Samir Abd El-Monem Bashandy

Samir Abd El-Monem Bashandy
National Research Center, Egypt | NRC · Department of Pharmacology

Ph.D

About

51
Publications
32,209
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
926
Citations
Citations since 2016
24 Research Items
701 Citations
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140

Publications

Publications (51)
Article
Full-text available
Hyperlipidemia is a gear in a big cascade leading to fatal disease ending in death especially among elderly patients. The reduction in serum cholesterol may alter or save the human life away from cardiovascular risks. Due to what called “drug side effects” and the failure of modern medicine to control this issue. So, the use of natural products in...
Article
Full-text available
Melatonin (ML) is a potent antioxidant that reduces oxidative stress. This study was designed to examine the protective effect of melatonin on potassium dichromate- (PDC-) induced male reproductive toxicity. Forty rats were divided into five groups: the control group, rats administered PDC orally (10 mg/kg body weight) for eight weeks, rats adminis...
Article
The present study evaluate the ability of water extract of mandarin (Citrus reticulata) peel to mitigate the hepatorenal toxicity of potassium dichromate (K 2 Cr 2 O 7). Both doses of peel extract (200mg/Kg & 400mg/Kg) and K 2 Cr 2 O 7 (15mg/Kg) were orally administered to rats for eight weeks. Treatment of rats with mandarin peel extract along wit...
Article
Full-text available
Background: Diabetes mellitus is a global epidemic leads to multiple serious health complications, including nephropathy. Diabetic nephropathy is a serious kidney-related complication of type 1 or 2 diabetes that is prevalent in almost 40% of the people with diabetes. We examined whether folic acid and melatonin can reduce progression of nephropat...
Article
Full-text available
Traditionally, in many countries, various parts of the Adansonia digitata ( A. digitata ) tree have been used in the treatment of many clinical ailments including diarrhea and dysentery. The phytochemical screening has indicated that the leaf extract of A. digitata contains flavonoids, saponins, mucilage, steroids, and alkaloids. Thus, this paper a...
Article
The present work has been designed to investigate the hepatoprotective and renoprotective efficiency of alcoholic extract of Allium porrum and Bauhinia variegata leaves in thioacetamide-induced toxicity in adult Wistar rats. Allium porrum leaf extract, Bauhinia variegata leaf extract and their combinations were orally administered for 14 days then...
Article
Full-text available
The goal of this study was to determine the possible beneficial effect of olive oil (7 g/kg) with fig (1 g/kg) and date palm fruit (1 g/kg) extracts (OFD) on the toxicity hazards of doxorubicin (DOX) and (or) γ-radiation. The DOX-treated groups received doses of 2.5 mg/kg body weight via intravenous (IV) injection weekly for four consecutive weeks....
Article
The present study was carried out to evaluate the antioxidant property of whey protein and/or Nigella sativa Oil (NSO) against hepatotoxicity evoked by potassium dichromate(K 2 Cr 2 O 7). Designed for this purpose, we detected the 8 weeks challenge result of whey protein (100 and 200 mg/kg, p.o) with/or without Nigella sativa oil (5ml/kg, p.o) in c...
Preprint
Diethylnitrosamine (DEN) is a well-known carcinogen. The aim of the present study is to determine the role of olive oil (7 g/kg) with fig (1 g/kg) (OF) and/or date-palm (1 g/kg) (D) fruit extracts during DEN administration to male Wistar rats. The OF-DEN and/or D-DEN treated groups received the antioxidant treatments orally and daily for 2 weeks be...
Article
Full-text available
Background: The liver disease is one of the most important traditional public health problems in Egypt. Oxidative stress is attributed to such pathological condition that further contributes to the initiation and progression of liver injury. In the present study, we have investigated if the strong antioxidant power of Nicotinamide (NA), Vitamin B2...
Article
Spirulina platensis,a blue-green alga, has vastly therapeutic properties and it is used as food supplement. This study aims to evaluate the protective effect of Spirulina platensis against arsenic hepatorenal toxicity based on its antioxidantproperties,free-radical scavenger and immunological properties. Oral administration of sodium arsenite (6.3m...
Article
Full-text available
Abstract | Chemotherapy and radiotherapy are among the traditional methods used in cancer treatment and they cause toxicity to normal cells. The purpose of the present study is to determine the possible hepatoprotective role of olive oil (7 g/kg) with fig (1 g/kg) and date-palm fruit (1 g/kg) extracts (OFD) together as potent antioxidants in allevi...
Article
Full-text available
Hepatocellular carcinoma (HCC) is one of the most life-threatening cancers. The present study was designed to chronologically analyze the HCC chemically induced by diethylnitrosamine (DEN) in male Wistar rats during 27 weeks. DEN was given to rats in drinking water (100 mg/L) to induce HCC. In the present study, the DEN administered groups recorded...
Article
Full-text available
The present research studied the influence of zinc oxide nanoparticles (ZnO-NPs; 5mg, 7.5mg, 10 mg/Kg IP) on the liver and kidney injuries motivated by thioacetamide (TAA; 100mg/Kg IP).Each treatment was carried out three times weekly for eight weeks .ZnO-NPs relieved the decrease of hepatic or renal reduced glutathione (GSH), catalase (CAT) and su...
Conference Paper
Full-text available
The present study was designed to determine the possible protective effects of the olive oil (7 g/kg) with fig (1 g/kg) and date-palm fruit (1 g/kg) extracts (OFD) against the toxicity hazards of doxorubicin (DOX) which was used as chemotherapy of cancer and/or γ-radiation which was used as radiotherapy of cancer. The DOX-treated groups were inject...
Article
Full-text available
Objective To investigate the role of zinc in reducing the deleterious effects of cadmium on male gonads. Methods Rats were injected subcutaneously with CdCl2 and ZnCl2 at dose level of 2.2 mg/kg (1/40 of LD50 of cadmium per day). Results The rats treated with cadmium exhibited a significant increase in levels of testicular malondialdehyde, tumor ne...
Article
Full-text available
The present study aimed to examine the protective role of Spirulina platensis ( S. platensis ) against arsenic-induced testicular oxidative damage in rats. Arsenic (in the form of NaAsO 2 at a dose of 6.3 mg/kg body weight for 8 weeks) caused a significant accumulation of arsenic in testicular tissues as well as a decrease in the levels of testicul...
Article
Full-text available
The effects of Cadmium (Cd) exposure and the treatment with Zinc (Zn) on immune functions of splenocytes and cultured lymphocytes of rats were studied. The exposure of rats to Cd was at a dose of 2.2 mg/kg CdCl2, injected subcutaneously four times weekly for 2 months. Rats were supplemented with Zn (2.2 mg/kg ZnCl2, injected subcutaneously four tim...
Article
Full-text available
The present study was undertaken to investigate the protective effect of the filamentous cyanobacterium Spirulina platensis (S. platensis) on mercury (II) chloride (HgCl(2))-induced oxidative damages and histopathological alterations in the testis of Wistar albino rats. The animals were divided into four equal groups, i) control, ii) HgCl(2), iii)...
Article
Full-text available
This study investigated the protective effects of melatonin and folic acid against carbon tetrachloride (CCl4)-induced hepatic injury in rats. Oxidative stress, liver function, liver histopathology and serum lipid levels were evaluated. The levels of protein kinase B (Akt1), interferon gamma (IFN-gamma), programmed cell death-receptor (Fas) and Tum...
Article
Full-text available
Background Studies have demonstrated that vitamin C supplementation enhances the immune system, prevents DNA damage, and decreases the risk of a wide range of diseases. Other study reported that leukocyte vitamin C level was low in diabetic individuals compared with nondiabetic controls. Aim of the work To study the effect of vitamin C on oxidative...
Article
Full-text available
In the present study Spirulina platensis has been investigated as a possible modifier of mercury induced hepatic damages and alteration of lipid profile in albino rats. The results revealed that the rats treated with mercuric chloride (HgCl2) showed a significant increase in levels of blood hydroperoxide, aspartate aminotransferase (AST), alanine a...
Article
Full-text available
Studies have demonstrated that vitamin C supplementation enhances the immune system, prevents DNA damage, and decreases the risk of a wide range of diseases. Other study reported that leukocyte vitamin C level was low in diabetic individuals compared with nondiabetic controls. To study the effect of vitamin C on oxidative stress, blood lipid profil...
Article
The present study was carried out to investigate the potential protective effect of β-carotene against cadmium (Cd) induced hepatotoxicity. Male albino rats were used in the present experiments and divided into three groups. First group served as control, second group injected with CdCl2 (sc) at dose level of 2.5 mg k-1 b.wt. and third group inject...
Article
Full-text available
The present work,is devoted,to study,the lead (Pb) toxicity in experimental,Wistar male rats exposed to 2% lead acetate in drinking water and hence to evaluate the risk on human workers who were environmentally and occupationally exposed to similar toxicity. A total of thirty two Wistar male rats were equally divided into four groups, A, B, C, and...
Article
Full-text available
High plasma level of cholesterol or triglycerides was associated with poor semen quality and direct adverse effects on testicular function that may lead to male infertility. The effect of fixed oil of Nigella sativa (N. sativa) on male fertility in normal and hyperlipidemic rats was studied. Induction of hyperlipidemia was done by feeding rats on a...
Article
Full-text available
Introduction: Oxidative stress with subsequent lipid peroxidation has been postulated as one mechanism for lead toxicity. The protective action of vitamins C and E against lead affects lipid hydroperoxide level and liver functions in male rats has been studied. Results: Administration of lead acetate (2%) in dirinking water for 3 months elevates pl...
Article
Full-text available
The influence of Zinc (Zn) on Cadmium (Cd) intoxication was investigated in male rats. The exposure of the rats to Cd (2.2 mg kg 1 CdCl2, injected subcutaneously 4 times weekly for 2 months) caused alterations in ultrastructure of liver as manifested by deterioration of mitochondrial cristae, deposition of large amount of collagen fibrils and a hyp...
Article
Full-text available
Tamoxifen was given orally to two groups of pregnant fe-male rats (0.4 mg/kg/day). First group before implantation –(day 1-3 post coitus), and the second after implantation (day -7-9 post coitus) with a control group given a saline only. After the last day of treat-ment blood samples were collected from the eye blood vessel of the females. The anal...
Article
Full-text available
Tamoxifen was given orally to two groups of pregnant female rats (0.4 mg/kg/day). First group before implantation ?(day 1-3 post coitus), and the second after implantation (day -7-9 post coitus) with a control group given a saline only. After the last day of treatment blood samples were collected from the eye blood vessel of the females. The analys...
Article
This study examined the reproductive toxicity of lead in male rats exposed to 2% lead acetate in drinking water for six weeks and the protective activity of vitamin E. In lead-treated males, the weights of the body, vas deferens, seminal vesicle and prostate gland decreased significantly by 45%, 33%, 35% and 42% respectively, while the weight of th...
Article
Beeinflussung des Glukose-Stoffwechsels durch Chloroquin Langund Kurzzeiteffekte von Chloroquin (CAS 54-05-7) auf den Glukose Stoffwechsel von Ratten wurden untersucht. Chronische Langzeitbehandlung von Chloroquin (5 und 10 mg/kg KG, 6mal wöchentlich für 6 Monate) bewirkten eine Reduktion des Serumglukose-, Insulin-, Kalzium-, Kalium- und Protein-S...
Article
The hypoglycemic activity of a daily oral dose (1 g/kg) of a 10% decoction of an Egyptian widely used folk antidiabetic herbal preparation (PSP) and glibenclamide (Glib) were studied in alloxanized male rats for eight weeks. PSP is a mixture of equal portions of the powdered seeds od A. vera, L. termis, T. foenum-graecum, C. myrrha, B. critica and...

Network

Cited By

Projects

Projects (5)
Project
Revealing the possible synergistic action of the extra-virgin olive oil with fig and date-palm fruit extracts against the toxicity hazards of doxorubicin and ionizing radiation
Project
The treatment allocations of Hcc (Phytotherapy, Chemotherapy, and Radiotherapy).