Sae-Ock Oh

Sae-Ock Oh
Pusan National University | PNU · Anatomy

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932
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Publications

Publications (932)
Article
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Ovarian cancer (OC) is the second most common female reproductive cancer and the most lethal gynecological malignancy worldwide. Most human OCs are characterized by high rates of drug resistance and metastasis, leading to poor prognosis. Improving the outcomes of patients with relapsed and treatment-resistant OC remains a challenge. This study aime...
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Vascular diseases are complex conditions orchestrated by multiple factors, including cellular components, biochemical stimuli, and mechanical forces. Despite the advancement of numerous therapeutic approaches, the global mortality associated with the diseases continues to escalate owing to a lack of understanding of the underlying pathologies. Tiss...
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UNC13 family (also known as Munc13) proteins are evolutionarily conserved proteins involved in the rapid and regulated secretion of vesicles, including synaptic vesicles and cytotoxic granules. Fast and regulated secretion at the neuronal and immunological synapses requires multiple steps, from the biogenesis of vesicles to membrane fusion, and a c...
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Hematopoietic stem cells (HSCs) reside in specific microenvironments that facilitate their regulation through both internal mechanisms and external cues. Bone marrow endothelial cells (BMECs), which are found in one of these microenvironments, play a vital role in controlling the self-renewal and differentiation of HSCs during hematological stress....
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Atherosclerosis is characterized by the deposition and accumulation of extracellular cholesterol and inflammatory cells in the arterial blood vessel walls, and 27-hydroxycholesterol (27OHChol) is the most abundant cholesterol metabolite. 27OHChol is an oxysterol that induces immune responses, including immune cell activation and chemokine secretion...
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Background Recycling of integrin via endosomal vesicles is critical for the migration of cancer cells, which leads to the metastasis of pancreatic cancer and devastating cancer-related death. So, new diagnostic and therapeutic molecules which target the recycling of endosomal vesicles need to be developed. Methods Public databases including TCGA,...
Article
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Background Emerging evidence has demonstrated that PIWI-interacting RNAs (piRNAs) play important roles in various physiological processes and contribute to cancer progression. Moreover, piRNAs and PIWI protein levels are associated with the prognosis and chemoresistance of various cancers. The limitations of biomarkers challenge early detection and...
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Cancer cell heterogeneity is a serious problem in the control of tumor progression because it can cause chemoresistance and metastasis. Heterogeneity can be generated by various mechanisms, including genetic evolution of cancer cells, cancer stem cells (CSCs), and niche heterogeneity. Because the genetic heterogeneity of CSCs has been poorly charac...
Article
Despite advances in diagnostic and therapeutic methods, the prognosis of patients with hepatocellular carcinoma (HCC) remains poor due to the delay in diagnosis. Herein, we aimed to discover a highly sensitive and specific biomarker for HCC based on genomic big data analysis and create an HCC-targeted imaging probe using carbon nanodots (CNDs) as c...
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Background: The aim of this study was to develop a scoring system to stratify the risk of papillary thyroid cancer (PTC) and to select the proper management. Methods: We performed a systematic search of MEDLINE and Embase. Data regarding patients' prognoses were obtained from the included studies. Odds ratios (ORs) with statistical significance...
Article
Background/aim: Because 50% of uveal melanoma metastasize within 10 years of diagnosis, there is urgent need for accurate prognostic factors. Materials and methods: To identify genes that can act as prognostic factors in uveal melanoma, we performed survival analyses using three independent cohorts. Using log-rank test and univariate cox regress...
Preprint
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Gravitational waves provide a unique tool for observational astronomy. While the first LIGO--Virgo catalogue of gravitational-wave transients (GWTC-1) contains eleven signals from black hole and neutron star binaries, the number of observations is increasing rapidly as detector sensitivity improves. To extract information from the observed signals,...
Article
Full-text available
Gravitational waves provide a unique tool for observational astronomy. While the first LIGO--Virgo catalogue of gravitational-wave transients (GWTC-1) contains eleven signals from black hole and neutron star binaries, the number of observations is increasing rapidly as detector sensitivity improves. To extract information from the observed signals,...
Preprint
Full-text available
Background: MED30 is an evolutionarily new member of the mediator complex thatcan bridge transcription factors and preinitiation complexfor the transcription. Pancreatic cancer is highly chemo-resistant andis the fourth leading cause of cancer-related deaths. Rapid progression and poor prognosis of pancreatic cancer result in shortened survival rat...
Article
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Background: Prognostic genes or gene signatures have been widely used to predict patient survival and aid in making decisions pertaining to therapeutic actions. Although some web-based survival analysis tools have been developed, they have several limitations. Objective: Taking these limitations into account, we developed ESurv (Easy, Effective,...
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Relapse of acute lymphoblastic leukemia (ALL) is dangerous and it worsens the prognosis of patients; however, prognostic markers or therapeutic targets for ALL remain unknown. In the present study, using databases such as TARGET, GSE60926 and GSE28460, we determined that KIF2C and its binding partner, KIF18B are overexpressed in patients with relap...
Article
Accurate prediction of malignancies is important in choosing therapeutic strategies. Although there are many genetic and cytogenetic prognostic factors for acute myeloid leukemia (AML), prognosis is difficult to predict because of the heterogeneity of AML. Prognostic factors, including messenger RNA (mRNA) expression, have been determined for other...
Article
Introduction: Zinc finger homeobox 4 (ZFHX4) is a crucial molecular regulator of tumor-initiating stem cell-like functions. Objective: This study aimed to determine the role of ZFHX4 in the progression of ovarian serous cystadenocarcinoma (OSC). Methods: Differential gene expression among low-stage (stages I and II), high-stage (stages III and IV...
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Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. Novel biomarkers of ccRCC may provide crucial information on tumor features and prognosis. The present study aimed to determine whether the expression of γ-aminobutyric acid (GABA) A receptor subunit θ (GABRQ) could serve as a novel prognostic marker of ccRCC. GABA is...
Article
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The beta-2 adrenergic receptor (ADRB2) regulates the proliferation, apoptosis, angiogenesis, migration, and metastasis of cancer cells. However, its function in the progression of clear cell renal cell carcinoma (ccRCC) is unknown. Here, we report that ADRB2 can be a novel prognostic factor for patients with ccRCC. The differential expression of AD...
Article
Objective: Renal cell carcinoma (RCC) is the most typical type of kidney cancer in adults. Hypercalcemia is a well known paraneoplastic syndrome associated with RCC and recent studies have reported that hypercalcemia is closely related to the poor prognosis of RCC patients. Clear cell RCC (ccRCC) is the most common and aggressive subtype of RCC. A...
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Transmembrane p24 trafficking protein 3 (TMED3) is a metastatic suppressor in colon cancer and hepatocellular carcinoma. However, its function in the progression of clear cell renal cell carcinoma (ccRCC) is unknown. Here, we report that TMED3 could be a new prognostic marker for ccRCC. Patient data were extracted from cohorts in the Cancer Genome...
Article
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Background Advances in genomics have greatly improved the survival rate in cancer patients. However, due to genetic heterogeneity, pancreatic ductal adenocarcinoma (PDAC) is still difficult to diagnose early, and its survival rate is extremely low. Therefore, we identified biomarkers that predict the prognosis of PDAC patients using independent coh...
Article
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Objective Thyroid cancer is the most common malignant endocrine tumor, and its incidence has continuously increased worldwide over the past three decades. We focused on the association of multifocal PTC with mRNA expression to characterize how molecular and histopathologic features relate to multifocality. Design A retrospective cohort study. Pat...
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The cover image is based on the Original Article BRAF‐positive multifocal and unifocal papillary thyroid cancer show different messenger RNA expressions by Kyoungjune Pak et al., DOI: 10.1111/cen.13928.
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With the growing requirement for novel prognostic biomarkers for pancreatic cancer, many studies have focused on clinical and/or genomic variables. Although many studies have been performed, carbohydrate antigen 19-9 is the only biomarker in clinical use. Therefore, the present study examined whether γ-secretase genes, including presenilin (PSEN),...
Article
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There is a growing need for the discovery of new prognostic factors for cases where the scoring and staging system of hepatocellular carcinoma (HCC) does not result in a clear definition. We analyzed whether AP‐2 complex subunit mu (AP2M1) expression could be a new prognostic marker for HCC based on the roles of AP2M1 in influencing hepatocyte grow...
Article
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Although pathological observations provide approximate prognoses, it is difficult to achieve prognosis in patients with existing prognostic factors. Therefore, it is very important to find appropriate biomarkers to achieve accurate cancer prognosis. Renal cell carcinoma (RCC) has several subtypes, the discrimination of which is crucial for proper t...
Article
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As the importance of personalized therapeutics in aggressive papillary thyroid cancer (PTC) increases, accurate risk stratification is required. To develop a novel prognostic scoring system for patients with PTC (n = 455), we used mRNA expression and clinical data from The Cancer Genome Atlas. We performed variable selection using Network‐Regulariz...
Preprint
Background: The advances of genomics have greatly improved the survival rate cancer patients. However, due to genetic heterogeneity, pancreatic ductal adenocarcinoma (PDAC) is still difficult to diagnose early and the survival rate is extremely low. Therefore, we identified biomarkers that predict the prognosis of PDAC patients by using independent...
Article
Full-text available
With the recent emphasis on the importance of personalized genomic medicine, studies have performed prognostic stratification using gene signatures in cancers. However, these studies have not considered gene networks with clinical data. Therefore, this study aimed to develop a novel prognostic score using grouped variable selection for patients wit...
Article
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Backgrounds/Aims Discovery of new prognostic factors for cases in which the pancreatic cancer scoring and staging system does not result in a clear definition is imperative. We examined the role of Human AlkB homolog H5 (ALKBH5) as a prognostic marker for pancreatic cancer. Methods Patient data were extracted from the International Cancer Genome C...
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Centrosome-associated proteins are recognized as prognostic factors in many cancers because centrosomes are critical structures for the cell cycle progression and genomic stability. SAC3D1, however, is associated with centrosome abnormality, although its prognostic potential has not been evaluated in hepatocellular carcinoma (HCC). In this study, 3...
Article
Background: Certain nuclear envelope proteins are associated with important cancer cell characteristics, including migration and proliferation. Abnormal expression of and genetic changes in nuclear envelope proteins have been reported in acute myeloid leukemia (AML) patients. Transmembrane protein 18 (TMEM18), a nuclear envelope protein, is involv...
Article
Generating accurate prognoses is extremely important for treating patients with cancer. Prognostic prediction based on messenger RNA (mRNA) expression has shown superior clinical value to other markers for some cancers but is not currently used for acute myeloid leukemia (AML). Lipid metabolism is associated with biological aspects of cancer progre...
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Purpose: Coronary artery diseases (CADs) are the leading causes of death in the world. Recent studies have reported that differentially expressed microRNAs (miRNAs) are associated with prognosis or major adverse cardiac events (MACEs) in CAD patients. In a previous meta-analysis, the authors made serious mistakes that we aimed to correct through a...
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Accurate prediction of prognosis is critical for therapeutic decisions regarding cancer patients. Many previously developed prognostic scoring systems have limitations in reflecting recent progress in the field of cancer biology such as microarray, next-generation sequencing, and signaling pathways. To develop a new prognostic scoring system for ca...
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High rates of glucose transport via solute carrier (SLC2A, GLUT) family members are required to satisfy the high metabolic demands of cancer cells, and because of this characteristic of cancer cells 2-¹⁸fluoro-deoxy-D-glucose (¹⁸FDG)-PET has become a powerful diagnostic tool. However, its sensitivity for hepatocellular carcinoma (HCC) is lower than...
Article
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Transportation between the cytoplasm and the nucleoplasm is critical for many physiological and pathophysiological processes including gene expression, signal transduction, and oncogenesis. So, the molecular mechanism for the transportation needs to be studied not only to understand cell physiological processes but also to develop new diagnostic an...
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Parameter estimates of GW150914 were obtained using Bayesian inference, based on three semi-analytic waveform models for binary black hole coalescences. These waveform models differ from each other in their treatment of black hole spins, and all three models make some simplifying assumptions, notably to neglect sub-dominant waveform harmonic modes...
Article
Zinc-fingers and homeoboxes 1 (ZHX1) is a nuclear transcription repressor and known to be involved in cell differentiation and tumorigenesis. However, the pathophysiological roles of ZHX1 have not been characterized in glioblastoma. We examined ZHX1 expression in glioblastoma patients’ tissues and analyzed overall survival of the patients based on...
Article
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Zinc fingers and homeoboxes (ZHX) is a transcription repressor family that contains three members; ZHX1, ZHX2, and ZHX3. Although ZHX family members have been associated with the progression of cancer, their values as prognostic factors in cancer patients have been poorly examined. Renal cell carcinoma (RCC) is a highly heterogeneous, aggressive ca...
Data
ZHX1/3 and other targets (VEGFB, USF2, ARPC5, and NMI) were found to be inversely associated with ccRCC progression. Correlation coefficients were calculated by Pearson’s correlation analysis. The expressions of ZHX1 and VEGFB or USF2 were inversely related with correlation coefficients of -0.52 and -0.62 for VEGF-B and USF2 (p <0.001 for both). In...
Data
Mean and median survival of patients with ccRCC according to expressions of ZHX family members. (DOCX)
Data
Kaplan-Meier plots for disease specific survival in patients with ccRCC. (A-C) Disease specific survivals for ccRCC patients were presented based on low and high expression of ZHX family members. (ZHX1 (low: n = 203, high: n = 219): p = 0.009; ZHX2 (low: n = 210, high: n = 211): p = 0.820; ZHX3 (low: n = 255, high: n = 162): p = 0.124). (D) The mea...
Data
Kaplan-Meier plots for overall survival in the second cohort patients with ccRCC. (A-C)Overall survivals for ccRCC patients were analyzed using the second cohort and the results were presented based on low and high expression of ZHX family members using maximal AUC value. Several statistical tests to analyze survival curve are Log-rank, Gehan-Bresl...
Data
Mean and median survival of patients with ccRCC in early and advanced stages. (DOCX)
Data
Univariate and multivariate analysis of prognostic markers in patients with ccRCC for overall survival. (DOCX)
Data
Kaplan-Meier plots of expressions of ZHX family members in subgroup of platelet count. (A-C) Overall survivals for ccRCC patients in low and normal count and elevated count of platelet based on ZHX1-3 expression (ZHX1 –low and normal count of platelet (low: n = 199, high: n = 199): p = 0.009, elevated count of platelet (low: n = 19, high: n = 17):...
Data
Kaplan-Meier plots of expressions of ZHX family members in subgroup of serum calcium level. (A-C) Overall survivals for ccRCC patients in low and normal level and elevated level of serum calcium based on ZHX1-3 expression (ZHX1 –low and normal level of serum calcium (low: n = 176, high: n = 171): p = 0.037, elevated level of serum calcium (low: n =...
Data
Correlation between ZHX2 expression and clinical characteristics in ccRCC. (DOCX)
Data
Correlation between ZHX3 expression and clinical characteristics in ccRCC. (DOCX)
Article
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Same- and opposite-sign charge asymmetries are measured in lepton+jets \( t\overline{t} \) events in which a b-hadron decays semileptonically to a soft muon, using data corresponding to an integrated luminosity of 20.3 fb−1 from proton-proton collisions at a centre-of-mass energy of \( \sqrt{s}=8 \) TeV collected with the ATLAS detector at the Larg...
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We present the result of searches for gravitational waves from 200 pulsars using data from the first observing run of the Advanced LIGO detectors. We find no significant evidence for a gravitational-wave signal from any of these pulsars, but we are able to set the most constraining upper limits yet on their gravitational-wave amplitudes and ellipti...
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Differential cross sections are presented for the prompt and non-prompt production of the hidden-charm states X(3872) and ψ(2S), in the decay mode J/ψπ+π−, measured using 11.4 fb−1 of pp collisions at \( \sqrt{s}=8 \) TeV by the ATLAS detector at the LHC. The ratio of cross-sections X(3872)/ψ(2S) is also given, separately for prompt and non-prompt...
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IL-7 signaling via IL-7R α and common γ -chain ( γ c) is necessary for the development and homeostasis of T cells. Although the delicate mechanism in which IL-7R α downregulation allows the homeostasis of T cell with limited IL-7 has been well known, the exact mechanism behind the interaction between IL-7R α and γ c in the absence or presence of IL...
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Background: Osteosarcoma is the most common primary bone malignancy. We meta-analyzed the prognostic value of altered miRNAs in patients with osteosarcoma. Methods: Sources from MEDLINE (from inception to August 2016) and EMBASE (from inception to August 2016) were searched. Studies of osteosarcoma with results of miRNA and studies that reported...
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A measurement of the calorimeter response to isolated charged hadrons in the ATLAS detector at the LHC is presented. This measurement is performed with 3.2 nb\(^{-1}\) of proton–proton collision data at \(\sqrt{s}=7\) \(\,\mathrm{TeV}\) from 2010 and 0.1 nb\(^{-1}\) of data at \(\sqrt{s}=8\) \(\,\mathrm{TeV}\) from 2012. A number of aspects of the...
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A measurement of the \(t\bar{t}Z\) and \(t\bar{t}W\) production cross sections in final states with either two same-charge muons, or three or four leptons (electrons or muons) is presented. The analysis uses a data sample of proton–proton collisions at \(\sqrt{s} = 13\) TeV recorded with the ATLAS detector at the Large Hadron Collider in 2015, corr...
Data
Survival kinetics of WT LN T cells in presence or absent of IL-7 with or without Na-azide. Cell survival was determined by gating on propidium iodide negative cells. Data are summary of three independent experiments (mean and SEM).
Article
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A measurement of the ZZ production cross section in the ℓ−ℓ+ℓ′ −ℓ′ + and \( {\ell}^{-}{\ell}^{+}\nu \overline{\nu} \) channels (ℓ = e, μ) in proton-proton collisions at \( \sqrt{s}=8 \)TeV at the Large Hadron Collider at CERN, using data corresponding to an integrated luminosity of 20.3 fb−1 collected by the ATLAS experiment in 2012 is presented. T...