Saahil Arora

GD Goenka University | GOENKAUNI · Department of Pharmacy School of Medical & Allied Sciences

The most important variable that affects a drug's bioavailability is its aqueous solubility. One of the biggest issues facing the pharmaceutical business is improving water solubility, which is the key to improving therapeutic efficacy. During the first screening procedure, over 50% of recently created medications are discovered to be insoluble or...

A simultaneous study is very important analytical parameter which helps to assess compatibility of mixture of drugs. UV spectrophotometer is one of the simplest and efficient methods to assess simultaneous parameters. Due to its economical approach, we have used UV spectrophotometer. Curcumin and Gentamicin sulphate have zero crossing points of 420...

Effective drug delivery to target sites is critical for achieving desired therapeutic outcomes. However, the poor permeability of certain drugs poses significant challenges in achieving adequate drug concentrations at the desired locations. Biomimetic hydrogels have emerged as a promising approach to enhance the penetration of poorly permeable drug...

Diabetes is a chronic metabolic disorder affecting millions of people and needs to be addressed. Alternativestrategies are required for better diabetes management, as evidenced by the high costs of modern medicines. The field of herbalmedicine research has been gaining significant importance in the last few decades, and the demand to use natural pr...

Objective: The lack of drugs to effectively cross the stratum corneum (SC), has recently been a significant barrier to transdermal administration. In order to increase the effectiveness of transdermal distribution, this issue has been solved through the development of micron-scale needles. The objective is to develop, formulate and evaluate biocomp...

The oral route is the most common route of administration of drugs. Over 90% of all the available marketed pharmaceutical products are oral formulations. Oral drugs are used in different courses of treatment including the prevention of tooth decay. Tooth decay is the permanent damage of the enamel which leads to the formation of cavities. It can be...

Achyranthes bidentata has been used to treat asthenia of lower limbs, painful backs & knees, atherosclerosis & many other ailments for a very long time. It is found that A. bidentata has many pharmacological activities such as anticancer & immunomodulatory activities, antiosteoporosis, neurotrophic & neuroprotective effects. In Chinese medicine sys...

The objective of the study is to prepare the nano particles of 5-fluorouracil with targeted delivery to the colon with enhancement of bioavailability and decrease the side effects of the drug. 5-Fluorouracil�loaded PLGA nanoparticles were developed by double solvent evaporation technique method. Characterization was carried out by determination of...

The pollution arising from pharmaceutical industry is increasingly considered to be a serious threat to environmental ecosystem as it effects the human health all around the world. Pharmaceuticals have the ability to get into the environmental surroundings at almost all their life cycle stages (disposal, use, and production), that means they have t...

In this review article we have given an outline of the pharmaceutical processes and there pollutants. Traditional treatments for wastewater, like active sludge, it is not enough to completely remove the active ingredients of the drug and other components of the contaminated water. Clinical garbage is a kind of clinical garbage that incorporates unu...

Transdermal patches are the cutting-edge drug delivery approach that may be utilized to bypass hepatic first-pass metabolism and to increase absorption for effective systemic effects. By using HPMC, Eudragit L-100, Plasticizer, and Permeation Enhancer in varying proportions, the Astaxanthin drug patch was prepared by SIT technique. For Astaxanthin...

Microneedle expands as therapeutics and diagnostics thereby dramatically affecting the delivery system in health care. MN arrays are made of several micron-sized needles with a height usually between 25 and 2000 µm, of various forms and compositions such as silicon, metal, and biodegradable polymers. With the help of current developments in additiv...

Total vaporization solid-phase microextraction (TV-SPME) is a type of extraction technique in which a specific solvent dissolves the analyte. Then a tiny amount of solvent is taken to the vial of SPME. Then, the solvent vaporizes in the SPME vial, and sampling is carried out on the headspace of the SPME fiber. As a result, the partitioning phase of...

Nanotechnology has captured the interest of experts in drug delivery due to exciting preliminary study findings from multidisciplinary investigations. Dendrimers are a preferred carrier for drugs due to their highly controllable dendritic structural nature. Researchers have put a lot of time and effort into advancing dendrimer-based hybrid pharmace...

Transferosome, being very flexible and deformable nature to cross stratum corneum are selected for enhancing the transdermal delivery of fusidic acid. The present research work comprised formulation of fusidic acid transferosome using modified reverse phase evaporation process and characterised for particle size, zeta potential, entrapment efficien...

Standard plot of Thiocolchicoside was constructed in distilled water, 0.01M PBS, n-octanol, ethanol, methanol, 0.9% w/v NaCl and mixture of acetonitrile: water (70:30). Peak of stock solution was observed at a particular wavelength (λmax) and various dilutions of that stock solution were prepared and absorbance value of every dilution was observed...

The development of a biodegradable, biocompatible, stimulating, and targeted delivery system has been guided by innovation in material science. One promising approach for improving the efficiency of hybrid drug delivery is to hybridize different materials. They are hybridizing different materials, where each part may play a critical role in an effe...

ABSTRACTSarcopenia is a societal health issue owing to population density shifts and characterized by musclemass and muscle function loss due to age. Despite many efforts to develop treatment strategies forsarcopenia, exceptionally restricted therapies are still available for clinical use. Mostpharmacological drugs studied too far have been hormona...

Psoriasis is an inflammatory skin which is chronic disorder with epidermal (acanthosis) hyperplasia and extreme inflammation as erythematous lesions. The penetration and neovascularization of inflammatory cells resulting from epidermis hyperproliferation with incomplete keratinocyte differentiation irregular horn cell formation are characterized by...

The aim of this study to find out the role of biomaterial cross carmellose sodium and Eudragit s100 is to control the drug release drug dosage form into a particular site, colon, which is part of large intestine. The drug Budesonide was used as a model drug. In this study nine formulations (F1-F9) were prepared using different concentration of poly...

Triple-negative breast cancers (TNBCs) form a heterogeneous group of breast carcinomas that lack expression of estrogen receptor, progesterone receptor and epidermal growth factor receptor 2. In the past decade, immune checkpoint inhibitors (ICIs) have revolutionized the arena of cancer immunotherapy. Early results are now accumulating from trials...

Permeability glycoprotein (P-gp), a multispecific drug transporter belonging to the multidrug resistance (MDR) gene subfamily, is mainly responsible for efflux of diffused intracellular drugs, resulting in poor drug bioavailability. P-gp is overexpressed in the blood-brain barrier, gastrointestinal tract (GIT), kidney, liver, pancreas, and cancerou...

An objective of present invention is to provide a lactobionic acid conjugated polyphosphazene based nanodelivery of primaquine for liver targeting to check antimalarial activity. Yet another objective of present invention is to provide lactobionic acid conjugated polyphosphazene based nanodelivery of primaquine wherein the lactobionic acid is conju...

Polymers have been utilized to deliver the drug to targeted site in controlled manner, achieving the high-therapeutic efficacy. Polymeric drug conjugates having variable ligands as attachments have been proved to be biodegradable, stimuli sensitive and targeted systems. Numerous polymeric drug conjugates having linkers degraded by acidity or intrac...

72415 PMID:22247858 [ABSTRACT] [FULL TEXT] [PDF] [Mobile Full text] [EPub] [CITATIONS] [PubMed] 8,960 836 10 REVIEW ARTICLE Scientific basis for the therapeutic use of Cymbopogon citratus, stapf (Lemon grass).79796 PMID:22171285 [ABSTRACT] [FULL TEXT] [PDF] [Mobile Full text] [EPub] [CITATIONS] [PubMed] 8,853 433 15 REVIEW ARTICLES Clinical aspects...

Oral mucositis is one of the major side effects of cancer chemotherapy (30-76%) and radiotherapy (over 50%). Current palliative treatments of oral mucositis include specialized agents like pelifermin, platelet derived factors etc. or oral hygienic agents which suffered from various drawbacks like systemic side effect, least effect owing to fast was...

Osteoporosis (means porous bones) is the condition in which a low bone mass and altered microarchitecture of the bone leads to increased risk of fracture. The various conventional as well as novel delivery systems have been used in the treatment of osteoporosis. In the current review we give a brief introduction about the various novel delivery sys...

Poor aqueous solubility impedes a drug's bioavailability and challenges its pharmaceutical development. Pharmaceutical development of drugs with poor water solubility requires the establishment of a suitable formulation layout among various techniques. Various approaches have been investigated extensively to improve the aqueous solubility and poor...

Poor aqueous solubility impedes a drug's bioavailability and challenges its pharmaceutical development. Pharmaceutical development of drugs with poor water solu-bility requires the establishment of a suitable formulation layout among various techniques. Various approaches have been investigated extensively to improve the aqueous solubility and poor...

The demand for novel drug delivery technologies is ever increasing though majority of the drugs are administered via oral, inhalation, transdermal and parenteral route. However, there are large numbers of therapies, particularly protein-based, gene-based and vaccine-based that cannot be delivered by this route for example insulin, growth hormones a...

Amlodipine besylate is a potent calcium channel blocker used for the treatment of hypertension, congestive heart failure and angina pectoris. Amlodipine besylate avoids the adverse effect of amlodipine in racemic mixtures. A highly precise and cost effective RP-HPLC method with retention time of 2.60 minutes was developed for the estimation of...

M any skin diseases are based in the dermal layer of the skin like-acne, alopecia, psoriasis, herpes zoster, etc. Conventional topical formulations have not proved to be effective in managing these conditions because of poor retention in the skin. Some formulations do not penetrate through the stratum corneum and some pass through the skin very qui...

Drug regulation is totality of all measures-Legal, administrative and technical-which the governments take to assure the quality, efficacy and safety of drugs. With reports of number of tragic adverse events caused by use of drugs, more stringent controls have been imposed upon the procedures for marketing authorization of drugs. The research and d...

Helicobacter pylori (H. pylori), the major culprit for peptic ulcer, has a unique way of survival in harsh acidic environment of the stomach by colonizing deep in the gastric mucosal layer. Failure of conventional therapies against H. pylori for complete eradication has major limitations like low residence time of delivery system in stomach, poor p...

Scaffolds are implants or injects, which are used to deliver cells, drugs, and genes into the body. Different forms of polymeric scaffolds for cell/drug delivery are available: (1) a typical three-dimensional porous matrix, (2) a nanofibrous matrix, (3) a thermosensitive sol-gel transition hydrogel, and (4) a porous microsphere. A scaffold provides...

Amoxicillin-loaded microcapsules were prepared by ionotropic gelation of sodium alginate (ALG) with chitosan (CS) in presence of calcium chloride as gastroretentive delivery system. The effect of pH, concentration of ALG, CS and calcium chloride, and drug : ALG ratio were optimized in this study for minimizing the degradation of drug in acidic envi...

Stomach-specific floating tablet of metronidazole based on the buoyancy and bioadhesion concept was prepared with a purpose to retain the drug in stomach for longer duration and helps in releasing the drug in the antrum region of gastric mucosa, a safe heaven for Helicobacter pylori. This research work systematically studied the effects of various...

The present study has been undertaken to apply the concept of nanoparticulate mucopenetrating drug delivery system for complete eradication of Helicobacter pylori (H. pylori), colonised deep into the gastric mucosal lining. Most of the existing drug delivery systems have failed on account of either improper mucoadhesion or mucopenetration and no do...

The success of anti-cancer drug targeting is depends on the ability of the therapeutics to reach their desirable cellular and intracellular sites and minimizing action at the nonspecific sites. In the present study, anti-human epidermal growth factor receptor (HER-2, ErbB2) antibody anchored nanoparticles were prepared and evaluated for the assessm...

Clinical trials, also known as clinical studies, are designed to help us find out how to give a new treatment safely and effectively to people. A clinical trial is an organized research study designed to investigate new methods of preventing, detecting, diagnosing, or treating an illness or disease and attempt to improve a patient's quality of life...

The success of anti-cancer drug targeting is depends on the ability of the therapeutics to reach their desirable cellular and intracellular sites and minimizing action at the nonspecific sites. In the present study, anti-human epidermal growth factor receptor (HER-2, ErbB2) antibody anchored nanoparticles were prepared and evaluated for the assessm...

A dendrimer described as a macromolecule characterized by its highly branched 3D structure which provides a high degree of surface functionality and versatility. Dendrimers also referred to as the "Polymers of the 21 st century." Dendrimers components, namely (1) an initiator core (2) Interior layers (generations) composed of repeating units, radic...

Breast cancer remains one of the world's most devastating diseases. However, better understanding of tumor biology and improved diagnostic devices could lead to improved therapeutic outcomes. Nanotechnology has the potential to revolutionize cancer diagnosis and therapy. Various nanocarriers have been introduced to improve the therapeutic efficacy...

Management of postoperative pain relieve suffering and leads to earlier mobilization, shortened hospital stay, reduced hospital costs, and increased patient satisfaction. An effective postoperative management is not a standardized regime rather is tailored to the needs of the individual patient, taking into account medical, psychological, and physi...