Sandeep Mallya

Sandeep Mallya
Manipal Academy of Higher Education | MAHE · Life Science Center

MSc

About

25
Publications
4,178
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253
Citations

Publications

Publications (25)
Preprint
Full-text available
The miR-497/195 located at 17p13.1 is a highly conserved miRNA cluster whose abnormal expression is emerging as a key regulator of carcinogenesis. We performed a comprehensive analysis of the miR-497/195 to determine the prognostic utility and its role in cervical cancer (CC) using publicly available datasets. The in-silico analysis and validation...
Article
MicroRNAs play a significant role in nuclear and mitochondrial anterograde and retrograde signaling. Most of the miRNAs found inside mitochondria are nuclear genome encoded, with few mitochondrial genome encoded non-coding RNAs have been reported. In this study, we have identified 13 mitochondrial genome-encoded microRNAs (mitomiRs), which were dif...
Article
Optimal treatment of cancer requires diagnostic methods to facilitate therapy choice and prevent ineffective treatments. Direct assessment of therapy response in viable tumor specimens could fill this diagnostic gap. Therefore, we designed a microfluidic platform for assessment of patient treatment response using tumor tissue slices under precisely...
Preprint
Full-text available
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy associated with rapid progression and an abysmal prognosis. It is reported that chronic pancreatitis can increase the risk of developing PDAC by 16-fold. The overarching hypothesis is that some of the biological processes disrupted during the inflammatory stage show significa...
Preprint
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy associated with rapid progression and an abysmal prognosis. It is reported that chronic pancreatitis can increase the risk of developing PDAC by 16-fold. The overarching hypothesis is that some of the biological processes disrupted during the inflammatory stage show significa...
Article
Full-text available
Background Mitochondrial disorders are clinically complex and have highly variable phenotypes among all inherited disorders. Mutations in mitochondrial DNA (mtDNA) and nuclear genome or both have been reported in mitochondrial diseases suggesting common pathophysiological pathways. Considering the clinical heterogeneity of mitochondrial encephalopa...
Article
Full-text available
Background: Cervical cancer (CC) is one of the most common female cancers in many developing and underdeveloped countries. High incidence, late presentation, and mortality suggested the need for molecular markers. Mitochondrial defects due to abnormal expression of nuclear-encoded mitochondrial genes (NEMG) have been reported during cancer progres...
Article
Background Neurodegenerative disorders such as hereditary ataxia often manifest overlapping symptoms and are likely to be misdiagnosed based on clinical phenotypes. To identify the genes associated with such disorders for diagnostic purposes, geneticists often use high throughput technologies which generate an enormous amount of data on variants wh...
Article
Full-text available
Tumor hypoxia-induced downregulation of DNA repair pathways and enhanced replication stress are potential sources of genomic instability. A plethora of genetic changes such as point mutations, large deletions and duplications, microsatellite and chromosomal instability have been discovered in cells under hypoxic stress. However, the influence of hy...
Article
Objective: The altered miRNAs expression in cervical cancer tissue can be a critical player during tumorigenesis, may contribute to tumor cell heterogeneity and may determine distinct phenotypes within the tumor. Recent studies have highlighted the role of circulating miRNAs as a minimally-invasive biomarker and its potential as biosignature to co...
Article
MicroRNAs (miRNAs) are a class of noncoding RNA molecules which are involved in various cellular and physiological processes. Previously, studies have identified several miRNAs that are potential diagnostic biomarkers for various infectious diseases including tuberculosis. We have performed small RNA sequencing using the Ion Torrent PGM platform in...
Article
Full-text available
The complete genome sequences of two endophytic Streptomyces sp. strains, LUP30 and LUP47B, were analyzed. These strains were isolated from surface-sterilized roots of lucerne plants from South Australia and were found to promote the growth of the rhizobial partner in vitro and significantly increased nodulation and nitrogen fixation in lucerne pla...
Article
Full-text available
Multicomponent molecular modifications such as DNA methylation may offer sensitive and specific cervical intraepithelial neoplasia and cervical cancer biomarkers. In this study, we tested cervical tissues at various stages of tumor progression for 5-methylcytosine and 5-hydroxymethylcytosine levels and also DNA promoter methylation profile of a pan...
Article
Since the discovery of microRNAs (miRNAs), a class of noncoding RNAs that regulate the gene expression posttranscriptionally in sequence-specific manner, there has been a release of number of tools useful for both basic and advanced applications. This is because of the significance of miRNAs in many pathophysiological conditions including cancer. N...
Article
Full-text available
The complete genome sequences of three endophytic Streptomyces species were compared. Strains EN16, EN23, and EN27 were isolated from surface-sterilized roots of wheat plants from South Australia. In field trials, these strains are effective in suppressing fungal root diseases of wheat when added as spore coatings to wheat seed.
Article
With a purpose of accurate and simultaneous determination of DNA methylation from multiple loci in multiple samples, here, we are demonstrating a method to aid rapid DNA methylation detection of genomic sequences. Using genomic DNA of peripheral blood from 14 healthy individuals, DNA methylation in 465 CpG sites from 12 loci of genes (ADAM22, ATF2,...
Article
Full-text available
Here, we report the draft genome sequence of Burkholderia pseudomallei CM_Manipal, the causative agent of melioidosis isolated from a diabetic patient in Manipal, southern India. The draft genome consists of 107 contigs and is 7,209,157 bp long. A total of 5,600 coding sequences (CDSs), 60 tRNAs, 12 rRNAs, and one noncoding RNA (ncRNA) were predict...
Article
Full-text available
DNA methylation and its perturbations are an established attribute to a wide spectrum of phenotypic variations and disease conditions. Indian traditional system practices personalized medicine through indigenous concept of distinctly descriptive physiological, psychological and anatomical features known as prakriti. Here we attempted to establish D...
Article
Full-text available
Human variations related to immune response and disease susceptibility is well-documented in Ayurveda. Prakriti (body constitution) is the basic constitution of an individual established at the time of birth and distinguishes variations, into three broad phenotype categories such as vata, pitta and kapha. Variation in immune response is often attri...
Article
This study was undertaken to investigate the mitochondrial DNA (mtDNA) variation in non-malignant and malignant cervical tissue samples. We have identified 229 and 739 variations non-malignant and malignant tissues respectively distributed over 321 locations in the D-loop (50 in non-malignant and 166 in malignant; 216 variations), coding region (13...
Data
IL-6 signaling Pathway (Mus musculus) miRNA and gene expression microarray analysis Find miRNAs for target genes Identifier Mapping Mapping services Bioinformatics Tools miRNAs added to pathway WikiPathways BridgeDb Visualization PathVisio miRNAs visualized in the pathway Possible gene targets This work is a combined effort by the exchange students...
Data
IL-6 signaling Pathway (Mus musculus) miRNA and gene expression microarray analysis Find miRNAs for target genes Identifier Mapping Mapping services Bioinformatics Tools miRNAs added to pathway WikiPathways BridgeDb Visualization PathVisio miRNAs visualized in the pathway Possible gene targets This work is a combined effort by the exchange students...
Data
IL-6 signaling Pathway (Mus musculus) miRNA and gene expression microarray analysis Find miRNAs for target genes Identifier Mapping Mapping services Bioinformatics Tools miRNAs added to pathway WikiPathways BridgeDb Visualization PathVisio miRNAs visualized in the pathway Possible gene targets This work is a combined effort by the exchange students...
Conference Paper
Full-text available
In the early 2000s, microRNAs (miRNAs) were discovered as segments of a new class of highly conserved and small non-coding RNA molecules of 20-25 nucleotides that are transcribed from DNA. They do not translation into proteins, rather they inhibit protein expression by binding to the 3’untranslated regions (3’ UTRs) of specific mRNA targets (that i...

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Projects (2)
Archived project
Project
To isolate and characterise new strains of endophytic actinobacteria and to find applications for them