Samaa Abdullah

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Verified

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• Doctor of Philosophy
• Professor (Assistant) at Amman Arab University

Naringenin (NAR), a flavonoid mainly found in citrus and grapefruits, has proven anti-cancer activities. However, the poor water solubility and low bioavailability of NAR limits its use as a therapeutic agent. The aim of this study was to develop and optimize stable naringenin nanoemulsions (NAR-NE) using a Box–Behnken experimental design to obtain...

Dendritic cells (DCs) are professional antigen‑presenting cells, which are resident or proliferating in organs. Major histocompatibility complex (MHC) Class I and II on DCs in normal steady conditions process and present antigens including cancer antigens. Many approaches are used to enhance antigen presentation process of DCs and capture cancer ce...

A sustained-release formulation of 5-fluorouracil (5-FU) providing a polymeric coating in a nanosuspension comprising biopolymers for oral administration. The nanosuspension forms an insoluble sedimenting gel in the low pH environment of the stomach to speed gastric emptying. The sedimented insoluble gel becomes soluble in the pH environment of the...

5-fluorouracil (FU) is an anticancer treatment with disadvantages of a short half-life and the need for multiple intravenous administrations. The idea was to formulate oral sustained-release nanosuspensions of FU, which was utilizing drug-soy protein (Sp) solid dispersions, protein-polysaccharide gels, and sedimentation of insoluble gel formulation...

5-Fluorouracil is an anticancer drug with a short biological half-life. This study aimed to develop oral sustained-release nano-formulations of 5-Fluorouracil. 5-Fluorouracil-carrageenan coated particles were prepared and characterized. To formulate a suspension, the coated particles were encapsulated in an aqueous hydrodynamic gel of sodium algina...

This work presents the synthesis of a chitosan-based nanocomposite of crosslinked chitosan-citrate/SnO2 nanoparticles (CTN-CT/SnO2) for methyl blue (MB) dye removal from aqueous solutions. Box-Behnken design (BBD) was implemented to examine the impact of three variables on the adsorption of MB dye: A: CTN-CT/SnO2 dose (0.02–0.08 g), B: pH (4–10), a...

The pursuit of Sustainable Development Goals (SDGs) and the adoption of circular economy principles necessitate innovative approaches to resource management and environmental protection. This study introduces the development of a biomaterial (hereinafter, CTS/MP-OX) derived from chitosan and activated mangosteen (Garcinia mangostana L.) peel using...

This study investigates the development of a chitosan-based composite for advanced dye removal applications. The carboxylated chitosan-phthalic anhydride/hydroxyapatite (CTSPA/ HAP) composite was synthesised by integrating chitosan with hydroxyapatite and grafting carboxyl groups via phthalic anhydride. The material’s physicochemical properties wer...

This work developed a Schiff base-chitosan-vanillin/hydroxyapatite (CHI-VAN/HA) composite from natural resources for effective brilliant green (BG) dye removal from aquatic systems. Physicochemical analysis of CHI-VAN/HA was performed via several methods, including BET, XRD, FTIR, and SEM-EDX. The mean pore diameter and total pore volume of CHI-VAN...

Background: Methotrexate (MTX) is an antimetabolite that iswidely utilized in the treatment of pulmonary disorders. Designingan effective MTX-ABL co-delivery system is a complicated but intri-guing technique for improving targeted pulmonary treatment.Aim: The goal of this research is to improve the pulmonary deliv-ery and therapeutic effectiveness...

Herein, a sustainable biomaterial (hereinafter, CTO/MP-SA) of chitosan/chemically modified mango (Mangifera indica L.) peel using sulfuric acid (H2SO4) was produced to be an efficient adsorbent material for dye removal (safranin O, SAF-O) from aquatic environments. The chitosan/biomass composite (CTO/MP-SA) was characterized using elemental analysi...

Methotrexate (MTX) is classified as an antimetabolite. It’s commonly used to treat lung cancer. MTX is an immunosuppressant following the above-mentioned mechanism of action due to its poor selectivity. The tricky move is to investigate the solid dispersions and coating using a co-delivery system of MTX and Ambroxol (ABL). ABL is known for its, ant...

Herein, a sustainable biocomposite, referred to as CH/OTL-HS was prepared by combining chitosan with H2SO4 acid-modified olive tree leaves (Olea europaea). The physicochemical characteristics of CH/OTL-HS were investigated through various methods including CHNS-O, pHpzc, XRD, FTIR, BET, and FESEM. An evaluation was conducted to determine the effect...

In the present work, a polymeric nanocomposite adsorbent of cross-linked chitosan-adipic acid and SnO2 nanoparticles (CS-ADP/SnO2) was created for the adsorption of methyl orange (MO) dye from water. Response surface methodology (RSM) was used to examine how three factors affected the adsorption of the dye MO: time C (10–40 min), pH (4–10), and CS-...

The goal of the research was to develop a hydrophobic octanoate salt of chitosan (CS-OA) and use the salt as a nanoparticle platform for the delivery of curcumin (CUR) into prostate cancer cells. The nanoprecipitation technique was used to prepare the nanoparticles, which were measured for particle size and encapsulation efficacy relative to CUR-CS...

Herein, a biohybrid polymer nanocomposite of carboxylated chitosan- phthalate/SnO2 nanoparticles (CTS-PHA/SnO2) was developed for dye wastewater treatment i.e. removal of basic red 2 (BR2) dye. A study was conducted using response surface methodology (RSM) to analyse the impact of three factors on the adsorption of BR2 dye. These factors were CTS-P...

Employing sustainable biomaterials obtained from waste biomass and biopolymers provides a very promising method for eliminating organic dyes from wastewater. This study presents a novel adsorbent of modified dragon fruit peels and chitosan, addressing wastewater treatment and environmental waste management. Precisely, a bio-sourced multifunctional...

Silver nanoparticles were successfully incorporated into a melamine-based polymer, resulting in the synthesis of (Ag NPs@Bipy-PAN) through a reverse double solvent approach. The synthesised Ag NPs@Bipy-PAN polymer underwent extensive characterisation through Powder X-ray Diffraction (PXRD), Scanning Electron Microscopy (SEM), Transmission Electron...

Empagliflozin (EMP) is known for its poor safety and efficacy profile due to its fast body distribution and poor solubility. Accordingly, an oral long-acting and floating/raft-forming nano gel was optimized to release coated EMP nanoparticles, and the released EMP nanoparticles showed enhanced dissolution compared to raw EMP particles. To repurpose...

To address the prevalent genistein (GST) metabolism and inadequate intestinal absorption, an oral long-acting and gastric in-situ gelling gel was designed to encapsulate and localize the intestinal release of the loaded genistein-ginseng (GST-GNS) solid dispersion. Because of the high breast perfusion of GST upon oral absorption, the GST-GNS solid...

The goal of the study was to look into drug-polyelectrolyte complexation between ciprofloxacin (Cipro) and λ-carrageenan (CRG), and to employ the complex as a sustained-release matrix. The maximum binding capacity of the complexation was determined using the dialysis bag method and employed to prepare the complex. In comparison to Cipro, CRG, and t...

Although curcumin (CUR) has a well-researched anticancer profile, its application is constrained by its poor solubility and permeability. The goal of this work was to enhance the dissolution, cellular uptake, and cytotoxicity of CUR by using betaine (BET) as a carrier in CUR solid dispersions (SDs). At various weight ratios, CUR-BET co-precipitates...

Naringenin (NAR) is a natural anticancer, but it has not been developed for clinical use despite its therapeutic potential due to its low water solubility, low membrane permeability, first-pass metabolism, and low bioavailability. To overcome these problems, the optimization and preparation of NAR-Soy protein complex (NAR-Sp) led to the optimum rat...

Colon cancer (CC) is highly malignant and is considered the second cause of death worldwide. However, the overall CC survival rate is improving due to the rapid development of screening tools and improved treatment options. This raised the need to develop effective approaches for medical intervention. Moreover, CC is classified into four stages: st...

Wound refers to the damage to the physical and physiological integrity of the epidermal or dermal layer that leads to various other pathogenic abnormalities if not healed normally. Wound healing is a complex physiological process involving inflammatory, proliferative, and remodeling phases and various mechanisms such as cellular migration, producti...

Novel cross‐linked poly(methyl methacrylate) (PMMA) derivatives with different ratios of crosslinkers (2, 5, 10, 20, 30, 40, and 50 wt%) were synthesized using the condensation method between PMMA and bifunctional amino derivative cross‐linkers, o‐phenylenediamine (OPD), and m‐phenylenediamine (MPD). The final products were tested for antibacterial...

Resveratrol (Rv) is an antioxidant, anti-inflammatory, and anticancer agent. Rv's problem is the need for multiple oral administrations due to high metabolism and low physiochemical stability. This work aimed to develop sustained-release long-acting oral nanocomposites of Rv in an in-situ gelling film, which was achieved by the development of intes...

A sustained-release formulation of 5-fluorouracil (5-FU) providing a polymeric coating in a nanosuspension comprising sodium alginate and carrageenan for oral administration. The nanosuspension forms an insoluble sedimenting gel in the low pH environment of the stomach to speed gastric emptying. The sedimented insoluble gel becomes soluble in the p...

The aim of the study was to develop and evaluate the Ginkgo biloba nanocomplex gel (GKNG) as a long-acting formulation for the wound healing potential. Pharmaceutical analysis showed an average particle size of 450.14 ± 36.06 nm for GKNG, zeta potential +0.012 ± 0.003 mV, and encapsulation efficiency 91 ± 1.8%. The rheological analysis also showed...

An in situ gelling composition comprising nanoparticles comprising soy protein and a bioactive agent, and a sodium alginate film, wherein the nanoparticles are encapsulated in the film. The in situ gelling composition maybe incorporated into a solid dosage form or reconstituted with water for oral administration to a subject in need of sustained re...

5-Fluorouracil is an anti-metabolite drug used as one of the first line colon cancer treatment. 5-Fluorouracil has a short half-life of 16 minutes, which could be solved by the repetitive intravenous administrations. Repetitive intravenous administrations lead to the drug accumulation that increase the drug adverse effects and drug selectivity prob...

This study aimed to develop and evaluate sustained-release (SR) long-acting oral nanocomposites in-situ gelling films of resveratrol (Rv) to treat colorectal cancer. In these formulations, Rv-Soy protein (Rv-Sp) wet granules were prepared by the kneading method and then encapsulated in the sodium alginate (NA) dry films. The prepared nanocomposite...

This study aimed to develop gastro-retentive sustained-release ambroxol (ABX) nanosuspensions utilizing ambroxol-kappa-carrageenan (ABX-CRGK) complexation formulations. The complex was characterized by differential scanning calorimetry, powder x-ray diffractometer, and scanning electron microscopy. The prepared co-precipitate complex was used for t...

Ambroxol (ABX), as an efficient mucolytic agent in respiratory tract infections, had multiple disadvantages. Some of them are the short half-life and the need for multiple oral administration per day. The aim was to develop sustained-release aqueous suspensions of ABX utilizing drug-polymer complexation and raft-forming formulations. ABX-carrageena...

The aim was to develop sustained-release aqueous suspensions of ambroxol utilizing drug-polymer complexation and raft-forming formulations. Ambroxol-carrageenan (ABX-CRG) complexation was studied for the optimum binding capacity, which was used to prepare the complex by kneading and co-precipitation. The prepared complex was characterized by Fourie...

Due to its unique properties, such as biodegradability, biocompatibility, high amphiphilic property, and micelle formation, casein (CS) has been increasingly studied for drug delivery. We used CS as a drug carrier in solid dispersions (SDs) and evaluated the effect of its degradation by trypsin on drug dissolution from the dispersions. SDs of CS an...