
Sadafara Anand Pillai- PhD in Physical Chemistry
- Professor (Associate) at P. P. Savani University
Sadafara Anand Pillai
- PhD in Physical Chemistry
- Professor (Associate) at P. P. Savani University
Working in the field of surface, colloid and polymer science Email: sadafshirgar@rocketmail.com; sa.pillai@ppsu.ac.in
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40
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Introduction
Skills and Expertise
Current institution
P. P. Savani University
Current position
- Professor (Associate)
Publications
Publications (40)
Here we report comprehensive analysis of the influence of ionic liquids (ILs) on the physicochemical properties of an ethylene oxide–propylene oxide (EO–PO) star shaped block copolymer, Tetronic®1304 (total mol. wt = 10[ ]500 and %PEO = 40%) hereafter referred to as T1304, by employing cloud point (CP), viscosity, dynamic light scattering (DLS), sm...
Ethylene oxide-propylene oxide (EO-PO) block copolymer micelles are useful potential nanoreservoirs for the delivery of hydrophobic drugs. Considering that glycine is an excipient and can favorably affect the surface/micellar behavior and thus improve solubilization power/dispersion stability/wetting characteristics we have reported here studies on...
We report here calorimetric and scattering studies on two pharmaceutically important, commercially available nonlinear ethylene oxide-propylene oxide (EO-PO) octablock copolymers, Tetronic®1304 (T1304) and Tetronic®1307 (T1307) (with almost same molecular weight of polypropylene oxide (PPO) and varying %polyethylene oxide (PEO)), in the presence of...
2D Materials: Chemistry and Applications, Part 2 addresses the cutting-edge advancements in the synthesis, functionalization, and applications of two-dimensional materials, focusing on graphene and other emerging materials like boron nitride, germanene, silicene, and stanene. This volume explores the potential of these materials in energy storage,...
2D Materials: Chemistry and Applications, Part 2 addresses the cutting-edge advancements in the synthesis, functionalization, and applications of two-dimensional materials, focusing on graphene and other emerging materials like boron nitride, germanene, silicene, and stanene. This volume explores the potential of these materials in energy storage,...
Fillers play a crucial role as reinforcement in polymer science, enhancing the polymer matrix's inherent properties and, in some cases, leading to the development of composites with entirely novel and extraordinary characteristics. This chapter provides an extensive exposition of both organic and inorganic nanofillers utilized as reinforcement agen...
A comparative analysis of the micellar and solubilizing properties of two polyethylene glycol (PEG)-based amphiphilic biocompatible excipients: Gelucire® 48/16 (Ge 48/16) and Tetronics® 1304 (T1304), in the presence and absence of salt, was conducted. As there is a dearth of research in this area, the study aims to shed light on the behavior of the...
This manuscript explains the effect of biologically important additives on the micellar behavior of an ethylene oxide‐propylene oxide (PEO 101 ‐PPO 56 ‐PEO 101 ) based linear block copolymer, Poloxamer 407.The effect of common pharmaceutical excipients and three vital amino acids viz. alanine, glycine, and lysine (Ala, Gly, and Lys) is examined wit...
The unique amphiphilic property and versatile applications of block copolymers have enormously drawn attention of chemist, druggist, biologist for the last few decades. The coexistence of covalently linked hydrophobic and hydrophilic incompatible blocks, is mainly responsible for the amphiphilic property. They show properties like adsorption on the...
Here we report, the interaction of a star block copolymer T1304 and biologically important additive, bile salts (BS) in aqueous condition. Bile salts used for the system are sodium cholate (NaC), sodium taurocholate (NaTC) and sodium deoxycholate (NaDC). Mixed micelles of T1304-BS have been assessed by employing cloud point (CP), scattering [dynami...
Aqueous electrolyte presents in batteries have high ionic conductivity. They are economic, non-flammable and offer high energy density. However, restricted thermodynamic electrochemical stable potential window of water and its spilling suppresses the use of these batteries. To address these problems, development of a polymer-based electrolyte syste...
The present study reports a comparison on aggregation behavior of PEO-PPO star block copolymers Tetronics® 1304 and 1307 in the presence of toluene, phenols and methyl phenols viz. o-cresol, m-cresol, p-cresol. These organic compounds are frequently used in plastics, dyes, pesticides and pharmaceutical industries. Star block copolymers, Tetronics®,...
The present study deals with the self-assembly of a pure graft copolymer: Soluplus® and a non-ionic surfactant: Solutol® HS15 and focuses on their clouding behaviour [expressed as cloud point (CP)] in the presence of different additives viz. inorganic salts (NaF, NaCl, NaBr, NaI, NaNO3, KCl, KBr, KI), bile salts (sodium cholate-NaC, sodium taurocho...
Stimuli-responsive di-block copolymers viz. poly(N-isopropylacrylamide)m-block-poly(butyl-3-vinylimidazolium bromide)n [abbreviated as PNIPAMm-b-PBVIBn m = 50 and 100, n = 54 and 115] were synthesized using RAFT (Reversible addition−fragmentation chain-transfer) polymerization. Gel permeation chromatography (GPC) and nuclear magnetic resonance (¹H...
We herein report the micellization study on mixtures of poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) star-block copolymer, Tetronics®1304 (T1304) with several cationic conventional and Gemini surfactants (GS) using plethora of physicochemical techniques viz. cloud point (CP), tensiometry, fluorescence, dynamic light scattering (DLS) and sma...
Pluronics® and Tetronics® are used in industry for solubilizing various kinds of hydrophobic compounds since decades. In present study, moderately hydrophobic linear and star block copolymer viz. Pluronic® P104 and Tetronic® T1304 are employed for the solubilization of four polycyclic aromatic hydrocarbons (PAHs) viz. naphthalene (Np), anthracene (...
The present study is based on the interaction between three polyethylene oxide-polypropylene oxide-polyethylene oxide (PEO-PPO-PEO) triblock copolymers namely Pluronics® L81, P84 and F88 (with same PPO Mol. Wt. but 10,40 and 80% PEO, respectively) and the ionic surfactants (with 12-C chain but different polar head group charge viz. sodium dodecyl s...
Over the past few decades, polymeric micelles have attracted enormous attention due to their beneficial properties such as (i) core-shell structure, capable to accommodate hydrophobic drugs, boosting the overall solubility in aqueous medium; (ii) appropriate size which favors accumulation within the tumor, displaying improved permeability and reten...
Here we report comprehensive analysis on the influence of different alkyltriphenyl phosphonium (CnTPPBr) (with varying alkyl chain lengths) based cationic surfactants displaying analogical characteristics to ionic liquids (IL) on the physicochemical properties of an ethylene oxide–propylene oxide (EO–PO) triblock copolymer, Pluronic®, P103 (EO17-PO...
This study reports the effect of several cationic surfactants namely C16TABr,C16TPPBr, C16TBPBr, C16PyBr, C16TACl and C16TATs, each with 16C long alkyl side chain but different counterions and head groups on the micellar behavior of an ethylene oxide-propylene oxide (EO-PO) linear triblock copolymer, Pluronic® 103 from cloud point (CP), dynamic lig...
To have a better insight into the influence of 2,2,2- trifluoroethanol (TFE) and ethanol (EtOH) on self-assembly of commercially available ethylene oxide- propylene oxide (EO-PO) octa-block copolymers, Tetronics® 1304 and 1307 in aqueous solutions, here we report results based on small angle neutron scattering (SANS) and fluorescence techniques. Th...
Here we report, a comparative study on the micellization and phase behavior of two commercially available ethylene oxide – propylene oxide (EO-PO) octablock copolymers, Tetronics ® 1304 and 1307 (hereafter written as T1304 and T1307), in the presence of 2,2,2‑trifluoroethanol (TFE) and ethanol (EtOH) using cloud point (CP), dynamic light scattering...
The interaction of cinnamic acid (CA) and its analogues viz. p-coumaric acid (PCA) and caffeic acid (CFA) with core-shell micelles of a moderately hydrophobic Pluronic® P123 has been investigated using cloud point (CP), viscosity, dynamic light scattering (DLS), small-angle neutron scattering (SANS) and steady-state fluorescence measurements. These...
The temperature and pH dependent self-assembly of three star shaped ethylene oxide-propylene oxide (EO-PO) block copolymers (Tetronics® 304, 904 and 908) with widely different hydrophobicity was examined in aqueous solutions. Physico-chemical methods viz. viscosity, cloud point, solubilization along with thermal, scattering and spectral techniques...
Here we report micellar and micellization characteristics of single and mixed Tetronics® altered by the presence of urea using high sensitivity differential scanning calorimetry (HSDSC) and small angle neutron scattering (SANS). Three Tetronics® with almost identical polypropylene oxide (PPO) blocks but variable polyethylene oxide (PEO) blocks viz....
The presence of excess of denaturants like urea unfolds proteins and disfavours micellization of surfactants; the mode of interaction of urea has always been a matter of debate. Inspired by this need, the effect of urea on the monolayer and micellar characteristics of three polyethylene oxide/propylene oxide (PEO/PPO) starblock copolymers Tetronics...
Here we report, the effect of biologically important additives such as glucose, glycine, sodium chloride, urea and ethanol on the clouding and micellar behaviour of two commercially available ethylene oxide-propylene oxide (EO-PO) block copolymers (one linear triblock, Pluronic® P104 and other branched, starblock Tetronic® T1304) in aqueous environ...
Tetronic® 1307 (here after written as T1307) is a hydrophilic ethylene oxide-propylene oxide (EO-PO) star block copolymer with long EO chains (Total MW- 18000 and 70% EO). Although biocompatible, its use as a nanocarrier is restricted owing to its high critical micelle concentration (CMC) and temperature (CMT). We examined if the addition of glucos...
Due to the potential use and widespread applications of mixed micelles, herein we report the formation of rod-like micelles from the mixtures of a surface active ionic liquid (IL) and bile salt (BS). Mixed micelles of sodium deoxycholate (NaDC) and sodium cholate (NaC) with 1-decyl-3-methylimidazolium chloride (C10mim Cl) have been assessed by spec...