Sagar Kishor Savale

Zydus Lifesciences ltd · Technology Transfer - (F & D)

Human metapneumovirus (hMPV) is a recently identified member of a family of viruses that also includes respiratory syncytial virus and parainfluenza virus. Although identified in 2001 by investigators from the Netherlands, data suggest this is a common virus that has been responsible for respiratory illnesses for at least 50 years worldwide. Human...

GRANUREX® Technology

The implementation of the different coating composition on tablets' moving beds. It involves the simultaneous use of heated air for effective solvent evaporation. Besides, proper coating distribution will be completed by the tablet movement. It would be perpendicular to the application of coating composition.

Generally, excessive moisture or humidity in the processing area will result in an increase in sticking or picking. Also, increasing the amount of lubricant in a formulation can improve product release, but too much lubricant (most common is magnesium stearate) can negatively impact tablet compact-ability and hardness.

The eyes are the most sensitive organ of our body, but eye health is often neglected in today’s fast-paced world. We are constantly surrounded by screens, digital devices, and environmental pollutants that can lead to various eye-related issues. One such problem is “eye flu,” known as viral conjunctivitis.

Minitab is data analysis, statistical and process improvement software tool used by organizations worldwide to improve quality and reduce costs.

In the pharmaceutical industries, fluid bed granulation is a widely used method of manufacturing flowable particles ideal for tablet compression.

The coronavirus is a family of viruses that can cause a range of illnesses in humans including common cold and more severe forms like SARS and MERS which are lifethreatening.

Plan: In Vivo Brain-Distribution Studies of Rutin loaded Nanoemulsion for Nose to Brain Delivery. Preface: The aim of present investigation is to develop in vivo Brain-Distribution analysis for nose to brain targeting of Rutin loaded Nanoemulsion (RU-NE) via olfactory and trigeminal nerve pathways. Methodology: For nose to brain drug delivery analy...

In recent years the nasal route has received a great deal of attention as a convenient and reliable method for the systemic administration of drugs. Present review highlights the potential of nasal mucosa as an administration route for targeting the central nervous system (CNS), in particular, the brain. Delivery of drugs to the brain is a most for...

The Technology Transfer is both integral and critical to drug discovery and development process for new medicinal products this process gives necessary information for technology transfer from R&D to PDL/T.T/MS&T department and development of existing product to the production for commercialization. The article highlights the objective, reasons for...

Pharmaceutical calculation are used to develop formulations and process evaluation purpose.

The present study was aimed at developing a Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) method for simultaneous determination of curcumin (CRM) and gefitinib (GFT) in bulk, plasma and brain homogenate. hydrochlorothiazide was used as an internal standard (IS). A new simple, rapid, selective, precise and accurate RP-HPLC method h...

Genotoxicity is a word in genetics defined as a destructive effect on a cell's genetic material (DNA, RNA) affecting its integrity. Genotoxins are mutagens; they can cause mutations. Genotoxins include both radiation and chemical genotoxins. A substance that has the property of genotoxicity is known as a genotoxin. There are three primary effects t...

Curcumin (CRM) is a golden pigment from turmeric, has been linked with anticancer, antioxidant, anti-inflammatory and antidiabetic properties. This article provides a brief about the conformation, solubility estimation, morphology, in vitro and in vivo bioavailability curcumin. In vitro release was conducted pH 1.2 phosphate buffers (94.02 ± 0.25),...

Tuberculous lymphadenitis is a chronic, specific granulomatous inflammation of the lymph node with caseation necrosis, caused by infection with Mycobacterium tuberculosis or related bacteria.

The present study was aimed at developing a reversed phase high performance liquid chromatography (RP-HPLC) method for simultaneously determination of curcumin (CRM) and gefitinib (GFT) in bulk, plasma and brain homogenate and hydrochlorothiazide was used as an internal standard. A new simple, rapid, selective, precise and accurate reverse phase hi...

Aceclofenac, a non-steroidal anti-inflammatory agent is frequently prescribed for the long term treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis.Aceclofenac transdermal patch were fabricated by solvent evaporation technique on mercury substrate and Centre composite rotable design response surface model (CCRD-RSM) was emp...

Aceclofenac is an analgesic and anti-inflammatory drug that reduces fever, pain, and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. Development of microspheres is a promising technology for controlled release and drug targeting. Various types...

The Metformin HCL Gastroretentive Floating Sustained released Tablet is formulated by the Wet Granulation technique. This Tablet is containing both Effervescent as well as Non Effervescent system. The HPMC K 100 Swellable polymer is responsible for the Floating. (Non Effervescent system) and The Sodium Bicarbonate is responsible for the effervescen...

Objective: Much attention has been given to lipid-based formulation with particular emphasis on self-micro emulsifying drug delivery system (SMEDDS) to improve the solubility and oral bioavailability of lipophilic as well as hydrophilic drugs. Method: Various reports were taken from review or research articles published in journals, data from vario...

Nanoemulsion Containing Rutin for Nose to Brain delivery by passing BBB for treatment of brain tumor.

Plan: RP-HPLC method development and validation for the simultaneous estimation of curcumin and Gefitinib in bulk. Preface: RP-HPLC chromatographic method the been widely employed in the determination of individual components in a mixture or fixed dose combination. For the ternary mixture containing Curcumin and Gefitinib, no chromatographic method...

Plan: we have developed new a method for quantitative estimation of Rutin hence no UV spectroscopic method is available for the quantitative analysis of rutin for bulk analysis. Preface: U.V Spectrophotometric method has been widely employed for determination of analyte in a mixture. Our aim is to develop spectroscopic method for estimation of the...

In-process quality control (IPQC) tests was important to remove problems from every stage in production and maintain the quality of the In-process product with standards as specified in the pharmacopoeias. The quality of FP depends on in-process control (IPC) tests because it helps to incorporate excellence within the products. The qualitative and...

Plan: Development and Validation of a method for the UV simultaneous determination of curcumin and Gefitinib. Preface: U.V Spectrophotometric method have been widely employed in determination of individual components in a mixture or fixed dose combination. For the ternary mixture containing Curcumin and Gefitinib, no spectrophotometric method for s...

Objective: In this era of competition, quality is a prime factor of importance. The principles of quality have been described by the ICH guidelines: Q8 Pharmaceutical development, Q9 Pharmaceutical quality risk management and Q10 Pharmaceutical quality system. Quality-by-design is a recent concept which has been added as an annex to ICH Q8. It is a...

Curcumin (CRM) is a polyphenolic compound and it is used for treatment of several inflammatory diseases, Alzheimer‟s, and brain cancer. CRM having major activity to inhibit vascular endothelial growth factor (VEGF) is responsible for angiogenesis. Curcumin (CRM) loaded Nanoemulsion (NE) was fabricated by Vortexing technique and Centre composite rot...

Quercetin-flavonoid-polyphenolic has gained attention in prevention of brain cancer. The low permeability of Quercetin (QUR) across the blood-brain-barrier (BBB) leads to its insufficient delivery which in turns result in low therapeutic index. Therefore, developing a novel approaches enhancing the CNS delivery of QUR are required for the treatment...

Objective: Present research work was intended to Design and Development gefitinib loaded microemulsion by applying CCRD-response surface model. Material and method: Gefitinib loaded microemulsion was fabricated by Vortexing technique and Centre composite rotable design response surface model (CCRD-RSM) was employed; three factors such as oil, surf...

Objective: The Sulforhodamine B (SRB) assay was measure drug-induced cytotoxicity and cell proliferation for large-scale drug-screening applications. Its principle is based on the ability of the protein dye sulforhodamine B to bind electrostatically and pH dependent on protein basic amino acid residues of trichloroacetic acid-fixed cells. Under mil...

Objective: The Aim of present review highlights transport of drug in nose to brain via olfactory and trigeminal nerve pathway by passing blood brain barrier (BBB). Nose to brain drug delivery has received a great deal of attention as a non-invasive, convenient and reliable drug delivery system for the systemic and targeted administration of drugs....

Objective: The main objective of present investigation is an to formulate, develop fast dissolving buccal film of Vildagliptinas a antipsychotic drug by using combination of natural and synthetic polymer, to evaluate the films and to study the various formulation of drug release kinetic pattern. Methodology: In the present work, fast dissolving fil...

Objective: UV Spectrophotometric Method Development and Validation for quantitative estimation of Gefitinib. Our aim is to develop spectroscopic method for estimation of the Gefitinibin ternary mixture by using U.V spectrophotometry. Methodology: The method was validated as per ICH guidelines. The recovery studies confirmed the accuracy and precisi...

The present study was aimed at developing a reversed phase high performance liquid chromatography (RPHPLC) method for determination of curcumin (CRM) in plasma and hydrochlorothiazide was used as an internal standard. The separation was achieved by using C-18 column (Qualisil BDS C18, 250 mm x 4.6 mm I.D.) coupled with a guard column of silica, mob...

Aim: Development and Validation of a method for the UV determination of Curcumin. Objective: U.V Spectrophotometric method have been widely employed in determination of Curcumin in a mixture or fixed dose combination. For the ternary mixture containing Curcumin, no spectrophotometric method for evaluation has been reported so far. Thus our aim is t...

Objective: Quercetin-flavonoid-polyphenolic has gained attention in prevention of brain cancer. The low permeability of Quercetin (QUR) across the blood-brain-barrier (BBB) leads to its insufficient delivery which in turns result in low therapeutic index. Therefore, developing a novel approaches enhancing the CNS delivery of QUR are required for th...

Objective: Rutin-flavonoid-polyphenolic has gained attention in prevention of brain cancer. The low permeability of Rutin (RU) across the blood-brain-barrier (BBB) leads to its insufficient delivery which in turns result in low therapeutic index. Therefore, developing a novel approaches enhancing the CNS delivery of RU are required for the treatmen...

Rutin-flavonoid-polyphenolic has gained attention in prevention of brain cancer. The low permeability of Rutin (RU) across the blood-brain-barrier (BBB) leads to its insufficient delivery which in turns result in low therapeutic index. Therefore, developing a novel approaches enhancing the CNS delivery of RU are required for the treatment of Cancer...

Protein and Peptide drug delivery system are the Novel drug Delivery System. Proteins and peptides are the most abundant components of biological cells. They exist functioning such as enzymes, hormones, structural element and immunoglobulin. The twenty different naturally occurring amino acids join with each other by peptide bonds and build polymer...

The Metformin HCL Micro Beads is formulated by the Ionotropic Gelation Method. The CMC is a Swellable polymer is responsible for the Sustained release action or activity. A combination of CMC (Carboxy Methyl Cellulose) and Sodium Alginate shows better sustained release activity. The PreparedSustained released Micro Beadsis Evaluated In terms of bul...