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54
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Introduction
Current institution
Additional affiliations
August 2024 - present
October 2010 - December 2013
Publications
Publications (54)
Background and Aims
Due to the reduction in immunity caused by auto‐splenectomy and the consequent opsonic antibody shortage, patients with SCD are more susceptible to encapsulated organism infections, especially asymptomatic urinary tract infection (ASM‐UTI). This study investigated the prevalence of ASM‐UTI and compared urine and hematology param...
Background: Due to the reduction in immunity caused by auto-splenectomy and the consequent opsonic antibody shortage, patients with SCD are more susceptible to encapsulated organism infections, especially asymptomatic urinary tract infection (ASM-UTI). This study investigated the prevalence of asymptomatic urinary tract infection and compared urine...
Background: Sport training places significant demand on athletes, motivating them to seek strategies to enhance performance and maintain competitiveness. The use of ergogenic aids has become prevalent in sport, although not without potential risks. Hibiscus-ginger juice, rich in vitamins and minerals, has been suggested to improve metabolism, aid i...
Benign prostatic hyperplasia is a major pathophysiologic event that presents a high risk for prostate cancer (the second most frequently diagnosed cancer in men). The prognosis of conventional therapy for BPH remains poor due to treatment failures. Thus, natural remedies such as botanical drugs remain a promising alternative therapy to be explored...
Assessment of the burden of disease and techniques for clinical diagnosis could ultimately help in schistosomiasis control. This study assessed the impact of exercises and water intake on ova recovery during laboratory diagnosis and schistosomiasis-associated urinary symptoms and quality of life (QOL) among inhabitants of Dendo, an endemic communit...
The psychosocial climate of universities becomes very important because of the increasing student enrolment, academic-administrative duties, the quest for promotion, the fast-changing mode of lesson delivery, all leading to work overload. This study aims to examine the influence of psychosocial factors on burnout of employees of a public university...
Background: Because of the essential nature of the work of medical laboratory professionals, continuing development in knowledge and skills is indispensable. The study aimed at identifying and prioritizing the development and training needs of medical laboratory professionals in Ghana. This is expected to help in developing focused continuing profe...
Background
Because of the essential nature of the work of medical laboratory professionals, continuing development in knowledge and skills is indispensable. The study aimed at identifying and prioritizing the development and training needs of medical laboratory professionals in Ghana. This is expected to help in developing focused continuing profes...
This study aimed to investigate the extent to which work-related burnout and psychosocial environment predicted intention to leave employment. This cross-sectional survey sampled 1 222 Ghanaian university employees (females = 37.1%; age range = 18 to above 60 years; mean years of work experience = 5 years, SD = 3.1 years). The employees completed D...
Background:
In recent times, cervical dysbiosis which mostly causes and aggravates infections is highlighted for its role in immune modulation in cervical dysplasia, which promotes the shifting of Th1 phenotype immunity to Th2 phenotype immunity. This study therefore estimated and compared the levels of circulatory IL-4, IL-6, IL-10, TNF-α, and IF...
Background
Adequate knowledge and proper practices coupled with knowledge of the burden of disease are necessary for the eradication of Schistosoma infection. This study assessed knowledge, attitude, and practice (KAP) as well as health outcomes related to Schistosoma haematobium infection at Kwahu Afram Plains North District (KAPND).
Methods
A cr...
Cervical cancer (CC) continues to be a global burden, and a disease of public health interest, especially in low-and middle-income countries. This study explored the knowledge and awareness of human papillomavirus (HPV) infection and CC and the risk-behavioral characteristics of an adult female population in rural Ghana. A total of 274 women, aged...
Invasive fungal infections (IFI) and medical mycology receive little attention in Ghana. However, the present evolution of biomarker assays for IFI, offers an opportunity for an increased access to fungal laboratory testing in resource-limited settings, and probably make a case for availability of essential antifungal agents. Using surveys and pers...
Background: Because of the essential nature of the work of medical laboratory professionals, continuing development in knowledge and skills is indispensable. The study aimed at identifying and prioritizing current development and training needs of medical laboratory professionals in Ghana in order that there can be a focused continuing professional...
Schistosoma haematobium continues to pose a significant public health burden despite ongoing global control efforts. One of several barriers to sustained control (and ultimately elimination) is the lack of access to highly sensitive diagnostic or screening tools that are inexpensive, rapid, and can be used at the point of sample collection. Here, w...
Objective
The use of agarose in nucleic acid electrophoresis is the gold standard. However, agarose is very expensive and not readily available in resource limited developing countries like Ghana. Hence, finding a more affordable and readily available alternative to agarose will be a major boost to molecular research in developing countries. This s...
Schistosoma haematobium continues to pose a significant public health burden despite ongoing global control efforts. One of several barriers to sustained control (and ultimately elimination) is the lack of access to highly sensitive diagnostic or screening tools that are inexpensive, rapid, and can be utilized at the point of sample collection. Her...
Introduction: COVID-19 pandemic has had a greater psychological impact on patients with chronic ailments such as diabetes mellitus, tuberculosis, and HIV/AIDS compared to those without chronic conditions. We explored the psychological impacts of COVID-19 among people living with diabetes mellitus in Ghana.
Methods: this study employed a hospital-b...
Objective
The use of agarose in nucleic acid electrophoresis is the gold standard. However, agarose is very expensive and not readily available in resource limited developing countries like Ghana. Hence, finding a more affordable and readily available alternative to agarose will be a major boost to molecular research in developing countries. This s...
There is a global rise in the emergence of infectious diseases and the enigmatic coronavirus disease 2019 (COVID-19) being the most recent one. It is ravaging the world with little understanding of its etiology and factors affecting its transmission dynamics. Meanwhile, seasonal variations in weather are major factors impacting infectious disease t...
There is a global rise in the emergence of infectious diseases and the enigmatic coronavirus disease 2019 (COVID-19) being the most recent one. It is ravaging the world with little understanding of its etiology and factors affecting its transmission dynamics. Meanwhile, seasonal variations in weather are major factors impacting infectious disease t...
Coronavirus disease 2019 (COVID-19) since its declaration as a pandemic by world health organization (WHO) has spread across the various continent with little known about the most effective public health response for containing and mitigating the transmission of the epidemic. It is important to state that some authors have published on the lessons...
Background. HIV infection is marked by the production of cytokines by infected cells and cells of the immune system. Variations in the levels of cytokine in HIV-infected individuals significantly impact the role of the immune system with the possibility to affect the course of HIV disease by either exacerbating or suppressing HIV replication. Aim....
Hepatitis B viral infection (HBV) remains a global health threat. About 257 million people currently living with HBV worldwide. HBV is prevalent in sub-Saharan Africa with prevalence of >8% established including West Africa. Though Anti-HBV vaccines existed since 1982, as the single most important Hepatitis B prevention measure. Ghana started activ...
Background : Cardiovascular diseases (CVD) continue to be a major cause of death among post-menopausal women. We sought to assess cardiovascular risk among pre- and post-menopausal women living within the Cape Coast Municipality by comparing the lipid profiles and other emerging biomarkers of CVD, i.e. the atherogenic index of plasma (AIP), viscera...
This study reports the electrochemical activities of a novel ion substituted-Hydroxyapatite (HAp) material in contact with HeLa cells. The work was performed to evaluate the inhibitory effects of various concentrations of HAp on ion transfer mechanisms in HeLa cells. The materials (n = 2: HAp1 and HAp3) were prepared at different stirring times fro...
This study reports the electrochemical activities of a novel ion substituted-Hydroxyapatite material in contact with HeLa cells. The work was performed to evaluate the inhibitory effects of various concentrations of the material on the ion transfer mechanisms in HeLa cells. The materials (n=2: HAp1 and HAp3) were prepared at different stirring time...
Abstract Background The need to study the outcome of Antiretroviral Therapy (ART) among Human Immunodeficiency Virus (HIV) infected individuals in Ghana, a sub-Saharan African country crucial in the era of the “Treat All” policy. The aim of this study was to analyze selected determinants of immunological and virological response to ART among HIV in...
Background: Intestinal parasitic infections are common in the developing world, particularly among communities with low socio-economic status. Many of these infections are very often neglected making them a major public health problem. Objectives: This study was conducted to determine the prevalence of intestinal parasite infections among primary s...
Background:
Mercury is a toxic metal with its effects on human health ranging from acute to chronic in a very short time of exposure. Artisanal and small-scale gold mining (ASGM) is the main source of direct human exposure to mercury.
Aim:
To access the effect of mercury exposure on the renal function and level of personal protective equipment (...
Background
Urogenital schistosomiasis is a widely contracted parasitic helminth infection often associated with haematological abnormalities.
Aim
We investigated the relationship between the haematological profile and the intensity of schistosomiasis among children in the Yeji district.
Materials and Methods
A total of 100 participants comprising...
Background. Malaria is known to have devastating effects on mortality in tropical and subtropical regions with the effect being magnified in people with weakened immunity such as those in pregnancy. We assessed the effect of malaria on renal function of pregnant women receiving antenatal care in a mesoendemic area of Ghana. Methodology. A case-cont...
Background: Schistosoma haematobium co-infection with S. mansoni and soil-transmitted helminthes afflict most-at-risk populations in endemic communities in the developing world. Aim: This study investigated S. haematobium co-infection with soil-transmitted helminthes, and host risk factors in two communities in the central region of Ghana. Methods:...
Asymptomatic bacteriuria (ASB) is a major risk factor for urinary tract infections in most-at-risk populations. This study determined ASB positivity, common uropathogens, antimicrobial resistance (AMR) and risk factors of ASB among tertiary female students. A cross-sectional study was conducted on randomly recruited resident female students (n = 15...
Background:
Malaria ranks among the major health and developmental challenges facing some of the poorest countries in tropical and sub-tropical regions across the globe. We determined urinary abnormalities and its relationship with parasite density in children ≤12 years with Plasmodium falciparum infection.
Materials and methods:
From December 2...
Background: Intestinal parasitosis remains a major public health burden in developing countries such as Ghana. The burden of disease is heaviest among vulnerable populations and yet epidemiologic data from these populations are limited.
Objectives: The present study aimed at assessing the prevalence and risk factors of intestinal parasitosis among...
Background:
Sigma metrics provide a uniquely defined scale with which we can assess the performance of a laboratory. The objective of this study was to assess the internal quality control (QC) in the clinical chemistry laboratory of the University of Cape Cost Hospital (UCC) using the six sigma metrics application.
Materials and Methods:
We used c...
Background: Daily routine laboratory procedures may involve the use of the plasma of whole blood samples. However, assuming that all the plasma is used and there is the need to conduct a full blood count (FBC), what is the next logical move for the medical laboratory scientist? Is it possible to salvage the situation by possibly reconstituting the...
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Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play a major role in tumor-induced immunosuppression, which hampers effective immunotherapeutic approaches. β-Glucans have been reported to function as potent immunomodulators to stimulate innate and adaptive immune responses, which contributes to their anti-tumor proper...
Recent studies using an internal transcribed spacer (ITS)-based real-time polymerase chain reaction (PCR) for the detection of Schistosoma DNA in urine samples has shown high sensitivity and specificity when performed on controls and known microscopy-positive samples. In this study, using 730 urine samples collected from children in five primary sc...
Leptin modulates T cell function and plays an important role in autoimmune diseases. Our study aimed to explore the role of leptin and T helper type 17 (Th17) cells in Hashimoto's thyroiditis patients. Twenty-seven patients with Hashimoto's thyroiditis (HT) and 20 healthy controls were enrolled into the current study. A modest increase of plasma le...
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β-Glucans have been shown to function as a potent immunomodulator to stimulate innate and adaptive immune responses, which contributes to their anti-tumor property. However, their mechanisms of action are still elusive. Glucocorticoid-induced TNF receptor ligand (GITRL), a member of the TNF superfamily, binds to its receptor, GITR, on both effector...
Follicular helper T (Tfh) cells are recognized as a distinct CD4+ helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of autoimmune disease. So far, only one study investigated the circulating Tfh cells increased in a subset of SLE patients. Since rela...
Rheumatoid arthritis (RA), a chronic autoimmune form of inflammatory joint disease, progressively affects multiple joints with pathological changes in the synovia, cartilage, and bone. Numerous studies have suggested a critical role for glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR) in the pathogenesis of autoim...
Corynebacterium pyruviciproducens (C. pyruviciproducens), a newly discovered Corynebacterium, is gram-positive, non-flagellate, non-spore-forming lipophilic rod. No known pathogenic components of Corynebacteria have been found in this new bacterium, such as diphtheria toxin and tuberculostearic acid. In the present study, referring to Propionibacte...
Background:
IL-4 is a cytokine that induces differentiation of naive helper T cells into Th2 cells. Once activated by IL-4, Th2 cells subsequently produce additional IL-4.
Objective:
To examine the effect of IL-4 on IL-17 production and its effect in Collagen-Induced Arthritis (CIA) mice.
Method:
In this study, a chicken collagen-II-induced ex...
The study was undertaken to assess potential sources that might transmit Hospital Acquired Infections in the Volta Regional Hospital of Ghana.
A total of 218 swabs were taken over a six month study period of two weeks sampling bi-monthly from 33 different door handles, taps, desk surfaces and lavatories and 15 different surfaces in the theatre befo...
Intestinal helminths are among the most common and widespread of human infections, contributing to poor nutritional status, anaemia and impaired growth. Anaemia and iron deficiency in pregnancy is a major public health problem in developing countries, but their causes are not always known. The objective of this study was to assess the prevalence an...
The study aimed at determining the presence, type and nature of bacterial contamination of Ghanaian currency notes in circulation. One hundred currency notes of different denominations were randomly collected from sellers on the major streets and markets of the Cape Coast Metropolis into sterile paper bags, shaken in universal bottles with 10ml ste...
The study aim at comparing the antimicrobial (antifungal) properties of garlic, ginger and lime on Aspergillus flavus, Aspergillus niger and Cladosporium herbarum using organic and water base extraction. Pure cultures of the test fungal were isolated from rotten vegetables, air spora, and a swab of the skin surface whilst filtered plant extracts we...
