Sameera Senanayake

Queensland University of Technology | QUT · School of Public Health and Social Work

BackgroundA new preference-based measure (MacNew-7D) has recently been developed to allow condition-specific data to be used to capture the quality of life in health economic evaluations in cardiology; however, a general population value set has not yet been developed. This study developed a population utility value set for the MacNew-7D heart dise...

Atrial fibrillation (AF) is a prevalent problem worldwide and a common cause of hospitalization, poor quality of life, and increased mortality. Although several treatments are used, the use of ablation and antiarrhythmic drug therapy has increased in the past decade. However, debate continues on the most suitable option for heart rhythm control in...

Purpose Preference-based quality of life measures (PBMs) are used to generate quality-adjusted life years (QALYs) in economic evaluations. A PBM consists of (1) a health state classification system and (2) a utility value set that allows the instrument responses to be converted to QALYs. A new, oral health-specific classification system, the Early...

The provision of effective care models for children with neurodevelopmental delay or disability can be challenging in resource constrained healthcare systems. Economic evaluations have an important role in informing resource allocation decisions. This review systematically examined the scope and methods of economic models evaluating interventions f...

Introduction: There is a severe shortage of donor organs globally. There is growing interest in understanding how a 'soft opt-out' organ donation system could help bridge the supply and demand gap for donor organs. This research aims to estimate the cost-effectiveness and budget impact of implementing a 'soft opt-out' organ donation system for kid...

Background: The Radboud Oral Motor Inventory for Parkinson's disease (ROMP) is a patient-rated assessment measuring patients' perceptions of speech, swallowing, and saliva control among patients with idiopathic Parkinson's disease (IPD). Objective: The present study was carried out to adapt and validate the Sinhala version of the ROMP questionna...

Mental health disorders among children and youth are causing significant burden on health care systems. Hence, identifying cost-effective interventions is important for effective mental health care allocation. Although model-based economic evaluations are an essential component of assessing cost-effectiveness, evidence are limited in the context of...

Aims This study described emergency department (ED) resource use patterns and associated costs among patients with heart disease in their last 3 years of life in a high-income country. Methods This study used linked data from ED and death registry databases in Australia. A random sample of 1000 patients who died due to any cause in 2017, and who h...

Fluoride varnish application is an effective intervention in controlling dental caries. Objective of this study was to evaluate the effectiveness of six monthly application of sodium fluoride varnish in prevention of dental caries in deciduous teeth, permanent incisors and molars in children between six and seven years in a low resource setting, Sr...

Documented literature includes mixed interpretations of the impact of paternal alcoholism on psychobehavioral well-being of offspring. A systematic review and a meta-analysis would facilitate the accurate establishment of this association. This review was done to evaluate the effects of paternal alcohol use disorder (AUD) or problem drinking (PD) o...

INTRODUCTION: The HealthPathways programme is an online health information system used mainly in primary health care to promote a consistent and integrated approach to patient care. AIM: The aim of this study is to perform a scoping review of the methodologies used in published impact and outcomes evaluations of HealthPathways programmes. METHODS...

Background Compared to other available renal replacement therapies, such as dialysis (haemo-dialysis and peritoneal-dialysis), renal transplantation is known to improve survival and quality of life of patients with end-stage renal disease. However, donor kidneys are a scarce resource and health systems around the world have not been able to meet th...

Background Kidney graft failure risk prediction models assist evidence-based medical decision-making in clinical practice. Our objective was to develop and validate statistical and machine learning predictive models to predict death-censored graft failure following deceased donor kidney transplant, using time-to-event (survival) data in a large nat...

Background Oral Health Related Quality of Life (OHRQoL) measures have emerged as an important oral health outcome that is able to reveal the subjective burden of illness due to oral diseases. The association between sociodemographic and socioeconomic factors, clinical dental conditions and OHRQoL indicators has been investigated in adolescent popul...

Background Economic-evaluations using decision analytic models such as Markov-models (MM), and discrete-event-simulations (DES) are high value adds in allocating resources. The choice of modelling method is critical because an inappropriate model yields results that could lead to flawed decision making. The aim of this study was to compare cost-eff...

Objectives Most of the paediatric quality‐of‐life instruments in oral health research are not preference‐based measures, thus cannot be used in economic evaluations. The Early Childhood Oral Health Impact Scale (ECOHIS) is one such instrument which assesses oral health impact on children's quality of life among three‐ to five‐year‐olds. With increa...

Aims: People living with heart disease are at elevated risk of hospitalisation during the last years of their life. The aim of this study was to describe hospitalisation-related usage patterns, and associated cost burden, for patients living with heart disease in the last six years of their life. Methods and results: The study was an observation...

Background Kidney graft failure risk prediction models assist evidence-based medical decision-making in clinical practice. Our objective was to develop and validate statistical and machine learning predictive models to predict death-censored graft failure following deceased donor kidney transplant, using time-to-event (survival) data in a large nat...

Chronic kidney disease (CKD) where etiology cannot be attributed to any known etiology is named CKD of uncertain etiology (CKDu). The main aims of this study were to assess the prevalence of diabetes mellitus (DM), treatment coverage, and glycemic control and its effect on renal function of patients with DM in a rural community affected by CKDu in...

The world is facing an unexpected challenge of a newly emergent pandemic, COVID-19. It has led tounprecedented impacts on public health and economy. As of 27 May 2020, there have been 5,593,148 casesof COVID-19 worldwide, with 350,509 deaths. In the absence of a disease specific therapeutics or vaccine forthis novel virus, different combinations of...

Background Unintentional injuries among adolescents is a major public health problem the world over. A great majority of the annual deaths among adolescents is due to unintentional injuries; it is also the leading cause of death among adolescents in the world. The aim of this study was to estimate the incidence of injuries and their associated fact...

Background: Matching survival of a donor kidney with that of the recipient (longevity matching), is used in some kidney allocation systems to maximize graft-life years. It is not part of the allocation algorithm for Australia. Given the growing evidence of survival benefit due to longevity matching based allocation algorithms, development of a sim...

Objective To assess the cost effectiveness of remaining waitlisted in hope of a superior quality kidney, compared to transplanting an inferior quality kidney without waiting Methods A Markov modelling approach was used to compare the cost per quality-adjusted life year (QALY) gained from remaining waitlisted in hope of a receiving a deceased donor...

Physical activity including exercises, is encouraged as it promotes healthy living. Products containing beetroot (Beta vulgaris), a commonly found food item have been used as popular exercise-supplements in the modern world. Beetroot contains high levels of nitrate which has ergogenic properties. Time trial performances and oxygen consumption capac...

Objective To assess the cost effectiveness of remaining waitlisted in hope of a superior quality kidney, compared to transplanting an inferior quality kidney without waiting Methods A Markov modelling approach was used to compare the cost per quality-adjusted life year (QALY) gained from remaining waitlisted in hope of a receiving a deceased donor...

Objectives: The study had two main aims. First, we assessed the cost-effectiveness of transplanting deceased donor kidneys of differing quality levels based on the Kidney Donor Profile Index (KDPI). Second, we assessed the cost-effectiveness of remaining on the waiting list until a high-quality kidney becomes available compared to transplanting a l...

Background Unintentional injuries among adolescents is a major public health problem globally. It is the commonest cause of death in age 10 to 19 years throughout the world. Aims This analysis aimed to estimate the incidence of injuries and their associated factors among school-going adolescents of ages 13-17 using the data of the most recent Glo...

Background Oral Health Related Quality of Life (OHRQoL) measures have emerged as an important oral health outcome that is able to reveal the subjective burden of illness due to oral diseases.The association between socio-demographic and socio-economic factors, clinical dental conditions and OHRQoL indicators has been investigated in adolescents’ co...

Background Oral Health Related Quality of Life (OHRQoL) measures have emerged as an important oral health outcome that is able to reveal the subjective burden of illness due to oral diseases. The association between socio-demographic and socio-economic factors, clinical dental conditions and OHRQoL indicators has been investigated in adolescents’ c...

Background Adolescence period is associated with psycho-social issues which affect their day to day activities and go beyond their adolescent age group. It has been recorded that prevalence of psycho-social issues are rising globally. The aim of this study was to estimate the prevalence and factors associated with the selected attributes of psycho-...

Background An optimum adolescence is associated with a psycho-social and cognitive development. These developments affects the interactions in the day-to-day activities of young people and have impacts on their lives beyond the adolescence age-group. The prevalence of psycho-social problems among adolescents are on the rise. The aim of this study w...

Background Patients with HF are at a higher risk of rehospitalisation and, as such, significant costs to our healthcare system. A non-invasive method to collect body fluids and measure Gal-3 could improve the current management of HF. In this study, we investigated the potential prognostic utility of salivary Galectin-3 (Gal-3) in patients with hea...

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Objectives The aims of this study were to: identify the evidence on cost‐effectiveness of school‐based interventions for caries prevention globally up to 2019; summarize key characteristics of interventions applied within this setting; summarize the reporting quality of previous studies; and to identify and analyse knowledge gaps. Methods A scopin...

The world is facing an unexpected challenge of a newly emergent pandemic, COVID-19. It has led to unprecedented impacts on public health and economy. As of 27 May 2020, there have been 5,593,148 cases of COVID-19 worldwide, with 350,509 deaths. In the absence of a disease specific therapeutics or vaccine for this novel virus, different combinati...

Background: Health systems are under pressure to deliver more effective care without expansion of resources. This is particularly pertinent to diseases like chronic kidney disease (CKD) that are exacting substantial financial burden to many health systems. The aim of this study is to systematically review the Cost Utility Analysis (CUA) evidence g...

Background Unintentional injuries among adolescents, is a major public health problem world over. A great majority of the annual deaths among adolescents are due to unintentional injuries, with this being the leading cause of death among them, throughout the world. The aim of this study was to estimate the incidence of injuries and their associated...

Background Unintentional injuries among adolescents is a major public health problem world over. A great majority of the annual deaths among adolescents is due to unintentional injuries; being the leading cause of death among them throughout the world. The aim of this study was to estimate the incidence of injuries and their associated factors amon...

Background Unintentional injuries among adolescents is a major public health problem the world over. A great majority of the annual deaths among adolescents is due to unintentional injuries; it is also the leading cause of death among adolescents in the world. The aim of this study was to estimate the incidence of injuries and their associated fact...

Background Unintentional injuries among adolescents is a major public health problem the world over. A great majority of the annual deaths among adolescents is due to unintentional injuries; it is also the leading cause of death among adolescents in the world. The aim of this study was to estimate the incidence of injuries and their associated fact...

Background: Mapping algorithms can be used to convert scores from a non-preference based instrument to health state utilities. The objective of this study was to develop mapping algorithms which will enable the Minnesota Living with Heart Failure Questionnaire (MLHFQ) scores to be converted into EQ-5D-5L utility scores that can be used in heart fa...

Introduction: The current epidemic of chronic kidney disease (CKD) in Sri Lanka is ascribed to the exponential increase in the number of CKD patients, which cannot be attributed to any known etiology (CKDu). The aim of this study is to describe the health related quality of life (HRQOL) and the associated factors among CKD/CKDu patients in a rural...

Background: Matching survival of a donor kidney with that of the recipient (longevity matching), is use in some kidney allocation systems to maximize graft-life years. It is not part of the allocation algorithm for Australia. Given the growing evidence of survival benefit due to longevity matching based allocation algorithms, development of a simil...

Background Matching survival of a donor kidney with that of the recipient (longevity matching), is use in some kidney allocation systems to maximize graft-life years. It is not part of the allocation algorithm for Australia. Given the growing evidence of survival benefit due to longevity matching based allocation algorithms, development of a simila...

Background Matching survival of a donor kidney with that of the recipient (longevity matching), is used in some kidney allocation systems to maximize graft-life years. It is not part of the allocation algorithm for Australia. Given the growing evidence of survival benefit due to longevity matching based allocation algorithms, development of a simil...

Background Matching survival of a donor kidney with that of the recipient (longevity matching), is used in some kidney allocation systems to maximize graft-life years. It is not part of the allocation algorithm for Australia. Given the growing evidence of survival benefit due to longevity matching based allocation algorithms, development of a simil...

The objective of the study was to determine the prevalence of anxiety symptoms and describe the association with illness severity, quality of life (QOL) and current medications among patients with BPAD who are currently in remission. A descriptive cross-sectional study conducted among outpatient clinic patients at the University Professorial Unit o...

Background: A mechanism to predict graft failure before the actual kidney transplantation occurs is crucial to clinical management of chronic kidney disease patients. Several kidney graft outcome prediction models, developed using machine learning methods, are available in the literature. However, most of those models used small datasets and none o...

Abstract Background Oral Health Related Quality of Life (OHRQoL) measures play an important role in understanding subjective patient experiences in oral health care. The Oral Impact on Daily Performance (OIDP) scale is a validated OHRQoL tool that measures the impact and extent to which an individual’s daily activities may be compromised by their o...

Background Oral Health Related Quality of Life (OHRQoL) measures play an important role in understanding subjective patient experiences in oral health care. The Oral Impact on Daily Performance (OIDP) scale is a validated OHRQoL tool that measures the impact and extent to which an individual’s daily activities may be compromised by their oral healt...

Background Oral Health Related Quality of Life (OHRQoL) surveys play an important role in understanding subjective patient experiences in oral health care. The Oral Impact on Daily Performance (OIDP) scale is a validated OHRQoL tool that measures the impact and extent to which an individual’s daily activities may be compromised by their oral health...

Background Dental caries among children is a significant public health problem world over with multiple factors playing a major role as risk factors in initiation and contnuation of the disease. Fluoride varnish application is an effective intervent in preventing dental caries. Objective of this study was to evaluate the effectiveness of six monthl...

Background: A mechanism to predict graft failure before the actual kidney transplantation occurs is crucial to clinical management of chronic kidney disease patients. Several kidney graft outcome prediction models, developed using machine learning methods, are available in the literature. However, most of those models used small datasets and none o...

Background Oral Health Related Quality of Life (OHRQoL) surveys play an important role in understanding subjective patient experiences in oral health care. The Oral Impact on Daily Performance (OIDP) scale is a validated OHRQoL tool that measures the impact and extent to which an individual’s daily activities may be compromised by their oral health...

Introduction : Machine learning has been increasingly used to develop predictive models to diagnose different disease conditions. The heterogeneity of the kidney transplant population makes predicting graft outcomes extremely challenging. Several kidney graft outcome prediction models have been developed using machine learning, and are available i...

Introduction : Stroke is a leading disease accounting for burden of chronic NCDs especially in lower and lowermiddle income (LMI) settings. Quality of Life (QOL) is considered as an important facet of determination of success of patient management. EQ-5D-3L is a generic QOL tool. It provides an index score amalgamating responses for five descriptiv...

Introduction: Stroke is a leading disease accounting for burden of chronic NCDs especially in lower and lower-middle income (LMI) settings. Quality of Life (QOL) is considered as an important facet of determination of success of patient management. EQ-5D-3L is a generic QOL tool. It provides an index score amalgamating responses for five descripti...