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February 2016 - September 2020
Education
February 2016 - September 2020
January 2010 - March 2013
September 2004 - June 2009
Publications
Publications (4)
To overcome the problems associated with the use of doxorubicin (DOX), such as low solubility, high toxicity, and side effects, a redox and pH-sensitive drug delivery system based on a star-like copolymer of folate-modified poly (ethylene glycol) (PEG) and biodegradable castor oil was developed. Redox-sensitive disulfide linkage and pH-sensitive im...
Novel dual redox/pH-sensitive star-like amphiphilic sucrose-oligo(butyl fumarate)(thioglycolic acid conjugate)-SS-poly(ethylene glycol) (Suc-OBF(TGA)-SS-PEG) copolymers and their self-assembled micelles were prepared and utilized for intracellular doxorubicin delivery. Importance of changing the hydrophobic chain length on micelles properties was i...
Linear and star-like redox-sensitive amphiphilic block copolymers have been studied as anticancer drug delivery systems. However, few reports directly compared the properties of those two structures especially when they are used as nanocarriers for antitumor drugs. To address this, a novel star-like copolymer and its linear counterpart were synthes...
Gastric and intestinal mucosal damage is the commonest adverse effect of NSAIDs. Their use is associated with a significant risk of hemorrhage, erosions, and perforation of both gastric and intestinal ulcers. NSAID-induced ulcers can be prevented largely through co-administration of a proton pump inhibitor to block acid secretion in the stomach. Al...
