Sakshi Gupta

Sakshi Gupta
SGT University · Department of Mathematics

PhD (Mathematics) CSIR UGC-NET
Assistant Professor Mathematics

About

5
Publications
196
Reads
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23
Citations
Citations since 2016
5 Research Items
23 Citations
20162017201820192020202120220246810
20162017201820192020202120220246810
20162017201820192020202120220246810
20162017201820192020202120220246810

Publications

Publications (5)
Article
Petri net (PN) is one of the promising computational and mathematical formalisms used to represent and study the behavior of complex metabolic networks. The various available analysis techniques of PN could be used to validate and analyze the network in different scenarios. Plasmodium falciparum is one of the threatening parasites which causes mala...
Chapter
Petri nets (PNs) have been widely utilized for modelling and analysing different expert systems which are characterized by concurrency, parallelism and conflicts. Due to the complex and dense nature of metabolic networks, modelling of these systems is needed to understand their topology. Petri net is one of the extensively used mathematical tools f...
Article
Tuberculosis is one of the life-threatening diseases globally, caused by the bacteria Mycobacterium tuberculosis. In order to control this epidemic globally, there is an urgent need to discover new drugs with novel mechanism of action that can help in shortening the duration of treatment for both drug resistant and drug sensitive tuberculosis. Myco...
Chapter
Petri net is a potential mathematical and graphical modelling tool, used to examine the properties of various complex discrete event and distributed systems. In this paper, a Petri net variant, called Fuzzy Petri net (FPN) has been used to represent Fuzzy Production propositions of a rule based system, where a fuzzy production proposition explains...
Article
Due to the complexity of the metabolic pathways, their modeling has been a great challenge for the researchers. Various mathematical models have been developed and are continuing to be developed to model and study metabolic pathways. In this article, the authors have described Petri nets (PNs) as a recommender system to model one of the metabolic p...

Questions

Question (1)
Question
Velocity of the reaction with two substrates using Michaelis Menten equation is given by:
V =(VAB)/(Kia Kb + Ka B + Kb A + AB)
where V is the maximal velocity, A and B are the substrate concentrations, Ka and Kb are Michaelis Menten constants for each substrate and Kia is the inhibition constant for substrate A.
Can anyone please explain the term "inhibition constant for substrate A"? Does it mean inhibition constant of an enzyme for the substrate A?
For example, for the reaction oxaloacetate + acetyl-CoA -> Citrate + CoA , catalyzed by citrate synthase, how to search for the value of Kia in the literature/databases? Do I need to search for inhibition constant of citrate synthase for acetyl-CoA?
Thank you!

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