Samad Nejad Ebrahimi

Samad Nejad Ebrahimi
Shahid Beheshti University | SBU · Department of Phytochemistry

PhD

About

254
Publications
56,651
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
4,026
Citations
Introduction
Screening of Iranian plant extracts against antiprotozoal, cytotoxic, antioxidants, and antimicrobial activities Isolation, purification and structure elucidation of new natural products and determination of absolute configuration by in silico CD spectra simulation Establishment of pilot-scale extraction and enrichment of natural extracts by adsorbent resin Formulation and encapsulation standardized extracts by lipid-based nano/microcarriers
Additional affiliations
January 2015 - present
Shahid Beheshti University
Position
  • Professor (Assistant)
June 2013 - March 2015
University of Basel
Position
  • PostDoc Position
April 2009 - May 2013
University of Basel
Position
  • Researcher
Education
July 2013 - December 2014
University of Basel
Field of study
  • Natural Product Discovery
April 2009 - May 2013
University of Basel
Field of study
  • Natural Products Isolation, Medicinal Plant
September 2002 - March 2005
Shahid Beheshti University
Field of study
  • Phytochemistry

Publications

Publications (254)
Article
The new trends in drying technology seek a promising alternative to synthetic preservatives to improve the shelf-life and storage stability of food products. On the other hand, the drying process can result in deformation and degradation of phytoconstituents due to their thermal sensitivity. The main purpose of this review is to give a general over...
Article
Full-text available
Abstract: Designing strategies for an effective transformation of food waste into high-value products is a priority to address environmental sustainability concerns. Coffee silverskin is the major by-product of the coffee roasting industry, being rich in compounds with health benefits. Such composition gives it the potential to be transformed into...
Article
Natural preservatives were predominantly developed to eliminate the use of synthetic preservatives for food and agriculture industries. Multi-component nanoemulsions (MCN) with significant antibacterial activity should be proper candidates as natural preservatives. This research aimed to formulate a multi-component phospholipid-based nanoemulsion (...
Article
Full-text available
Background: Phenolic compounds are one of the main groups of secondary metabolites responsible for multiple biological and pharmacological properties that play a vital role in improving human health quality. Encapsulation by spray dryer creates protection toward the phenolic compounds as an efficient way for increasing product performance. Method:...
Method
This document specifies measurement protocols and test conditions to determine alterations to protein secondary structure induced by their interaction with nanomaterials using ultraviolet circular dichroism (UV-CD) spectroscopy. This document does not apply to the characterization of conformational changes of disordered proteins. https://www.iso....
Article
Epilepsy is one of the common brain disorders, estimated to have a prevalence of about 1%. Several neurological side effects of antiepileptic drugs (AEDs) include cognitive impairment, depression, and hepatotoxicity. The Iranian flora is a rich source of medicinal plants. Several in vivo studies have examined the anticonvulsant activity of Iranian...
Preprint
With the aim of quality improvement, the effects of foliar application of phenylalanine at 5 concentrations on grape ( Vitis vinifera cv. Qızıl Uzum) berry compositions were studied. The studied parameters included antioxidant activity, total phenolics, total flavonoids, total anthocyanin, catalase, phenylalanine ammonia-lyase enzyme activity, and...
Article
Plant endophytes are known as one of the newest natural sources for producing secondary metabolites and novel antibiotics. In the present study, endophytic fungi isolated from the corms of Crocus caspius Fisch. & C.A.Mey. ex Hohen. (Iridaceae) were characterized for the first time. Six fungal endophytes were isolated and their antibacterial activit...
Article
The Phytochemical profiling of the root extract of Salvia leriifolia, an endemic plant of Iran, was investigated and 16 abietane diterpenes were isolated, and three were original compounds. 1D and 2D NMR and HRMS performed structural elucidation. The absolute configuration of the previously unreported compounds was determined by circular dichroism...
Poster
Full-text available
Rheumatoid arthritis (RA) is an auto-immune and chronic disease. Various cytokines such as chemokines, interleukins, as well as tumor necrosis factors-α (TNF-α) involve in RA. Inflammation, apoptosis, Carcinogenesis and viral replication hindrance are some substantial TNF-α roles. Plethora and disorder in TNF-α production cause common diseases, inc...
Article
A green protocol was proposed for the extraction and separation of high-value phenolic compounds (PCs) from grape (Vitis vinifera L.) pomace. The most important variables for scale-up purposes including extraction time (4-16 h), temperature (40-80 ℃), and solvent-to-feed ratio (8-40 ml. g⁻¹) on the extraction efficiency and yield of PCs were scruti...
Article
Four sesquiterpene lactones, astrodaucanolide A-D (1-4) with unique structures, toghether with two known phenylpropanoid esters (5 and 6) were isolated from a flower extract of Astrodaucus orientalis. The structures were established by 1D and 2D NMR spectroscopy and high-resolution mass spectrometry (HRESIMS), and the absolute configuration of 1-4...
Article
Eight undescribed cassane diterpenes, pterolobirins C−J, together with two known analogs, were isolated from the roots of Pterolobium macropterum. Their structures were characterized by extensive spectroscopic techniques including NMR, MS, ECD and X-ray crystallographic spectroscopy. The absolute configuration of pterolobirin J was confirmed by sin...
Article
Full-text available
The quorum-sensing (QS) system allows organisms to communicate and form virulence factors such as biofilm. Pseudomonas aeruginosa is one of the Gram-negative bacteria leaving many casualties every year. In the past years, the bacteria's QS system has gained attention as a valuable target to design and develop new efficient antibiotics. Nature has a...
Article
Full-text available
Phytochemical investigation on the acetone extract of Salvia mirzayanii Rech. f. and Esfand. afforded seven new isoprenoids including six new sesterterpenoids salvimirzacolide A-F ( 1–6 ), and one new nor-diterpenoid ( 7 ). Their structures were established by comprehensive spectroscopic and spectrometric data analysis (1D and 2D NMR, HRMS) and DP4+...
Article
Full-text available
Tetrataenium nephrophyllum belonging to the Apiaceae family grows widely in the West Azerbaijan province of Northwestern Iran. It is an aromatic plant that has been used as food spices by local people. In this research work, the phytochemical composition of n-hexane extract from the aerial parts of this plant has been investigated. The fractionatio...
Article
The purpose of this study was to prepare functional formulations using two different types of Punica granatum (pomegranate) peels extracts (the native and the enriched extract), as an important source of polyphenolic compounds such as punicalagin and ellagic acid. These two extracts were microencapsulated by a spray-drying technique. Polyphenol con...
Article
Full-text available
Background: Ultrasonic assisted extraction (UAE) is a robust and efficient method as a desirable alternative to conventional strategies for extracting active ingredients from different parts of plants. Coupling this technique with hydrodistillation is an effective method for producing essential oil from plant material. Objective: In this study, we...
Article
Full-text available
Background: Common horsetail (Equisetum arvense L.), is widely used in the bone and nail strengthen herbal products due to the presence of minerals, especially silica. Objective: Agro-morphological and phytochemical diversity, and the silica content of the E. arvense populations (EAPs) collected from Iran along with two commercial samples from Russ...
Article
Full-text available
Two seco-norabietane diterpenes with unique structures, namely abrotafuran and abrotacid, were isolated from the roots of Salvia abrotanoides (Kar.) Sytsma. The compounds were characterized by 1D and 2D NMR spectroscopic techniques, ECD, and HR-ESIMS experiments. Plausible biosynthetic pathways of abrotafuran and abrotacid were proposed. These comp...
Article
Full-text available
Numerous deaths worldwide have been caused by the coronavirus pandemic and are currently progressing with successive mutations and a lack of appropriate and definitive treatment. One of the drug targets to control the replication of the virus and treat this disease is to block the ion channel of the virus. This will lead to its death by disturbing...
Article
Full-text available
Gunnera tinctoria, an underexplored invasive plant found in Azores, Portugal, was studied regarding its nutritional, antioxidant, and antitumoral properties. Higher antioxidant activity was found in baby leaves, followed by adult leaves and inflorescences. A phenolic fraction of the plant was enriched using adsorbent resin column chromatography (Di...
Article
Full-text available
Bauhinia holophylla leaves, also known as "pata-de-vaca", are traditionally used in Brazil to treat diabetes. Although the hypoglycemic activity of this medicinal plant has already been described, the active compounds responsible for the hypoglycemic activity have not yet been identified. To rapidly obtain two fractions in large amounts compatible...
Article
Full-text available
Background: Medicinal plants play a significant role in preventing and treating diseases due to their traditional uses. Objective: The aim of the study was to isolate, purify and identify phytochemicals from the n-hexane extract of Teucrium hircanicum L. roots and evaluate the antioxidant activity of the extract and its purified compounds. Methods:...
Article
Centella asiatica (L.) Urban (Apiaceae) is a commercial medicinal plant, which is rich in pentacyclic triterpenes (PTs) named centellosides including asiaticoside and madecassoside as triterpene saponins in addition to their corresponding sapogenins (asiatic acid and madecassic acid). These are well-known bioactive compounds in C. asiatica due to t...
Article
Quorum sensing (QS) is a bacterial communication mechanism that regulates the production of many pathogenic factors, including the formation of pigments and the ability to form biofilms that are essential for chronic infections. For discovering new inhibitors on the formation of biofilm formation, over 700 synthetic and natural compounds have been...
Article
Junipers (Juniperus spp.) are important pharmaceutical plants, and they are commonly grown in the northern hemisphere because of the various medicinal properties attributed to the Juniperus genus. However, despite their pharmaceutical and also industrial importance, and despite plant diversity being a common topic of research among professional bre...
Article
Noscapine is a natural product first isolated from the opium poppy (Papaver somniferum L.) with anticancer properties. In this work, we report the synthesis and cellular screening of a noscapine-based library. A library of novel noscapine derivatives was synthesized with modifications in the isoquinoline and phthalide scaffolds. The so generated li...
Article
Full-text available
Salvia leriifolia is an endemic to Iran belongs to Lamiaceae. This plant has numerous valuable properties, including analgesics, anti-inflammatories, sedatives, antioxidants and has significant applications in the medical, pharmaceutical and food industries. The purpose of this study was to evaluate the chemical composition and antioxidant activity...
Article
Full-text available
Pomegranate juice (PJ) is a well-known nutritional drink that has been widely consumed due to its health benefits. However, sedimentation of polyphenol, browning, and contamination of microorganisms are problems of fresh juice. This research aimed to evaluate the effect of ozone and ultrasound treatment on pasteurization and disinfection of PJ. The...
Article
Salvia limbata is of great importance in terms of the pharmaceutical industry. Therefore, it is important to investigate the main factors that affect its essential oil composition. Although some investigations have been done in the field of the phytochemistry of S. limbata, the present study investigates, for the first time, the effect of growth st...
Article
Full-text available
Fractionation of an EtOAc extract of the roots of Perovskia abrotanoides yielded 28 diterpenoids, including 12 new analogues, 1-12. The structures of these diterpenoids were established using comprehensive spectroscopic data analysis, including 1D and 2D NMR, high-resolution electrospray ionization mass spectrometry, electronic circular dichroism s...
Preprint
Full-text available
Background: The novel coronavirus (2019-nCoV) causes a severe respiratory illness that was unknown in the human before. Its alarmingly quick transmission to many countries across the world resulted in a worldwide health emergency. It has caused a notable percentage of morbidity and mortality. Therefore, an imminent need for drugs to combat this dis...
Article
Full-text available
bstract Background: The current outbreak of Coronavirus Disease 2019 (SARS-CoV-2) led to public health emergencies all over the world and made it a global concern. Also, the lack of an effective treatment to combat this virus is another concern that has appeared. Today, increasing knowledge of biological structures like increasing computer power br...
Article
Full-text available
The emergence of viral pneumonia caused by a novel coronavirus (CoV), known as the 2019 novel coronavirus (2019-nCoV), resulted in a contagious acute respiratory infectious disease in December 2019 in Wuhan, Hubei Province, China. Its alarmingly quick transmission to many countries across the world and a considerable percentage of morbidity and mor...
Article
Full-text available
Highlights Graphical Abstract Article Info Abstract * Corresponding author: Saffariha@ut.ac.ir (M. Saffariha) RESEARCH PAPER • Forage quality of Salvia limbata was affected by phenological stages and altitudes. • The highest percentage of N, CP, ME, and DMD were achieved in the vegetative stage. • The highest ADF was obtained in in the seed ripenin...
Article
Four undescribed and 17 known diterpenoids were isolated from the roots of Zhumeria majdae Rech.f. & Wendelbo. Using 1D and 2D NMR spectroscopy, ECD spectroscopy, and HRESIMS data analysis, the structures of the undescribed compounds were elucidated. The anti-proliferative activity of isolated compounds was evaluated against HeLa and MCF7 cancer ce...
Article
Full-text available
Three new compounds ( 1 – 3 ) with unusual skeletons were isolated from the n -hexane extract of the air-dried aerial parts of Hypericum scabrum . Compound 1 represents the first example of an esterified polycyclic polyprenylated acylphloroglucinol that features a unique tricyclo-[4.3.1.1 1,4 ]-undecane skeleton. Compound 2 is a fairly simple MPAP,...
Article
Full-text available
Background: A bioassay-guided fractionation technique was used to evaluate the active constituents of the perennial plant L. officinale W.D.J. Koch (Apiaceae) against multidrug resistant (MDR) Mycobacterium tuberculosis. Methods: Column chromatography was used to isolation of compounds from L. officinale and spectroscopic methods including 1D and 2...
Preprint
Full-text available
Background The present study investigates the effect of growth stage (vegetative, flowering and seed ripening) and altitude (1500, 2000 and 2500 m above sea level) on the content and chemical composition of S. limbata essential oil which belongs to Lamiaceae family.ResultsAccording to the oil analysis, 28 components representing 96.5% to 99.7% of t...
Article
The application of essential oil nanoemulsions (EO-nano) are growing to overcome the serious problem of bacterial resistance. Pseudomonas aeruginosa as a pathogenic bacterium could form biofilms which resist antibiotics and leads to serious infections in hospitals and microbial contaminations in industrial settings. In this research, five different...
Article
Twelve new pyridine-4(1H)-one derivatives, namely, 8-demethoxywaltherione F (1), waltheriones R-V (2, 6, 7, 10, and 11), 1-methoxywaltherione O (3), (S)-15-hydroxywaltherione G (4), (8R)-8-hydroxywaltherione M (5), (9S,13S)-2-hydroxymethylwaltherione C (8), (9S,10S,13S)-10-hydroxywaltherione C (9), and (S)-13-methoxywaltherione V (12), as well as m...
Article
Full-text available
Background: The relative values of secondary metabolites may be impacted by harvesting time and post-harvest drying methods. Objective: The effects of various harvesting stages of flower and drying methods were investigated on the quality and quantity of secondary metabolites of A. chamissonis Less. grown in the field. Methods: The flowers were har...
Article
Alzheimer’s disease (AD) is a devastating neurodegenerative disease affecting 47 million people worldwide. While acetylcholinesterase (AChE) inhibitors such as donepezil and galantamine are leading drugs in the symptomatic treatment of AD, new AChE inhibitors continue to be explored for improved potency and selectivity. Herein, a molecular networki...
Article
Full-text available
Background: Green synthesized nanoparticles (NPs) from agricultural wastes is an area of great interest due to it is eco-friendly and profitable. Zinc oxide is an inorganic UV-filter commonly used as UV-blocker in a different industry. Methods: Zinc oxide nanoparticles (ZnO NPs) were successfully biosynthesized using Zn(NO3)2 as a substrate by poly...
Article
The first step in introducing a medicinal plant into farming systems and industrial pharmacology is the realization of its metabolic profile and biological features. In the present study, ten Verbascum species including V. cheirantifolium, V. erianthum, V. macrocarpum, V. punalense, V. sinuatum, V. songaricum, V. speciosum, V. stachidiforme, V. tha...
Article
Ruscus hyrcanus Woronow a commercially important ornamental and medicinal plant belonging to the Asparagaceae family, has various applications in Iranian traditional medicine due to its diuretic, appetizing, cathartic, vasoconstrictor, anti-hemorrhage, ant-nephritis, anti-infection, aperient and anti-varicose properties. In the present study, morph...
Article
Full-text available
Four prenylated flavonoids, including isosophoranone, sophoraflavanone G, alopecurone J, alopecurone P, and a resveratrol derivative HPD (2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b] furan-3,4,6-triol), were isolated from the roots of Sophora pachycarpa. The cytotoxic activity of obtained compounds was evaluated against A2780, A549, HeLa, and HCT116 hum...
Article
Background: Zataria multiflora Boiss. (Lamiaceae) has been found in Iran, Afghanistan, and Pakistan. Z. multiflora called ‘Avishane Shirazi’ in Persian is used as a seasoned in many foods in Iran. The literature survey demonstrated that Z. multiflora has immunostimulant, pain-relieving, antinociceptive, anti-inflammatory, antioxidant, antibacterial...
Article
Full-text available
The cucumber moth (CM), Diaphania indica (Saunders) (Lepidoptera: Pyralidae), is a major lepidopteran pest of cucur-bitaceous plants that caterpillars feed on vegetative tissue of the plants and thereby cause loss of crops. Previous work has shown that volatile organic compounds (VOCs) released by host plants attract gravid CM females for ovipositi...
Article
The biotransformation of a mixture of resveratrol and pterostilbene was performed by the protein secretome of Botrytis cinerea. Several reaction conditions were tested to overcome solubility issues and to improve enzymatic activity. Using MeOH as cosolvent, a series of unusual methoxylated compounds was generated. The reaction was scaled-up, and th...
Article
In the present study, productivity, essential oil variability and antioxidant activity of Ferula assa-foetida oleo-gum-resin (OGR) collected at different collection times (July, August, September, and October) were studied by using GC-FID-MS and DPPH assay. The amount of OGR (g/plant) and its oil content significantly affected by the collection tim...
Article
PurposeZhumeria majdae, a unique species of the Zhumeria genus, is an endemic Iranian plant in the Lamiaceae family. Phytochemical investigation and biological activity of this plant are rarely reported. The current study aimed to find new antiprotozoal compounds from the roots of Z. majdae and to determine the absolute configuration of isolated co...
Article
Salvia leriifolia Benth is a perennial herbaceous plant and belongs to the Lamiaceae family; distributes among dry and warm regions in Iran. In the present study, the chemical compositions and antibacterial activity of essential oils from aerial parts of S. leriifolia collected from six natural habitats in North-East of Iran have been investigated....
Article
Two new polyketides, named koninginin T (1) and U (2), were isolated from Phomopsis stipata - an endophytic fungus isolated from Styrax camporum Pohl. The structures of polyketides 1 and 2 were defined through the analysis of spectroscopic data. Antifungal and acetylcholinesterase inhibitory activities of these compounds were evaluated using TLC bi...
Article
Full-text available
A new phthalide, namely 7-methoxy-3-propylidenephthalide (1), along with two known compounds (2, 3) were isolated from the roots of the edible herb Levisticum officinale W.D.J. Koch, commonly known as lovage and well known in traditional medicine for its spasmolytic and diuretic effects. The structure of the new compound was established by HRMS and...
Article
Phytochemical investigation of the alkaloid extract of the aerial parts of Psychotria nemorosa led to the isolation and characterization of 10 azepine-indole alkaloids, i.e., cimitrypazepine (1), fargesine (2), nemorosines A (3), and B (12), nemorosinosides A-F (4-9), as well as two β-carboline derivatives, 10-hydroxyisodolichantoside (10) and 10-h...
Article
Licorice (Glycyrrhiza glabra L.) as a strategic and highly valuable medicinal plant in Iran with numerous beneficial pharmaceutical properties contributes substantially to Iranian herbs exports. In the present study, variation of cultivated licorice populations was assessed via morphological, phytochemical and simple sequence repeats (SSRs) markers...
Article
Ruscus hyrcanus Woron., a valuable medicinal plant belongs to the Asparagaceae, is growing in the forests of Hyrcanian ecoregion in northern of Iran. In the present study, molecular authentication of the plant was studied. Four taxa of Ruscus L. along with some species from the genus Danae racemosa and Maianthemum japonicum were selected and the ph...
Article
Marine organisms are an important source of chemical compounds which are appropriate for use as therapeutic agents. Among them, Sea pens produce valuable chemical compounds being used as anti-cancer drugs. The aim of this study was to investigate anti-cancer property of extracted and purified compounds from marine organism Sea pen and evaluate thei...