Saeideh Mazloomzadeh

Saeideh Mazloomzadeh
Zanjan University of Medical Sciences | ZUMS · Department of Biostatistics and Epidemiology

MD. PhD

About

117
Publications
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Publications

Publications (117)
Article
Background: The global SARS-CoV-2 pandemic has disrupted health systems and put a huge strain on hospitals and healthcare workers. Prioritizing COVID-19 patients in hospitals caused irreversible harm to cardiac patients. Although multiple studies have shown that ST-segment elevation myocardial infarction (STEMI) patients have worse admission circum...
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Introduction Coronary artery disease (CAD) is the leading health complication worldwide because of its high prevalence and mortality. The association between CAD susceptibility and the rs599839 (C/T) polymorphism in the human proline and serine-rich coiled-coil (PSRC1) was reported in a genome-wide association study. To validate this association, w...
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Background Prompt interventions prevent adverse events (AE) in hypertrophic cardiomyopathy (HCM). We evaluated the pattern and the predictive role of feature tracking (FT)-cardiac magnetic resonance (CMR) imaging parameters in an HCM population with a normal left ventricular ejection fraction (LVEF) and a low fibrosis burden. Methods The CMR and c...
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Background Patients’ rights are integral to medical ethics. This study aimed to perform sentiment analysis and opinion mining on patients’ messages by a combination of lexicon-based and machine learning methods to identify positive or negative comments and to determine the different ward and staff names mentioned in patients’ messages. Methods The...
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Anxiety, stress, and fear can adversely affect the mental and physical health of people. The present study aimed to examine the association of these emotional response indicators with outcomes (recurrence, hospitalization, and mortality) in coronavirus 2019 (COVID-19) patients. A prospective cohort study was conducted between February 2020 and July...
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Background: Lifestyle modifications, especially improving nutritional patterns and increasing physical activity are the most important factors in preventing obesity and metabolic syndrome in children and adolescents. For this purpose, the following interventional study was designed to investigate the effects of educational programs for students, a...
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Background Pulmonary hypertension (PH) is a fatal disease where on-time treatment can change the prognosis. The selection of treatment is dictated by the severity of PH. The cardiac index (CI) is a robust indicator of PH severity. This trial aimed to find out the association between electrocardiogram (ECG) data and CI as a prognostic factor of PH....
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Background: In traditional Persian medicine, Drimia maritima, with the popular name Squill, has been used to alleviate phlegm dyspnea. Squill has also been shown to have anti-inflammatory and anticholinergic properties. The goal of this research was to see how effective and safe Squill-Oxymel was in treating COPD patients. Method: Forty-two COPD...
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Introduction: Subclinical hypothyroidism during pregnancy can be associated with numerous adverse outcomes. The purpose of this study was to compare short-term adverse pregnancy outcomes in treated versus nontreated patients who fall within the numerical range of thyroid-stimulating hormone (TSH) between the Iranian and American reference ranges....
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Background: During community-wide outbreaks, patients and their families may suffer from anxiety after making behavioral changes. This study aimed to investigate the anxiety, knowledge, and lived experiences of families with COVID-19 patients admitted to medical centers. Methods: The present multi-center study was conducted by a mixed method usi...
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Background: The aim of the present study was to investigate the effect of heparin (1000 IU/mL) in the blood sample on the results of venous blood gases of patients admitted to the cardiac intensive care unit. Materials and methods: The present double-blind randomized clinical trial study was performed on 282 samples from 141 patients admitted to...
Article
Introduction Resistin is considered as an important adipocytokine that may have an association with obesity and insulin resistance. The association of resistin gene polymorphism with type 2 diabetes has been proved. In this study, we aim to investigate the association between polymorphism (rs1862513 RETN) of the promoter resistin gene and susceptib...
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Objective To assess the effect of statin treatment versus placebo on clinical outcomes in patients with covid-19 admitted to the intensive care unit (ICU). Design INSPIRATION/INSPIRATION-S was a multicenter, randomized controlled trial with a 2×2 factorial design. Results for the anticoagulation randomization have been reported previously. Results...
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(1) Background: Current evidence suggests that salivary markers of oxidative stress are indicative of clinical disease indices such as the papillary bleeding index (PBI) and the caries index (CI). The aim of this study was to assess the relation of oxidative stress markers with oral dental caries and periodontal problems in a pediatric population....
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Background: Exclusive breastfeeding (EBF), especially during the first six months of life, is one of the primary health indicators in infants. Objectives: The present study intended to describe the frequency of EBF in infants and its determinants until six months after birth. Methods: This longitudinal study was conducted on 673 mother-newborn pair...
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Background: Cardiomyopathies are characterized by structural and functional abnormalities of myocardium that will probably lead to premature death from arrhythmia and/or progressive heart failure. Myocarditis is an inflammatory disease of the myocardium diagnosed by histological criteria definitively. To date, most information about the natural his...
Preprint
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Background Evidence is growing for the efficacy of platelet-rich plasma (PRP) in knee osteoarthritis (OA). Here, we investigated the effects of PRP and placebo by performing a randomized, double-blind, within-person between knees comparison of measurements. Methods Thirty patients with equal radiographic grades of OA in both knees received a single...
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Introduction: Semaphorin 3A (Sema 3A) is a secreted protein, which plays an integral part in developing the nervous system. It has collapse activity on the growth cone of dorsal root ganglia. After the development of the nervous system, Sema 3A expression decreases. Neuropilin 1 is a membrane receptor of Sema 3A. When semaphorin binds to neuropilin...
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Aim of the study: An inverse correlation between excessive body weight and response to cholecalciferol in vitamin D deficiency (VDD) has been reported but no adjusted or conventional dose and treatment period has universally been recommended by the paediatric guidelines for obese children. In this study, we explored the efficacy of vitamin D supple...
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Background and Objectives: Among significant factors that cause satisfaction of hospitalized patients are the care and respect within confines of the patient's rights shown by the health care providers. The present study was carried out to determine the level of respect offered by midwifery Staff at Ayatollah Mousavi Hospital, Zanjan. Materials and...
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‫Background and Objectives: Vaginal childbirth with least intervention and reliance on empowerment and participation of mothers can improve physical and mental outcomes of childbirth. This study aimed to compare personal control and its related factors, pain and labor outcomes in physiological and routine childbirth groups. Materials and Methods: T...
Article
Background: Cognitive impairment is the most important feature of schizophrenia leading to severe functional disability. To identify pathways that improve pathophysiological neurocognition in schizophrenia is a current challenge for the development of goal-directed clinical interventions. In the present study, we investigated the effects of raloxi...
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Insulin resistance in gestational diabetes increases maternal and fetal complications. Tumor necrosis factor-alpha (TNF-α) is an inflammatory factor associated with insulin resistance. The aim of this study was to determine the association between pregnancy serum TNF-α level and postpartum insulin resistance in patients with gestational diabetes me...
Article
Background: Self-efficacy is an important motivational factor that can be affected by physiological responses such as stress. Objective: The study aimed to determine the effect of stress management counseling on self-efficacy and continuity of exclusive breastfeeding in mothers. Materials and Methods: This randomized controlled trial was carried...
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Background: Numerous studies confirmed significant decrease in tissue DCN expression is associated to tumor progression and metastasis in certain types of cancer including PC. However, the potential prognostic value of tissue DCN in PC has not yet been investigated. Methods: A total number of 40 PC and 42 patients with BPH were investigated for...
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Background: Considering the evidence indicating the neuronal protective effects of curcumin in previous studies, this double-blind, randomized, placebo-controlled, and parallel-group trial was aimed at exploring the possible nanomicelle curcumin (SinaCurcumin®, nano-micellar soft gel)- mediated impact on sleep, fatigue, and quality of life (QoL) in...
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Introduction: Electrocardiographic (ECG) corrected QT (QTc) interval and dispersion were used as prognostic variables in adult patients and limited studies showed the relationship between QTc prolongation and dispersion with some clinical situations in newborn babies. Aim: In the present study, we compared the electrocardiographic (ECG) variable...
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Background: The association between Metabolic syndrome (MetS), its components and mortality has not been clearly established. The aim of this study was to determine the effects of Mets and its components on all cause and cause-specific mortality and to examine whether MetS or its components were better predictors of mortality. Methods: In this retr...
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Background HbA1C has been a known predictor and diagnostic test for diabetes type 2. However, this test has not yet been widely studied in GDM and more importantly no cutoff point has been defined for HbA1C in GDM. We investigated the efficacy of screening during first and second trimester of pregnancy and defined appropriate cutoff points accordin...
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Abstract Background: Reduction in the level of tissue decorin is a hallmark of many types of cancer including breast carcinoma. However, reduced decorin expression has also been reported in several types of benign tumors to the extent that it has been proposed as a tissue marker to differentiate malignant from benign tumors. The aim of this study...
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Background and Objective: Type 2 diabetes is a metabolic disease which could be prevented using a healthy lifestyle. Non-adherence to treatment regimens in diabetes is still a public health problem, globally. This study was conducted to determine the treatment regimens adherence in Type2 diabetes in Zanjan, 2015. Materials and Methods: A cross-sect...
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Abstract Background Polycystic ovary syndrome (PCOS) is the main cause of female infertility. Interactions among genetic, biochemical, and immunological factors can affect the pathogenesis of PCOS. As a proinflammatory cytokine, tumor necrosis factor-α (TNF-α) plays an important role in this regard. The present study aimed to evaluate the associati...
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Background and Objective: The allergens in the closed environments and at home because of the constant contact can cause severe and permanent allergies. In this study, the frequency and the clinical findings were evaluated in patients who were allergic to domestic allergens. Materials and Methods: In this study, all the patients with a positive ski...
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Background Metabolic syndrome (MS) is a collection of metabolic disorders which leads to early cardiovascular disease and diabetes type II. Regarding the wide range of its prevalence in Iran, this systematic review and meta-analysis determined the overall prevalence of the metabolic syndrome in Iran. Methods In this systematic review and meta-anal...
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Background Cognitive impairment is the most important feature of schizophrenia that leads to severe social and functional disability. Improving neurocognitive physiopathologic aspect of schizophrenia is a current challenge to identify the pathway to develop goal directed clinical interventions in practice. In the current study we investigated the e...
Article
Background and Objective: Behcet’s syndrome is a chronic vasculitis disease that affects multiple organs, including the eyes. Since the involvement of eyes due to inflammation can lead to blindness, therefore it is important that the identifying factors that are associated with increased inflammation be recognized. In recent years the potential rol...
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The asthma treatment and control might be associated with significant burden on family and community thus exploring other therapeutic plans could be desirable. The aim of this study was to investigate the effect of salt space on clinical findings and peak expiratory flow rate among children with asthma. In this randomized crossover trial, 34 patien...
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Introduction: Behcet’s disease (BD) is a chronic systemic autoinflammatory vasculitis which is handled by the variety of proteins like cytokines. Therefore, cytokines are considered as one of the prototypic factors during inflammatory responses of BD. Consequently, the present study was designed for evaluation of cytokine profiles in Iranian BD cas...
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BackgThere are differences in the age at menarc he in different countries and it seems that in recent decades gradually the age of puberty is declining. The aim of the present study was to determine the age at menarche and its related factors in school girls in Zanjan city , Iran. Materials and Methods T his cross - sectional study was conducted...
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Background Women's satisfaction with childbirth is an important measure of the quality of maternity care services. This study aims to address factors related to women's childbirth satisfaction in physiological and routine childbirth groups. Materials and Methods This descriptive-analytical study was conducted among 340 women in physiological and r...
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Background: Delinquency means occurring actions or behaviors that are against the rules and values of a community. It is believed that knowing factors related to delinquency is the most effective issue for crime prevention. The aim of this study was to determine the relationship of psychological disorders and socioeconomic factors with the juvenile...
Article
Background The proportion of newborns recalled during neonatal screening programs for congenital hypothyroidism (CH) varies substantially by country and may be higher in settings where povodine iodine (PVP-I) is used during delivery. We assessed this hypothesis by substituting PVP-I for chlorhexidine (CHL) and evaluated the reduction in the recall...
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Introduction: The serum immunoglobulin free light chain (FLC) assay quantities of free kappa (κ) and lambda (λ) light chains. This assay has prognostic value in plasma cell proliferative disorders. There are limited data on serum FLC in B-cell malignancies. Objectives: The aim of this study was to compare the known prognostic factors in non-Hodgkin...
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Objectives: This study aimed to determine the prevalence of genital and sexually transmitted infections and its related factors in married women in Iran. Methods: We conducted a cross-sectional study of 4 274 married women living in urban and rural areas of the Zanjan province from 2012 to 2013. We used stratified cluster sampling to select the...
Article
Background: Procalcitonin (PCT) levels are increased in sepsis. In most previously conducted research, PCT levels were found to increase during septic shock. Objectives: The purpose of this study was to compare PCT levels with CRP and ESR levels in children with systemic inflammatory response syndrome (SIRS), sepsis, and septic shock. Methods: This...
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Objectives: Diabetic nephropathy is an important long-term complication of diabetes mellitus which appears to be partially mediated by an increase in secretion of transforming growth factor-β (TGF-β). Fibromodulin, the small leucine-rich proteoglycan, has been proposed to be the potent TGFβ1 modulator. In this study, the therapeutic effects of rec...
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Background and Objective: Metabolic syndrome comprises a collection of metabolic disorders such as insulin resistance, hypertension, dyslipidemia and central obesity. Patients with this syndrome are highly predisposed for mortality due to cardiovascular disease. The importance of prompt diagnosis of metabolic syndrome threatening the population of...
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Background: Currently, a comprehensive program for screening and early detection of cervical cancer does not exist in Iran. This study aimed to determine the prevalence of abnormal Papanicolaou (Pap) smears and some related factors among women living in Zanjan, Iran. Materials and methods: This cross-sectional study was conducted in 2012 in Zanj...
Article
Atherosclerosis is a pathologic disorder which has an important role in the occurrence of coronary heart disease. It is determined as a focal, inflammatory proliferative response to several types of endothelial damage. Apolipoprotein B which is a requirement in the sustenance of cholesterol homeostasis, and is the major protein component of low den...
Article
Background and Objective: Previous studies indicate an inverse association of serum 25-hydroxyvitamin-D level with obesity, metabolic syndrome and cardiovascular events. This study was aimed to assess metabolic syndrome correlation with serum Vit-D levels of physicians in Zanjan city (Iran). Materials and Methods: In an analytical cross-sectional s...
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Comparison between the efficacy of ceftriaxone and monocytes on improvement of neuron protection and functional recovery after spinal cord injury (SCI) in rat. Rats were randomly divided into three groups of ten. Spinal cord injury was performed on rats under general anesthesia using the weight dropping method. Ceftriaxone was injected intraperiton...
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Gestational diabetes mellitus (GDM) affects nearly 5% of pregnancies. Significant proportion of the women with previous GDM develops type 2 diabetes mellitus (T2DM) in the next years, which indicates a higher risk in them than in the general population. We conducted this study to determine the risk factors and incidence of abnormal glucose level an...
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Background: Diabetes mellitus is a common immune mediated disorder. The aim of the present study is to evaluate the level of serum and salivary IgA levels in patients with Type 1 diabetes. Material and method: In this case control study, serum and salivary IgA levels of patients with diabetes type 1 and similar non diabetes subjects were measure...
Article
Elevated LDL/HDL ratio is an important risk factor for predicting atherosclerosis. Paraoxonase-1 protects LDLs from oxidative modifications and has a protective effect against atherosclerosis. Two common polymorphisms, Q192R and L55M, in PON1 gene can affect PON1 levels and function. The aim of this study was to evaluate the frequency PON1 polymorp...
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Multiple sclerosis (MS) is the most common disease caused by an inflammatory demyelinating process in the central nervous system and characterized by the disseminated demyelination of nerve fibers in the brain and spinal cord. MS is a leading cause of disability in young adults and is accompanied by considerable socioeconomic consequences. It is be...
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Cancer of the prostate is an important and potentially fatal disease in humans, but its etiology is yet undefined. Previous observations have shown that heavy metals play various roles in human health. The heavy metals zinc, cadmium, lead, and copper (Zn, Cd, Cu, and Pb) are known to be associated with prostate cancer, but their functions are uncle...
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Background and purpose: While learner-centered language teaching has been advocated in higher education in the recent years, teacher-centered pedagogical styles seem to be predominant in several instructional settings. The bottom line is that all teachers must be equipped with a deep knowledge of pedagogical improvements and use them as instruction...
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Objective: To investigate the consistency of direct microscopic examination and ELISA for determination of Giadia in stool specimen. Method: Study population consisted of children with any clinical symptoms of Giardia infestation since last two weeks. Fresh stool specimen was collected from each child. The stools specimens were assessed by two meth...
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Objective: To determine the impact of calcium and phosphorus on radiological and biochemical characteristics of osteopenia in premature infants. Methods: The randomised clinical trial study was conducted at Valie-e-Asr Hospital of Zanjan city, Iran, from December 2010 to June 2011. It involved monitoring 40 premature neonates over a period of si...
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Background: Problem-based learning (PBL) is one of the most commonly used educational methods in medical schools of different countries. By working through this method, students think critically, generate ideas, and acquire the knowledge and skills required to become a doctor. Objectives: This study aimed to compare problem-based learning with l...
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Background Gastric cancer is the second most common cause of death in the world. A few serum markers in patients with gastric cancer have been identified that are able to predict disease recurrence and prognosis. We hypothesise that the ratio of neutrophils to lymphocytes (NLR) to be a predictive factor for the prognosis of systemic inflammation th...
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Patients who had positive skin tests to at least one allergen were enrolled to study. They were visited and evaluated for symptoms and accompanying disorders. The season of symptom appearance or exacerbations were also assessed. Then associations of symptoms and complications with skin test results were analyzed by SPSS soft ware. Results: Four hun...