Samuel E Cooper

Samuel E Cooper
University of Texas at Austin | UT · Dell Medical School

PhD

About

27
Publications
4,072
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
312
Citations
Citations since 2017
25 Research Items
306 Citations
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
Introduction
I study human fear and anxiety, and their precipitants, mechanisms, and consequences. I use classical and instrumental conditioning paradigms as an investigative framework. More recently, I have become interested in using multivariate approaches to examine the structure of psychopathology, and then link that structure and broadband personality individual differences to neurobehavioral fear and anxiety mechanisms, particularly fear generalization. https://github.com/SamuelECooper
Additional affiliations
September 2013 - September 2018
University of Minnesota Twin Cities
Position
  • Instructor
September 2009 - June 2013
City University of New York - Hunter College
Position
  • Research Assistant
Education
September 2013 - August 2019
University of Minnesota Twin Cities
Field of study
  • Clinical Science and Psychopathology

Publications

Publications (27)
Article
Laboratory experiments using fear conditioning and extinction protocols help lay the groundwork for designing, testing, and optimizing innovative treatments for anxiety-related disorders. Yet, there is limited basic research on fear conditioning and extinction in obsessive-compulsive disorder (OCD). This is surprising because exposure-based treatme...
Article
Heightened generalization of conditioned fear and avoidance to safe stimuli resembling threat is a key feature of pathological anxiety and might contribute to the increased prevalence of anxiety-related disorders among women. Though rodent studies have documented over-generalized fear in females versus males, analogous work in humans is sparse, and...
Article
Dimensional models of obsessive-compulsive (OC) symptoms, as seen in obsessive-compulsive disorder (OCD), are instrumental in explaining the heterogeneity observed in this condition and for informing cutting-edge assessments. Prior structural work in this area finds that OC symptoms cross-load under both Negative Affectivity and Psychoticism traits...
Article
Full-text available
Generalization of conditioned fear is adaptive in some situations but maladaptive when fear excessively generalizes to innocuous stimuli with incidental resemblance to a genuine threat cue. Recently, empirical interest in fear generalization as a transdiagnostic explanatory mechanism underlying anxiety-related disorders has accelerated. As there ar...
Article
Full-text available
Given the increasing use of threat conditioning and generalization for clinical‐translational research efforts, establishing test–retest reliability of these paradigms is necessary. Specifically, it is an empirical question whether the same participant evinces a similar generalization gradient of conditioned responses across two sessions with the i...
Article
Generalization of conditioned fear to stimuli resembling a conditioned danger-cue (CS+) is proposed as a key mechanism of clinical anxiety. Given that threat contingencies can be ever changing in day-to-day life, the impact of such changes on generalization is critical to understanding how generalization manifests in the lives of those with and wit...
Preprint
Full-text available
Our capacity to measure diverse aspects of human biology in vivo has developed rapidly in the past decades, but the rate at which these techniques have generated translatable insights into the biology of psychopathological conditions has lagged far behind. This slow progress is partly due to the poor sensitivity, specificity, and replicability of m...
Article
Several decades of rodent neurobiology research have identified a network of brain regions that support Pavlovian threat conditioning and extinction, focused predominately on the amygdala, hippocampus, and medial prefrontal cortex (mPFC). Surprisingly, functional magnetic resonance imaging (fMRI) studies have shown inconsistent evidence for these r...
Preprint
Recent research has investigated the relationship between rigid political ideologies and underlying cognitive functions, highlighting discrepancies on how different ‘cognitive styles’ are defined and measured in relation with different shapes of social rigidity. Cognitive rigidity is often operationalized using problem solving which translates into...
Preprint
Given the increasing use of threat conditioning and generalization for clinical-translational research efforts, establishing test-retest reliability of these paradigms is necessary. Specifically, it is an empirical question whether the same participant evinces a similar generalization gradient of conditioned responses across two sessions with the i...
Preprint
Introduction: Acceptance and commitment therapy (ACT) has a rapidly developing evidence base, with few studies in the developing world or humanitarian context. A recent trial of a guided self-help intervention derived from ACT reported significant positive findings, but the extent to which the central principles of this intervention were maintained...
Preprint
Objective: Generalization of conditioned fear is adaptive in some situations but maladaptive when fear excessively generalizes to innocuous stimuli with incidental resemblance to a genuine threat cue. Recently, empirical interest in fear generalization as a transdiagnostic explanatory mechanism underlying anxiety-related disorders has accelerated....
Article
Substance use exacerbates psychosis, mania, depression, and poor functioning in people with first episodes of psychosis (FEP) and is associated with poor treatment outcomes, even when it does not reach the level of a formal disorder. Impaired insight and substance use are common issues that may interfere with treatment outcomes among people experie...
Article
Overgeneralization of conditioned fear to safe stimuli that resemble a previously-learned threat-cue is a well-studied correlate of clinical anxiety, yet whether conditioned disgust generalizes remains unknown, as does the extent to which such generalization is associated with disgust-related traits and maladaptive outcomes. The present study addre...
Article
Full-text available
People diagnosed with schizophrenia have been broadly observed to experience deficits in clinical and cognitive insight; however, less is understood about how these deficits are related. One possibility is that these deficits co-occur among people when other deficits in cognition are present, such as in executive function, social cognition, and met...
Preprint
Full-text available
Dimensional models of obsessive-compulsive (OC) symptoms, as seen in obsessive-compulsive disorder (OCD), are instrumental in explaining the heterogeneity observed in this condition and have received considerable empirical support. Normative models of personality partially align with OC symptoms; however, maladaptive personality models present a mo...
Preprint
Full-text available
-now published at NBR- Laboratory experiments using fear conditioning and extinction protocols help lay the groundwork for designing, testing, and optimizing innovative treatments for anxiety-related disorders. Yet, there is limited basic research on fear conditioning and extinction in obsessive-compulsive disorder (OCD). This is surprising because...
Preprint
Full-text available
Overgeneralization of conditioned fear to safe stimuli that resemble a previously-learned threat-cue is a well-studied correlate of clinical anxiety, yet whether conditioned disgust generalizes remains unknown, as does the extent to which such generalization is associated with disgust-related traits and maladaptive outcomes. The present study addre...
Preprint
Full-text available
-Under review- Heightened generalization of conditioned fear and avoidance to safe stimuli resembling threat is a key feature of pathological anxiety and might contribute to the increased prevalence of anxiety-related disorders among women. Though rodent studies have documented over-generalized fear in females versus males, analogous work in humans...
Article
Full-text available
The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical structural model of psychological symptoms formulated to improve the reliability and validity of clinical assessment. Neurobiology can inform assessments of early risk and intervention strategies, and the HiTOP model has greater potential to interface with neurobiological measures...
Article
Generalization of Pavlovian fear to safe stimuli resembling conditioned-danger cues (CS+) is a widely accepted conditioning correlate of clinical anxiety. Though much of the pathogenic influence of such generalization may lie in the associated avoidance, few studies have assessed maladaptive avoidance decisions associated with Pavlovian generalizat...
Article
A central conditioning correlate of clinical anxiety is the over-generalization of Pavlovian fear to safe stimuli resembling conditioned danger cues (CS+). Though much of the pathogenic influence of such generalization may lie in the unnecessary behavioral avoidance it evokes, few studies have examined maladaptive avoidance associated with Pavlovia...
Article
Objective: Heightened generalization of fear from an aversively reinforced conditioned stimulus (CS+, a conditioned danger cue) to resembling stimuli is widely accepted as a pathogenic marker of posttraumatic stress disorder (PTSD). Indeed, a distress response to benign stimuli that "resemble" aspects of the trauma is a central feature of the diso...
Article
Full-text available
Empirically-supported theories posit that individuals with generalized anxiety disorder (GAD) experience uncomfortable affective states and distress in response to perceived emotionally-laden contexts (e.g., interpersonal situations), and are motivated to avoid emotional content through worry. Although we have extensive self-report and physiologica...

Network

Cited By

Projects

Project (1)
Project
Broadly, identifying categorical and dimensional candidate individual differences in conditioned generalization processes with relevance to anxiety pathology and link them back to personality/hierarchical psychopathology structure.