Samir Derouiche

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Verified

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• Professor
• Professor (Full) at University of Eloued

This study investigated the therapeutic effect of niosomes loaded Sonchus maritimus extract (SmE-N) on testicular disorder in rats that was brought on by a high-fructose diet (HFD). The physical stability analysis of the formulated S. maritimus-loaded niosomes was performed using standard protocols, and the morphological characterization was carrie...

Introduction: There is a growing interest in producing green nanoparticles with a variety of biological activities. For that, the leaf extract of Phragmites australis was used to mediate copper nanoparticle (CuNPs) synthesis, and its antioxidant, antihemolytic, anti-inflammatory, and anticancer effects were evaluated. Materials and Methods: The cha...

The objective was to develop liposomes as a new drug delivery system (NDDS) containing basil extract and to investigate their therapeutic and protective effects against toxicity caused by exposure to metribuzin in the lungs and heart. For in vivo study, 24 male albino Wistar rats were divided into four groups (n = 6), control group, metribuzin-trea...

This investigation was aimed to evaluation of Doxorubicine a chemotherapy substance induced hepatotoxicity and the preventive effect of ObE-MgNPs in rats. Standard procedures were used to extract bioactive molecules and test qualitative phytochemical substances. Furthermore, visual observation, FT-IR spectroscopy, and scanning electron microscopes...

Sweet Basil (Ocimum basilicum L.) is regarded as a significant plant. They include a wide variety of bioactive substances, particularly phenolic substances which contribute to the plant’s alleged health advantages. The objective of this study was to identify and characterize the phytochemical profile of sweet basil using GC-MS analysis. By using st...

The aim of this study was the use of rhizomes aqueous extract of Phragmites australis to mediate copper nanoparticles synthesis and evaluate their biological and pharmacological activities. The characterization of the CuNPs was done using different techniques. The antioxidant and anti-inflammatory activities were assessed using two methods for each...

Purpose: Antibiotics are drugs used to treat and prevent bacterial infections. The emergence of antibiotic resistance in bacterial strains is one of the most important problems facing global health care. There are several alternatives to get rid of antibiotic resistance, including nanoparticles, which is the subject of this study on how to use Mang...

One of the most destructive diseases of the twenty-first century is cancer, which has given rise to significant concerns among medical professionals and academics alike. In order to achieve victory in the fight against cancer, a multitude of therapeutic modalities are currently being investigated. Nanotechnology has emerged as a significant field o...

Our study aimed to investigate the effect of polyherb (formulated by some plants) and ZnNPs (formulate by green synthesis) on physiological, biochemical alterations and oxidative stress induced by experimental diabetes in rats. For this purpose, 24 female albino Wistar rats were randomly divided into 6 groups (n=4); healthy rats (Control), healthy...

Our study aimed to investigate the effect of polyherb (formulated by some plants) and ZnNPs (formulate by green synthesis) on physiological, biochemical alterations and oxidative stress induced by experimental diabetes in rats. For this purpose, 24 female albino Wistar rats were randomly divided into 6 groups (n=4); healthy rats (Control), healthy...

This investigation aimed to evaluate the effect of Ocimum basilicum L. aqueous extract (ObE) on hepatotoxicity induced by doxorubicin in rats. Standard procedures were used to extract bioactive compounds and to analyze phytochemical compounds quantitatively and qualitatively. The in-vivo study was performed using 15 female albino rats that were gro...

Metribuzin is an herbicide belonging to the triazinone group, which is incorporated as a weed killer in wheat, potatoes, tomatoes, etc. The aim of this study was to evaluate the effect of metribuzin as a cause of cardiovascular disease. Human exposure to Metribuzin occurs through inhalation and ingestion, usually in agricultural settings. However,...

This study aims to assess the biological impacts and phytochemical compounds present in the leaves of Phragmites australis. Standard protocols were used for qualitative and quantitative chemical screening, where DPPH and FRAP assays were used to estimate the antioxidant activity. Regarding the anti-inflammatory potential, it was tested through the...

Context: In poultry production, oxidative stress is unavoidable and impacts the physiological, behavioral, and biochemical conditions of developing chickens, ultimately lowering the quality of their meat. Objectives: This literature review aims to draw attention to how oxidative stress affects poultry production and gastrointestinal function, speci...

This study aims to study the local conditions of extensive or semi-intensive breeding and the study of the growth of lambs and ewes from birth to the 10th, 30th and 70th days. To achieve this goal, we relied on several criteria such as age, weight, Average Daily Gain, Milk production with sex, age and breeding system factors. This study shows that...

This study aimed to evaluate the therapeutic effect of niosomes loaded with Sonchus maritimus extract conjugated with linoleic acid on hematological changes and cardiac dysfunction in albino Wistar rats caused by a high fructose diet. Four boxes of six male Albino Wistar rats were randomly divided into four groups. The control group was fed a stand...

Objective: The goal of the present work was the identification and quantification of the phenolic profile of sweet basil using LC-ESI-MS and to evaluation the ability of this plant to synthesise manganese nanoparticles MnO NPs and evaluation of their catalytic and thrombolytic activities. Material and methods: Standard procedures were used to extra...

The aim of this study was to investigate phytochemicals, the antioxidant, anti-inflammatory, hemolysis assay of Ephedra alata Qualitative analysis of phytochemicals and quantitative analysis of total phenolics and flavonoids were prepared by using standard protocols. Qualitative phytochemical analysis revealed that the aqueous extract show richness...

Cardiovascular system is primarily considered as the human body's transport system. The cardiovascular system keeps life pumping through the body. Understanding the functions of the cardiovascular system, along with its various pathways of veins, arteries and capillaries, is essential in the provision of safe and effective care. Cardiovascular dise...

The purpose of the current study was to assess how doxorubicin treatment affected the heart and liver oxidative stress indicators in female Wistar rats. For in-vivo study, ten female albino Wistar rats were divided into two groups (n=5), control group and doxorubicin treated group. GSH, MDA levels and SOD, GST activities in heart and liver were mea...

Abstract Metabolic syndrome (MetS) is a combination of metabolic disorders that co-occur, among them dyslipidemia, insulin resistance, hyperglycemia, oxidative stress, and pro-inflammatory states. It further increases the risk of developing different chronic diseases, which can even lead to death, as reported by international health institutions. T...

Background and Aims: Chronic Kidney Disease (CKD) is one of the most important complications of diabetes. Many physiological and biochemical changes may cause these complications to appear. The objective of this study was to evaluate the variation oxidative stress for the diagnosis and prediction of renal complication in type 2 diabetic patients. M...

Cancer is one of the most devastating disorders of the 21st century, creating a major concern among clinicians and researchers. Many different treatment strategies are being tried to fight the war against cancer have been tested. Various inorganic nanoparticles have been investigated to induce cytotoxicity in cancer cells and one of the successfull...

Sonchus maritimus belongs to Asteraceae family. It is a well-known medicinal plant for its phytochemicals and therapeutic values. This paper aimed to investigate the phytochemicals, Gas chromatography analysis of leaves aqueous extract of Sonchus maritimus and to estimate its anti-inflammatory propriety. Quantitative and qualitative phytochemical i...

The objective of this review study is to shed light on the effective role played by nanotechnology, especially nanoparticles, in the medical field. We take nanoparticles of zinc, nanoparticles of magnesium, and nanoparticles of copper, as examples. The conventional methods of developing NPs are costly and produce very toxic product, so the need of...

This investigation was aimed to study the effect of leaves aqueous extract of Ocimum basilicum L. (ObE) for prevention of cardiotoxicity and heart failure induced by doxorubicin in rats. For in-vivo rats study, 15 female albino Wistar rats were divided into 3 groups (n = 5); control group, doxorubicin treated rats group (DOX) and rats co-treated wi...

This study investigated the influence of cadmium (Cd) and copper (Cu) heavy metals on germination, metabolism, and growth of zucchini seedlings (Cucurbita pepo L.). Zucchini seeds were subjected to two concentrations (100 and 200 μM) of CdCl2 and CuCl2. Germination parameters, biochemical and phytochemical attributes of embryonic axes were assessed...

Introduction and Aim: Coronary artery disease (CAD) is a pathological process described by atherosclerosis plaque in the epicardial arteries. CAD is a chronic process that begins during adolescence and slowly progresses through life. Several traditional risk factors genetics and environmental, involve in the development of atherosclerosis process....

Our study aimed to investigate the im-pact of purslane (P. oleracea) and zinc as a ther-apeutic approach to physiological and biochem-ical alterations induced by Alzheimer disease (ALZ) in rats. For this purpose, 18 males albino Wistar rats were randomly divided into 4 groups (n=6); healthy rats (Control), untreated Alzhei-mer rats (Exp ALZ), Alzhe...

One of the major roles of nanotechnology in the pharmaceutical field is to provide a facility to improve drug delivery systems and design smart nanocarriers with the potential to deliver specific biomolecules to the target site for treatment. This study evaluated Sonchus maritimus-loaded niosomes (SmE-N) in hepatic encephalopathy induced by a high-...

Background: Sweet Basil (Ocimum basilicum L.) is regarded as a significant plant. They include a wide variety of bioactive substances, particularly phenolic substances which contribute to the plant's alleged health advantages. Aim: The objective of this study was to identify and characterize the phenolic profile of sweet basil using HPLC-Q-TOF-MS i...

One of the major roles of nanotechnology in pharmaceutical field is to provides a facility to improve the drug delivery systems and design smart nanocarriers which have the potential to deliver specific biomolecules to the target site for treatment. In this study, we were evaluated a niosomes loaded Sonchus maritimus (SmE-N) on hepatic encephalopat...

The popularity and demand for high-quality date palm fruits (Phoenix dactylifera L.) have been growing, and their quality largely depends on the type of handling, storage, and processing methods. The current methods of geometric evaluation and classification of date palm fruits are characterised by high labour intensity and are usually performed me...

One of the most serious health issues facing worldwide today is diabetes mellitus. Although they have inevitable adverse effects, conventional antidiabetic medications are effective. However, plants might also provide an alternate source of anti-diabetic chemicals. This study was focused on determining the antioxidant activities of the leaves aqueo...

Basil (Ocimum basilicum L) is a plant that belongs to the Lamiaceae family and is known for its pharmacological and therapeutic properties, as it is rich in active biological substances, which endow it with antioxidant and anti-inflammatory activities. Many people from all over the world use basil in traditional medicine, including North African co...

Background and Aims: More than 1.55 million women of reproductive age have polycystic ovary syndrome (PCOS) in the world; PCOS is an important disease threatens public health, linked to psychological, metabolic, and reproductive problems. The aim of our work was an evaluation of some risk factors, oxidative stress and Cardiovascular Risk among PCOS...

The aim of this work is to assess the impact of red clay on the physiological and biochemical alterations in rats exposed to lead acetate. The experimental study was carried out in the laboratory on 18 male Wistar rats, which were divided into three groups of six rats in each, the first group served as control, the second group contaminated with le...

This investigation aimed to characterize the green synthesized selenium nanoparticles using Sonchus maritimus L. extract and evaluate their antioxidant and antibacterial properties. Moreover, acute toxicity of nanoparticles was performed in Wistar rats. The synthesis of SeNPs was confirmed by Ultraviolet-visible, Fourier Transform Infrared Spectros...

This study aims at evaluating some risk factors and the variation of certain hematological and oxidative stress markers in women with stroke disease. The observation (clinical study) was done on 130 voluntary women, divided into metabolic syndrome patients with and without stroke disease. Risk factors were estimated by Chi-square test. Results demo...

Self-medication is a very common and alarming practice practiced by many people and can pose health risks, which awakens the importance of knowing this practice among all groups of society and cardiovascular risks it may entail on their health. This study aims to identify the extent of the prevalence of self-medication among the population in the u...

The objective of this work is to study the effects of green Clay on changes in biochemical, haemato-logical, oxidative stress and histopathological parameters in rats acutely exposed to lead acetate. The experimental study carried out in the laboratory on 18 male Wistar rats which divided into three groups of six rats in each, the first group serve...

Honey has been made from some variety of date (Phoenix dactylifera L) Ghars, Tinicin and Tekermist (Tantbocht). The aim of this study is to determine different phytochemical compound and antioxidant properties of honey dates from Ouedrigh and Ouedsouf regions. The physical properties of these samples were very high significantly differences (p<0.00...

To assess the impact of heavy metals (cadmium, copper) on the germination, metabolism and growth of zucchini seedlings ( Cucurbita pepo L.), a test was conducted 'in vitro' on the germination and growth of zucchini seedlings, subjected to two concentrations (100 and 200 μM) of CdCl 2 and CuCl 2 . The germination parameters, as well as the biochemic...

The robe is made from the date palm fruit for the use in nutritional and medicinal fields. The main aim of this investigation was to identify the phytochemical and mineral contents in two varieties of date "Robe" Ghars and Tekrmist (Tantbocht) of Algerian Phoenix dactylifera L. and to evaluate the effect of consumption of dates robe on anemia disea...

Our study aimed to investigate the effect of ZnNPs formulated by spinach extract (SPE-ZnNPs) fluoride induced hepato-renal toxicity in rats. 18 male rats were divided into three groups (n=6); Control, NaF and NaF + SPE-ZnNPs. various biological parameters and histopathological analysis were estimated. Phytochemical of spinach and characterizations...

Our study aimed to investigate the toxic effect of sodium fluoride (NaF) on some biological and histological markers in rats. Twelve male rats were divided into two groups (n=6), Control receved normal water and diet and NaF group received normal diet and water contaminated with NaF (400ppm) during 8 weeks. Various biochemical, hematological and ox...

Objective: To investigate the effect of Spinacia oleracea on biochemical alterations and renal oxidative stress induced by Fluoride in rats. Materials and methods: Eighteen Male Wistar rats were randomly divided into 3 groups (n=6); Control, Fluoride (NaF) rats and NaF rats treated with Spinacia oleracea. Treatments were given to rats for 21 days....

Background: Ischemic stroke is a common disease that affects the blood vessels in the brain. This disease is considered one of the most dangerous ailments that affect the nervous system all over the world. Objectives: The aim of this study was to evaluate some hematological and biochemical parameters in men with ischemic disease in Touggourt (Alger...

The objective of this work was to study the protective effect of zinc acetate and Zinc Nanoparticles biosynthesized by Aristolochia longa extract against variations in biochemical parameters and oxidative stress in rats exposed to nickel. Twenty female Wistar rats divided into four groups (n=5); Control, Nickel, Nickel + zinc, Nickel + ZnNPs. Nicke...

Background Purslane has wide acceptability as a potherb in Central Europe, Asia, and Mediterranean region, it is very used in traditional Chinese medicine (TCM) to treat fever, dysentery, diarrhea, carbuncles, eczema, and to remove toxic substances. Our study aimed to investigate the impact of purslan on physiological and biochemical alterations in...

Introduction: Lead is a chemical element that exists in nature. It is recognized as one of the most toxic and harmful heavy metals,

Objective: To investigate the effect of polyherb (formulated by some plants) on physiological, biochemical alterations and oxidative stress induced by experimental diabetes in rats. Materials and methods: Twenty female albino Wistar rats were randomly divided into 4 groups (n=5); Control, Polyherb, diabetic rats and Diabetic rats treated with polyh...

The objective of this work is to study the protective effect of Aristolochia longa against the variation of biochemical parameters and oxidative stress in rats exposed sub acutely to nickel. This is an experimental study carried out in the laboratory on 15 female Wistar rats divided into three groups (n=5), the first group of which serves as a cont...

Breastfeeding has benefits for the health and development of the baby, but also for the mother. the aim of this study is to assess certain risk factors of breast milk deficiency in women during lactation. The study was based on 150 voluntary individuals divided into Breastfeeding women with milk with average age of 31.11±4.56 years old and Breastfe...

Introduction: Hepatitis B infection is a severe global public health issue. It is the 10th biggest cause of death worldwide. Objective: This review focuses on the relationship between oxidative stress and the risk of developing of acute and chronic hepatitis B complications. Methods: The data were collected by searching Science Direct, Google Schol...

The objective of this work was to study the effect of using Aquilaria malaccesis spice on some biological parameters in pregnant rats exposed to lead-contaminated drinking water. Twenty (20) female rats were randomly divided into four groups (n = 5): control, pregnant rats, pregnant + Pb and pregnant +Pb+ A. malaccensis (Aq). Lead (200 mg/kg b.w.)...

The goal of this study was to see how ZnNPs (a green synthesis formulation) affected the physiological, biochemical, and oxidative stress changes generated by experimental diabetes in rats. Twenty female albino Wistar rats were randomly separated into four groups (n=5): control, zinc nanoparticles, diabetic rats, and diabetic rats treated with zinc...

This study aimed to synthesize ZnNPs using S. oleracea and evaluate their antioxidant, anti-inflammatory, and antibacterial capacities. The nanoparticles were characterized by using analytical techniques. Antioxidant activity of SpE-ZnNPs was studied done FRAP assay also the anti-inflammatory and antibacterial activities of both Spinach and SpE-ZnO...

Purpose: Coronavirus disease (COVID-19) has killed a large number of people, threatening public health around the world. Many drugs and materials that have an antiviral therapeutic effect are still being tested, including silver nanoparticles. Materials and Methods: It has been proven that Synthesis of silver Nanoparticles (Ag NPs) (Ag NPs) posses...