s. R. Sheela

Introduction Cervical cancer might intensify the psychological distress among patients with cervical cancer and the distress caused by the diagnosis and treatment. So, depression and anxiety are at higher levels in patients with cervical cancer. Yoga Nidra and Pranayama are thought to reduce the aftereffects of chemotherapy and radiotherapy potenti...

Objective: Altered methylation patterns of insulin-like growth factor (IGF)-axis genes in small for gestational age (SGA) have been reported in different populations. In the present study, we analyzed the methylation status of IGF-axis genes in the placenta of appropriate for gestational age (AGA) and SGA neonates of South Indian women. Methods:...

Background: Stem cells exist in niches in the cervical tissue at squamocolumnar junction, which when infected with HR-Human Papilloma Virus undergo malignant transformation to cancer stem cells and have a role in carcinogenesis and metastasis. The expression of CD44, P16, and Ki67 in high-grade squamous intraepithelial lesion (HSIL) and squamous c...

Aims and objectives: The aim is to determine the frequency of potential drug-drug interactions (pDDIs) and to analyze the clinically relevant drug interactions among hypertensive pregnant women. Materials and methods: This was an observational, cross-sectional study conducted at a tertiary care hospital. The prescriptions of the hypertensive pre...

Triplet heterotopic pregnancy refers to the presence of specifically 3 concurrent gestations with at least 1 being abnormally implanted. Heterotopic pregnancy is rare and estimated to occur in about 1 per 30,000 spontaneous pregnancies while a higher prevalence may occur in assisted reproduction techniques that may reach up to 1 case per 100 in som...

Preeclampsia (PE) is a multifactorial pregnancy specific disorder with complexity in pathophysiology. Many markers have been evolved but none of them was specific. The aim of the study was to compare the maternal serum soluble endoglin (sEnd) levels in pre-eclamptic & normotensive pregnant women in early and late gestational weeks. A total of 300 s...

Objective: IGF-axis and mitotic capacity of cells play a vital role in fetal growth. We compared IGF1, IGF2, and IGFBP3 protein levels, mitotic indices, IGFR1 and IGFR2 mRNA expression in appropriate for gestational age (AGA) and small for gestational age (SGA) neonates of Indian women. Methods: Cord blood (n = 80) and placental samples (n = 40) we...

Aim: To assess the presence of HPV among women who were visiting gynaecological out patient department for any cervix related reason. Material and Methods: Cervical scrapings were collected using Cytobrush. Pap smear results were collected from the pathology department and Histopathological confirmation for high grade lesions was also collected. PC...

Recent studies have reported that nucleic acid oxidation is elevated in preeclampsia. Furthermore, it is known that products of nucleic acid oxidation are eventually removed through the urine. The aim of this study was to check whether urine can be used as a non-invasive specimen to analyse nucleic acid oxidation in preeclampsia. We carried out a c...

Introduction: Cervical cancer is the 3rd most common cancer among women worldwide. p16 biomarker is the surrogate marker in cervical cancer and can be detected by Immunohistochemistry (IHC). Aim: To evaluate the association of IHC p16INK4a expression in tissue sections and Enzyme-linked Immunosorbent Assay (ELISA) p16INK4a protein in plasma of pair...

Background: Cervical cancer is one of the common cancers in females. The common method of screening is Pap test which has low sensitivity. Hence, better methods are explored with different biomarkers, of which estimation of P16 protein can be opted in early detection of cervical cancer. Materials and methods: Seventy cases and seventy controls w...

Background Normal cervical epithelium does not express programmed death ligand-1 (PD-L1) protein. Expression of PD-L1 has been reported in 50% cells of cervical carcinoma. Approximately 17% of adenocarcinomas and 35% of squamous cell carcinomas (SCC) of the cervix express PD-L1. Objectives To determine the expression of PD-L1 in invasive SCC of th...

Introduction and Aim:Preeclampsia is a pregnancy specific hypertensive disorder and its complications are associated with maternal morbidity and mortality. The intention of the study is to determine early placental and endothelial dysfunction markers in first and second trimesters of pregnancy for the prediction of preeclampsia. Materials and Metho...

Objectives Preeclampsia (PE) is a multisystemic disorder portrayed by the new beginning of circulatory pressure more noteworthy than 140/90 mmHg and proteinuria with 0.3 g in a 24 h on dip stick emerging after 20 weeks of incubation. The hidden pathophysiology of PE includes endothelial brokenness and vasospasm beginning principally in the placenta...

Objective To evaluate the apelin (APLN) −1860 T > C (rs56204867) polymorphism and maternal serum apelin 13 levels in preeclampsia and its association with blood pressure. Methods This case-control study was conducted in department of Biochemistry, Sri Devaraj Urs Medical College, Karnataka, India. A total of 181 subjects were enrolled in the study...

Introduction: Pre-eclampsia is a pregnancy specific disorder, characterised by the onset of hypertension and proteinuria. Pre-eclampsia is the leading cause of maternal, perinatal morbidity and mortality. The exact cause of pre-eclampsia is not known clearly and needs to be explored.Aim: To evaluate the maternal serum apelin 13 levels among pre-ecl...

Preeclampsia (PE) is the most common hypertensive disease of pregnancy, leads to maternal, perinatal morbidity and mortality, which accounts for 2-8% of pregnancies. Preeclampsia is characterized by new onset of hypertension and proteinuria after 20 weeks of gestation.The exact cause of preeclampsia is not clear. Aim of this study is to investigate...

Introduction: Cervical cancer is the most common cancer among females. P16 is the surrogate marker for cervical carcinoma. This study aimed to evaluate the association of P16 marker with clinic-pathological parameters in squamous cell carcinoma of uterine cervix. Methods: This was a cross-sectional study. Histological confirmed cases of squamous ce...

Background: Preeclampsia (PE) is a pregnancy specific disorder, characterized by new onset of hypertension and proteinuria after 20 weeks of gestation. It is one of the leading causes of maternal and perinatal morbidity and mortality. The etiology of the disease process in not known. There is an urgent need for a 1st trimester marker for the predic...

Background: Preeclampsia (PE) is a pregnancy specific, hypertensive disorder. It affects 2-8% pregnancies. Oxidative stress and systemic inflammation are proposed to contribute significantly to the preeclampsia pathophysiology. The present study, aim is to determine and compare the markers of oxidative stress, endothelial dysfunction, systemic infl...

Objective: Cervical cancer is a common cancer in females. Clinicopathological features vary and are heterogeneous in different studies. This study was taken up to know the clinicopathological correlation in squamous cell carcinoma (SCC) of the cervix in our population. Methods: This is a cross-section study. Histologically confirmed cases of squamo...

Apelin protein is an endogenous ligand of Apelin Receptor (APJ). APJ is a member of G-protein coupled receptor family. Both apelin and its receptor express extensively in the human body. Apelin receptor activation occurs by its cognate peptide ligand, apelin and many physiological effects, including vasodilation, vasoconstriction, angiogenesis, flu...

Introduction: Morphometric analysis of various parameters of the cells is done to classify the lesion as benign or malignant. It is an objective assessment which reduces the variability due to subjective visual assessment. Authors have done the nuclear morphometric analysis in ectocervix and endocervix tissue sections. Aim: To evaluate the signific...

Objective: To evaluate the association of protein carbonylation with preeclampsia and its correlation with urinary protein misfolding. Method: Protein carbonyl and misfolded protein levels were measured in the midstream urine sample (58 preeclamptic and 44 normotensive pregnancy) by ELISA and Congo Red Dot assay respectively. Results: Signific...

Placental protein 13 (PP13), a glycan binding protein predominantly expressed in syncytiotrophoblast, dimeric in nature, lacks N-terminal signal peptide, bypasses the endoplasmic reticulum, and secretes into maternal circulation as exosomes or microvesicles. PP13 has jelly roll fold conformation with conserved carbohydrate recognition domain which...

Objectives: To evaluate the presence of urinary congophilia amongIndian patients with preeclampsia. Study design: A prospective case control study in which congophilia of urine samples from preeclamptic pregnant women (n = 62) and normotensive pregnant women (n = 65) was compared by using Congo Red Dot Blot assay. Main outcome measures: Presen...

Background Anemia is one of the most common nutritional deficiency disorders affecting the pregnant women in the developing countries. Anemia during pregnancy is commonly associated with poor pregnancy outcome and can result in complications that threaten the life of both mother and fetus. Objective The objective of the study was to estimate the p...

AIM: Our purpose was to know phospholipase A2 activity and its gene PLA2G4α polymorphism was an inflammatory marker in preeclampsia compared with normotensive pregnancies. Efforts were made to determine the association of PLA2 and its gene. Study Design: longitudinal observational study Methods: 4ml of blood were obtained from preeclampsia (n=51)...

Objective: The objectives of the present study were to evaluate the activity of phospholipase A2, plasma elastase enzymes and to assess relation with an inflammatory marker high sensitive C-reactive protein (hs-CRP) in nonpregnant before and after delivery of normotensive pregnant and preeclamptic women. Methods: The study population consists of th...

Aim: To determine maternal thyroid hormone status and lipid profile in preeclampsia. Study Design: A prospective case control study consist of two groups such as group 1 normotensive non-preeclamptic group and group 2 as cases with clinically diagnosed preeclampsia Place and Duration of Study: Department of Obstetrics and Gynaecology, RL Jalappa Ho...

Prevalence of anemia among pregnant women in rural population of Kolar district Ravishankar Suryanarayana1, Anil Navale Santhuram2, Muninarayana Chandrappa2, Prathima Shivajirao3, Sheela Shikaripur Rangappa4 1Department of Statistics, Sri Devaraj Urs Medical College, Kolar, Karnataka, India. 2Department of Community Medicine, Sri Devaraj Urs Medica...