Sabir Nishanbaev

• DSc in Chemistry
• Laboratory Head at Yunusov Institute of the Chemistry of Plant Substances

BACKGROUND Saffron petals are usually considered as waste after saffron harvest. However, saffron petals contain many important phytochemical components (e.g. quercetin and kaempferol), which may alleviate oxidative damage in human cells. RESULTS The contents of flavonoids and crocin in different parts of saffron were analyzed. The protective effe...

Secondary metabolites present in Crocus sativus L. petals (saffron) grown in Uzbekistan, were studied for the first time. According to the results of phytochemical studies, it was observed that biowaste contains a large amount of biologically active flavonoids, anthocyanins, carotenoids, phenolic carbonic acids, terpenoids, saponins, micro- and mac...

Amino acids (AA) of individual parts (stigma, stamens, petals) of flowers of Crocus sativus L. (saffron) growing in Uzbekistan were studied for the first time. 20 AAs were identified in the samples, which 8 were nonessential, 8 were irreplaceable, 4 were partially nonessential amino acids. The total amount of AA in the stigmas was 11.35001 mg/g, in...

In this work, the effect of sophoroflavonoid (SFL) and flavonoids of narcissus on respiration and oxidative phosphorylation processes of liver mitochondria of rats poisoned by haloxyfop-R-methyl and indoxacarb pesticides was studied in in vivo experiments depending on the dynamics of 10, 20, 30, 40 days. Experimental animals were divided into IV mo...

High-molecular-mass saturated FAs 22:0, 24:0, and 26:0, which totaled from 1.16 (PhL) to 1.99% (GL), and their monounsaturated analogs 22:1n9 and 24:1n9 were identified in NL from A. persarum seeds. These FAs were present in reserve lipids of several other genera of plants in the family Fabaceae (Thermopsis, Chamaecytisus, Caragana) [13]. Thus, dat...

ABSTRACT: Broccoli extract mainly contains polyphenols and glucosinolates (GSLs). GSLs can be hydrolyzed by gut microorganisms into isothiocyanates (ITCs) and other active substances. These substances have anticancer, antiinflammatory, antimicrobial, and atherosclerosis-reducing functions. In this study, a high concentration (2000 μmol/L GSLs and 24...

Brassica vegetables, especially broccoli, have health benefits such as anticancer activity, which are attributed to isothiocyanate (ITC), products of glucosinolate hydrolysis. This study aimed to explore the effect of cooking time and addition of exogenous myrosinase (MYR) from moringa seeds on the yield of ITCs. The results showed that raw broccol...

Rumex confertus Willd. – sorrel is important in pharmacology and the food industry. It is used in diseases of the gastrointestinal tract, kidneys, as anti-helminth, anti-cyngotic, hemostatic, wound healing, vasoconstrictive, antitumor, in stomatitis, colds, as well as leaves are eaten. Rumex pamiricus Rech. f., is promising for introduction into th...

This article discusses the results of research on the chemical composition of volatile compounds and the main biologically active substances in the raw material of climate-adapted medicinal chamomile (Matricaria chamomilla L.) in the Khorezm Oasis, belonging to the Asteraceae family. Based on the results obtained, Matricaria chamomilla L. is consid...

Triticosecale (triticale) is a cereal crop obtained by crossing wheat and rye. The purpose of this study is to analyze the neutral lipids (NL) and fatty acids of seed samples from the world collection: triticale - №. 1 - "M 2A x Kla "S" (NC 24801), №. 2 - Untitled (NC 24869) and №. 3 - "Papion" (NC 24881) originating from Mexico, preserved m the Na...

Cynara scolymus L. (spiny artichoke) is a herbaceous perennial plant of the family Asteraceae. The plant is widely cultivated in many countries as a vegetable crop. In the 80-s of the last century, the artichoke was bred in Azerbaijan for fodder purposes. Artichoke contains glycolic, quinic, caffeic acids, up to 15% carbohydrates, vitamins C, group...

An essential condition for ensuring the required level of quality of pharmaceutical products is the procedure for standardization and quality control of a medicinal product at all stages of its life cycle. The development of a methodology for standardizing the mandatory quality indicator "foreign impurities" using chromatographic research methods i...

Introduction. The topic of free radicals and their associated antioxidants is being discussed a lot these days. Antioxidants help neutralize free radicals before they damage cells. Antioxidants naturally fight free radicals and harmful effects in the human body. The body can get antioxidants in natural form from external sources, flavonoids and pol...

CHEMICAL ANALYSIS OF THE CROCUS SATIVUS PLANT INTRODUCED IN THE FLORA OF UZBEKISTAN

Methods for determining the quality and quantity of biologically active substances in Crocus sativus plant raw materials introduced in the Republic of Uzbekistan have been developed and analyzed. The sum of biologically active substances from the raw material was extracted by the method of extraction using organic solvents of different polarity, an...

Butyrolactone 1 was isolated from the EtOAc fraction of the EtOH extract of the aerial part of Geranium charlesii (Aitch. & Hemsl.) Vved. The configurations of all chiral centers of 1 were established by an X-ray crystal structure analysis. The structure of 1 was (3S,4R,5S,6R,7S)-3-p-hydroxyphenyl-5,6,7-trihydroxyoxolan-1,4-olide or the trivial nam...

Volatile compounds of essential oil and hexane extract of Achillea filipendulina Lam flowers were studied by gas chromatography-mass spectrometry. As a result of the carried out studies, 23 chemical components were identified in the composition of essential oil, among which were dominated camphor (28.5%), α-thujone (20.8%), endo-borneol (10.3%), sa...

The study of this composition effects on biochemical parameters of blood serum and rats liver homogenate in a model of acute toxic hepatitis caused by the introduction of an oil solution of carbon tetrachloride showed that the orally administered composition at a dose of 100 mg/kg on the 7th day of administration improves the indicators of oxidativ...

According to our research, it was defined that, the hexane extracts of the raw material of M.chamomilla L., introduced in 2019 and 2020, contained 13 volatile biologically active compounds, in which its the main components were carbohydrates - n-pentacosane, ndocosane, n-nonacosane and terpenoids - camphor, bisabololoxide B, bisabololoxide A.

As a result of the GC-MS analysis of volatile compounds of the roots of G. collinum 37 compounds were identified. The main components were trans-3,4-dimethyl-2-pentene (3.4%), α-thujone (2.0%), camphor (6.5%), isolongifolene (8.8%), β-cedrene (2.1%), α-chamigrene (4.5%), longiborneol (28.9%) and 2-epi-β-cedrene-3-one (4.0%).

It was established that sawaranin (1) exists in the form of a mixture of two equilibrium conformational forms in solution, which is due to the presence of an ordinary bond at С4-С5 in molecule. However, in our case, in the 1H NMR spectrum of freshly prepared solution of single crystals of 1 in DMSO-d6, were observed the proton signals of one confor...

According to the results obtained, no dynamic state of liver mitochondrial edema was observed for 40 days in healthy group I experimental animals taken as controls. However, hepatic mitochondrial obstruction in experimental group II animals treated with haloxyphop-Rmethyl pesticide increased by 59.0±3.5% at 10 days and by 65.7±4.6% at 20 days, and...

High performance liquid chromatography (HPLC) is one of the most effective methods for the analysis of complex mixtures of substances, widely used in the chemical technology of plant substances. For the first time, we have carried out the quantitative determination of a number of phenolic compounds in alcoholic extracts of the aboveground part of h...

Олинган натижаларга кўра, 10, 20, 30 ва 40 кунлик назорат гуруҳи ҳайвонларининг жигар митохондриясида МДА миқдори динамикаси ўзгармаслиги аниқланди. Аммо ИНД билан заҳарлантирилган II гуруҳ ҳайвонларни жигар митохондриясининг МДА миқдори 10, 20, 30 ва 40 кунлик динамикаси ортиб бориши аниқланди. ИНД таъсирида каламушларнинг жигар митохондрияси ЛПОн...

Geranium rotundifolium L. (Geraniaceae) is an annual herbaceous plant that grows on rocky slopes and screes in the lower and middle mountain belts of Central Asia [1]. Herein, we communicate results from studies of phenolic compounds in the EtOAc fraction (70 g) of the EtOH (70%) extract of the aerial part of G. rotundifolium (3.0 kg). isolated the...

A new butyrolactone that was called charlesolide and the known phenolic compounds gallic acid (3,4,5-trihydroxybenzoic acid) and its methyl gallate and ethyl gallate derivatives were isolated from roots of Geranium charlesii (Aitch. & Hemsl.) Vved. Their structures were elucidated using IR, UV, and NMR spectra and comparisons with those of standard...

A phytochemical investigation of the EtOAc fraction of the EtOH extract of the aerial part of Lepidolopha komarowii C. Winkl. (Asteraceae) showed that this plant produced biologically active phenolic compounds. Herein, the chemicalcomposition of the CHCl3 fraction of the EtOH extract of the aerial part of L. komarowii is communicated. Chromatograph...

Qualitative and quantitative analysis of furocoumarins in Ficus carica leaves is very di|cult due to the high content of concomitant low molecular weight secondary metabolites. In this regard, a method for the qualitative studying of Ficus carica leaves has been developed, which is in the preliminary removal of low molecular weight metabolites from...

Определение количественного содержания «Виметрол»а в суспензии по метронидазолу УФ-спектрофотометрическим методом.

В монографии обобщены сведения научной литературы по географическому распространению, степени изученности химического состава и биологической активности экстрактов и выделенных индивидуальных соединений растений рода Alhagi Tourn. ex Adans. мировой флоры. Впервые полно представлены структуры более 460 соединений, относящихся к классам алкалоидов, т...

Dried and ground aerial part of Alhagi persarum (2.0 kg) was extracted (5×) at room temperature with EtOH (70%). The combined aqueous EtOH extract was concentrated to 0.5 L, diluted with hot H2O (1:1), and back-extracted sequentially with CHCl3 (5 × 400 mL), EtOAc (5 × 400 mL), and n-BuOH (6 × 400 mL). The EtOAc fraction was chromatographed over a...

The studied antihypoxants - Geranyl, Catacin, as well as Cavergal, Mildronate, increase the survival rate of animals in conditions of myocardial infarction. Medical their introduction contributes to the normalization of disturbed metabolism in the heart muscle, thereby maintaining the proper level of the main hemodynamic parameters: the average acc...

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Catacin - isolated from the plant Polygonium coriarium, showed almost the same activity as Cavergal and Mildronate in antihypoxic and antioxidant activity. The positive effect was established both in intact animals and in conditions of pulmonary edema. Treatment with Catacin, as well as with Mildronate, not only eliminated the characteristic signs...

Development of a method for determining the quality and quantity of biologically active substances in plant raw materials.

Cогласно проведенным фитохимическим исследованиям показано, что нарингенин, изомирицитин, нарциссин и генистин из надземной части растения Alhagi persarum выделены впервые, а флавонолы нарциссин и его агликон изорамнетин, которые продуцируются в мажорных количествах практически во всех видах растений рода Alhagi и являются хемотоксонометрическими м...

In the review summarized the scientific literature on geographical distribution, the degree of knowledge of the chemical composition and biological activity of extracts and isolated individual compounds of the genus Alhagi Tourn. ex Adans. of the world flora. The structures of the isolated 300 compounds are presented belonging to the alkaloids, ter...

In the review summarized the scientific literature on geographical distribution, the degree of knowledge of the chemical composition and biological activity of extracts and isolated individual compounds of the genus Alhagi Tourn. ex Adans. of the world flora. The structures of the isolated 300 compounds are presented belonging to the alkaloids, ter...

The volatile compounds o f hexane and benzene extracts from the aerial part o f Polygonum coriarium Grig. were studied by chromatography-mass spectrometry. As a result o f the conducted research, 20 components were identified in the composition o f hexane and benzene extracts, among which prevail: a-thujone (34,9 and 25,9%), camphor (19,2 and 22,4%...

The volatile compounds of hexane, benzene extracts and essential oils (EOs) isolated by steam-and hydrodistillation methods from aerial part of Alhagi canescens were studied by GC-MS analysis. Seventeen components were found in the hexane and benzene extracts, among them palmitic acid (25.2 and 22.1%), neophytadiene (7.3 and 22.3%), cis-chrysanthen...

В настоящее время исходя из особой ценности и широкого применения Crocus sativus L., впервые развёрнуты работы по его интродуцированию в Республике Узбекистан. Цель: фитохимические исследование вторичных метаболитов лепестков цветочных корзинок шафрана посевного, интродуцированного в Ташкентском оазисе.

Целью данной работы являются фитохимическое исследование летучих компонентов цветочных лепестков C. sativus L. культивируемой в Андижанской области.

As a result of the studies, two flavonols were first isolated from Crocus sativus L. petals: kaempferol and kaempferol-3-O-beta-D-sophoroside.

A sufficiently pronounced antihypoxic and antioxidant activity was exhibited by the sum of proanthocyanidins isolated from Polygonum coriarium, which we conventionally called “Catacin”. As a reference drug, Mildronate (Grindeks, Latvia) was used. The data obtained indicate that the studied activity of catacin in the optimal dose was quite comparabl...

The experiments were carried out on outbred white rats. Rats were divided into 2 groups - mature (age 9 months) and young (3 months). Animals were kept on a standard diet without restriction of access to food and water. The experiments were carried out in vitro, proanthocyanidin was used in concentration of 1 μg / ml. When studying the effects of p...

Currently, on the basis of special value and widespread use of C. sativus L., work on its cultivation was launched for the first time in Uzbekistan. It is known that the qualitative and quantitative compositions of secondary metabolites in plants can vary depending on the place of growth and the growing season. In this regard, we began studies on t...

This is to certify that NISHANBAEV SABIR has attended the the 13 International Symposium on the Chemistry of Natural Compounds October 16-19,2019, Shanghai

Currently, based on the special value and widespread use of C. sativus, the works on its introduction in Uzbekistan were first time launched. Due to the fact that the qualitative and quantitative compositions of secondary metabolites in plants can change depending on the place of growth and the vegetation season, we carried out a qualitative and qu...

In the world flora the genus is represented by 7 species, namely Alhagi pseudalhagi (M.Bieb.) Desv. ex Shap., A. maurorum Medik., A. canescens (Regel) B. Keller & Shap., A. kirghisorum Schrenk., A. sparsifolia Shap., A. graecorum Boiss., and A. persarum Boiss. Buhse. The distribution analysis shows that the Central Asia (including Uzbekistan), whe...

The chromatographic separation on a column of extractive substances mixture from chloroform, ethyl acetate and n-butanol fractions of the 70% alcohol extract from the aerial part of Lepidolopha komarovii, resulted in seven substances of phenolic nature: caffeic acid (1), luteolin (2), quercetin (3), luteolin-7-O-β-D-glucopyranoside (cynoraside) (4)...

In continuation of our research, two new phenolic compounds, 5 - epi - sawaranin (1) (diastereoisomer of sawaranin [2] ), with composition С 14 Н 16 О 7 , m.p. 231 - 233 °C, R f 0.27, (chloroform - methanol - acetic acid - ethyl acetate, 9:3:0.5:0.5), as well as a new butyrolactone, which we named charlesolid (2), with composition С 23 Н 24 О 10 ,...

The revealed ability of polymer proanthocyanidins to level out the phenomena of hypoxia was quite clearly revealed by us on the models of hypoxia of the brain, heart, and lungs. The most active in these pathologies were the polymeric proanthocyanidins from Geranium saxatile (geranyl), Polygonium coriarium (catacin) and Alhagi pseudalhagi (alkahine)...

The volatile compounds of hexane, benzene extracts and essential oils (EOs) isolated by steam- and hydrodistillation methods from aerial part of Alhagi canescens were studied by GC-MS analysis. Seventeen components were found in the hexane and benzene extracts, among them palmitic acid (25.2 and 22.1%), neophytadiene (7.3 and 22.3%), cis-chrysanthe...

By conducted investigations for the first time were studied the composition of the volatile components of flower petals and stigmas of the Crocus sativus L., introduced in the Tashkent and Fergana oases of the Republic of Uzbekistan. The main components of hexane and benzene extracts of C. sativus L. were б-isophorone and safranal. The total amount...

The article contains the data on the distribution of Geranium collinum Steph in the flora of Central Asia, ex Willd. - geranium hill, belonging to the family of geranium - Geraniaceae. In all of its parts the plant characterizes by the presence tannins, flavonoids, organic acids, carbohydrates. It is noted that the preparations of geranium hill hav...

The component composition of the benzene and hexane extracts of the plant Polygonum coriarium flora of Uzbekistan has been studied. A comparative analysis shows that, in the hexane and benzene extracts of the aerial part of Polygonum coriarium, the major vestiges are bicyclic monoterpenoid alpha-thujone and camphor, as well as acyclic diterpene neo...

The aim of this work is the phytochemical research had not previously studied Geranium transversale Vved. ex Pavlov. Phenolic compounds from the aerial part (stems, leaves, thorns and flowers) of G. transversale - Vved. ex Pavlov (family Geraniaceae) growing in Uzbekistan were studied. For the first time from this type of Geranium by column chromat...

В данном сообщении приводятся результаты исследования химического состава эфирных масел, полученных методами гидро- и пародистилляции из надземной части Lepidolopha komarovii, собранной в период начала цветения во отрогах Нуратинского хребта Джизакской области в окрестностях поселка Ухум, на высоте 1600 м, а также приведены данные in vitro скрининг...

The volatile compounds of hexane and benzene extracts were studied by GC-MS analysis, as well as were investigated the composition of essential oils obtained by steam and hydrodistillation from the aerial part of Alhagi persarum Boiss. & Buhse, collected during the flowering period in the Fergana region of the Republic of Uzbekistan. As a result of...

Quantitative NMR based evaluation of main components of stigmas and petals from the Crocus sativus

Studied the volatile components of ONOPORDUM ACANTHIUM Intruded in Tashkent Oasis by GC-MS method

The method of column chromatography and rechromatography with silica gel and Sephadex LH-20 from the aerial part of the Alhagi persarum, growing in Uzbekistan, identified three substances of flavonoid nature. The structure of the isolated compounds was established by chromatographic, spectral methods and comparison with reliably known samples.

GC-MS analysis of nonpolar components of Crocus sativus stigmas introduced to Andijan region of Uzbekistan

Методам колоночной хроматографии и рехроматографии из надземной части Alhagi kirghisorum Schrenk. - верблюжья колючка киргизская, произрастающего в Узбекистане, выделена одна фенолкарбоновая кислота и три вещества флавоноидной природы. Выделенные соединения идентифицированы, спектральными (ИК-, УФ- и ЯМР-спектры), хроматографическими методами и сра...

For phytochemical studies Crocus korolkowii to isolated the secondary metabolites the aerial part was extracted with hexane and benzene

We investigated compositions o f lipids o f this plant flowers. The total lipids were extracted from previously dried-up and pounded flowers by chloroform-methanol (2:1, v/v). The yield o f lipids was up to 1.5%. For establishment the group composition the total lipids were divided by column chromatography on silica gel, the neutral lipids (NL) was...

Целью данной работы являются фитохимическое исследование летучих компонентов цветочных лепестков C. sativus L. культивируемой в Андижанской области. Летучие соединения лепестков C. sativus L. (компоненты эфирного масла) получали методом гидродистилляции из воздушно сырого сырья в течение 3 ч с использованием стеклянной колбы и насадки Клевенджера....

Целью данной работы является фитохимическое изучение летучих компонентов О. acanthium, культивируемого в Ташкентском оазисе. Для извлечения летучих соединений экстракцию воздушно-сухих образцов измельченных подземных и надземных частей растения (в отдельности) проводили трехкратно гексаном и бензолом последовательно. Анализ полученных экстрактов пр...

Phenolcarbonic acid (caffeic acid) and three flavonoid (luteolin, cynarosid, quercetin) substances isolated from the aerial part of Lepidolopha komarovii, growing in Uzbekistan by column chromatography and rechromatography. The isolated compounds were identified by spectral (UV, IR, 1H and 13C NMR spectra), chromatographic methods and comparison wi...

By column chromatography and rechromatography from the aerial part o f Alhagi canescens, growing in Uzbekistan isolated one cyclic alcohol (D-pinitol) and three isoflavonoid (daidzein, formononetin and ononin) nature substances. The structures o f the isolated compounds were established by chromatographic, spectral methods (IR-, UV-, and NMR-spectr...

By column chromatography and rechromatography from the aerial part ofAlhagi kirghisorum Schrenk. - camel thorn Kirghiz, growing in Uzbekistan, isolated one phenolcarbonic acid (gallic acid) and three substances of flavonoid ((+)cathechin, narcissin and rutin) nature substances. The isolated compounds are identified, spectral (IR-, UV- and NMR- spec...

The volatile compounds of hexane, benzene extracts and essential oils (EOs) isolated by steam- and hydrodistillation methods from aerial part of Alhagi canescens were studied by GC-MS analysis. Seventeen components were found in the hexane and benzene extracts, among them palmitic acid (25.2 and 22.1%), neophytadiene (7.3 and 22.3%), cis-chrysanthe...

В данном сообщении приведены результаты изучения фенольных соединений корней G. collinum собранной в конец вегетации в Зааминском районе Джиззахской области.

В результате разделения были выделены три индивидуальных фенольных соединений - галловая кислота (1), этилгаллат (2) и (+)-катехин (3). Идентификацию выделенных веществ осуществляли на основании сравнительного изучения их спектральных данных (ИК-, УФ-, :Н-, 13С- ЯМР спектров) и физико-химических свойств с таковыми, описанными в литературе, а также...

This review summarizes the available data on the biological activity of extracts of from Alhagi Tournex Adans. genus plants. Pharmacological studies of different extracts shown that the Alhagi genus plants are promising sources of valuable biologically active compounds.

By column chromatography and rechromatography from the aerial part of Alhagi canescens, growing in Uzbekistan isolated one cyclic alcohol and three flavonoid nature substances. The structures of the isolated compounds were established by chromatographic, spectral methods (IR-, UV-, and NMR-spectra) and by comparison with authentically known samples...

The component composition of the secondary metabolites Aspergillus egypticusHT-166S isolated from stem of Heliánthus tuberósusplant, which has the ability to strongly inhibit the activity of pancreatic α-amylase, was studied. Qualitative analysis of phytocompounds showed that among metabolites there wereterpenoids, tannins, flavonoids, glycosides,...

Secondary metabolites of the aerial parts of Crocus korolkowii

The phenolic compounds from the aerial part (stems, leaves and flowers) of Geranium charlesii (Aitch. & Hemsl.) Vved. (Geranium of charles from family Geraniaceae) growing in Uzbekistan were studied. For the first time from this type of geranium by column chromatography from ethyl acetate and n-butanol fraction of 70% ethanol extract sequentially i...

To tally 58 compounds identified from benzene and hexane extracts o f the aerial parts o f Hypericum scabrum L. and Hypericum perforatum L by using o f the gas chromatography-mass spectral analysis, 35 components identified for the first time from Hypericum species.

Фитохимические исследования впервые показали, что надземная часть A. racemifera является источником биологически активных флавоноидов: апигенина (1), космосиина (2), кемпферола (3), 6-гидроксикампферола-7- О -b-D-глюкопиранозид (4), астрагалин (5) и кверцитрин (6).

Volatile compounds from the aerial parts of four Alhagi species groving in Uzbekistan

Herein we communicate results from GC/MS analyses of hexane and benzene extracts of four Alhagispecies collected during flowering in various oblasts of Uzbekistan, i.e., A. canescens, July 27, 2014, in the vicinity of Togai, Uzbekistan District, Fergana Oblast; A. persarum, July 31, 2014, in the vicinity of Sardoba, Akaltyn District, Sirdaryo Oblas...

From bark of the Platanus orientalis L. individually isolated one monomeric and two dimeric proanthocyanidine. The isolated compounds identified on the basis of spectral (IR-, UV-, NMR-spectrums) data and comparing them with valid samples.

The resulting compounds are identified as gallic acid (1), (+)-catechin (2) and (-)-epicatechin (3). The identification of substances selected were based on data UV, IR and 13C NMR spectra and their comparison with those described in the literature.