Sanath Rajapakse

Sanath Rajapakse
University of Peradeniya | UOP · Department of Molecular Biology and Biotechnology

BSc, M.Phil, PhD

About

96
Publications
24,289
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784
Citations
Citations since 2017
29 Research Items
454 Citations
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
Additional affiliations
April 2006 - present
University of Peradeniya
Position
  • Professor

Publications

Publications (96)
Article
Full-text available
Recently, self-cleaning/superhydrophobic surface modifications have become an important and demandable field in the textile industry. Superhydrophobicity is the leading property in obtaining dirt and dust-free self-cleaning surfaces. However, water is essential for removing dust or dirt particles from a superhydrophobic surface. In this study, anot...
Article
Type II restriction enzymes (REs) which can cleave double stranded DNA in a sequence specific manner have many applications in recombinant DNA technology and are considered the workhorses of molecular biology. This study was carried out to screen bacterial communities for restriction enzymes. Soil and water samples were screened for isolation of ba...
Article
Full-text available
Modulation of the host immunity is one of the important functions rendered by the human gut microbiota. Tumor cells are able to exploit the host immune system for their survival and spread within the host. Cancer immunotherapy is one of the therapeutic strategies that are used to stimulate the host anti-tumor immune response against cancer cells. I...
Conference Paper
Full-text available
Melicope lunu-ankenda is an important medicinal plant of the family Rutaceae, commonly distributed in the mid-country wet and montane zones in Sri Lanka and tropical regions of Asia. Previous studies have displayed the chemistry and bioactivity of the plant found in various regions in Asia. This study focuses on the bioactivities of the leaf and ba...
Article
Full-text available
Dehydration of 96.4 vol% ethanol was carried out using three biomaterials: rice straw, paddy husk and castor oil to identify a cheap biomaterial for ethanol dehydration. Dehydration using rice straw and paddy husk was separately carried out by circulating 96.4-vol% ethanol through a glass tube filled with the biomaterial. The concentration of the c...
Article
Inflammation is a protective mechanism against invading pathogens and tissue damage. However, the inflammatory process is implicated in a wide range of diseases affecting all organs and body systems. Nitric oxide — a multifunctional signaling molecule that plays a critical role in systemic blood pressure homeostasis, prevention of platelet aggregat...
Article
The epidemic of chronic kidney disease of unknown etiology (CKDu) that contributes significantly to morbidity and mortality rates among dry-zonal farming communities has become a public health priority in Sri Lanka. Though a large number of hypotheses were introduced as causative factors, none of them have been confirmed so far. As drinking water q...
Preprint
Full-text available
Type II restriction enzymes (REs) which can cleave double stranded DNA in a sequence specific manner have many applications in recombinant DNA technology and are considered the work horses of molecular biology. Soil and water samples were screened for isolation of bacteria, harboring restriction enzymes. Cell lysates of isolated bacteria were incub...
Article
Full-text available
Mg/Al Layered Double Hydroxides (LDHs) were functionalized to immobilize the serine protease, trypsin. Three methods were implemented for immobilization: physical adsorption, entrapment and covalent cross-linking. Trypsin was immobilized in Mg/Al- NO3- LDH via simple adsorption. The same LDH host was modified with Sodium Dodecyl Sulphate (SDS) whic...
Article
Full-text available
Rhizobia are well-reputed biological nitrogen fixing organisms due to their proficiency in symbiotic root nodule formation with leguminous plants. Gliricidia sepium is a widely distributed legume which hosts a wide range of rhizobia. Few studies have been carried out to identify the stress tolerant rhizobial populations inhabiting G. sepium in Sri...
Article
Full-text available
Glutathione Peroxidase activity in whole blood is well correlated with the Selenium (Se) levels in cattle hence can be used effectively to assess the supply of Se to farm animals. In this study, Se status of cattle from five different geographic regions of Sri Lanka were assessed based on glutathione peroxidase (GSH-Px) activity. The GSH-Px activit...
Article
Full-text available
Chitinases belong to a diverse family of enzymes among many other hydrolytic enzymes of the pitcher fluid of Nepenthes sp. There are no existing studies on identification of chitinases in Nepenthes distillatoria the only representative of the genus Nepenthes in Sri Lanka. In this study an assay procedure was developed and optimized to detect the ch...
Article
Full-text available
Purpose: Gliricidia sepium is a wide spread multipurpose legume plant which is effective in nitrogen fixation and host to many Rhizobial strains. However, few studies have been carried out to identify and characterize the Rhizobial populations inhabiting G. sepium in Sri Lanka. The main objective of this study was to isolate and identify the stress...
Article
Full-text available
Discovering and monitoring anuran populations that are in decline, and ascertaining boundaries for cryptic and rare species, is a challenge for their conservation management. Here, we integrate three techniques, bioacoustics (call), niche modeling and DNA barcoding as a test case to investigate how the combination of these methods can enhance searc...
Conference Paper
Full-text available
Type II Restriction enzymes (REs) can be used to cleave double stranded DNA in a sequence specific manner to produce fragments with desired ends. Herein, we report the first attempt to screen and isolate REs from bacteria in Sri Lankan soil and water samples collected from different regions of the country. Bacteria isolated from samples were grown...
Article
Full-text available
For the past hundred years since the discovery of vitamin A, the field of research associated with retinoids has been well evolved due to advances in molecular biology, chemistry, biochemistry and medicine. Vitamin A is an essential component in diet. Major derivatives of vitamin A such as retinol, retinaldehydes and retinoic acid are collectively...
Article
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Corypha umbraculifera L., the long lived monocarpic palm belonging to Arecaceae, is rare in the wild and is a possible candidate, which can be developed as an economic plant in Asia. However, little information is available about propagation of this species from seeds. Thus, we aimed to investigate the basic seed biology of this species and to faci...
Conference Paper
Full-text available
Legume plants have the ability to fix atmospheric nitrogen symbiotically with the association of Rhizobium that inhabits the root nodules. Cletoria ternatea L. is a legume, which grows naturally in dry and less fertile lands. It has the ability to fix nitrogen even under harsh environmental conditions. The present study was aimed at screening the R...
Article
Full-text available
Background Samples of 226 new improved and 21 indigenous rice (Oryza sativa L.) varieties were collected from the rice fields in three climatic zones of Sri Lanka and concentrations of 18 trace elements (Li, B, Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, Pb and Bi) were measured giving particular emphasis on Se, Cd and As using ICP-MS....
Conference Paper
Full-text available
Biological nitrogen fixation is an important natural process widely used in agriculture and forestry. Legume plants have the ability to fix atmospheric nitrogen symbiotically with the association of Rhizobium that inhabits the root nodules of these plants. Mimosa pudica which belongs to the family Fabaceae is a weed that grows naturally in a wide r...
Article
Full-text available
The genus Piper has high commercial importance as it contains cultivated crops (black pepper and betel) and medicinal plants that are mostly used in traditional medicine. In Sri Lanka the genus Piper is represented by ten species including five wild species. It is necessary to examine their chemical composition and morphology as they have received...
Article
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Phosphorous deficiency (PD) tolerance is a pivotal trait that is advantageous if present in modern day high performing rice varieties. However most of the frequently grown mega rice varieties lack this trait leading to expensive application of artificial phosphate fertilizer results secondary consequences such as environmental pollution and higher...
Article
Full-text available
Antibiotics are powerful medicines that are used either to inhibit bacterial growth or to destroy bacteria. There are eight different types of antibiotics and the most suitable antibiotic for a particular disease is prescribed by a clinician. Overuse of antibiotics may cause severe problems such as side effects and development of resistance to such...
Article
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Tephrosia is a genus of medicinally important perennial shrubs or herbs distributed in warm temperate and tropical regions, and belongs to Family Fabaceae. The genus is represented in Sri Lanka with 10 species. The objective of the present study was to interpret interspecific relationships of Tephrosia species in Sri Lanka using phenetic and phytoc...
Conference Paper
Full-text available
Secondary metabolites produced by plants and animals have biochemical effects in man, animals and other plants. The huge amounts of such compounds have a broad range of effects, from being acute deadly to being healthy or curative. Objective: This research project was undertaken to investigate some pharmacological properties of five medicinal plant...
Article
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Sweet orange (Citrus sinensis), a key fruit species, is considered as a primary ingredient in herbal medical formulations against ailments such as food borne diseases. Sour orange (C. aurantium) is also very famous as a medicinal plant. There are six commonly grown sweet orange cultivars in Sri Lanka (Arogya, Bibila sweet, MKD, Sisila, BAN and MT)...
Article
Sweet orange (Citrus sinensis), a key fruit species, is considered as a primary ingredient in herbal medical formulations against ailments such as food borne diseases. Sour orange (C. aurantium) is also very famous as a medicinal plant. There are six commonly grown sweet orange cultivars in Sri Lanka (Arogya, Bibila sweet, MKD, Sisila, BAN and MT)...
Article
Full-text available
The genus Piper which is the largest genus in the family Piperaceae is economically important as it comprises with valuable crop species as well as several wild species. Although ten species of genus Piper are recorded in Sri Lanka, their interspecific relationships were not well studied. Therefore, the aim of this study was to determine interspeci...
Conference Paper
Full-text available
PREPARATION OF NIOBIUM-DOPED TITANIUM DIOXIDE NANO RODS USING REFLUXING SOL-GEL METHOD R.B.S.D. Rajapaksha1,2, C.A. Thennakoon1,2 and R.M.G. Rajapakse1,2* 1Department of Chemistry, University of Peradeniya, Peradeniya 20400, Sri Lanka 2Postgraduate Institute of Science, University of Peradeniya, Peradeniya, Sri Lanka *rmgr@pdn.ac.lk TiO2 has been...
Conference Paper
In Sri Lanka, no large scale systematic search of its biological agents has been conducted. Thus bioactivity of Sri Lankan endemics remains largely unknown. The present study is aimed on the bioactivity of medicinally important endemic plant Acrotrema uniflorum Hook [Dilleniaceae, Gon-diva(S)]. Acrotrema uniflorum is distributed in shady moist plac...
Research
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ABSTRACT Genus Tephrosia (Fabaceae) commonly known as ‘Pila’ in Sri Lanka. Some Tephrosia spp. are used in many traditional therapeutic preparations in Sri Lanka and in some other countries. Increased use of Tephrosia in traditional therapeutic systems has developed a great demand for these species. Thus production of planting materials for commerc...
Research
Full-text available
Flueggea leucopyrus belongs to family Phyllanthaceae, commonly known as ‘Katupila’or ‘Heen katupila’ and has become increasingly popular as an ingredient in several traditional therapeutic systems in Sri Lanka as well as in other Asian countries. A Questionnaire survey was carried out using a hundred population sample to determine the awareness of...
Article
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Previously, we reported that the medaka testis abundantly expresses the mRNA for trypsinogen, which is a well-known pancreatic proenzyme that is secreted into and activated in the intestine. Currently, we report our characterization of the medaka trypsin using a recombinant enzyme and show that this protein is a serine protease that shares properti...
Article
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We previously reported that the serine protease plasmin plays a role in follicle rupture during ovulation in the teleost medaka. In this study, we showed that urokinase-type plasminogen activator 1 (Plau1) is a physiological activator of plasminogen. Morphological analyses revealed that in the preovulatory follicle, plau1 mRNA was detected in assoc...
Article
Full-text available
Dairy cattle industry plays a prominent role in Sri Lankan economy because of the very high consumption of dairy milk and dairy products. Artificial Insemination is frequently used to inculcate improved performances such as high milk yield and better adaptability to the cows. However, the accuracy and outcome of Artificial Insemination is sometimes...
Conference Paper
Full-text available
No: 441 (Poster) Food, Nutrition and Livestock The development of dairy sector in Sri Lanka is very important for the sustainable economic development. Economically important traits such as milk yield and meat quality are quantitative traits. Hence, the identification of QTL (Quantitative Trait Loci) responsible for economically important traits is...
Conference Paper
Full-text available
No: 485 Food, Nutrition and Livestock Substitution of expensive meat types with cheaper or unaccepted meat types is a major problem associated with the meat industry in Sri Lanka. Chicken meat adulteration with cat meat has been reported from many countries, including India. Therefore, a part of this study was focused on differentiating chicken and...
Conference Paper
Full-text available
No: 441 (Poster) Food, Nutrition and Livestock The development of dairy sector in Sri Lanka is very important for the sustainable economic development. Economically important traits such as milk yield and meat quality are quantitative traits. Hence, the identification of QTL (Quantitative Trait Loci) responsible for economically important traits is...
Article
The synthesis and characterization of ZnO-nanoparticle-incorporated natural rubber latex foam (NRLF) are described in this article. ZnO nanoparticles were added as the primary gelling agent by the replacement of the microsized ZnO particles, whereas the control sample of the NRLF was made without the addition of any ZnO particles. ZnO nanopowder wa...
Article
The synthesis and characterization of ZnO-nanoparticle-incorporated natural rubber latex foam (NRLF) are described in this article. ZnO nanoparticles were added as the primary gelling agent by the replacement of the microsized ZnO particles, whereas the control sample of the NRLF was made without the addition of any ZnO particles. ZnO nanopowder wa...
Data
Full-text available
makes every effort to ensure the accuracy of all the information (the "Content") contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in...
Article
Silver nanoparticles are often applied to textiles for their strong antimicrobial activity and potential uses in various applications. The treatment of fabrics with silver nanoparticles has often involved complex or expensive processes, required surface post treatment, lacked durability and altered desirable properties related to the comfort of the...
Article
Full-text available
Silver nanoparticles (SNP) incorporated potassium oleate (KOL) soap by in situ reduction of silver nitrate by trisodium citrate (TSC) was described. Novel incorporation method of SNP into the natural rubber latex foam (NRLF) was successfully carried out by mixing 4 parts per hundred rubber (pphr) of SNP incorporated KOL soap in to the natural rubbe...
Article
Full-text available
The molecular properties and roles of luteinizing hormone (Lh) and its receptor (Lhcgrbb) have not been studied for the medaka (Oryzias latipes), which is an excellent animal model for ovulation studies. Here, we characterized the medaka Lh/Lhcgrbb system, with attention to its involvement in the ovulatory process of this teleost fish. In the medak...
Data
makes every effort to ensure the accuracy of all the information (the "Content") contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in...