Sachiko Saito

• Saito Sachiko Taste and Smell Institute

We previously reported that cortical activities of the transition between the parietal operculum and the insula (area G) showed to increase in a concentration-dependent manner using stimuli containing 30 mM to 1 M NaCl. We investigated, in this study, the relationship between the magnitude of the activity with the shortest latency and the perceived...

Autonomic and olfactory dysfunctions are considered markers for preclinical diagnosis in Parkinson's disease (PD), because pathological changes in these systems can start before motor symptoms develop. We investigated whether cardiac sympathetic function and olfactory function are associated in PD. Participants comprised 40 nondemented patients wit...

The curry odorant of the odor stick identification test for Japanese (OSIT-J) is useful in screening for olfactory impairment in Japanese subjects. The present study was designed to determine the most useful odorant of the OSIT-J in screening for olfactory impairment in Japanese subjects. We studied olfactory impairment screening with the OSIT-J in...

In magnetoencephalogram studies, the primary gustatory area, area G, is not always seen in the same coronal plane in both hemispheres. We investigated possible asymmetry in right-handed and left-handed individuals by functional MRI. Group analyses revealed a significant difference in the antero-posterior coordinates of the area G between the right...

In this study, effects of odor description (positive/neutral/negative) on various cardiovascular responses, as well as subjective responses such as odor perceived intensity and pleasantness were examined. The odor used was anise seed oil, unfamiliar odor to the Japanese people. This study was conducted in accordance with the Declaration of Helsinki...

The relationship between neuronal activity in the human gustatory cortex and the concentrations of taste stimuli is not well understood. In this study, we recorded changes in the magnetic fields of the human brain in response to four concentrations of NaCl (30 mM, 100 mM, 300 mM, and 1 M) and measured the magnitude and shortest latency of the equiv...

The purpose of the present study was to clarify the olfactory functions of Japanese patients with idiopathic Parkinson's disease (IPD) using the odor stick identification test for Japanese (OSIT-J). Fifty-four non-demented IPD patients (33 men and 21 women), ranging in age from 43 to 81 years (69.7+/-8.1 years) and 50 age- and gender-matched health...

The purpose of this study, which comprised 2 experiments, was to investigate cognitive effects on odor perception. An odor was presented using an olfactometer. In Experiment 1 ("continuous" presentation), anethole, an odor unfamiliar to most Japanese individuals, was presented continuously for 1 session (20 min), whereas in Experiment 2 ("intermitt...

抄録 我々は，においの知覚におよぼす認知的要因の効果について検討している．先の研究1）において，ある同一のにおい刺激に対して異なる教示（ポジティブおよびネガティブ教示）を与えた場合，同一の実験参加者が両方の教示条件を経験する実験計画だと（被験者内計画），順序効果（学習要因）が有意で，教示による感覚強度の差は有意ではないことを報告した．そこで本研究では，実験参加者が一方の教示（ポジティブあるいはネガティブ教示）のみ経験する実験計画（被験者間計画）のもとで教示の効果を検討した．装置はKobal式オルファクトメーターを使用した．実験参加者は，実験で使用されるにおい刺激（アネトール）に関する説明（ポジティブ，ネガティブな内容のいずれか）を受け，その後におい刺激が断続的に計60回呼吸非同期で鼻腔に提示...

The odor stick identification test for Japanese (OSIT-J) has been shown to be useful for detecting and evaluating olfactory disturbances in Japanese people. We studied the usefulness of OSIT-J in screening for olfactory disturbances in 83 Japanese participants (49 male, 34 female) participating in an executive checkup at NTT West Kanazawa Hospital...

A 3 M NaCl solution does not stimulate the trigeminal nerve in the human tongue. Objectives. In rats, the trigeminal nerve has been reported to respond when the tongue is stimulated by a solution with an NaCl concentration of 0.4 M or greater. We have attempted to clarify whether or not relatively high concentrations of NaCl stimulate the trigemina...

There are several studies showing the hedonics of odor affects human brain responses.In preceding studies,however,the hedonics of odor was decided by experimenters'settings,not by participants'own ratings.This might be one reason of disagreement of activated brain areas among preceding studies.Thus, in this study,the odor stimulations were grouped...

The odor identification is strongly influenced by the social and cultural factors; therefore, the odorants used in a smell identification test should be familiar to the test population. In addition, the device used in the test is desired to be simply handled and retain odor quality over time. We developed a novel stick-type odor presentation kit th...

A new olfactory test, the odor stick identification test for Japanese (OSIT-J), has been developed in Japan. To determine if the OSIT-J would be effective cross-culturally, we administered the test to 52 US and 50 Japanese subjects reporting normal olfactory function. The average composite OSIT-J test score for US subjects was significantly lower (...

To investigate the influence of experience on odor perception the responses of 40 Japanese and 44 age-matched German women to everyday odorants were compared. Subjects were presented with six 'Japanese,' six 'European' and six 'international' odorants and asked to rate them on intensity, familiarity, pleasantness and edibility, and to describe asso...

In recent years, a new stick-type odor identification test has been developed in Japan. Thirteen odors familiar to Japanese people are used in this test. In this study, we evaluated the suitability of the odor stick identification test for Japanese (OSIT-J) in patients with olfactory disturbances. We then compared the results with those for T&T olf...

We examined the laterality of the human gustatory neural pathway by measuring gustatory-evoked magnetic fields (GEMfs) and demonstrating the activation of the human primary gustatory cortex (PGC). In patients whose chorda tympani nerve had been severed unilaterally on the right side, we stimulated the normal side (i.e., left side) of the chorda tym...

The precise location of the primary gustatory area (PGA) in humans has not been determined conclusively, regardless of intensive studies with various non-invasive brain imaging. Analysis of brain function by fMRI and PET is based on changes in the regional cerebral blood flow (rCBF) several seconds after electrical neural activity. Thus, these tech...

The odor stick identification test for Japanese (OSITJ) is the latest in measuring olfactory identification. It consists of 13 odorants familiar to the Japanese population. We studied the relationship between the Japanese standard olfactory test (T & T olfactometer) and the OSITJ in 182 patients with olfactory disturbance. The identification ratio...

The odor stick identification test (OSIT) is a new test of olfactory function recently developed for Japanese people. The purpose of the present study was to evaluate this test in relation to T&T olfactometry and the cross-cultural smell identification test (CC-SIT) by applying to 110 Japanese patients with olfactory disturbance. The averaged recog...

We studied the suitability of the Odor Stick Identification Test for the Japanese (OSIT-J) in patients suffering from olfactory disturbance. In 120 patients with olfactory disturbance (age range 12-85 years) there were statistically significant correlations between the odor identification rate on the OSIT-J, the results of the Japanese standardized...

Evoked potentials are widely used in clinical medicine for objective evaluation of sensory disturbances. However, gustatory evoked potentials (GEPs) have not been extensively studied due to lack of agreement among investigators regarding the waveforms. In this study GEPs and gustatory magnetic fields (GEMfs) were simultaneously recorded from five s...

When taste stimuli are presented with specific odor stimuli, the perceived intensity of taste is enhanced, a phenomenon called odor-induced taste enhancement. There is a possibility, however, that the odor substances might have stimulated the taste receptors in the oral cavity as well as odor receptors in the nasal cavity because the odor substance...

The adsorption of beer constituents on a lipid membrane, measured using a lipid-coated quartz crystal microbalance, showed a significant correlation with its bitter intensity and bitter duration in a sensory evaluation. The isohumulones and tetrahydroisohumulones increased the adsorption of beer on the lipid membrane. It appears that sensory bitter...

AC-7700, a novel combretastatin A-4 derivative, suppresses the growth of solid tumors by inhibiting tumor perfusion. We evaluated the antitumor activity of AC-7700 on solid tumors in two experimental models, an advanced tumor model (murine colon 26 (c26) adenocarcinoma, colon 38 (c38) adenocarcinoma, MethA fibrosarcoma, Sarcoma 180 (S180), Lewis lu...

The relation between tumor tissue blood flow (tBF) reduction and antitumor effects was investigated. Changes in tBF of normal tissues (liver, kidney cortex, bone marrow and brain cortex) and tumors (Yoshida sarcoma subline, LY80 and Sato lung carcinoma, SLC) due to i.v. administration of AC7700 (1, 3, 10 mg/kg), one of the combretastatin A-4 deriva...

Gustatory activated regions in the cerebral cortex have not been identified precisely in humans. In this study we recorded the magnetic fields from the brain in response to two tastants, 1 M NaCl and 3 mM saccharin. We estimated the location of areas activated sequentially after the onset of stimulation with magnetic source imaging. We investigated...

Several clinical examinations have so far been developed for patients with gustatory disturbances. However, most of them are based on the subjective reports by patients, not suitable to disclosing their psychogenic symptoms or fake diseases. Thus, the objective examinations have long been awaited. Whereas, the evoked EEG or MEG measurement has been...

Magnetic fields (MFs) from gustatory stimulation with 1 M NaCl and 3 mM saccharin were recorded from the human brain by using a whole-cortex SQUID system. The averaged onset latency of MFs was 93 ms for NaCI and 172 ms for saccharin and no response was obtained for water. A high correlation coefficient was noted between the difference of onset MFs...

Fluctuations in women’s sensory sensitivity, feelings, and behavior during the menstrual cycle have been suggested. Most studies of olfactory sensitivity have suggested increased sensitivity during the ovulatory phase [1,2,3]. However, several reports have noted a secondary peak during the luteal phase [1] and some have reported no changes during t...

After a 3-day exposure to 0.1 microM 1-beta-D-arabinofuranosylcytosine (ara-C) in culture, growth was inhibited to 5.6% in MOLT-4F, 25% in Raji, and 91% in Daudi cells compared with control. Growth inhibition was more profound when exposure time was extended up to 7 days. Inhibition of DNA synthesis varied with sensitivity to ara-C. Plateau levels...

Many studies suggest that perceptual learning plays an important role in olfaction. A cross-cultural study has demonstrated that everyday experience influences on judgment of pleasantness, familiarity, and even ... http://www.tulips.tsukuba.ac.jp/mylimedio/dl/page.do?issueid=566714&tocid=100033611&page=1-5

筑波大学学術博士学位論文・平成3年3月25日授与 (乙第663号)