Saif U Munshi

Saif U Munshi
Bangabandhu Sheikh Mujib Medical University | BSMMU · Department of Virology

MBBS, M Phil, PhD

About

58
Publications
10,902
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381
Citations
Additional affiliations
October 2003 - present
Bangabandhu Sheikh Mujib Medical University
Position
  • Professor (Associate)
October 2003 - April 2017
Bangabandhu Sheikh Mujib Medical University
Position
  • Professor

Publications

Publications (58)
Article
Full-text available
Transmission of dengue virus depends on the presence of Aedes mosquito. Mosquito generation and development is known to be influenced by the climate. This study was carried out to examine whether the climatic factors data can be used to predict yearly dengue cases of Dhaka city, Bangladesh. Monthly reported dengue cases and climate data for the yea...
Article
Full-text available
Although HIV causes immune deficiency by infection and depletion of immunocytes, metabolic alterations with clinical manifestations are also reported in HIV/AIDS patients. Here we aimed to profile metabolite changes in the plasma, urine, and saliva of HIV/AIDS patients, including those on anti-retroviral therapy (ART). Metabolic profiling of bioflu...
Article
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The surrogate markers of HIV/AIDS progression include CD4 T cell count and plasma viral load. But, their reliability has been questioned in patients on anti-retroviral therapy (ART). Five microRNAs (miRNAs) - miR-16, miR-146b-5p, miR-150, miR-191 and miR-223 in peripheral blood mononuclear cells (PBMCs) were earlier found to assign HIV/AIDS patient...
Article
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Background Serum-based rapid HIV testing algorithm in Bangladesh constitutes operational challenge to scaleup HIV testing and counselling (HTC) in the country. This study explored the operational feasibility of using whole blood as alternative to serum for rapid HIV testing in Bangladesh. Methods Whole blood specimens were collected from two study...
Article
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Hepatitis E, which is endemic to resource-poor regions of the world, is largely an acute and self-limiting disease, but some patients have an increased susceptibility to develop fulminant hepatitis. The pathogenesis of hepatitis E in humans is poorly characterized. To understand the metabolic pathways involved in the pathophysiology of hepatitis E,...
Article
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The coding-complete genome sequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was obtained from 39 nasopharyngeal swab samples collected in January 2022 from Dhaka, Bangladesh, during the 3rd wave of the COVID-19 pandemic, using Illumina MiniSeq sequencing technology. Sequence analysis showed that all of them belonged to the W...
Article
Full-text available
At the beginning of the coronavirus disease 2019 (COVID-19) pandemic in Bangladesh, there was a scarcity of ideal biocontainment facilities to detect the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a risk group of 3 organisms. Molecular detection of SARS-CoV-2 must be performed in a BSL-2 laboratory with BSL-3-equivalent infection...
Article
Full-text available
Background: Hepatitis E virus (HEV) infection is endemic in Bangladesh and there are occasional outbreaks. The molecular characteristics and pathogenesis of endemic and outbreak HEV strains are poorly understood. We compared the genetic relatedness and virulence associated mutations of endemic HEV strains with outbreak strains. Methods: We analy...
Article
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Mutations, deletions, and the emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may pose a serious health threat. Here, we report the genome sequences of SARS-CoV-2 viruses that were collected from SARS-CoV-2-infected patients during the end phase of the first wave of the COVID-19 pandemic in Dhaka, Banglades...
Article
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The health care systems in resource limited countries are facing major challenges in dealing with Coronavirus disease (COVID-19). In Bangladesh, a steady increase in the number of COVID-19 cases since its first report on March 8, 2020, has led to an increased demand for COVID-19 detection facilities throughout the country. The detection of severe a...
Article
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Background: Rickettsial diseases are difficult to diagnose in Bangladesh due to low index of suspicion and lack of diagnostic facilities in most laboratories especially in rural areas. Immunofluorescence assay (IFA) is the gold standard serological test for diagnosis of Rickettsial diseases. For serological diagnosis of rickettsial diseases, use of...
Article
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SARS-CoV-2 initially emerged in Wuhan, China in late 2019. It has since been recognized as a pandemic and has led to great social and economic disruption globally. The Reverse Transcriptase Real-Time Polymerase Chain Reaction (rtRT-PCR) has become the primary method for COVID-19 testing worldwide. The method requires a specialized laboratory set up...
Article
Full-text available
Coronavirus disease-19 (COVID-19) was first identified in Wuhan, China, and spread gradually throughout the world. There are multiple reports of prolonged viral shedding in people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, such findings have not been documented in Bangladesh. Herein, we present a case of me...
Article
Full-text available
Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 RNA (SARS-CoV-2 RNA). It usually manifests by fever and/or respiratory illness. Here, we present a case of COVID-19 patient who initially presented ocular symptoms like redness, itching, and watery discharge. Afterward, the patient developed fever and ano...
Article
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not available. Bangladesh Journal of Infectious Diseases, April 2020;7(suppl_1):S63-S65
Article
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Background: Interferon-gamma induced protein 10 (IP-10), a chemokine is suggested to be involved in liver injury during Hepatitis B virus infection (HBV). The increase of IP-10 is a critical step for recruitment of inflammatory cells to the local focus of the liver and hepatopathology. This study was designed to assess the correlation of IP-10 gene...
Article
Full-text available
Background & Objectives: Adult female Aedes aegypti mosquitoes require blood for development of their eggs to replenish their offspring. During blood feeding, ingestion of pathogens can occur which transmits the pathogens to the host during subsequent blood feeding. To study transmission and pathogen growth in mosquitoes, different feeding systems...
Article
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Background: Foxp3 Treg can inhibit activation, proliferation and effector functions of several kinds of other immune cells, including CD4+ and CD8+ T cells, natural killer (NK) and NKT cells and dendritic cells (DC). As such, Foxp3 Treg cells are widely considered to be the principal mediator of dominant self-tolerance immune homeostasis. In HBV...
Article
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p> Background : Hepatitis B virus (HBV) infection is one of the major global health problems and this virus has many variants that differ from epidemiological distributions, transmission sources, clinical outcomes, diagnostic assays as well as therapeutic responses. HBV was also divided into 9 different subtypes which has distinct geographical dist...
Article
Full-text available
Transmission of Hepatitis B Virus (HBV) usually occurs due to the transfusion of blood or blood products from chronic HBV (CHB) or occult HBV infected (OBI) patients. Besides serological tests e.g. HBsAg and anti‐HBc (total), detection of HBV‐DNA is necessary for the diagnosis of OBI patients. Different nucleic acid tests (NATs) including real‐time...
Article
Full-text available
The natural history and treatment outcome of hepatitis B viruses (HBV) infection is largely dependent on genotype, subgenotype, and the presence or absence of virulence associated mutations. We have studied the prevalence of genotype and subgenotype as well as virulence and drug resistance associated mutations and prevalence of recombinant among HB...
Data
Recombination analysis of the 12 HBV isolates from the study using RDP4 v 4.55 program. HBV isolates were considered recombinant if detected by 5 out of 6 program (RDP, BootScan, Max Chi, Chimaera, SisScan and Topol). Recombinant isolate, recombination group major and minor parents and identity, recombinant break points, size of the recombinant fra...
Data
The HBV reference genome sequence and sequences isolated from Bangladesh in this study used for phylogentic analysis. Genotype, subgenotype, GenBank accession number and country of origin of the reference sequences used for phylogenetic analysis. BD_HBV followed by isolate number, GenBank accession number and subgenotype of the HBV isolates from th...
Data
Potential NAr mutations including reported NAr mutations and novel NAr mutations identified in the present study. Potential NAr mutations including reported NAr mutations and novel NAr mutations identified in the present study among different genotypes are presented. (DOCX)
Data
Distribution of all NAR mutations identified in RT region. Schematic presentation of six HVB RT domain functional regions and (F, A, B, C, D, and E) five regions (F-A, A-B, B-C, C-D, and D-E) connecting the functional regions. Functional regions are presented as box and regions between functional regions as lines. The start and end amino acid posit...
Article
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p>Hepatitis E virus (HEV) infection is responsible for more than half of acute viral hepatitis (AHV) with high feto-maternal complications. Bangladesh has high prevalence of HEV infection among pregnant women. This study was undertaken to observe fetal -maternal outcome of HEV infection in Bangladeshi pregnant women . For this purpose a total of 56...
Article
Dengue viral infections are diagnosed by detecting dengue NS1 antigen and dengue specific IgM/IgG antibody by traditional serological tests using patient's blood. Recently saliva is being used employed for diagnosis of different infectious diseases including dengue. In the present study, dengue NS1 antigen and anti-dengue IgM/IgG antibody were dete...
Article
Full-text available
Hepatitis C virus (HCV) causes chronic infections that mainly affect the liver leading to hepatic fibrosis followed by development of cirrhosis and hepatocellular carcinoma (HCC). Several factors including HCV genotype have been proposed to associate with the clinical outcome of HCV infection.This study was aimed to determine whetherthere is any si...
Article
Full-text available
Interferon-gamma induced protein 10 (IP-10), a chemokine is suggested to be involved in liver injury during Hepatitis B virus infection (HBV). The increase of IP-10 is a critical step for recruitment of inflammatory cells to the local focus of the liver and hepatopathology. This study was designed to assess the correlation of IP-10 gene expression...
Article
Full-text available
Aim Elucidating differences in gene expression may be useful in understanding the molecular pathogenesis and for developing specific markers for the outcome of hepatitis B virus (HBV) infection. In the present study, expressions of host gene interferon gamma-inducible protein (IP-10), p53, and Foxp3 were studied in hepatocytes of patients with chro...
Article
Full-text available
Elucidating differences in gene expression may be useful in understanding the molecular pathogenesis and for developing specific markers for the outcome of Hepatitis B virus infection. IP-10, p53 and Foxp3 were studied in liver cells to investigate a possible link between selected host gene expression and outcome of viral hepatitis B infection. The...
Conference Paper
Full-text available
Elucidating differences in gene expression may be useful in understanding the molecular pathogenesis and for developing specific markers for the outcome of Hepatitis B virus infection. IP-10, p53 and Foxp3 were studied in liver cells to investigate a possible link between selected host gene expression and outcome of viral hepatitis B infection. The...
Article
Full-text available
Background and aim Assessment of therapeutic response is important for monitoring the prognosis and to take decision for cessation of nucleoside analogues therapy in chronic hepatitis B patients. In addition to serum alanine aminotransferase (ALT), hepatitis B virus (HBV) deoxyribonucleic acid (DNA) load and HBeAg status, identification of molecula...
Article
Full-text available
The epidemics of Influenza-A virus infection are of two distinct types – regional (seasonal) epidemics and global pandemic. The seasonal epidemic occurs annually or biannually among partially immune populations, and pandemic occurs at irregular and unpredictable intervals ranging from 11 to 30 years or more among the non-immune populations. The pan...
Article
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p> Backgrounds: As there is no published data regarding the response to Anti-retroviral therapy (ART) among HIV patients from Bangladesh. The present study was designed to determine the immunological and virological responses of HIV infected Bangladeshi adults starting ART. Objectives: To monitor the changes of CD4 and CD8 T-lymphocyte count and Vi...
Conference Paper
Full-text available
Background: Hepatitis E, caused by the hepatitis E virus (HEV), is endemic to developing countries where it manifests as large waterborne outbreaks and sporadic cases. Though generally self-limited with a low mortality rate, some cases progress to fulminant hepatic failure with high mortality. Thus it is believed that the host response plays an imp...
Article
Full-text available
Serum samples from 465 subjects aged between 1 and 25 years were tested for antibody against hepatitis A virus (HAV) [anti-HAV IgG and IgM] to determine the seroprevalence of HAV antibody and do a cost-benefit analysis for decision making about vaccination against HAV among the general population of Bangladesh. A high prevalence of anti-HAV (74.8%)...
Article
Full-text available
Human Immunodeficiency Virus (HIV) Hepatitis B virus (HBV) Hepatitis C virus (HCV) and syphilis share certain epidemiological characteristics. In the post highly active antiretroviral therapy (HAART) era life expectancy of patients with HIV has increased and the focus has now shifted to the management of concurrent illnesses such as chronic HBV and...
Article
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p>No Abstarct Bangladesh J Med Microbiol 2007; 01 (01):1-3 DOI: http://dx.doi.org/10.3329/bjmm.v1i1.20487 </p
Article
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HLA typing was carried out for HLA -A1 and HLA -B8 antigens among 40 Rubella specific immunoglobulin G (RSIgG) positive and 10 RSIgG negative subjects by employing microlympohocytotoxicity technique in viable (>85%) lymphocytes separated from fresh blood. Among these, HLA-A1 antigen was detected in 20 (50%) of RSIgG positive and 4 (40%) of RSIgG...

Questions

Questions (2)
Question
Why in HIV/AIDS CD4:CD8 ratio is considered? Why not CD8:CD4 ratio? 
Question
Why am I getting such lines in graph while using real time PCR machine for LAMP ?   Please see the graph. 

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