Saad Al-lahham

Saad Al-lahham
University of Groningen | RUG · Department of Pathology and Medical Biology

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22
Publications
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1,216
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Publications

Publications (22)
Article
Full-text available
Pellitory plant (Parietaria judaica (PJ)) is one of the most widely used Arabian traditional medicinal plants due to its ability to cure several infectious diseases and other illnesses. The current study is aimed at assessing the phytoconstituents, antilipase, antiamylase, antimicrobial, and cytotoxic characters of the Pellitory plant (Parietaria j...
Article
Introduction Throughout history, therapeutically active plant products have received substantial attention due to their valuable role in the discoveries of specific medications. The aim of this study was to assess, for the first time, the antimicrobial, antioxidant, antilipase, anti-α-amylase and cytotoxic properties of four fractions derived from...
Preprint
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Medicinal properties of Euphorbia tirucalli L. have been investigated in vitro. Water extract from the plant latex was freeze dried and tested against 3 digestive enzymes and showed IC50 as 39.8±0.22, 79.43±0.38 and 316.22±0.3 for lipase, alpha- glucosidase and alpha- amylase, respectively. These results were incomparable with drugs such as acarbos...
Article
Full-text available
Background: Childhood obesity is rising in developed and developing countries, while childhood underweight is rising mainly in developing countries. Childhood underweight has been shown to increase a child's risk of rapid weight gain. Overweight and obese children are more likely to become obese adults, which increases the risk of type-II diabetes...
Article
Many phytochemicals have medicinal properties including anti-inflammatory, antioxidant and cytotoxic activities. The current study aims to estimate and identify the chemical composition of Calamintha fenzlii Vis. leaves volatile oil and to evaluate its cytotoxic, anti-inflammatory and antioxidant properties. The volatile oil (VO) of C. fenzlii leav...
Article
Centaurea cyanoides Wahlenb aqueous, methanol, acetone, and hexane fractions has been evaluated for their phytochemical constituents, antioxidant and antibacterial activities. The fractions of were studied in order to support its use in the traditional medicine. Antioxidant activity was assessed employing 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-r...
Article
Plants have been used by human being in the treatment and prophylaxis of various diseases since thousands of years ago. Chrozophora obliqua is an aromatic plant that possesses beneficial health properties in traditional medicine. However, other properties of Chrozophora obliqua such as antioxidant, antimicrobial, and helminthicidal properties have...
Article
Full-text available
Introduction In traditional medicine, many pharmacological activities have already been ascribed to the genus of Teucrium plant. These include antirheumatic antispasmodic, anthelmintic, diuretic, hypoglycemic, and anticancer effects. The recent investigation aimed to characterize and estimate the chemical composition, anti-inflammatory, antioxidant...
Article
Background Many recent studies have shown that medicinal plants, which have been used worldwide through the past history in the folkloric medicine, harbor a significant number of novel metabolic compounds with potent pharmacological properties. In several countries, the aerial parts of the Methods Phytochemical assessments were based on standard a...
Article
Full-text available
Lipid droplets (LDs) hypertrophy in adipocytes is the main cause of energy metabolic system dysfunction, obesity and its afflictions such as T2D. However, the role of adipocytes in linking energy metabolic disorders with insulin regulation is unknown in humans. Human adipocytes constitutively synthesize and secrete insulin, which is biologically fu...
Article
Full-text available
Angiopoietin-like protein 4 (ANGPTL4/FIAF) has been proposed as a circulating mediator between the gut microbiota and fat storage. Here, we show that transcription and secretion of ANGPTL4 in human T84 and HT29 colon adenocarcinoma cells is highly induced by physiological concentrations of short-chain fatty acids (SCFA). SCFA induce ANGPTL4 by acti...
Article
Full-text available
Colon cancer is a serious health problem, and novel preventive and therapeutical avenues are urgently called for. Delivery of proteins with anticancer activity through genetically modified bacteria provides an interesting, potentially specific, economic and effective approach here. Interestingly, bone morphogenetic protein 2 (BMP-2) is an important...
Article
Full-text available
Adipose tissue is a primary site of obesity-induced inflammation, which is emerging as an important contributor to obesity-related diseases such as type 2 diabetes. Dietary fibre consumption appears to be protective. Short-chain fatty acids, e.g. propionic acid, are the principal products of the colonic fermentation of dietary fibre and may have be...
Article
Full-text available
Background: Obesity promotes inflammation in adipose tissue (AT) and this is implicated in pathophysiological complications such as insulin resistance, type 2 diabetes and cardiovascular disease. Although based on the classical hypothesis, necrotic AT adipocytes (ATA) in obese state activate AT macrophages (ATM) that then lead to a sustained chron...
Article
Full-text available
Undigested food is fermented in the colon by the microbiota and gives rise to various microbial metabolites. Short-chain fatty acids (SCFA), including acetic, propionic and butyric acid, are the principal metabolites produced. However, most of the literature focuses on butyrate and to a lesser extent on acetate; consequently, potential effects of p...
Article
Dietary fibre (DF) has been shown to be protective for the development of obesity, insulin resistance and type 2 diabetes. Short-chain fatty acids, produced by colonic fermentation of DF might mediate this beneficial effect. Adipose tissue plays a key role in the regulation of energy homeostasis, therefore, we investigated the influence of the shor...
Article
Full-text available
The gastrointestinal tract is a complex niche and the main port of entry of many pathogens that trigger a wide range of diseases like inflammatory bowel disease (IBD) and colon cancer. Antibodies are effective for treating such diseases, but a system capable of local delivery at the site of the pathology, thus avoiding systemic side effects, is not...
Article
Abstract Obesity and its associated low-grade inflammation and pathological consequences, including insulin resistance and type-2 diabetes, pose a great challenge to the health systems nowadays. Adipose tissue is a primary site of obesity-induced inflammation which is emerging as an important contributor to the obesity-related diseases. The factors...

Questions

Question (1)
Question
I am trying to isolate adipocytes as well as SVF. however I find it very difficult to separate adipocytes from the oil layer. in addition it is hard to get a pellet of SVF. Can anybody help?

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