Salmiah Ismail

Introduction Colorectal cancer (CRC) is common, with a worldwide incidence estimated at more than 1 million cases annually. Therefore, the search for agents for CRC treatment is highly warranted. Inositol-6 phosphate (IP6) is enriched in rice bran and possesses many beneficial effects. In the present study the effect of IP6 on autophagy-mediated de...

This study evaluated anticancer potential of three Terminalia species, Terminalia muelleri, Terminalia bellerica, and Terminalia laxiflora and also their phytochemical content were determined. Anticancer potential of the plant extracts was measured according to MTT assay. The results showed that T. muelleri methanolic extract was active against bre...

Inflammatory bowel diseases (IBD) encompass at least two forms of intestinal inflammation: Crohn's disease and ulcerative colitis (UC). Both conditions are chronic and inflammatory disorders in the gastrointestinal tract, with an increasing prevalence being associated with the industrialization of nations and in developing countries. Patients with...

Colorectal cancer is the second leading cause of cancer-associated deaths that suggests more effort is needed to prevent/control this disease. Herein, for the fi rst time, we investigate in vitro the effi cacy of allicin against colon tumorigenesis HT-29 human colon cancer cells. Allicin is an active compound of garlic possesses many health related...

The objective of this study is to evaluate the effect of allicin (10mg/kg body weight, orally) in an experimental murine model of UC by administering 2.5% dextran sodium sulfate (DSS) in drinking water to BALB/c mice. DSS-induced mice presented reduced body weight, which was improved by allicin administration. We noted increases in CD68 expression,...

Colorectal cancer (CRC) is common, with a worldwide incidence estimated at more than 1 million cases annually. Therefore, the search for chemotherapeutic agents for the treatment of CRC is highly warranted. Inositol-6 Phosphate (IP6), is enriched in rice bran, possess many beneficial effects. Autophagy is a physiologic process that allows degradati...

Allium hirtifolium Boiss. known as Persian shallot, is a spice used as a traditional medicine in Iran and, Mediterranean region. In this study, the chemical composition of the hydromethanolic extract of this plant was analyzed using GC/MS. The result showed that 9-hexadecenoic acid, 11,14-eicosadienoic acid, and n-hexadecanoic acid are the main con...