Sajgo Szilard

Sajgo Szilard
MaxWell Biosystems

PhD

About

8
Publications
2,044
Reads
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158
Citations
Introduction
Scientist with 10 years research experience in the field of ophthalmology, covering multiple aspects of retina analysis from developmental RNA-sequencing to behavior, physiology and human disease modelling. Highly collaborative, self-motivated, analytical, published scientist adept to independently manage projects and communicate progress with accurate scientific reasoning.
Additional affiliations
January 2021 - present
MaxWell Biosystems
Position
  • Fellow

Publications

Publications (8)
Article
Full-text available
We report the retinal expression pattern of Ret, a receptor tyrosine kinase for the Glial Derived Neurotrophic Factor (GDNF) family ligands (GFLs), during development and in the adult mouse. Ret is initially expressed in Retinal Ganglion Cells (RGCs), followed by Horizontal Cells (HCs) and Amacrine Cells (ACs), beginning with the early stages of po...
Article
Visual information is conveyed from the eye to the brain by distinct types of retinal ganglion cells (RGCs). It is largely unknown how RGCs acquire their defining morphological and physiological features and connect to upstream and downstream synaptic partners. The three Brn3/Pou4f transcription factors (TFs) participate in a combinatorial code for...
Article
Ganglion cells (GCs), the retinal output neurons, receive synaptic inputs from bipolar and amacrine cells in the inner plexiform layer (IPL) and send information to the brain nuclei via the optic nerve. Although GCs constitute less than 1% of the total retinal cells, they occur in numerous types and are the first neurons formed during retinal devel...
Article
Full-text available
SINEs (Short INterspersed Elements) are widely distributed among eukaryotes. Some SINE families are organized in superfamilies characterized by a shared central domain. These central domains are conserved across species, classes and even phyla. Here we report the identification of two novel such superfamilies in the genomes of gastropod and bivalve...
Article
During development transcription factor combinatorial codes define a large variety of morphologically and physiologically distinct neurons. Such a combinatorial code has been proposed for the differentiation of projection neurons of the somatic and visceral components of cranial nerves. It is possible that individual neuronal cell types are not spe...
Article
Visually evoked compensatory head movements (Optomotor responses) or eye movements (Optokinetic responses) are extensively used in experimental mouse models for developmental defects, pathological conditions, and testing the efficacy of therapeutic manipulations. New Method. We present an automated system to measure Optomotor and Optokinetic respon...
Article
Full-text available
Background: Genetic targeting methods have greatly advanced our understanding of many of the 20 Retinal Ganglion Cell (RGC) types conveying visual information from the eyes to the brain. However, the complexity and partial overlap of gene expression patterns in RGCs call for genetic intersectional or sparse labeling strategies. Loci carrying the C...

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