Sandeep Grover

Sandeep Grover

Epidemiologist/Biostatistician/Bioinformatician
Large scale epidemiological, clinical and genetic investigations

About

107
Publications
22,620
Reads
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1,516
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Introduction
Being a geneticist with a statistical background, I have been actively involved in studying influence of epidemiology and genetics on disease susceptibility and drug response. I hope to be counted in my field with a strong background in epidemiology, statistics and clinical research. My current interest include use of GWAS and MR to unearth causal association of biomarkers with rare and common diseases.
Additional affiliations
April 2016 - October 2019
Institut für Medizinische Biometrie und Statistik
Position
  • PostDoc Position
September 2013 - August 2015
Charité Universitätsmedizin Berlin
Position
  • PostDoc Position
October 2008 - July 2014
Institute of Genomics and Integrative Biology
Position
  • PhD
Education
October 2008 - July 2014
Institute of Genomics and Integrative Biology
Field of study
  • Pharmacogenetic studies of antiepileptic drugs
May 2002 - May 2004

Publications

Publications (107)
Chapter
Full-text available
Confounding and reverse causality have prevented us from drawing meaningful clinical interpretation even in well-powered observational studies. Confounding may be attributed to our inability to randomize the exposure variable in observational studies. Mendelian randomization (MR) is one approach to overcome confounding. It utilizes one or more gene...
Article
Full-text available
Objective: To examine causal associations between risky behavior phenotypes and Parkinson disease using a mendelian randomization approach. Methods: We used 2-sample mendelian randomization to generate unconfounded estimates using summary statistics from 2 independent, large meta-analyses of genome-wide association studies on risk-taking behavio...
Article
Full-text available
Objectives: Lymphatic filariasis (LF) represents a parasitic disease caused by filarial nematodes. While some infected individuals present an asymptomatic course, others suffer severe chronic lymphatic pathology, including lymphoedema (LE), hydrocele, and elephantiasis. Several studies have shown that host genetic factors influence LF susceptibili...
Article
Importance Aortic stenosis (AS) and coronary artery disease (CAD) frequently coexist. However, it is unknown which genetic and cardiovascular risk factors might be AS-specific and which could be shared between AS and CAD. Objective To identify genetic risk loci and cardiovascular risk factors with AS-specific associations. Design, Setting, and Pa...
Article
Background and objectives: The role of body mass index (BMI) in Parkinson disease (PD) is unclear. Based on the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in PD (Courage-PD) consortium, we used 2-sample Mendelian randomization (MR) to replicate a previously reported inverse association of genetically predicted BMI w...
Article
Aims A mutation in the SMARCA4 gene which encodes BRG1, a common catalytic subunit of switch/sucrose non-fermentable chromatin-remodelling complexes, plays a vital role in carcinogenesis. SMARCA4 mutations are present in approximately 10% of non-small cell lung cancers (NSCLC), making it a crucial gene in NSCLC, but with varying prognostic associat...
Article
Full-text available
Objective First-generation and second-generation endometrial ablation (EA) techniques, along with medical treatment and invasive surgery, are considered successful lines of management for abnormal uterine bleeding (AUB). We set out to determine the efficacy of first and second-generation ablation techniques compared with medical treatment, invasive...
Conference Paper
Background Lymphatic filariasis (LF) is a parasitic disease caused by filarial nematodes. An estimated 40 million individuals infected with the filarial nematodes present with the symptomatic LF manifestations of lymphedema (LE) and hydrocele. These symptoms develop in only a subgroup of infected people, and host genetics have been attributed to th...
Article
Full-text available
KRAS G12C mutation (mKRAS G12C) is the most frequent KRAS point mutation in non-small cell lung cancer (NSCLC) and has been proven to be a predictive biomarker for direct KRAS G12C inhibitors in advanced solid cancers. We sought to determine the prognostic significance of mKRAS G12C in patients with NSCLC using the meta-analytic approach. A protoco...
Article
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Background Tumor mutation burden (TMB) has been validated as a predictive biomarker for immunotherapy response and survival in numerous cancer types. Limited data is available on the inherent prognostic role of TMB in early-stage tumors. Objective To evaluate the prognostic role of TMB in early-stage, resected non-small cell lung cancer (NSCLC)....
Article
Full-text available
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is associated with increased pregnancy complications. Despite effective vaccination strategies for the general population, the evidence on the safety and efficacy of Coronavirus disease 2019 (COVID-19) vaccinations in pregnancy is limited due to a lack of well-powered studies. The present...
Article
Abstract Importance: Solid cancer patients following SARS-CoV-2 vaccination are likely to have a lower seroconversion rate than healthy adults. Seroconversion between those with and without cancer is likely to vary moderately or to be restricted to specific subgroups. Therefore, we sought to conduct a systematic review and meta-analysis to identif...
Article
Abstract Importance: Solid cancer patients following SARS-CoV-2 vaccination are likely to have a lower seroconversion rate than healthy adults. Seroconversion between those with and without cancer is likely to vary moderately or to be restricted to specific subgroups. Therefore, we sought to conduct a systematic review and meta-analysis to identif...
Article
Importance: Solid cancer patients following SARS-CoV-2 vaccination are likely to have a lower serocon-version rate than healthy adults. Seroconversion between those with and without cancer is likely to vary moderately or to be restricted to specific subgroups. Therefore, we sought to conduct a systematic review and meta-analysis to identify risk fa...
Article
Background: Epidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties. Objective: We used results from genome-wide association studies (GWASs) to study the genetic correlation between PD and different cancers to identify co...
Article
Full-text available
Background: In breast, prostate, and other epithelial tumors, circulating tumor cells (CTC) in peripheral blood may predict survival. Our study evaluated the prognostic significance of baseline and postoperative CTC in patients with early non-small cell lung cancer (NSCLC) through a meta-analytic approach. Methods: Prospective studies comparing sur...
Article
Introduction: Tumor budding is an established prognostic factor in various solid tumors, including colorectal cancers and oral squamous cell carcinomas. However, its role is unclear and needs to be defined for squamous cell carcinoma of the lung (LSCC). Hence, we conducted a systematic review and meta-analysis investigating the prognostic role of...
Poster
Full-text available
Parkinson’s disease (PD) is the 2nd most common neurodegenerative disease (6.2 million people). Complex etiology with both genetic and environmental factors contributing to its development. Recent met-analysis of GWAS by the international Parkinson Disease Genomics Consortium (IPDGC) identified 78 loci, which explain only a fraction of heritability...
Article
Full-text available
BackgroundPD-1/PD-L1 inhibitors prolong survival in treatment-naïve, locally advanced, and metastatic non-small cell lung cancer (NSCLC) with positive PD-L1 expression (> 1%/ > 50%). Recent evidence has suggested that tumors with < 1% PD-L1 expression may also be predictive of PD-1/PD-L1 inhibiting agents.Methods Systematic review and meta-analysis...
Article
Full-text available
Background: Two studies that examined the interaction between HLA-DRB1 and smoking in Parkinson's disease (PD) yielded findings in opposite directions. Objective: To perform a large-scale independent replication of the HLA-DRB1 × smoking interaction. Methods: We genotyped 182 single nucleotide polymorphism (SNPs) associated with smoking initia...
Article
Full-text available
Our aim was to determine whether the genetic liability to sleep and pain-related traits have a causal effect on risk of neurodegeneration in individuals of predominantly European ancestry. We selected five neurodegenerative disorders, namely, age-related macular degeneration (AMD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), mult...
Article
Full-text available
Pneumonia, an acute respiratory tract infection, is one of the major causes of mortality worldwide. Depending on the site of acquisition, pneumonia can be community acquired pneumonia (CAP) or nosocomial pneumonia (NP). The risk of pneumonia, is partially driven by host genetics. CYP1A1 is a widely studied pulmonary CYP family gene primarily expres...
Article
Full-text available
Background Previous studies showed that lifestyle behaviors (cigarette smoking, alcohol, coffee) are inversely associated with Parkinson’s disease (PD). The prodromal phase of PD raises the possibility that these associations may be explained by reverse causation. Objective To examine associations of lifestyle behaviors with PD using two-sample Me...
Article
Full-text available
Background: Evidence on the role of curative metastasectomy (CM) for malignant melanoma (MM) patients is limited, especially in the current era of effective systemic therapy. A systematic review and meta-analysis were performed to ascertain the role of CM compared with incomplete or nonsurgical treatment for patients with MM. Methods: Medline, E...
Article
Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding. Objective: The aim is to examine the association between genetically predicted dairy intake and PD using two-sampl...
Article
Full-text available
Background There is limited evidence on the role of the type of lobectomy after primary lung cancer with postoperative cerebral infarction (CI). The purpose of this review was to evaluate the role of left upper lobectomy (LUL) in pulmonary vein thrombosis (PVT) and eventual CI.MethodsA search was performed on MEDLINE, Embase, and Web of Science fro...
Preprint
Full-text available
The risk for community acquired pneumonia (CAP) is partially driven by genetics. To identify the CAP-associated genetic risk loci, we performed a meta-analysis of clinically diagnosed CAP (3310 individuals) with 2655 healthy controls. The findings revealed CYP1A1 variants (rs2606345, rs4646903, rs1048943) associated with pneumonia. We observed rs26...
Article
Full-text available
Background: A recently published East Asian genome-wide association study of Parkinson;s disease (PD) reported 2 novel risk loci, SV2C and WBSCR17. Objectives: The objective of this study were to determine whether recently reported novel SV2C and WBSCR17 loci contribute to the risk of developing PD in European and East Asian ancestry populations...
Preprint
Full-text available
Objective To examine whether sleep and pain-related traits have a causal effect on the risk of neurodegeneration. Design Two-sample Mendelian randomization using an inverse-variance weighted (IVW) estimate of the summary effect estimates. Setting Genetic data on sleep and pain-related traits and neurodegenerative disorders (NDD) from various cohort...
Article
Full-text available
Over the past two decades, our understanding of Parkinson's disease (PD) has been gleaned from the discoveries made in familial and/or sporadic forms of PD in the Caucasian population. The transferability and the clinical utility of genetic discoveries to other ethnically diverse populations are unknown. The Indian population has been under-represe...
Preprint
Full-text available
Background Impaired glucose and obesity are frequently observed in patients with Parkinson’s disease (PD), although it is unclear whether the impairment precedes or results from the neurodegeneration. Objective We aimed to assess whether glycemic and anthropometric traits can influence the risk of PD in 33,674 cases and 449,056 healthy controls us...
Article
Full-text available
Understanding patients’ genomic variations and their effect in protecting or predisposing them to drug response phenotypes is important for providing personalized healthcare. Several studies have manually curated such genotype–phenotype relationships into organized databases from clinical trial data or published literature. However, there are no te...
Preprint
Full-text available
OBJECTIVE: To investigate whether coexistence of various neurodegenerative disorders is coincidental or biologically connected. DESIGN: Two sample Mendelian randomization using summary effect estimates. SETTING: Genetic data taken on various neurodegenerative disorders from various cohorts comprising individuals predominantly of European ancestry....
Preprint
Full-text available
I examined the potential bi-directional causality between educational attainment (EA) (n = 766,345) and age related macular degeneration (AMD) (cases (n) =16144, controls (n) =17832) using the summary GWAS datasets on individuals with European ancestry. I used datasets on other late-onset neurodegenerative diseases including Alzheimers disease (AD)...
Preprint
Full-text available
Objective: Dopaminergic neurotransmission is known to be a potential modulator of risky behaviors including substance abuse, promiscuity, and gambling. Furthermore, observational studies have shown associations between risky behaviors and Parkinson's disease; however, the causal nature of these associations remains unclear. Thus, in this study, we...
Article
Full-text available
Background: Mendelian randomization (MR) is fast becoming a popular method to judge causality from routinely conducted observational studies. However, stringent underlying statistical assumptions, missing biological information, and high sample size requirement might make it prone to misuse. Furthermore, rapidly updating methodologies and increasi...
Article
Full-text available
Background: Nearly 40%–50% of the individuals fail to respond to first line antiepileptic drug (AED) monotherapy and 30% are refractory, which calls for the need to recognize predictive markers for treatment failure. This study aims to identify clinical factors predictive of a poor prognosis in patients on AED therapy. Materials and Methods: A pros...
Presentation
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A quick introduction to MR for beginners
Article
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Background: Alzheimer disease (AD) is a progressive neurodegenerative disease with a complex multifactorial etiology. Here, we aim to identify a biomarker pool comprised of genetic variants and blood biomarkers as predictor of AD risk. Methods: We performed a case-control study involving 108 cases and 159 non-demented healthy controls to examine...
Presentation
Full-text available
A quick introduction to quality control of GWAS
Data
Table S1. Gene‐wise summarized status of SNPs for final genotype‐phenotype correlation. Table S2. Association of variants in all epilepsy patients and seizure type subgroups. Table S3. Association of variants in all epilepsy patients and epilepsy type subgroups. Table S4. Gene‐gene interaction results for best models among SVC and ion channel ge...
Article
"Common epilepsies", merely explored for genetics are the most frequent, nonfamilial, sporadic cases in hospitals. Because of their much debated molecular pathology, there is a need to focus on other neuronal pathways including the existing ion channels. Methods: For this study, a total of 214 epilepsy cases of North Indian ethnicity comprising 59....
Article
Full-text available
Aim: The present study aimed to evaluate association of genetic variants on drug response and therapy optimization parameters in patients treated with first-line antiepileptic drugs (AEDs). Genetic variants from ion channels, their functionally related genes, and synaptic vesicle cycle (SVC) genes with a potential role in epilepsy pathophysiology...
Article
Full-text available
Introduction “Common epilepsies”, merely explored for genetics are the most frequent, nonfamilial, sporadic cases in hospitals. Because of their much debated molecular pathology, there is a need to focus on other neuronal pathways including the existing ion channels. Methods For this study, a total of 214 epilepsy cases of North Indian ethnicity c...
Article
Full-text available
CYP1A1 gene is involved in estrogen metabolism, and previously, we have reported association of variant rs2606345 with altered anti-epileptic drugs (AED) response in North Indian women with epilepsy (WWE). The present study aims to replicate the pharmacogenetic association, perform functional characterization and study its distribution within ethni...
Article
Full-text available
The possible association between Apolipoprotein E (ApoE) levels in the cerebrospinal fluid (CSF) and Alzheimer's disease (AD) has been studied extensively. However, previous findings have been inconsistent. We conducted a meta-analysis of observational studies, seeking to provide insights into ApoE's potential as a biomarker for AD. A systematic li...
Article
Full-text available
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by loss of memory and other cognitive functions. AD can be classified into familial AD (FAD) and sporadic AD (SAD) based on heritability and into early onset AD (EOAD) and late onset AD (LOAD) based on age of onset. LOAD cases are more prevalent with genetically comp...
Article
Full-text available
Context: Phenytoin (PHT) is one of the frontrunner drugs used as monotherapy in the management of epilepsy. It is also one of the most common drugs causing adverse drug reactions (ADRs). The aim of this study was to study the relationship between serum PHT levels and the age, gender, dosage and genetic polymorphisms in a North Indian population. Th...
Chapter
Systems pharmacology involves the application of systems biology approaches, integrating high throughput experimental data from different experimental techniques such as genomics and proteomics involving computational analytical approaches, to understand the mechanism of action of drugs, identify potential drug targets, use existing drugs for other...
Article
Full-text available
Literature indicates key role of glutamatergic pathway genes in antipsychotic response among schizophrenia patients. However, molecular basis of their underlying role in antipsychotic response remained unexplained. Thus, to unravel their molecular underpinnings, we sought to investigate interactions amongst GRM3, SLC1A1, SLC1A2, SLC1A3, SLC1A4 gene...
Article
Full-text available
Background: Neuroreceptors are considered to be primary drug targets and their abrupt signaling is a notable cause of interindividual drug response variability and treatment failure for complex neuropsychiatric diseases. In view of recent evidence, it is believed that common genetic risk factors mainly highly polymorphic neuroreceptors are being s...
Poster
Souce: http://www.eswiconference.org/core/wp-content/uploads/2014/03/5EIC_abstractbook_def.pdf Background: Pediatric seizures cause significant disease burden and distress to patients, parents and caregivers. Febrile seizures in children are commonly triggered by acute respiratory infections. Complicated febrile seizures and afebrile seizures may b...
Article
Full-text available
Aim: Warfarin, a widely used anticoagulant, exhibits large interindividual variability in dose requirements. CYP2C9 and VKORC1 polymorphisms in various ethnic groups have been extensively studied as genetic markers associated with variable drug response. However, allele frequencies of these variants have not been assessed in major ethnic groups in...
Article
Full-text available
Literature suggests that disease severity and neurotransmitter signaling pathway genes can accurately identify antipsychotic response in schizophrenia patients. However, putative role of signaling molecules has not been tested in schizophrenia patients based on severity of illness, despite its biological plausibility. In the present study we invest...
Poster
Source: http://www.isirv.org/site/images/stories/avg/documents/intranet/Tokyo/programe_abstract_book.pdf Objectives: Wheezing is a common symptom in early childhood, often triggered by acute respiratory infections and influenza like illness (ILI). At the same time, i.e. during the first 5 years of life, the majority of childhood vaccines are admini...
Poster
Source: http://espid2015.kenes.com/PublishingImages/scientific-information/espid-abstracts/ESPID%202014%20abstracts.pdf Background and Aims: Human Parechovirus (HPeV) infections may cause a variety of clinical symptoms in children, but syndromic surveillance data are currently lacking. This study aims to assess HPeV-associated disease burden in inf...
Article
Full-text available
Background: Influenza infections induce considerable disease burden in young children. Biomarkers for the monitoring of disease activity at the point-of-care (POC) are currently lacking. Recent methodologies for fluorescence-based rapid testing have been developed to provide improved sensitivities with the initial diagnosis. The present study aims...
Article
Full-text available
Alzheimer's disease (AD) is one of the leading genetically complex and heterogeneous disorder that is influenced by both genetic and environmental factors. The underlying risk factors remain largely unclear for this heterogeneous disorder. In recent years, high throughput methodologies, such as genome-wide linkage analysis (GWL), genome-wide associ...
Poster
Full-text available
Alzheimer’s disease (AD) is a genetically complex disease. The underlying risk factors remain largely unclear for this heterogeneous disorder. In recent years high throughput methodologies such as genome-wide expression profiling (GWE), genome-wide linkage analysis (GWL) and genome-wide association (GWA) studies have led to the identification of se...