Sachin S. Mali

ASHOKRAO MANE COLLEGE OF PHARMACY, PETH VADGAON, KOLHAPUR · M. Pharmacy Department of Pharmaceutics

Breast cancer (BC) is a complex disease that manifests with a malignancy of the mammary gland. Globally, the year 2020 witnessed 2.3 million diagnosis cases and 685,000 deaths due to breast cancer. Therefore, there is a dire need for the development of new anticancer drugs for BC. Traditional herbal medicine offers a rich source in the prospect of...

This process comprises obtaining data, developing efficient systems for the uses of obtained data, illustrating definite or approximate conclusions and self-corrections / adjustments. In general, AI is used for analyzing the machine learning to imitate the�cognitive tasks of individual. AI technology is exercised to perform more accurate analyses a...

Personalized medicine involves creating a treatment plan that is as unique as the patient's illness. In order to make significant progress in our comprehension of how an individual's distinct genomic profile predisposes them to specific diseases, the methodology depends on identifying genetic, epigenomic, and clinical data. Based on each patient's...

RNA-Based gene therapy requires therapeutic RNA that function in target cells without triggering unwanted immune response.RNA can be delivered to cells using nonviral drug delivery system, circumventing the limitation of viral delivery vectors. Described polymer-based, lipid-based and conjugative-based drug delivery system and distinguishes between...

Lipid-based nanocarriers have shown to be a good carrier and delivery system for a variety of pharmaceutical medications with low bioavailability over the past ten years, when compared to all other macromolecules. Furthermore, they demonstrate remarkable properties like low toxicity, affordable scalability of production, excellent biocompatibility,...

The process of finding new drugs could be completely transformed by artificial intelligence (AI), which offers increased speed, accuracy, and efficiency. Artificial intelligence (AI) has the potential to completely transform a wide range of pharmaceutical-related industries. An overview of artificial intelligence's advantages and uses in the pharma...

The optimal drug delivery system is as convenient and uncomplicated for the patient to use as oral solid dose forms, but it has a bioavailability similar to parenteral dosage forms. Transdermal drug delivery (TDD) has garnered attention as a non-invasive delivery method in recent times due to the emergence of several non-invasive administrations th...

Surgical settings are increasingly utilizing three-dimensional (3D) printing and modeling. Pre-operative surgery planning, inter-team communication, and patient education and counselling are just a few of the uses for this technology. Most studies on 3D technology have been conducted on adult populations, where it has been shown to be an effective...

Metformin, a biguanide glucose-lowering agent, is widely used for management of type 2 diabetes. It does not lead to weight gain, increased episodes of hypoglycaemia, or the promotion of insulin secretion. Metformin has been an ideal therapeutic option available for the patient with type II DM. metformin achieve a significance reduction in glycaemi...

The cases of bacterial multidrug resistance are increasing every year and becoming a serious concern for human health. Multidrug efflux pumps are key players in the formation of antibiotic resistance, which transfer out a broad spectrum of drugs from the cell and convey resistance to the host. Efflux pumps have significantly reduced the efficacy of...

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Isoxazole is five membered heterocyclic ring having a broad spectrum of pharmacological activities like anti-tubercular, anti-cancer, anti-bacterial, anti-fungal, anti-HIV, anti-inflammatory and anti-hypertensive activities. In the present research work we reported the synthesis of some novel isoxazoles by using various different substituted chalco...

Liposome are risen up out of self-shaping lipid bi-layer upon hydration; liposomal medicate have job in strong medication detailing to improve therapeutics. Liposome definitions assists with diminishing poisonousness and increment aggregation at the objective site. New techniques for liposome readiness dependent on lipid medicate communication o...

Pectin is a naturally occurring biopolymer. It has been used successfully for many years in the food and beverage industry as a thickening agent, a gelling agent and a colloidal stabilizer. In this review, study of the role of pectin polysaccharides, including its various pharmacological activity, such as its immuno-regulatory, anti-inflammatory, h...

One epic methodology around there is GRDDSs (Gastro Retentive Drug Delivery System). GRDDSs can enhance the controlled conveyance of medications that have a retention window by constantly discharging the medication for a delayed timeframe before it achieves its assimilation site.The reason for composing this survey was to explore, aggregate and pre...

To obtain actual practice in counseling patients in order for the pharmacist to become a more effective counselor, many educational institutions have started to incorporate pharmacy practice as a subject in the UG level and many developments have taken place in the PG level too. It can be the beginning of a snow ball effect and pharmacy educat...

Pellets are small free flowing; spherical particulates manufactured by the agglomeration of fine powder or granules. Different types of techniques used to produce pellets are referred to as pelletization techniques. In relation to pharmaceuticals, pellets offer high degree of flexibility in design and development of oral dosage form. They offer des...

Factorial Design Approach

One of the first group’s toaddress these patient safety issues was the NationalCoordinating Committee on Large Volume Parenteral (NCCLVP). Parenteral medications are products which are introduced in a manner which circumvents the body’s most protective barriers, the skin and mucous membranes, and, therefore, must be “essentially” free of bi...

In the present study, a novel floating oral drug delivery system was developed utilizing concept of controlled release in order to obtain a unique drug delivery system which could remain in the stomach and control the drug release for an extended period of time. Nizatidine microspheres were prepared by solvent evaporation and spray drying method by...

The inflammatory response represents a generalized response to infection or tissue damage and is designed to remove cellular debris, to localize invading organisms and arrest the spread of infection. NSAIDS are metabolized primarily in the liver. They vary in their half-lives and bioavailability. Given the multitude of available NSAIDs, the variabi...

The effect of ethanolic extract of Aristolochia indica was studied on experimentally induced nepharolithatic and urolithuasis in rats. Oxalate urolithiasis was produced by the addition of 0.75% ethylene glycol in the diet for a period for 30 days. Ethylene glycol treatment resulted in a significant increase in the levels of calcium and oxalate. Tre...

It is very important to know the layout of pharmacy for student apprentice pharmacist. The knowledge of proper arrangement of things in the pharmacy, during the training period, someone will not get problem for arrangement to be done in his own pharmacy. Student pharmacist who wants to registered pharmacist must know the drugs and cosmetic Act 1940...

This paper describes the antibacterial and antifungal activities and Minimum Inhibitory Concentration (MIC) of different solvent (pet. ether, chloroform, ethyl acetate, acetone, methanol and water) extracts of leaves, bark, root and inflorescence of Memecylon umbellatum burm. The percent yields from leaves, bark, root and inflorescence was found to...

Ibuprofen is one of the safest and most potent non-steroidal anti-inflammatory drugs (NSAID) available in the market. The objective of present study was to prepare and evaluate sustained release matrix tablets of ibuprofen using mucilage Lepidium sativum. Granules were prepared by wet granulation technique and were evaluated for angle of repose, b...

In present study, the attempts have been made to formulate sustained release tablets of lornoxicam by direct compression method. Based on viscosity grades different proportions of hydrophilic polymers (HPMC K4M, HPMC K15M, HPMC K100M) are used for preparation of lornoxicam sustained release matrix tablet. The drug excipient mixtures were subjected...

Ethylenediamine tetraacetic acid (EDTA) chelation therapy has been practiced since longtime for the treatment of cardiovascular diseases, alone or in combination with other treatments. It has been recommended as a harmless, relatively inexpensive and non-surgical method of restoring blood flow in atherosclerotic vessels. Ability of EDTA to form com...

The aim of the present study is to formulate and evaluate ciprofloxacin suspension using natural suspending agent. Trigonella foenum graecum Mucilage was used as natural suspending agent. Total 9 batches (C1-C9) were prepared by varying concentration of suspending agent from 0.5-2% and propylene glycol. Prepared suspension were evaluated by study...

To overcome these limitations of polymeric nanoparticles, lipids have been put forward as an alternative carrier, particularly for lipophilic pharmaceuticals.lipid nanoparticles are known as solid lipid nanoparticles (SLNs) and Nanostructured lipid carriers, which are attracting wide attention of formulators world-wide. SLNs and NLCs are colloidal...

Objective: Different dry extracts of Memecylon umbellatum Burm leaf obtained by various solvents such as petroleum ether, chloroform, ethyl acetate, acetone, methanol and chloroform water (IP) was screened to reap the benefits of its antioxidant and free radical scavenging properties using ascorbic acid as standard antioxidants. Methods: The in vit...

In the earlier period, drug delivery to the eye has been limited to topical application, redistribution into the eye following systemic administration or directs intraocular/per ocular injections. These novel systems offer manifold advantages over conventional systems as they increase the efficiency of drug delivery by improving the release profile...

Extraction of air dried root powder with six different solvents was carried out by soxhlet extraction. Extracts were dried under reduced pressure and screened for phytoconsituents. Maximum yield was obtained with acetone root extract (ARE) followed by methanolic extract while that of minimum with petroleum ether extract. Antibacterial activity of...

The commercial importance of IPRs has grown considerably, especially since the 1970s. Those national economies in which most IPR-holding corporations are concentrated have experienced a transformation in the composition of their exports in manufactures. Since 1970, for most developed countries, the contribution of advanced technologies to econom...

Dissolution testing is a valuable tool that provides key information about bioavailability or bioequivalency as well as batch to batch consistency of drug. Since the number of poorly soluble drug is increasing, the selection of adequate dissolution test for these becomes more and more important. Biorelevant is a term, used to describe a medium that...

Lepidium sativum is widely used as herbal medicine in India. It is widely available in market and has very low cost. Lepidium sativum have been widely used to treat a number of ailments in traditional system of medicine throughout India. Natural gums and mucilage as important part of formulation with the development of pharmaceutical dosage forms....

Present study investigated most efficient technique for the development of salbutamol sulphate loaded liposomes. Salbutamol sulphate is a selective β2 adrenoceptor agonist widely used in the treatment of bronchial asthma, chronic bronchitis and emphysema. Our work is mainly focused on in vitro studies of liposomal formulation encapsulated with salb...

A RP-HPLC method has been developed and validated for the estimation of telmisartan in bulk and pharmaceutical dosage form. A RP-HPLC isocratic separation was achieved on C18 column (250×4.6 mm i.d., 5µm) utilizing a mobile phase comprising of methanol and acetonitrile in the ratio of 90: 10(v/v) and the eluents from the column were detected usi...

Plants have used for more potent medicinal values from ancient. It possesses different chemical or active ingredients and shows different pharmacological actions. Memecylon umbellatum is a shrub or tree belongs to family Melastomataceae. It has good medicinal values. Standardization of plant has been carried out by using different physicochemical m...

Needle free injection techniques can be used to administer vaccines and medications in the pork industry. In this review we have discussed history of diabetes mellitus with its whole introduction, types of insulin, need for needle free insulin technology, insulin pumps, intraject drug delivery, current needle free devices in the market. Needle fre...

High-Throughput Screening (HTS) is an approach to drug discovery that has gained widespread popularity over the last two decades and has become a standard method for drug discovery in the pharmaceutical industry. Progress from traditional one-compound-at-a time approach, low throughput screening to high throughput screening involving fully automate...

Traditionally nanotechnology dealt with design, synthesis and application of materials along with devices at the nanometer scale. The application of nanotechnology in the field of health care and drug delivery has come under great attention in recent times. Nanorobots are considered a new possibility for the health sector to improve medical instrum...

The present research work gave an emphasis to develop topical microemulsion formulation of Artemisia pallens based oil (Davana oil). An Artemisia pallens oil based microemulsion formulation with tween 80 as surfactant and transcutol P as co-surfactant was developed for topical delivery. A variety of oil in water microemulsions were prepared using b...