Sahar Radwan

• Professor of Microbiology and Immunology
• Al-Azhar University

Introduction Chronic obstructive pulmonary disease (COPD) is a well-known respiratory illness, and COPD patients oscillate between a stable state and an exacerbated state. which can lead to disease deterioration. Studies suggest that respiratory microbiome dysbiosis plays a vital role in COPD exacerbation. However, the exact microbial composition a...

Multidrug-resistant (MDR) pathogens are a rising global health worry that imposes an urgent need for the discovery of novel antibiotics particularly those of natural origin. In this context, we aimed to use the metagenomic nanopore sequence analysis of soil microbiota coupled with the conventional phenotypic screening and genomic analysis for id...

Multidrug-resistant (MDR) pathogens are a rising global health worry that imposes an urgent need for the discovery of novel antibiotics particularly those of natural origin. In this context, we aimed to use the metagenomic nanopore sequence analysis of soil microbiota coupled with the conventional phenotypic screening and genomic analysis for ident...

Scientists can use the Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) protein 9 system, which is a powerful and flexible tool for changing the genome, to change only certain parts of the genome. This has helped researchers figure out how target genes work in biology and disease. CRISPR/Cas9 is made up of...

Background: Recognizing the complexity of viral carcinogenesis and its perspectives, we aimed to investigate one of the key genetic factors associated with breast cancer development, BRCA1,2 mutations, and its association with the presence of some oncogenic viruses like HPV, MMTV, and EBV DNAs in both blood and tissues of breast cancer (BC) patient...

In "genome editing," a type of genetic engineering, DNA is added, taken away, or changed in an organism's genome. Biomedicine, biotechnology, and synthetic biology, just to name a few, have all gained a lot from how often this method is used. Before the editing process can start, a Double-Strand Breaks (DSB) must be made in the DNA at a specific ge...

Aim: Inhibition of some quorum sensing (QS) regulated virulence factors via using non-antibiotic helping drugs to overcome antibiotic resistance problem. Introduction: P. aeruginosa is one of the major causes of. P. aeruginosa's virulence factors are highly controlled by QS systems which lead to antibiotics resistance. Targeting QS may be a promisi...

Purpose. Infective endocarditis (IE) is a major complication in patients with bacteremia of Staphylococcus (S.) aureus infection. Our aim was to determine the association of the major Staphylococcal superantigens (SAgs), including Staphylococcal enterotoxins (SEs) and toxic shock syndrome toxin-1 (TSST-1), among hospitalized patients diagnosed with...

Introduction Diabetes remains a growing public health concern in Egypt, as prevalence of Type II diabetes (TIID) has nearly tripled there in the last two decades. Egypt was ranked ninth worldwide in number of diabetes cases, with prevalence of 15.56% among adults. Recent studies have proposed that disturbance of gut microbiota could influence TIID...

Background: Gut microbiome could have central role in development of type 1 and type 2 diabetes mellitus (T1D) & (T2D). Objectives: The aim of the present study is to detect the composition of gut microbiota among T1D and T2D patients compared to healthy individuals. Methodology: The intestinal microbial composition of diabetic and heathy groups wa...

Background: Gut microbiome could have central role in development of type 1 and type 2 diabetes mellitus (T1D) & (T2D). Objectives: The aim of the present study is to detect the composition of gut microbiota among T1D and T2D patients compared to healthy individuals. Methodology: The intestinal microbial composition of diabetic and heathy groups wa...

Aim: Infective endocarditis (IE) is a major complication of Staphylococcus (S.) aureus infection in humans particularly those with bacteremia. Although Staphylococcus species are commensal on or in different parts of the human body, it is also known to be a serious pathogen causing bacteremia and sepsis that could lead to IE. Therefore, our aim was...

The study was based on immunological response to Legionella pneumophila exposure. Legionella IgG/IgA/IgM ELISA test system was used to detect antibodies in sera obtained from healthy hospital staff workers. The results obtained were compared with results obtained with blood donors' sera. This study was carried out to assess the risk of exposure of...

Stenotrophomonas maltophilia is an emerging multidrug resistant organism with an increasing incidence in hospital acquired infections particularly in developing countries. Despite intensive surveillance and preventive measures, treatment of invasive S. maltophilia infections is a great challenge because of the inherent multidrug resistance of this...

Acinetobacter baumannii is one of the predominant pathogens involved in hospital acquired infections worldwide. Despite intensive surveillance and preventive measures, these infections are major cause of high mortality rates. In this study a total of 375 A. baumannii isolates were isolated from a variety of clinical collected from 5 different hospi...

Antibiotic resistance among Multi drug resistant (MDR) Gram negative bacteria causing hospital acquired infections poses a great threat in ICU patients. The treatment of such infections has become increasingly problematic, due to their intrinsic and/or acquired resistance to variable classes of antibiotics. Moreover, the demonstrated ability of the...

Pseudomonas aeruginosa is one of the most predominant bacteria involved in nosocomial infections particularly in developing countries. Despite intensive surveillance and preventive measures, these infections are a leading cause of morbidity and mortality. In this study a total of 200 P. aeruginosa isolates were isolated from different clinical spec...

Infection control is a primary mean of disease prevention in all healthcare settings, including the dental office. Dentistry is a profession that involves constant risk of exposure to various environmental and human infectious agents; contamination can affect both staff and patients. The infection control measures applied in the academic dental cli...

Context: Propolis has traditionally been used in curing infections and healing wounds and burns. Objective: The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. Materials and methods: Different organogels were prepared by using soybean lecithin, isopropyl palmitat...

Nasopharyngeal carcinoma (NPC) is a unique tumor due to its etiology and endemic distribution. Ethnic and regional factors are found to strongly influence the risk of disease. The present study assesses the relationship between Epstein-Barr Virus (EBV) and Egyptian NPC and compare between detection of different markers in serum and tissue of NPC. M...

Background: Staphylococcus aureus is a leading cause of diseases ranging from mild skin and soft tissue infections to life-threatening illnesses. lukS that encodes production of Panton-Valentine leukocidin (PVL), is a cytotoxin that causes leukocyte destruction and tissue necrosis. Necrotizing pneumonia associated with PVL is a recent described cli...

Methicillin-resistant Staphylococcus aureus (MRSA) and sensitive Staphylococcus aureus (SSA) are responsible for a high proportion of nosocomial infections, which makes difficulty in treatment. MRSA infections are responsible for increased mortality rates, longer lengths of hospital stay, and higher rates of treatment failure compared to SSA infect...

Objectives: Epidemiological studies of statins have suggested a link between statin therapy and a decreased risk of bacterial infection. It has been proposed that the mechanism underlying this protective effect of statins relates to their known immunomodulatory and anti-inflammatory effects. The aim of this study is to explore the antibacterial eff...

The objective of the present investigation was to improve the dissolution rate of Fluconazol (Fluco), a poorly water-soluble drug, by solid dispersion (SDs) technique using a water-soluble carrier; Poloxamer 188 (PXM). The kneading method was used to prepare solid dispersions. A 3 2 full factorial design approach was used for optimization wherein t...