Saleem Hmoud Aladaileh

Saleem Hmoud Aladaileh
Al-Hussein Bin Talal University | AHU · Department of Medical Analysis

PhD Immunology and Biochemistry

About

50
Publications
28,475
Reads
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Citations
Additional affiliations
September 2014 - present
Al-Hussein Bin Talal University
Position
  • dean of college of science
September 2013 - present
Princess Aisha Bint Al-Hussein Faculty of Nursing - AHU
Position
  • Associate prof. of comparative immunology and biochemistry
September 2013 - present
Princess Aisha Bint Al-Hussein Faculty of Nursing - AHU
Position
  • Associate prof. of comparative immunology and biochemistry

Publications

Publications (50)
Article
Full-text available
The role of oxidative injury and inflammatory response in cardiovascular diseases and heart failure has been well-acknowledged. This study evaluated the protective effect of umbelliferone (UMB), a coumarin with promising radical scavenging and anti-inflammatory activities, on myocardial injury induced by isoproterenol (ISO) in rats. Rats received 5...
Article
Full-text available
This in silico work was carried out to reveal the proposed anti-fungal efficacy of some clove ingredient compounds against aspartate semialdehyde dehydrogenase, 6C8W and 6C85, enzymes from Blastomyces dermatitidis. The molecular docking simulation was implemented utilizing the Auto Dock 4.2. software. A set of 17 compounds were selected for this st...
Article
Nephrotoxicity is a major complication that limits the therapeutic application of cisplatin (CIS). Oxidative stress and inflammation are implicated in CIS-induced acute kidney injury (AKI) and apoptotic cell death. Punicalagin (PUN), a polyphenol in pomegranate, possesses promising anti-inflammatory and antioxidant activities, and its beneficial ef...
Article
Oxidative tissue injury and inflammatory responses play major roles in cardiovascular diseases and heart failure. Visnagin (VIS) is a natural bioactive component of Ammi visnaga, with promising radical scavenging and anti-inflammatory activities. This study explored the protective effect of VIS against isoproterenol (ISO)-induced acute myocardial i...
Article
Full-text available
Screening of phytochemical Ephedra alte crude extract by GC–MS and HPLC analysis indicated the presence of alkaloids, tannins, flavonoids, terpenoids, and phenolic acid in the extract. The total phenolic content of E. alte methanol extract was 39.43 mg of Gallic acid eq/g, crude E. alte with 56.74, and 2.42 µg Trolox equivalent antioxidant capacity...
Article
Oxidative tissue injury and inflammatory response are the main regulators of diabetic nephropathy (DN). The potential protective effect of galangin (Gal), a powerful flavonoid with several promising bioactivities, on hyperglycemia-induced kidney injury in a rat model of DN has been investigated in this study. A rat model of diabetes was induced by...
Article
Full-text available
In this study, vitamin D has shown greater efficacy of binding with M pro of COVID-19 compared to the recently recommended drugs. The docking study was simulated to streamline interaction effects of Vitamin D, Remdesivir, Chloroquine, Hydroxychloroquine, Aspirin, and Azithromycin complexes with the active site of M pro. Vitamin D is found to have t...
Article
Full-text available
Cardiovascular complications are the leading cause of morbidity in diabetes. Oxidative stress and inflammation are implicated in the development and progression of diabetic cardiomyopathy (DCM). This study explored the cardioprotective effect of galangin (Gal), a natural flavonoid with radical-scavenging and anti-inflammatory activities, in diabeti...
Article
Full-text available
Methotrexate (MTX) is a trusted anticancer agent; however, its multi-organ toxicity limits its clinical application, including nephrotoxicity. Punicalagin (PUN) is an ellagitannin found in the fruit peel of Punicagranatum with anti-inflammatory and antioxidant properties. The present study aimed to investigate the renoprotective effects of PUN in a...
Article
Full-text available
Aims: Cyclophosphamide (CP) is a broad-spectrum chemotherapy agent available to treat various malignancies; however, its nephrotoxicity limits its clinical use. Formononetin (FOR) is a bioactive isoflavone with encouraging biological activities. The current study explored and elucidated the possible protective/therapeutic effects of formononetin ag...
Article
Full-text available
Seventeen compounds from Syzygium aromaticum are selected for exo-β-(1,3)-glucanases inhibitory activity by using molecular docking study. The compounds are uploaded from the PubChem database and molecular docking with AutoDock 1.5.6 tools is carried out. The molecular docking scores indicate that stigmasterol and campesterol are of the highest pot...
Article
Full-text available
Novel coronavirus disease (COVID-19) has become a pandemic threat to public health. Vaccines and targeted therapeutics to prevent infections and stop virus proliferation are currently lacking. Endoribonuclease Nsp15 plays a vital role in the life cycle, including replication and transcription as well as virulence of the virus. Here, we investigated...
Article
Full-text available
Acute kidney injury (AKI) is a serious complication of methotrexate (MTX). This study explored the protective effect of the isoflavone formononetin (FN) against MTX nephrotoxicity with an emphasis on oxidative stress, inflammation, and nuclear factor (erythroid-derived 2)-like 2/heme oxygenase 1 (Nrf2/HO-1) signaling. Rats received FN (10, 20, and...
Article
This study aims to assess the microbial quality and spreading of Listeria species in popular traditional foods and dairy products available in Karak, Jordan. A total of 120 food samples were tested for Listeria species, Aerobic Plate Count, Enterobacteriaceae, Staphylococcus aureus, yeasts and molds. Four Listeria species were detected in all teste...
Article
This article focuses on the Selenium (Se) concentration of 143 plant species, including fruits, vegetables, cereals and herbs, from four different regions of Ma'an district in Jordan. Selenium concentration was determined by hydrid vapour generation combined with ICP optical emission spectrometry (HVG-ICP-OES) using a continuous flow system at the...
Article
Full-text available
The present study explored the antihyperlipidemic potential of a standardized methanolic extract of A. carambola leaf (MEACL) in high fat-diet (HFD)-fed rats. The standardized MEACL was orally administered at different doses (250, 500 and 1000 mg/kg) to HFD-induced hyperlipidemic rats for 5 weeks. Serum lipid profile, body weight changes, body mass...
Article
Full-text available
Cyclophosphamide (CP) is a widely used chemotherapeutic agent; however, its clinical application is limited because of its multi-organ toxicity. Galangin (Gal) is a bioactive flavonoid with promising biological activities. This study investigated the hepatoprotective effect of Gal in CP-induced rats. Rats received Gal (15, 30 and 60 mg/kg/day) for...
Data
Geobacillus sp. strain DVT3 16S ribosomal RNA gene, partial sequence GenBank: KX785174.1
Article
Full-text available
Plant growth and productivity are adversely affected by drought. The sound of shortage of water on growth, yield and yield quality has been well deliberated in plants. In most cases growth, yield and yield quality are diminished under drought environments. There are four major strategic categories that represent the plant adaptation to desert, whic...
Article
Full-text available
Antagonistic Bacillus sp. strain HMB8 and its concomitant Micrococcus sp. strain HMB7 were isolated from a healthy oral cavity of a volunteer. Phenotypic characteristics and 16S rRNA gene sequencing similarity confirmed that strain HMB8 belongs to Bacillus genus, whereas strain HMB7 belongs to Micrococcus genus. Isolated Bacillus sp. HMB8 exhibited...
Article
Full-text available
Jordan mainly southern part hosts immense diversity of several plant species genotypes. Yellow asphodel (Asphodeline lutea) along with other Asphodelus species was grown at Jordan. Asphodeline lutea is an edible plant and will become a threat due to overexploitation. This investigation was headed for studying the genetic diversity within A. lutea s...
Article
Full-text available
Twenty four fungal species were screened for their ability to produce alkaline L-methioninase on methionine-glucose liquid medium. Aspergillus ustus AUMC 10151 displayed the highest yield of enzyme (10.8 U/mg protein), followed by A. ochraceus and Fusarium proliferatum. Upon optimization of the submerged fermentation (SmF)conditions, the maximum en...
Research
Full-text available
The proPO system is an important humoral immune response among invertebrates. It has been found in many species, including the bivalves, C. gigas, Mytilusedulis,Pernaviridis andPernaperna(Coles and Pipe 1994; Asokan et al. 1997;Hellio et al. 2007). ProPO is present in the plasma or haemocyte compartments of hemolymph, or in both depending on the sp...
Article
Weekly survey of forensically important necrophagous Diptera was conducted using bottle-based baited during, January 2008 to January 2009 in the Balqa Governorate of Jordan. Sampling took place in three habitats: one is urban (Al-Salt), the other rural (Hummra), and the third is a natural habitat (Wadi-Shabi). Species diversity measures were estima...
Article
Full-text available
Aquaculture has long been seen as a sustainable solution to some of the world's growing food shortages. However, experience over the past 50 years indicates that infectious diseases caused by viruses, bacteria, and eukaryotes limit the productivity of aquaculture. In extreme cases, these types of infectious agents threaten the viability of entire a...
Article
This experiment was conducted to assess the effects of pollution on both the physiological and energetic characteristics (SFG) of Pteria aegyptiaca in the Gulf of Aqaba, Jordan. Four locations were chosen to represent both contaminated and uncontaminated locations. Phosphate Loading Berth (P) and the Industrial Area (I), represent contaminated loc...
Article
Full-text available
Phosphate is one of the main sources of pollution in the Gulf of Aqaba. Our study investigates the effects of phosphate ore on the marine snail, P. sulcatus (Born, 1778) immune system. The study site was at the Phosphate loading port (PLP). A total of Three locations were chosen around the phosphate port (L1 an L2) with a control/reference site loc...
Article
Full-text available
In this work an attempt was performed to investigate the in vitro ability of Lucilia sericata maggots to control fungi involved in superficial fungal infections. A novel GFP-modified yeast culture to enable direct visualization of the ingestion of yeast cells by maggot larvae as a method of control was used. The obtained results showed that the GFP...
Chapter
Full-text available
The food legume crops play a crucial role in terms of food and nutritional security and are an important pillar of sustainable food production globally. Food legume crops are important components of cropping systems and provide an opportunity to produce diversified food products for human consumption. Inclusion of these crops into agricultural prod...
Article
QX disease is a fatal disease in Sydney rock oysters caused by the protozoan parasite Marteilia sydneyi. The current study investigates the phagocytosis of M. sydneyi by Sydney rock oyster hemocytes. It also compares the in vitro phagocytic activities of hemocytes from oysters bred for QX disease resistance (QXR) with those of wild-type oysters. Af...
Chapter
Full-text available
The cool season legume crops are high value crops and play a vital role in crop diversification and economic viability of legume farming systems in dry ecologies. These annual legumes are grown in more than 120 countries across all the continents. A small group of countries; India, Turkey, Pakistan, Bangladesh, Nepal, Iran, Mexico, Myanmar, Ethiopi...
Article
The concentrations of six heavy metals (Pb, Cd, Zn, Fe, Cu, and Mn) in 10 samples of rainwater collected at the station of Al Hussein Bin Talal University Campus (AHU), Jordan during the winter time (1/12/06-3/3/07) were determined . In general, low concentrations in these samples were observed. The correlation coefficients for different metals wer...
Article
Our prior work has shown that the catecholamine hormone, noradrenaline, mediates environmental stress responses in Sydney rock oysters, resulting in impaired immunological function. In the current study, we tested the cellular basis of this stress response. Hemocytes were exposed to noradrenaline in vitro before cell morphology and viability were a...
Article
This study investigates the effects of noradrenaline injection on a range of immunological activities in Sydney rock oysters (Saccostrea glomerata). Noradrenaline caused a decrease in most of the immunological parameters tested. Phenoloxidase activities in both whole hemolymph and serum decreased significantly within the first 60 min of noradrenali...
Article
This study investigates the effects of two pathogen-associated molecular patterns (PAMPs), LPS and zymosan, on the Sydney rock oyster (Saccostrea glomerata) immune system. Phenoloxidase and phagocytic activities, total and differential haemocyte frequencies, as well as peroxide and superoxide concentrations were measured after the injection of lipo...
Article
Phenoloxidase (PO) activity was studied in Sydney rock oysters (Saccostrea glomerata). As in other molluscs, PO was found to exist as a pro-enzyme (proPO) in hemocytes. ProPO could be activated to PO by exogenous proteases (trypsin and chymotrypsin), exposure of hemocytes to pathogen-associated molecular patterns (PAMPs) and by the detergents, Trit...
Article
The anatomy, histology and ultrastructure of the thymus of a dipnoan, the Australian lungfish, Neoceratodus forsteri, was studied by light and transmission electron microscopy. The thymic tissue showed clear demarcation into a cortex and medulla with ample vascularization. Large cells including foamy and giant multinucleated cells with periodic aci...
Article
In this study, three major hemocyte types were identified in the Sydney rock oyster. They were characterized primarily by light and electron microscopy based on the presence or absence of granules and nucleus to cytoplasm ratios. Hemoblast-like cells were the smallest cell type 4.0+/-0.4microm and comprised 15+/-3% of the hemocyte population. They...
Article
The effects of starvation on various factors related to immunological defence in Sydney rock oysters (Saccostrea glomerata) were tested in controlled laboratory experiments. A range of parameters was assessed, including total haemocyte counts, and phenoloxidase (PO), superoxide, acid phosphatase and peroxidase activities. Condition indices were als...

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Projects

Projects (3)
Project
- Evaluation of the antihyperlipidemic , antioxidant activities of some malaysian plants. - Evaluation of the safety of these plants. - Evaluation of the cytotoxic effects of these plants using cell lines
Project
Rock varnish is the skinny outer layer of rock surfaces in arid and semiarid regions, it is composed of clay minerals cemented together by oxides and hydroxides of manganese and iron. Al-Jafer basin is located in the south Jordan in a region that classified as a arid and semi-arid region with mean annual rainfall of about 50 mm . The basin has a total area of 13500 km2, scattered with a plenty of rock varnishes. It is well known that microbial communities associated with desert environments play pivotal roles in various biogeochemical cycles. This project aims to conduct, for the first in Jordan, a phylogenetic and functional analysis of the microbial communities associated with rock varnish in the arid region of Al-Jafer basin, using Next-generation DNA sequencing methods for the 16S rRNA gene analyses