Saketh Kapoor

Saketh Kapoor
Indian Institute of Science | IISC · Department of Molecular Reproduction Development and Genetics

Doctor of Philosophy

About

32
Publications
4,536
Reads
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164
Citations
Citations since 2017
26 Research Items
139 Citations
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2017201820192020202120222023010203040
Introduction

Publications

Publications (32)
Article
In the present study, a targeted Multiple Reaction Monitoring‐based mass spectrometry approach (MRM‐MS) was developed to screen and identify protein biomarkers for brucellosis in humans and livestock. The selection of proteotypic peptides was carried out by generating in silico tryptic peptides of the brucella proteome. Using bioinformatics analysi...
Chapter
Induced pluripotency has indeed revolutionized the field of pluripotent stem cell biology for one and a half decades. However, embryonic stem cells (ESCs) have been finding their research application since the early eighties. Moreover, cell therapy applications using human ESCs had significant concerns such as ethical issues due to the destruction...
Article
Full-text available
Stem cell antigen-1 (Sca-1) is a glycosyl-phosphatidylinositol-anchored membrane protein that is expressed in a sub-population of muscle stem and progenitor cell types. Reportedly, Sca-1 regulates the myogenic property of myoblasts and Sca-1−/− mice exhibited defective muscle regeneration. Although the role of Sca-1 in muscle development and mainte...
Chapter
COVID-19 is the current day pandemic that has claimed around 1,054,604 lives globally till date. Moreover, the number of deaths is going to increase over the next few months until the pandemic comes to an end, and a second wave has also been reported in few countries. Most interestingly, the death rate among certain populations from the same COVID-...
Preprint
Stem cell antigen-1 (Sca-1) is a glycosyl-phosphatidylinositol-anchored membrane protein that is expressed in a sub-population of muscle stem and progenitor cell types. Reportedly, Sca-1 regulates the myogenic property of myoblasts and Sca-1 -/- mice exhibited defective muscle regeneration. Although the role of Sca-1 in muscle development and maint...
Article
Objective: Clefts of the lip, with or without cleft palate and cleft palate only, collectively called as orofacial clefts (OFCs) are one of the most common congenital malformations with varying degrees of penetrance and phenotype expressions. The aim of this study was to investigate the association between methylenetetrahydrofolate reductase (MTHF...
Article
COVID-19 caused by 2019 novel coronavirus (2019-nCoV2) also known as SARS-CoV-2 has manifested globally since January 2020. COVID-19 was declared as a pandemic by the WHO and has become a serious global health concern. Real-time PCR based and antibody-based assays are being used for the clinical detection of the virus in body fluids and nasopharyng...
Article
Full-text available
The ocular surface is subjected to regular wear and tear due to various environmental factors. Exposure to UV-C radiation constitutes an occupational health hazard. Here, we demonstrate the exposure of primary stem cells from the mouse ocular surface to UV-C radiation. Reactive oxygen species (ROS) formation is the readout of the extent of oxidativ...
Article
Full-text available
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide and the commonest liver cancer. It is expected to become the third leading cause of cancer-related deaths in Western countries by 2030. Effective pharmacological approaches for HCC are still unavailable, and the currently approved systemic treatments are unsatisfactory in...
Article
Full-text available
The transmembrane phosphoglycoprotein protein CD34 has conventionally been regarded as a marker for hematopoietic progenitors. Its expression on these cells has been leveraged for cell therapy applications in various hematological disorders. More recently, the expression of CD34 has also been reported on cells of nonhematopoietic origin. The list i...
Article
Full-text available
Wilson disease (WD) is an autosomal recessive disorder, characterized by excessive deposition of copper in various parts of the body, mainly in the liver and brain. It is caused by mutations in ATP7B. We report here the genetic analysis of 102 WD families from a south Indian population. Thirty-six different ATP7B mutations, including 13 novel ones...
Data
Supporting multiple Figures and Tables. (PDF)
Poster
Full-text available
This work is about oxidative damage to ocular surface cells/ stem cells upon exposure to UVC radiation and molecular changes.
Article
Full-text available
Background: Mutations in the glucocerebrosidase (GBA) gene have been associated with Parkinson's disease (PD). Several variants in the gene have been identified as risk factors for the development of PD, but there is difference in the prevalence of this mutation in various ethnic groups and countries. There is no published study related to this fi...
Article
Fluoride is a well-known compound for its usefulness in healing dental caries. Similarly, fluoride is also known for its toxicity to various tissues in animals and humans. It causes skeletal fluorosis leading to osteoporosis of the bones. We hypothesized that when bones are affected by fluoride, the skeletal muscles are also likely to be affected b...
Article
Full-text available
Triphala is an herbal formulation widely used in Ayurvedic medicine as a rejuvenation and revitalization therapy. Its constituents include a mixture of dried extracts from Phyllanthus emblica, Terminalia chebula and Terminalia bellirica. This formulation has been extensively investigated for its anti-cancer, anti-caries, anti-microbial, immunomodul...
Data
(A) List of mutations common in our study, Zheng et al. and Elghraoui et al. (B) List of INDELS common in our study, Zheng et al. and Elghraoui et al.
Data
List of transcripts identified in this study.
Data
A summary of results from proteogenomics analysis. (A) Novel genes. (B) Protein extensions. (C) Alternate start site.
Data
Representative MS/MS spectra of the proteins identified uniquely in our study and earlier reported to be absent in H37Ra.
Data
(A) List of mutations identified in H37Ra when data was aligned with H37Ra reference genome (Zheng et al.). (B) List of INDELS identified in H37Ra when data was aligned with H37Ra reference genome (Zheng et al.). (C) List of mutations identified in H37Ra when data was aligned with H37Ra reference genome (Elghraoui et al.). (D) List of INDELS identi...
Data
(A) List of mutations identified in H37Ra when data was aligned with H37Rv reference genome. (B) List of INDELS identified in H37Ra when data was aligned with H37Rv reference genome. (C) List of mutations in the promoter regions of 7 genes.
Data
(A) List of proteins and peptides identified by LC-MS/MS analysis Mycobacterium tuberculosis H37Ra strain. (B) Comparative analysis of the list of proteins identified in previous published data and data from this study
Article
Full-text available
H37Ra is a virulence attenuated strain of Mycobacterium tuberculosis widely employed as a model to investigate virulence mechanisms. Comparative high-throughput studies have earlier correlated its avirulence to the presence of specific mutations or absence of certain proteins. However, a recent sequencing study of H37Ra, has disproved several genom...
Conference Paper
Objective: The objective of the study was to investigate the frequency of mutations of the GBA gene in Indian patients with PD. Background: Mutations in the GBA (Glucocerebrosidase) gene have been associated with Parkinson’s disease (PD). Several mutations in the gene have been identified as a risk factor of PD but there is a difference in the pre...
Article
Full-text available
Mutations in PLA2G6 were identified in patients with a spectrum of neurodegenerative conditions, such as infantile neuroaxonal dystrophy (INAD), atypical late-onset neuroaxonal dystrophy (ANAD) and dystonia parkinsonism complex (DPC). However, there is no report on the genetic analysis of families with members affected with INAD, ANAD and DPC from...
Data
Supporting multiple Figures and Tables (pdf). (PDF)
Article
Full-text available
Coats plus syndrome is an autosomal recessive, pleiotropic, multisystem disorder characterized by retinal telangiectasia and exudates, intracranial calcification with leukoencephalopathy and brain cysts, osteopenia with predisposition to fractures, bone marrow suppression, gastrointestinal bleeding and portal hypertension. It is caused by compound...
Article
Full-text available
Congenital hereditary endothelial dystrophy 2 (CHED2) is an autosomal recessive disorder caused by mutations in the solute carrier family 4, sodium borate transporter, member 11 (SLC4A11) gene. The purpose of this study was to identify the genetic cause of CHED2 in six Indian families and catalog all known mutations in the SLC4A11 gene. Peripheral...
Article
Full-text available
Waardenburg syndrome (WS) is characterized by sensorineural hearing loss and pigmentation defects of the eye, skin, and hair. It is caused by mutations in one of the following genes: PAX3 (paired box 3), MITF (microphthalmia-associated transcription factor), EDNRB (endothelin receptor type B), EDN3 (endothelin 3), SNAI2 (snail homolog 2, Drosophila...

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