Saeed Soleyman-Jahi

Saeed Soleyman-Jahi
Brigham and Women's Hospital | BWH · Division of Gastroenterology, Hepatology and Endoscopy

MD - MPH

About

94
Publications
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753
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Publications

Publications (94)
Article
Full-text available
Abstract The prognostic role of matrix metalloproteinase-7 in gastric cancer survival has been widely evaluated. However, the results are controversial. We aimed to set up a meta-analysis to reach a conclusion on the prognostic significance of metalloproteinase-7 in gastric cancer survival as well as its association with clinicopathological paramet...
Article
Full-text available
OBJECTIVES: We aimed to investigate prognostic effects of plasma levels of ghrelin before and after gastrectomy in gastric cancer (GC). METHODS: We followed 81 GC patients up to 3 years in this study. They were candidates for curative gastrectomy with or without neoadjuvant chemotherapy. Plasma levels of total and active ghrelins before and after t...
Article
The RNA-binding protein Apobec1 complementation factor (A1CF) regulates posttranscriptional ApoB mRNA editing, but the range of RNA targets and the long-term effect of altered A1CF expression on liver function are unknown. Here we studied hepatocyte-specific A1cf-transgenic (A1cf+/Tg), A1cf+/Tg Apobec1-/-, and A1cf-/- mice fed chow or high-fat/high...
Article
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Rationale: RNA binding protein 47 (RBM47) is required for embryonic endoderm development but a role in adult intestine is unknown. Objective: We studied intestine-specific Rbm47 knockout mice (Rbm47-IKO) following intestinal injury and made crosses into Apcmin/+ mice to examine alterations in intestinal proliferation, response to injury and tumo...
Article
Background: Randomized clinical trials (RCTs) of computer-aided detection (CADe) system-enhanced colonoscopy compared with conventional colonoscopy suggest increased adenoma detection rate (ADR) and decreased adenoma miss rate (AMR), but the effect on detection of advanced colorectal neoplasia (ACN) is unclear. Purpose: To conduct a systematic r...
Article
Introduction: Irinotecan, a topoismorase 1 inhibitor, has been used for the treatment of colorectal cancer. It was shown that monotherapy alone is largely ineffective. The combination therapy was used for antitumor activity. The synergistic anticancer effects of oncolytic reovirus-infected secretome in combination with irinotecan and metformin are...
Poster
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Introduction: Pancreatic ductal adenocarcinoma (PDAC) has poor prognosis with 5-year survival rate of 10%, emphasizing the urgent need for exploring more effective therapeutic strategies. mRNA vaccines have shown promise in cancer therapy, which led us to design a multi-epitope mRNA using immunoinformatic approaches. Method: We explored immunogeni...
Poster
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Introduction: Cholangiocarcinoma (CCA) is an aggressive cancer with a five-year survival rate of less than 25%, which underscores the urgent need for advancements in the therapeutic strategies. In this study, we harnessed the power of multi-omics data integration to identify potential drug candidates that interact with multiple targets. Method: Ou...
Conference Paper
pathogenesis remains unclear. In this study, we aim to determine the function of SQLE in the tumor immune microenvironment, and its therapeutic implication for immune checkpoint blockade therapy in NASH-HCC. Methods: We established hepatocyte-specific Sqle knock-in and knockout mice, and they were given diethylnitrosamine (DEN) injection plus choli...
Article
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Regulating dietary fat absorption may impact progression of nonalcoholic fatty liver disease (NAFLD). Here we asked if inducible inhibition of chylomicron assembly, as observed in intestine-specific microsomal triglyceride transfer protein knockout mice (Mttp-IKO), could retard NAFLD progression and/or reverse established fibrosis in two dietary mo...
Article
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Mammalian C-to-U RNA editing was described more than 30 years ago as a single nucleotide modification in small intestinal Apob RNA, later shown to be mediated by the RNA-specific cytidine deaminase APOBEC1. Reports of other examples of C-to-U RNA editing, coupled with the advent of genome-wide transcriptome sequencing, identified an expanded range...
Article
Background RNA-binding motif protein 47 (RBM47) is a requisite cofactor in APOBEC1-dependent C-to-U RNA editing whose RNA targets are unknown. Aims Because Apobec-1 knockout mice are protected against polyposis in the ApcMin background, we asked if intestine-specific Rbm47 knockout mice (Rbm47IKO) exhibit altered tumor susceptibility, either spont...
Preprint
Mammalian C-to-U RNA editing was described more than 30 years ago as a single nucleotide modification in APOB RNA in small intestine, later shown to be mediated by the RNA-specific cytidine deaminase APOBEC1. Reports of other examples of C-to-U RNA editing, coupled with the advent of genome-wide transcriptome sequencing, identified an expanded rang...
Chapter
Full-text available
Gastric and esophageal cancers contribute to significant health burden and cancer-related mortality worldwide. Despite recent advances in diagnostic and therapeutic modalities, patients are still diagnosed at late stages and have low rates of survival. Recently, immunotherapeutic modalities have shown promising results in improving survival of pati...
Chapter
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Recent advances in basic immunology have revealed impressive breakthroughs in the field of cancer immunotherapy, inspiring oncologists to translate this knowledge to the treatment of different types of cancers. However, several hurdles limit the efficiency of immunotherapy in increasing the overall survival of patients (Fig. 31.1). These hurdles ra...
Article
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Thymic stromal lymphopoietin (TSLP) is a cytokine similar to IL-7, which is released by airway epithelial cells in response to injury and inflammation. Current literature is contradictory about the association between different single nucleotide polymorphisms (SNPs) of the TSLP gene and asthma development in different countries. We aimed to evaluat...
Conference Paper
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Objective: To investigate predicting factors of supernormal uncorrected or corrected distance visual acuity (UDVA or CDVA) (equal or above 15/10) one-year after refined transepithelial photorefractive keratectomy (Refined TransPRK). Methods: In this retrospective case-series, a total number of 155 eyes with myopia (mean [SD] = -3.53 ± 1.81 diopters...
Article
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Background Airway epithelial cells secrete Interleukin-33 in response to the different allergens. Several single nucleotide polymorphisms (SNP) of this cytokine have been reported to be involved in the development of asthma. We conducted this study to evaluate the impact of the two most common SNPs of the IL-33 gene (rs1342326 and rs3939286) and en...
Article
PURPOSE: To investigate predicting factors of visual acuity improvement and achieving uncorrected (UDVA) or corrected (CDVA) distance visual acuity supernormal vision (⩾ 15/10; Snellen 20/13) 1 year after refined transepithelial photorefractive keratectomy (TransPRK). METHODS: In this retrospective case series, a total of 155 eyes with myopia (mea...
Article
Full-text available
Background: Inadequate pain management is highly prevalent and is associated with significant costs and socioeconomic problems, which can lead to disparities in patient care. Specific groups are at higher risk of this problem. A few studies have evaluated the predictive risk factors of inadequate pain management. Objectives: This study evaluated...
Article
Full-text available
Ghrelin is an endogenous peptide hormone mainly produced in the stomach. It has been known to regulate energy homeostasis, stimulate secretion of growth hormone, and mediate many other physiologic effects. Various effects attributed to ghrelin contribute to many aspects of cancer development and progression. Accordingly, a large body of evidence ha...
Conference Paper
Full-text available
Purpose: To compare refined and conventional platforms of single-step transepithelial photorefractive keratectomy (TransPRK) in correction of different degrees of astigmatism. Setting: Bina Eye Hospital, Tehran. Methods: In this retrospective study, 113 and 129 eyes with astigmatism underwent refined and conventional TransPRK, respectively. Th...
Conference Paper
Full-text available
Purpose Our purpose is to compare refined and conventional methods of single-step transepithelial photorefractive keratectomy (TransPRK) in correction of moderate-high astigmatism. Methods In this study 33 and 24 eyes with moderate-high astigmatism (>2 D) underwent conventional and refined single-step, respectively. The same surgeon (SAM) performe...
Conference Paper
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Purpose: To compare functional outcomes after refined single-step TransPRK using same excimer platforms with different repetition rates (500 Hz and 1050 Hz) in correction of mild-moderate myopia. Setting: Bina Eye Hospital, Tehran Methods: In this prospective comparative case-series, patients with myopia (≤6 diopters) with or without asti...
Article
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Background Management of failed laparoscopic gastric plication (LGP), defined as weight regain or inadequate weight loss, is a challenging issue. Methods This prospective investigation was conducted in individuals with morbid obesity who had undergone LGP from 2000 to 2016. Patients with weight loss failure, weight regain, and regain-prone cases w...
Article
Gastric cancer (GC) is the second leading cause of cancer-related death world-wide. Despite improvements in prevention, early detection and various therapeutic options, the prognosis is still poor. GC is often diagnosed at an advanced stage with survivals less than 1 year. Chemotherapy as the mainstay of treatment in advanced stage is not of notabl...
Article
Full-text available
Background: Aprotinin is a nonspecific serine protease inhibitor, which can inhibit plasminogen-plasmin system and matrix metalloproteinases. Aprotinin has been investigated as an antitumor agent. However, its antineoplastic effects on breast cancer (BC) have not been investigated yet. Objectives: The objective of this study was to assess the in...
Article
Purpose: To determine demographic, surgical, and preoperative visual factors affecting the level of static and dynamic cyclotorsion (SC and DC) in eyes undergoing single-step transepithelial photorefractive keratectomy (TransPRK). Methods: In this cross-sectional study, 386 patients with different types of refractive errors scheduled for single-...
Conference Paper
Full-text available
Purpose To compare the long-term contrast sensitivity (CS) and higher- order aberrations of refined single-step TransPRK with conventional method in myopic eyes. Methods Patients with < 5 D of myopia with or without astigmatism were followed for 18 months. The same expert surgeon performed conventional (n = 88) and refined(n = 41) methods using a S...
Conference Paper
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Purpose: To assess photopic (P) and mesopic (M) contrast sensitivity (CS) in myopia in TransPRK and its predicting factors. Methods: The Schwind Amaris 500 was used. Hosmer-Lemeshow test was applied to study effects of surgical and visual parameters on postop PCS and MCS. Results: PCS and MCS improved significantly, 0.96 and 1.21 to 0.82 (P = .0015...
Conference Paper
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Purpose: To compare the long-term efficacy and safety visual outcomes of Refined single-step TransPRK with those of Conventional single-step TransPRK in correction of mild-moderate myopia. Setting: Bina eye hospital, Tehran Methods: In this prospective comparative interventional case-series, patients with myopia (<5 diopters) with or with...
Article
Transepithelial photorefractive keratectomy (PRK) was introduced to prevent complications from conventional PRK and femtosecond laser–assisted laser in situ keratomileusis (LASIK). In the 2-step platform, phototherapeutic keratectomy is followed by PRK. It did not show notable safety or efficacy superiorities over conventional PRK. In the conventio...
Article
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Purpose: Spinal cord injury (SCI) results in accelerated bone mineral density (BMD) loss and disorganization of trabecular bone architecture. The mechanisms underlying post-SCI osteoporosis are complex and different from other types of osteoporosis. Findings of studies investigating efficacy of pharmacological or rehabilitative interventions in SC...
Article
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The use of oral poliovirus vaccine in a worldwide scale has led to a 99.9% decrease in annual incidence of wild-type poliomyelitis and the eradication of serotype 2 poliovirus. However, the emergence of vaccine-derived polioviruses (VDPVs) is endangering the eradication program. Patients with combined immunodeficiencies are at increased risk of bot...
Conference Paper
Full-text available
Description To compare refined and conventional methods of single-step transepithelial photorefractive keratectomy (TransPRK) in correction of moderate-high astigmatism. Materials / Patients and Methods In this comparative interventional case-series, 33 and 24 eyes with moderate-high astigmatism (>2 D) underwent conventional and refined single-step...
Article
Purpose: To compare efficacy and safety of single-step transepithelial photorefractive keratectomy (PRK) with or without mitomycin C (MMC) in patients with mild to moderate myopia. Methods: Patients with mild to moderate myopia (≤ -5.50 diopters [D]) underwent single-step transepithelial PRK using the Amaris laser (SCHWIND eye-tech-solutions Gmb...
Conference Paper
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Purpose: To evaluate quantitative and qualitative visual outcomes of Transepithelial Photorefractive Keratectomy (TransPRK) in myopic patients with asymmetric astigmatism. Methods: Sixty four eyes (32 patients) with myopia and asymmetric astigmatism were recruited in this 18-month prospective study at Bina Eye Hospital, Tehran, Iran, from July 2...
Conference Paper
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Purpose: To evaluate visual outcomes after refined single-step Transepithelial Photorefractive Keratectomy (TransPRK) in hyperopic eyes. This is the longest follow-up and the first report of how this method affects contrast sensitivity (CS) in hyperopic eyes. Setting: Bina Eye Hospital, Tehran, Iran Methods: Thirty-nine eyes (23 patients)...
Article
Full-text available
Widespread administration of oral poliovirus vaccine (OPV) has decreased global incidence of poliomyelitis by ≈99.9%. However, the emergence of vaccine-derived polioviruses (VDPVs) is threatening polio-eradication program. Primary immunodeficiency (PID) patients are at higher risks of vaccine-associated paralytic poliomyelitis (VAPP) and prolonged...
Conference Paper
Full-text available
PURPOSE: To assess both quantitative and qualitative visual outcomes of Transepithelial Photorefractive Keratectomy (TransPRK) in myopic eyes with forme-fruste keratoconus (FFKC). Setting: Bina Eye Hospital, Tehran, Iran, from July 2013 to November 2016 METHODS: Thirty nine myopic eyes (19 patients) with FFCK, were recruited in a prospective interv...
Article
Background: Aprotinin is a nonspecific serine protease inhibitor, which can inhibit kallikrein and many downstream extracellular matrix degrading enzymes. In this study, we assessed inhibitory effects of aprotinin on local invasion of human breast cancer cell lines. Methods: We assessed effects of aprotinin on local invasion and survival of human b...
Conference Paper
Full-text available
Purpose: To investigate intrinsic and surgical parameters that independently predicate achievement of uncorrected distance visual acuity (UDVA) equal or above 15/10 (supervision) one-year after trans-epithelial photorefractive keratectomy (TransPRK). Method: In a prospective cohort study, 120 patients (120 right eyes) with myopia were recruited and...
Article
Context: Chronic pain needs to be evaluated with a standard instrument. The Brief Pain Inventory (BPI) is a pain assessment tool which has been validated in many languages. Objectives: The aim of the present study was to develop the Persian version of the Brief Pain Inventory (BPI-P) and also to evaluate the psychometric properties of the BPI-P...
Conference Paper
Full-text available
Background: Aprotinin is a nonspecific serine protease inhibitor, which can inhibit kallikrein and many downstream extracellular degrading enzymes. In this study, we assessed inhibitory effects of aprotinin on local invasion of human breast cancer cell lines. Methods: We assessed effects of aprotinin on local invasion and survival of human breast...
Article
Full-text available
AIM: To investigate quantitative and qualitative optical outcomes of single-step transepithelial photorefractive keratectomy (TransPRK) in high myopia. METHODS: In a prospective interventional case-series, 30 eyes with high myopia (-6.00 to -8.75 D) with (up to -3.00 D) or without astigmatism were enrolled from Bina Eye Hospital, Tehran, Iran. One-...
Conference Paper
Full-text available
Clinical outcomes of Transepithelial Photorefractive Keratectomy in asymmetric astigmatism PURPOSE: To evaluate quantitative and qualitative visual outcomes of Transepithelial Photorefractive Keratectomy (TransPRK) in myopic patients with asymmetric astigmatism. METHODS: Sixty four eyes (32 patients) with myopia and asymmetric astigmatism were rec...
Article
Purpose To evaluate the long-term quantitative and qualitative optical outcomes of 1-step transepithelial photorefractive keratectomy (PRK) to correct myopia and astigmatism. Setting Bina Eye Hospital, Tehran, Iran. Design Prospective interventional case series. Methods Eyes with myopia with or without astigmatism were evaluated. One-step transe...
Article
Full-text available
Widespread use of oral poliovirus vaccine has led to an ≈99.9% decrease in global incidence of poliomyelitis (from ≈350,000 cases in 1988 to 74 cases in 2015) and eradication of wild-type poliovirus serotypes 2 and 3. However, patients with primary immunodeficiency might shed vaccine-derived polioviruses (VDPVs) for an extended period, which could...
Conference Paper
Full-text available
Purpose: Mitomycin-C (MMC) is used to prevent postoperative corneal haze formation after different modalities of photorefractive keratectomy. The threshold ablation depth to indicate MMC application is controversial. We aimed to compare efficacy, stability and safety of single-step transepithelial photorefractive keratectomy (TransPRK) with or wi...
Article
Objectives: To assess the incidence rate as well as direct and indirect costs of non-fatal road traffic injuries (RTIs) in Iran in 2011. Methods: Data of the 2011 national household survey was used. In this survey, data on demographics, history and costs of injury were obtained in two steps; first, direct face-to-face interview and second, telep...
Article
Objective: This study aimed to estimate the prevalence of happiness and screen its determinant factors in pregnant Iranian women. Background: The psychological health status of a mother during pregnancy has a huge impact on clinical outcomes of pregnancy. Recent studies have demonstrated associations between mothers’ level of happiness and pregnanc...
Article
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Objective: Concern exists regarding the possible hazards to the personnel handling anti-neoplastic drugs. The purpose of the present study was to assess the genotoxicity induced by anti-neoplastic agents in oncology department personnel. Materials and methods: To do this, the frequency of chromosomal aberrations (CAs) induced in peripheral blood...
Article
Full-text available
Background: Different prognosis observed for patients of the same clinical stage in gastric cancer, emphasizes the fact that new biological prognostic factors are needed to complement clinical staging. We aimed to investigate the prognostic significance of plasma ghrelin in gastric cancer patients. Methods: In this prospective study, we included 83...
Article
Purpose: To investigate the safety, efficacy, and stability of transepithelial photorefractive keratectomy (PRK) for hyperopia. Methods: This interventional case series study at two sites included 55 eyes (31 patients) with hyperopia (0.50 to 6.00 diopters [D]), with or without astigmatism (0.00 to -3.00 D), that underwent one-step transepitheli...
Conference Paper
Full-text available
Purpose: Transepithelial Photorefractive Keratectomy (TransPRK) as one of new laser-assisted techniques was developed to decrease risk of mechanical damage after PRK and flap related complications and ectasia after LASIK. High cylindric refraction is one of the biggest challenges and controversies for refractive surgeons to select the safest and...
Conference Paper
Full-text available
Purpose: To investigate the correlation of demographic, ophthalmic and surgical parameters with dynamic cyclotorsion correction in patients undergoing Transepithelial Photorefractive keratectomy. Method: Three hundred sixty-five eyes (185 patients) were included from Bina Eye Hospital, Tehran, Iran. All of the cases underwent Trans-PRK within Febru...
Article
Full-text available
Background: Salmonella enterica serovar typhi (S. typhi) the cause of the acute febrile disease typhoid fever is the major public health problem in developing countries. Asymptomatic carriers are the main sources of typhoid. The aim of this study was to investigate methods for isolation and identification of S. typhi in asymptomatic carriers. Mater...
Conference Paper
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Purpose: To investigate higher order aberrations of myopic eyes undergoing trans-epithelial photorefractive keratectomy and surgical and preoperative visual parameters predicting it. Setting: TransPRK research group, Bina Eye Hospital, Tehran, Iran, from December 2012 to May 2014. Methods: 125 eyes (72 patients) with myopia±astigmatism we...
Conference Paper
Full-text available
Purpose To assess questionnaire-based subjective quality of vision results of trans-epithelial photorefractive keratectomy (TransPRK). Methods Fifty four patients (102 eyes) with different type of refractive errors were recruited in a prospective study at Bina Eye Hospital, Tehran, Iran, from July 2011 to September 2014. All of the cases underwent...
Article
Objective Pre-exposure of rats to normobaric hyperoxia (O2 ≥95%) may induce late preconditioning against renal ischemia-reperfusion (IR) injury. In this study we investigated probable mechanisms of IR injury such as the role of reactive oxygen species (ROS), renal antioxidant agents, and heat shock proteins (HSP) 32 and 70 during delayed hyperoxia-...