Sabah Ghazi

Vanderbilt University | Vander Bilt · Department of Pathology, Microbiology and Immunology

The promotion of the adoption of renewable energies in deprived and remote areas can be considered as an important step towards reduction of threats to the loss of biodiversity through community mobilization. One important outcome is mitigation of the deforestation processes through firewood collection. The aim is achievement of sustainable develop...

Human high-grade gliomas (HGGs) are known for their histologic diversity. To address the role of cell of origin in glioma phenotype, transgenic mice were generated in which oncogenic Ras and p53 deletion were targeted to neural stem/progenitor cells (NSPCs) and mature astrocytes. The hGFAP-Cre/Kras/p53 mice develop multifocal HGGs that vary histopa...

of a paper presented at Microscopy and Microanalysis 2011 in Nashville, Tennessee, USA, August 7–August 11, 2011.

Previous studies have shown that dibutyltin (DBT) interferes with the function of human natural killer (NK) cells, diminishing their capacity to destroy tumor cells, in vitro. DBT is a widespread environmental contaminant and has been found in human blood. As NK cells are our primary immune defense against tumor cells, it is important to understand...

This study investigated whether exposures to butyltins (BTs), tributylin (TBT), and dibutyltin (DBT) were able to alter cytosolic calcium levels in human natural killer (NK) cells. Additionally, the effects of cytosolic calcium ion increases on the activation state of mitogen-activated protein kinases (MAPKs) in NK cells were also investigated. NK...

Dibutyltin (DBT) is a widespread environmental contaminant. Detectable levels have been found in human blood. Natural killer (NK) cells are able to lyse tumor cells and virally infected cells. Previous studies have shown that DBT decreases the lytic function of NK cells. In this study we assessed the effects of those concentrations of DBT that decr...

ABSTRACT Tributyltin (TBT) has been used in wood preservation, marine antifouling paints, disinfection of circulating industrial cooling waters, and slime control in paper mills. Detectable levels have been found in human blood. Exposure to TBT decreases the tumor cell lysing (lytic) function of human natural killer (NK) lymphocytes. In this study...

Tributyltin (TBT) has been shown to disrupt the ability of natural killer (NK) cells to destroy tumor targets in vitro even at exposures of 25 nM for 24 h, but cell viability was not significantly impacted. Thus, evaluation of intracellular molecular events that regulate cell viability in TBT exposed NK cells are of interest. It has been suggested...

The purpose of this study was to investigate the role that tributyltin (TBT)-induced decreases in ATP levels may play in TBT-induced decreases in the tumor lysing (lytic) function of natural killer (NK) cells. NK cells are a subset of lymphocytes that act as an initial immune defense against tumor cells and virally infected cells. TBT is an environ...

Tributyltin (TBT), a toxic and widespread environmental contaminant, has been shown to inhibit natural killer (NK) cell cytotoxic function significantly. Inhibition of NK cell cytotoxic function has the potential to increase viral infections and tumor growth. Upon NK cell binding to lysis-sensitive tumor cells, an intracellular pathway is activated...

Natural killer (NK) cells are lymphocytes capable of destroying tumor cells and virally-infected cells without prior sensitization. In a previous study, we found that inhibition of adenylyl cyclase (AC) or cAMP-dependent protein kinase (PKA) decreased the ability of NK cells to destroy tumor cells. We also found that the environmental contaminant t...

Tributyltin (TBT) is a widespread environmental contaminant due to its use in marine antifouling paints and as an anti-microbial agent in other applications. There are measurable levels of TBT in some samples of human blood. Natural killer (NK) cells are lymphocytes capable of killing tumor and virally infected cells. Previously, we have shown that...

Mixtures of hyaluronan (HA), chondroitin sulfate (CS)-A and CS-C oligosaccharides were generated through the enzymatic digestion of the polysaccharides with either mammalian hyaluronidase or bacterial HA lyase or chondroitinase. Compared to mammalian enzymes, bacterial enzymes hydrolyze the polysaccharides through a different mechanism yielding che...

Butyltin (BT) compounds are known for their worldwide contamination. Dibutyltin (DBT) is used as a stabilizer in plastic products, and as a deworming agent in poultry. Poultry products have been shown to contain measurable levels of DBT. Drinking water has also been reported to contain BTs due to leaching from PVC pipes. We, and others, have found...

Tributyltin (TBT) was produced in large quantities for use in wood preservation, marine antifouling paints, disinfection of circulating industrial cooling waters and slime control in paper mills. TBT is found in dairy products, meat and fish. We and others have shown that there are measurable levels of TBT in human blood. BTs appear to increase the...

Natural killer (NK) cells are lymphocytes that kill tumor cells, virally infected cells and antibody coated cells. Butyltins (BTs) are used in industrial, agricultural and consumer applications and contaminate the global environment. Tributyltin (TBT) has been used for wood preservation, disinfection, antifouling marine paints, and slime control in...