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Publications (14)
Vitreo-retinal surgical techniques have transformed since the introduction of pars plana vitrectomy in 1970. Advancements include smaller gauge instrumentation, faster cut rates, improved illumination methods, wider-field viewing systems, and the use of various tamponade agents and perfluorocarbon.
Purpose:
The purpose of this study was to measure change in anterior lamina cribrosa depth (ALD) globally and regionally in glaucoma eyes at different intraocular pressures (IOP).
Methods:
Twenty-seven glaucoma patients were imaged before and after IOP-lowering procedures using optical coherence tomography. The anterior lamina was marked in appr...
Importance
Eyes of patients with glaucoma may be damaged during sleep.Objective
To measure strains in glaucoma eyes and control eyes produced by mechanical force or deformation of the eye from contact when one side of the face rests against a pillow.Design, Setting, and Participants
This study took place in a clinic-based setting among 22 patien...
The presence of non-autologous major histocompatibility complex class I (MHC-I) molecules on the surface of the grafted cells is one of the main reasons for their rejection in non-syngeneic hosts. We present a straightforward strategy to decrease the presence of MHC-I by shRNA inhibition of beta-2-microglobulin (B2M), a conservative light chain of...
LMAN1 is a type I transmembrane protein that selectively transports its cargo proteins from ER to ER-Golgi intermediate compartment (ERGIC) and Golgi. Lman1 is a direct target of the transcription factor NRL in mouse retina. Therefore, we examined the in vivo function of LMAN1 in retina. Although Lman1
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mouse eyes did not show abnormality in h...
One of the major obstacles to repair damaged myocardium with embryonic stem cell derived cardiomyocytes (ESC-CM) is their rejection by non-syngeneic hosts. We aimed to reduce the immunogenicity of these cells by downregulation of MHC class I molecules (MHC-I) on their surface. Cardiomyocytes were derived from mouse ESC in which puromycin resistance...
