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Saadi Abdul Vahab

Saadi Abdul Vahab
Manipal School of Life Sciences Manipal Academy of Higher Education · Biotechnology

M Sc., M. Tech (IIT KGP), Ph.D

About

29
Publications
7,359
Reads
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498
Citations
Citations since 2016
8 Research Items
337 Citations
20162017201820192020202120220204060
20162017201820192020202120220204060
20162017201820192020202120220204060
20162017201820192020202120220204060
Additional affiliations
August 2005 - present
Manipal Academy of Higher Education
Description
  • Designation: Associate Professor; Area: Molecular Genetics; Work: Teaching, Research and Diagnostics.
August 2005 - present
Manipal Academy of Higher Education
Position
  • Professor (Associate)
October 2000 - December 2002
Madurai Kamaraj University
Position
  • Resource person at the level of Research Associate
Description
  • Teaching in M Sc Biotechnology programme at the Department; and Research in Molecular Genetics of Familial Hypertrophic Cardiomyopathy in collaboration with Sree Chitra Tirunal Institute of Medical Sciences and Technology, Thiruvananthapuram.
Education
June 2002 - December 2003
Max-Planck Institute for Physiological and Clinical Research, AG Vosberg
Field of study
  • Molecular Genetics of Familial Hypertrophic Cardiomyopathy
July 1995 - July 2000
Indian Institute of Technology Kharagpur
Field of study
  • Biotechnology
July 1987 - February 1989
Indian Institute of Technology Kharagpur
Field of study
  • Department of Agricultural and Food Engineering

Publications

Publications (29)
Article
Pathophysiology of Plasmodium falciparum and Plasmodium vivax in malaria vis a vis host and the parasite genome interactions has been deciphered recently to present the biology of cerebral malaria, severe anaemia and placental malaria. Small non-coding RNAs have exhibited their potential to be considered as indicators and regulators of diseases. Th...
Article
The risk for recurrence of non disjunction trisomy 21 is conventionally considered to be less than 1%. Within a span of 3 years, we observed recurrence of non disjunction trisomies in four families. The objective of the present study was to determine low level mosaicism in either of the couple and to identify the parental origin of additional chrom...
Article
Full-text available
Background: Radical cure of Plasmodium vivax malaria requires treatment with a blood schizonticide and a hypnozoitocide (primaquine) to eradicate the dormant liver stages. There has been uncertainty about the operational effectiveness and optimum dosing of the currently recommended 14-day primaquine (PQ) course. Methods: A two centre, randomized...
Article
Full-text available
The original version of this article unfortunately contained a mistake. Ambika Devi K was not listed among the authors. The corrected authorship is given below
Article
The more than 1.5 billion people who live in South Asia are correctly viewed not as a single large population but as many small endogamous groups. We assembled genome-wide data from over 2,800 individuals from over 260 distinct South Asian groups. We identified 81 unique groups, 14 of which had estimated census sizes of more than 1 million, that de...
Preprint
The more than 1.5 billion people who live in South Asia are correctly viewed not as a single large population, but as many small endogamous groups. We assembled genome-wide data from over 2,800 individuals from over 260 distinct South Asian groups. We identify 81 unique groups, of which 14 have estimated census sizes of more than a million, that de...
Thesis
Severe forms of malaria in humans is caused by Plasmodium falciparum and Plasmodium vivax.Malaria infection is the results of complex membrane sorting and signaling. Erythrocyte membrane lipid rafts proteins regulate membrane sorting and signaling processes and hence lipid raft proteins (Gαs and β2AR) and the interacting proteins (ADORA2A and GRK5)...
Article
Evaluation of multiplex ligation dependent probe amplification as a tool for diagnosis and carrier detection in families with a dystrophinopathy: We set out to evaluate multiplex ligation dependent probe amplification (MLPA) as a tool for diagnosis and carrier detection in families with a dystrophinopa hy. Fifty three Indian families with provision...
Article
In the erythrocytes, malaria parasite entry and infection is mediated through complex membrane sorting and signaling processes. We investigated the effects of single-locus and multilocus interactions to test the hypothesis that the members of the GPCR family genes, adenosine A2a receptor (ADORA2A) and G-protein coupled receptor kinase5 (GRK5), may...
Article
The essential route to blood parasitaemia in malaria, erythrocyte invasion is facilitated by activation of the G-protein coupled receptor signaling pathway mediated by the β2-adrenoreceptor as one of the proteins on the surface of red blood cells. The effectiveness of bronchodilators and inhaled corticosteroids in the clinical treatment for asthma...
Article
Bacterial artificial chromosomes (BACs) are used in genomic variation studies due to their capacity to carry a large insert, their high clonal stability, low rate of chimerism and ease of manipulation. In the present study, an attempt was made to create the first genomic BAC library of an anonymous Indian male (IMBL4) consisting of 100,224 clones c...
Article
Full-text available
There are many studies documenting increased prevalence of periodontal infection in women with preeclampsia. But, very few studies have attempted to establish causal relationship between the two. To find out causal circumstantial evidence by isolating specific periodontal pathogens in oral and placental samples. Antenatal periodontal screening and...
Article
Full-text available
The pro-inflammatory cytokine interleukin-1 (IL-1) is a key modulator of host responses to microbial infection and a major modulator of extracellular matrix catabolism and bone resorption, and polymorphisms in the IL-1 gene cluster have been associated with an increased risk of developing severe adult periodontitis. A case control study was perform...
Article
Prenatal diagnosis of 3 HBB gene mutations causing β-thalassemia and hemoglobin D Punjab segregated in a South Indian nuclear family is reported along with a method identified as control for maternal cell contamination (MCC). Amplicons of the HBB gene from genomic DNA obtained from the blood of a thalassemic first child (proband), both parents, and...
Article
Gayathri R, Abdul vahab Saadi, Bhat KM, Bhat S, Satyamoorthy K. 2011. Allele, genotype and composite genotype effects of IL-1A+4845 and IL-1B+3954 polymorphisms for chronic periodontitis in an Indian population. Indian J Dent Res. 22(4): 126-132
Article
Full-text available
ABSTRACT Genomic aneuploidy is a common cause of human genetic disorders and cytogenetic analysis of metaphase karyotypes remain the standard method to identify aneuploidies and balanced translocations. Quantitative Fluorescence PCR (QF-PCR) is an alternative method in which DNA polymorphic markers on chromosomes, is used to determine the presence...
Article
Full-text available
Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds including thiopurine drugs such as 6-mercaptopurine, 6-thioguanine and azathioprine. TPMT activity exhibits genetic variation and shows tri-modal distribution with 89-94% of individuals possessing high activity, 6-11% intermediate act...
Article
Murugesan R, Abdul vahab Saadi, Patra S, Rao R, Rao J, Rai P, Gopinath PM, Kapaettu Satyamoorthy K. 2010. Thiopurine S-methyltransferase allele (TPMT, *2, *3B and *3C) and genotype frequencies in an Indian population. Exp Ther Med,1(1):121-127
Article
Murugesan R, Abdul Vahab Saadi, Patra S, Rao R, Rao J, Rai P, Gopinath PM, Kapaettu Satyamoorthy K. 2010. Thiopurine S-methyltransferase allele (TPMT, *2, *3B and *3C) and genotype frequencies in an Indian population. Exp Ther Med,1(1):121-127
Article
Full-text available
The transmembrane P-glycoprotein that functions as a drug-efflux transporter coded by ATP-binding cassette, subfamily B, member 1/Multidrug Resistance 1 (ABCB1/MDR1) gene is considered relevant to drug absorption and elimination, with access to the central nervous system. Effects of three ABCB1 single nucleotide polymorphisms (SNPs) in genotypic an...
Article
Mutations causing familial hypertrophic cardiomyopathy (HCM) have been described in at least 11 genes encoding cardiac sarcomeric proteins. In this study, three previously unknown deletions have been identified in the human cardiac genes coding for beta-myosin heavy chain (MYH7 on chromosome 14) and myosin-binding protein-C (MYBPC3 on chromosome 11...
Article
Vosberg H, Waldmüller S, Sakthivel S, Abdul Vahab Saadi, Rakesh P G, Goloubenko M, Tharakan J M, Richard P, Schwartz K, Rajamanickam C. (2003) Novel deletions in MYH7 and MYBPC3 identified in Indian families with familial hypertrophic cardiomyopathy. Abstract No 180, Europ J of Heart Failure 2 (1): 35 supplements (2003)
Conference Paper
Mutations causing familial hypertrophic cardiomyopathy (HCM) have been described in at least 11 genes encoding cardiac sarcomeric proteins. In this study. three previously unknown deletions have been identified in the human cardiac genes coding for beta-myosin heavy chain (MYH7 on chromosome 14) and myosin-binding protein-C (MYBPC3 on chromosome 11...
Article
Sakthivel S, Waldmüller S, Abdul Vahab Saadi, Joseph PK, Rakesh PG, Padmakumar R, Tharakan JM, Richard P, Schwartz K, Rajamanickam C, Vosberg H. Novel mutations in MYH7 and MYBPC3 of an Indian family causing Hypertrophic Cardiomyopathy. Abstract published by International Society for Heart Research (ISHR) XVII World Congress, Canada July 2001. J Mo...

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