Sampad Jana

• PhD
• PhD Student at KU Leuven

A practical and strightforward approach that enables for the first time, the synthesis of enantiomerically pure 1,4,5- trisubstituted, 1,5-disubstituted, and fused 1,2,3 triazoles derivatives has been developed. The synthesis employs enantiomerically pure amino esters derived from amino acids and commercially available ketones under metla-free cond...

A practical and straightforward approach that enables for the first time, the synthesis of enantiomerically pure 1,4,5-trisubstituted, 1,5-disubstituted, and fused 1,2,3 triazole derivatives has been developed. The synthesis employs enantiomerically...

We report the selective decomposition of bis(1,2,3‐triazoles) under rhodium(II) catalysis. The bis(1,2,3‐triazoles) undergo an intramolecular transannulation reaction via an azavinylcarbene intermediate, resulting in the formation of polycyclic dihydroindoles containg a fused triazole ring. magnified image

Three series of aza-artemisinin derivatives were synthesized for studies of anticancer activity. The first series of compounds were prepared via copper(I)-catalyzed azide alkyne cycloaddition, so called “click reaction”, starting from propargyl derivatives of 11-aza-artemisinin and various azides, whereas the second and third series of compounds we...

The Gewald three-component reaction yielding highly substituted 2-aminothiophene heterocycles has been known for a long time and holds an extraordinary potential in pharmaceutical industry. Herein, we describe a four-component reaction initiated by the conjugate addition of different indole derivatives to α, β-unsaturated carbonyl compounds. This i...

Artemisinin and synthetic derivatives of dihydroartemisinin are known to possess various biological activities. Post-functionalization of dihydroartemisinin with triazole heterocycles has been proven to lead to enhanced therapeutic potential. By using our newly developed triazolization strategy, a library of unexplored fused and 1,5-disubstituted 1...

A practical, straightforward, and highly regioselective Zn(OAc)2 mediated method towards propargyl triazoles has been developed for the first time from commercially available enolizable ketones and propargyl amine. Post functionalization of this triazole leads to unique N,C-linked bis-triazoles in excellent yield.

NH-1,2,3-triazole moieties are a part of the design of various biologically active compounds, pharmaceutical agents and functional materials. Unfortunately, the applications of this heterocycle are still underexplored due to the lack of a general synthetic protocol. Here we outline a novel, general and facile metal-free pathway that enables the dir...

An unprecedented selective preparation of 1,5-disubstituted 1,2,3-triazoles from readily available primary amines, enolizable ketones and 4-nitrophenyl azide as a renewable source of dinitrogen is developed.

An unprecedented approach that enables the direct and selective preparation of 1,5-disubstituted 1,2,3-triazoles from abundantly available building blocks such as primary amines, enolizable ketones and 4-nitrophenyl azide as a renewable source of dinitrogen via an organocascade process has been developed. Furthermore, this efficient methodology als...