
Samuel AcquahUniversity of Cape Coast | UCC · Department of Medical Biochemistry
Samuel Acquah
BSc., MSc., MSc., PhD
About
29
Publications
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Introduction
My interest is in diabetes-infection interaction, trying to understand how infection contribute to the development of diabetes and its associated complications. In this regard, I am interested in all biochemical pathways implicated in the pathogenesis of, especially, type 2 diabetes mellitus, in malaria-endemic regions of the globe. I am convinced that the rising incidence of diabetes in the Sub-Saharan Africa, cannot be adduced to just the rising spate of obesity alone.
Additional affiliations
August 2021 - July 2024
September 2017 - July 2021
August 2017 - present
Publications
Publications (29)
The phosphatase and tensin homolog (PTEN) gene acts as a tumor suppressor by regulating the PI3K/AKT pathway, crucial for cell growth and survival. Mutations or loss of PTEN are common in breast cancer, leading to uncontrolled cell growth. Understanding PTEN’s role is vital for targeted therapies. 276 formalin-fixed paraffin-embedded (FFPE) breast...
Background
Malaria in pregnancy can have adverse outcomes if untreated. Both malaria and pregnancy are associated with insulin resistance and diabetes. Although malaria is treated prophylactically with gestational diabetes mellitus (GDM) screened for in pregnancy as part a routine antenatal care, their impacts have not been examined in terms of oth...
Background: Scientific information on the impact of malaria on the risk of developing type 2 diabetes mellitus (T2DM) after recovery from the coronavirus disease 2019 (COVID-19) is limited in the Ghanaian context. The purpose of this study was to examine the association between selected risk markers of T2DM in falciparum malaria patients post-COVID...
Background and Aims
Obesity and overweight are major public health threat affecting many people globally. This study aimed to examine the role of nutrition knowledge (NK), attitude, practices, and dietary diversity (DD) on the prevalence of obesity among market women in Cape Coast, Ghana.
Methods
This cross‐sectional study was conducted at Abura a...
Background
Scant West African data on non‐alcoholic fatty liver disease (NAFLD) means there is little representation of this population in the modelling used to derive biomarkers and predictive indices for risk stratification of patients for the presence of hepatic steatosis. This study evaluates the performance of the fatty liver index (FLI), hepa...
Type 2 diabetes mellitus (T2DM) continues to increase in incidence within the ageing population of the globe. Patients with T2DM have a 2-4 times higher risk of experiencing an adverse cardiovascular event than their non-diabetic counterparts. Total cholesterol, low-density lipoprotein (LDL), triglycerides and high-density lipoprotein (HDL) cholest...
The coronavirus disease 2019 (COVID-19) pandemic continues to cause havoc to many countries of the globe, with no end in sight, due to nonavailability of a given vaccine or treatment regimen. The pandemic has so far had a relatively limited impact on the
African continent, which contributes more than 93% of global malaria burden. However, the limit...
Malaria and diabetes continue to affect millions of people globally. Although global malaria burden is declining gradually, that of diabetes seems to be increasing. Sub-Saharan Africa with the greatest burden of malaria is predicted to house the greatest proportion of incidence of diabetes by 2030. This prediction though hinges on expected increase...
Background: The World Health Organization recommends the implementation of interventions focused on the early detection of clinical risk factors for cardiovascular disease (CVD) as effective strategies for the control of CVD in low resource settings. However, due to health system resource constraints, surveillance capacity for the identification of...
Aim: To investigate the concept of obesity paradox in diabetes
patients and nondiabetic control in the Cape Coast Metropolis of
Ghana. Materials and Methods: Levels of leptin, adiponectin,
total antioxidant power (TAP), lipid peroxides, and C‑reactive
protein (CRP) were assessed in 115 diabetics and an equal number
of control respondents. Furthermo...
Background: Recent evidence implicates malaria as a likely risk factor for the development of type 2 diabetes mellitus (T2DM) through insulin resistance. However, the nature of malaria-induced insulin resistance and its relation to parasitaemia as well as the influence of multiple episodes on insulin resistance are unknown. As a result, the current...
Objective: To investigate the relationship between obesity, insulin resistance, and lipid profile in type 2 diabetes patients and nondiabetic controls in the Cape Coast Metropolis of Ghana. Patients and Methods: Levels of fasting blood glucose (FBG), glycosylated hemoglobin, lipid profile, insulin resistance, and β-cell function were measured in 11...
Background: To investigate effects of falciparum malaria on circulating levels of leptin and adiponectin in type 2 diabetes mellitus (T2DM) and non-diabetic controls in relation to measures of adiposity.
Methods: Levels of leptin and adiponectin were measured in 100 type 2 diabetics and 100 age-matched controls before and during falciparum malaria...
Information on the extent to which oxidative stress and inflammation occur in the presence of
falciparum
malaria and type 2 diabetes mellitus in the same individual is limited. This study sought to investigate the extent of inflammation and oxidative stress in adult uncomplicated malaria by measuring fasting levels of lipid peroxides, C-reactive pr...
Background: Intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) has been adopted as policy by most countries in sub-Saharan Africa. This cross-sectional study assessed the prevalence of IPTp-SP usage for prevention of malaria among pregnant women as well as evaluated factors associated with IPTp-SP use during...
Objective: To investigate the effects of falciparum malaria on lipid profile and atherogenic indices of type 2 diabetics and non-diabetic adults in the Central Region of Ghana. Methods: Plasma lipid profile comprising total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL) and triglycerides (T...
The study aimed at investigating the effects of adult uncomplicated malaria on insulin resistance. Fasting levels of blood glucose
(FBG), glycosylated hemoglobin (HbA1c), and serum insulin were measured in 100 diabetics and 100 age-matched controls before
and during Plasmodium falciparum malaria. Insulin resistance and beta cell function were compu...
ORIGINAL ARTICLE © Copyright AJMS Objective: To investigate the effects of falciparum malaria on lipid profile and atherogenic indices of type 2 diabetics and non-diabetic adults in the Central Region of Ghana. Methods: Plasma lipid profile comprising total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL), low-density lipoprotein chol...
Objective:
To assess the burden of maternal malaria and HIV among pregnant women in Ghana and to determine the risk of anemia among women with dual infection.
Methods:
A cross-sectional study was conducted at 4 hospitals in the Sekondi-Takoradi metropolis, Ghana. The study group comprised 872 consenting pregnant women attending prenatal care cli...
The role of herbalists in the management of malaria in Ghana is yet to be recognized despite the proliferation of antimalarial herbal products produced by the herbalists, on the Ghanaian mar-ket. This study was carried out to ascertain the role of herbalists in the management of severe and uncomplicated malaria among children in the Shama-Ahanta Ea...
Purpose: To ascertain the prevalence of dyslipidaemia in diabetics in Cape Coast. Methods: This preliminary outpatient-based cross-sectional study was conducted in 79 diabetic patients (22 males and 57 females) receiving treatment at the Central Regional Hospital (CRH) in the Cape Coast Metropolis. Serum lipid profiles of the fasting diabetic patie...
Evidence-based practice in medicine requires clinical signs and symptoms of malaria to be con-firmed by microscopic detection of the parasite in blood sample of patients. In some cases, how-ever, such signs and symptoms persist without microscopic detection of the parasite in blood smears, making it difficult for treatment decision to be made by me...
A community-based cross-sectional study was designed to assess knowledge on signs, symptoms and treatment options for malaria in Bakaano, a suburb of Cape Coast, to determine the extent to which malaria is managed at homes. Our observations showed that the community had good knowledge of signs and symptoms of malaria. Of the 200 randomly selected r...
Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and urea levels were assessed in 27 males (mean age 32.33 yrs) and in 34 females (mean age 27.85yrs) Ghanaian rural dwellers to determine the functional status of their liver (ALT/AST) and kidney (Urea). No significant (P≥0.05) differences were observed between the sexes in all...
Two drying methods were investigated to determine if drying is possible without affecting the quality of starch. The drying methods were solar dryer (53-55 °C) and electrically powered tray dryer (60 °C). The physicochemical properties of starch from five sweetpotato were evaluated after dehydration using the two methods. The results showed that dr...
Questions
Question (1)
what is the best and cheapest approach to measure response of GLUT4 to infection?