Samuel Acquah

Samuel Acquah
University of Cape Coast | UCC · Department of Medical Biochemistry

BSc., MSc., MSc., PhD

About

20
Publications
2,734
Reads
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103
Citations
Introduction
My major research interest is in diabetes-malaria interaction, trying to investigate how malaria can influence the development of diabetes and its associated complications. In this regard, I am interested in all biochemical pathways implicated in the pathogenesis of, especially, type 2 diabetes mellitus, in malaria-endemic regions of the globe. I am convinced that the rising incidence of diabetes in the Sub-Saharan Africa, cannot be adduced to just the rising spate of obesity alone.
Additional affiliations
August 2021 - present
University of Cape Coast
Position
  • Head of Department
September 2017 - July 2021
University of Cape Coast
Position
  • Head of Faculty
August 2017 - present
University of Cape Coast
Position
  • Professor (Associate)

Publications

Publications (20)
Article
Full-text available
The coronavirus disease 2019 (COVID-19) pandemic continues to cause havoc to many countries of the globe, with no end in sight, due to nonavailability of a given vaccine or treatment regimen. The pandemic has so far had a relatively limited impact on the African continent, which contributes more than 93% of global malaria burden. However, the limit...
Article
Full-text available
Malaria and diabetes continue to affect millions of people globally. Although global malaria burden is declining gradually, that of diabetes seems to be increasing. Sub-Saharan Africa with the greatest burden of malaria is predicted to house the greatest proportion of incidence of diabetes by 2030. This prediction though hinges on expected increase...
Article
Full-text available
Background: The World Health Organization recommends the implementation of interventions focused on the early detection of clinical risk factors for cardiovascular disease (CVD) as effective strategies for the control of CVD in low resource settings. However, due to health system resource constraints, surveillance capacity for the identification of...
Article
Full-text available
Aim: To investigate the concept of obesity paradox in diabetes patients and nondiabetic control in the Cape Coast Metropolis of Ghana. Materials and Methods: Levels of leptin, adiponectin, total antioxidant power (TAP), lipid peroxides, and C‑reactive protein (CRP) were assessed in 115 diabetics and an equal number of control respondents. Furthermo...
Article
Full-text available
Background: Recent evidence implicates malaria as a likely risk factor for the development of type 2 diabetes mellitus (T2DM) through insulin resistance. However, the nature of malaria-induced insulin resistance and its relation to parasitaemia as well as the influence of multiple episodes on insulin resistance are unknown. As a result, the current...
Article
Full-text available
Background: To investigate effects of falciparum malaria on circulating levels of leptin and adiponectin in type 2 diabetes mellitus (T2DM) and non-diabetic controls in relation to measures of adiposity. Methods: Levels of leptin and adiponectin were measured in 100 type 2 diabetics and 100 age-matched controls before and during falciparum malaria...
Article
Full-text available
Information on the extent to which oxidative stress and inflammation occur in the presence of falciparum malaria and type 2 diabetes mellitus in the same individual is limited. This study sought to investigate the extent of inflammation and oxidative stress in adult uncomplicated malaria by measuring fasting levels of lipid peroxides, C-reactive pr...
Article
Full-text available
Background: Intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) has been adopted as policy by most countries in sub-Saharan Africa. This cross-sectional study assessed the prevalence of IPTp-SP usage for prevention of malaria among pregnant women as well as evaluated factors associated with IPTp-SP use during...
Article
Full-text available
Objective: To investigate the effects of falciparum malaria on lipid profile and atherogenic indices of type 2 diabetics and non-diabetic adults in the Central Region of Ghana. Methods: Plasma lipid profile comprising total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL) and triglycerides (T...
Article
Full-text available
The study aimed at investigating the effects of adult uncomplicated malaria on insulin resistance. Fasting levels of blood glucose (FBG), glycosylated hemoglobin (HbA1c), and serum insulin were measured in 100 diabetics and 100 age-matched controls before and during Plasmodium falciparum malaria. Insulin resistance and beta cell function were compu...
Article
Full-text available
ORIGINAL ARTICLE © Copyright AJMS Objective: To investigate the effects of falciparum malaria on lipid profile and atherogenic indices of type 2 diabetics and non-diabetic adults in the Central Region of Ghana. Methods: Plasma lipid profile comprising total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL), low-density lipoprotein chol...
Article
Full-text available
Objective: To assess the burden of maternal malaria and HIV among pregnant women in Ghana and to determine the risk of anemia among women with dual infection. Methods: A cross-sectional study was conducted at 4 hospitals in the Sekondi-Takoradi metropolis, Ghana. The study group comprised 872 consenting pregnant women attending prenatal care cli...
Article
The role of herbalists in the management of malaria in Ghana is yet to be recognized despite the proliferation of antimalarial herbal products produced by the herbalists, on the Ghanaian mar-ket. This study was carried out to ascertain the role of herbalists in the management of severe and uncomplicated malaria among children in the Shama-Ahanta Ea...
Article
Full-text available
Purpose: To ascertain the prevalence of dyslipidaemia in diabetics in Cape Coast. Methods: This preliminary outpatient-based cross-sectional study was conducted in 79 diabetic patients (22 males and 57 females) receiving treatment at the Central Regional Hospital (CRH) in the Cape Coast Metropolis. Serum lipid profiles of the fasting diabetic patie...
Article
Evidence-based practice in medicine requires clinical signs and symptoms of malaria to be con-firmed by microscopic detection of the parasite in blood sample of patients. In some cases, how-ever, such signs and symptoms persist without microscopic detection of the parasite in blood smears, making it difficult for treatment decision to be made by me...
Article
A community-based cross-sectional study was designed to assess knowledge on signs, symptoms and treatment options for malaria in Bakaano, a suburb of Cape Coast, to determine the extent to which malaria is managed at homes. Our observations showed that the community had good knowledge of signs and symptoms of malaria. Of the 200 randomly selected r...
Article
Full-text available
Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and urea levels were assessed in 27 males (mean age 32.33 yrs) and in 34 females (mean age 27.85yrs) Ghanaian rural dwellers to determine the functional status of their liver (ALT/AST) and kidney (Urea). No significant (P≥0.05) differences were observed between the sexes in all...
Article
Full-text available
Two drying methods were investigated to determine if drying is possible without affecting the quality of starch. The drying methods were solar dryer (53-55 °C) and electrically powered tray dryer (60 °C). The physicochemical properties of starch from five sweetpotato were evaluated after dehydration using the two methods. The results showed that dr...

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Question (1)
Question
what is the best and cheapest approach to measure response of GLUT4 to infection?

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