrarenal vasoconstriction occurs earlier. Measuring flow resistance in the renal circulation, Renal Resistive Index (RRI), could become part of vital organ function assessment using Doppler ultrasound. Our aim was to determine wheth...
Data
ROC curves of seven most significant univariate predictors of AKI stage 2 and 3. (TIF)
Data
Multivariate regression analysis for AKI stage 2 and 3 including pre-admission eGFR. Chronic renal insufficiency is an important risk factor for AKI. On request of the reviewer, we therefore performed an additional multivariate analysis including pre-admission eGFR (as measured with the CKD EPI method) in addition to the most significant other vari...

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