S. M. Banan Khojasteh

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• Ph. D of Anatomical Sciences
• Professor (Associate) at University of Tabriz

Dyslipidemia is characterized by abnormal lipid levels in the bloodstream and can be influenced by liver diseases and smoking. Nicotine exposure and liver damage are linked to lipid metabolism impairments. This study investigated the effects of nicotine on dyslipidemia in a cholestasis rat model using bile duct ligation (BDL) to establish liver fib...

Background. Polycystic ovary syndrome (PCOS) is one of the endocrine diseases of the reproductive system, with a prevalence of 5‒10% in women, and one of its symptoms is an increase in the serum amount of pro-inflammatory adipokines from adipose tissue. Methods. This study was performed on six groups of 6 female rats, including a sham group, an es...

Nicotine is an alkaloid compound commonly found in tobacco smoke. This compound, as an agonist of nicotinic acetylcholine receptors (nAChRs), binds to these receptors and induces many downstream intracellular signaling pathways. Numerous studies have shown that nicotine leads to changes in the expression of microRNAs (miRs). Among these miRs, miR-1...

Background Air pollution is considered one of the risk factors for stroke prevalence in the long term and incidence in the short term. Tabriz is one of the most important industrial cities in Iran. Hence, air pollution has always been one of the main concerns in environmental health in the region. Method The patient data were retrieved from electr...

بیماری دیس‌لیپیدمی به معنای هر گونه اختلال در سطح سرمی چربی‌های خون می باشد. با توجه به اینکه کبد محل اصلی متابولیسم چربی است، آسیب به این اندام با تغییرات در متابولیسم لیپیدها همراه است. هدف از این تحقیق بررسی اثرات تجویز نیکوتین بر دیس لیپیدمی در مدل تجربی کلستازیس می باشد. از روش بستن مجرای صفراوی برای ایجاد مدلی از بیماری فیبروز کبدی در موش های...

The present study has investigated whether circulating estrogen level variations in the pro-estrus and estrus phases of the intact rats and estrogen depletion in the ovariectomized animals (OVX) adjust the formalin-induced nociceptive behaviors. During the pro-estrus and estrus phases of rats’ estrus cycle and in the OVX rats, 17β-estradiol and ICI...

Aim: MicroRNAs can be regarded as biomarkers for gastric cancer (GC) diagnosis in the early stages. This study assesses the expression levels of miR-362-3p, miR-362-5p and miR-363-5p as potential biomarkers for GC. Materials & methods: The expression levels of the miRNAs in 90 pairs of GC and adjacent normal tissue samples were analyzed by quantita...

Toxoplasmosis is a common infection between humans and animals with a global prevalence, which is caused by the initial infection of pregnant women with an obligate intracellular parasite called Toxoplasma gondii and the transfer of this protozoan to the fetus, which may cause minor to severe damage in the fetus and newborn. The definitive host of...

Background: Carbon tetrachloride (CCl4) causes damages to the testicles, liver, kidneys, lungs and brain. In the present study, we investigated protective effects of Sophora pachycarpa root extract on testicular damage, liver histopathology and sex hormone levels in CCl4 intoxicated male rats. Methods: In present study the rats were divided into 6...

Background Chemotherapy is a predominant strategy for breast cancer (BC) treatment and paclitaxel (PTX) has been known as a conventional chemotherapeutic drug. However, insensitivity of BC cells to PTX limits the anti-tumor effects of this agent. MicroRNAs are closely related to BC which are suggested as therapeutic factors in the combination thera...

BACKGROUND: Vanadium and zinc are identified as low-concentration elements in the body of living organisms with a wide range of activities. Their insulin-like activity, through regulating the metabolism of carbohydrates, lipids, and eliminating the secondary symptoms of the disease, clearly demonstrates the ability of these elements to improve diab...

Background: The combined restoration of tumor-suppressive microRNAs (miRs) has been identified as a promising approach for inhibiting breast cancer development. This study investigated the effect of the combined restoration of miR-424-5p and miR-142-3p on MCF-7 cells and compared the efficacy of the combined therapy with the monotherapies with miR-...

The deregulation of microRNAs (miRs) has been identified in tumor development. Indeed, the restoration of tumor-suppressive miRs has been associated with inhibited tumor development in various cancers. Herein, we aimed to evaluate the impact of combined miR-383-5p restoration, as a tumor-suppressive miR, with taxol therapy in suppressing MDA-MB-231...

Inroduction & Objective: The importance of histophysiological and histochemical study of the uterus, cervix and vagina in mammals is due to pathological examinations of these organs in infectious and metabolic diseases and infertility treatment. The aim of this study was to investigate the histophysiological and histochemical features of these orga...

Introduction Breast cancer (BC) is the most significant threat to women’s life. To demonstrate its molecular mechanisms, which results in BC progression, it is crucial to develop approaches to enhance prognosis and survival in BC cases. Areas covered In the current study, we aimed to highlight the updated data on the oncogenic and tumor suppressiv...

زمینه و هدف: روده ها به دلیل هضم و جذب مواد غذایی و جذب آب، هضم گوارشی، انجام فعالیت میکروبی، تولید ایمونوگلوبین در بدن جوندگان عضو مهمی می باشند. هدف از مطالعه حاضر، بررسی بافت‌شناسی روده همسترطلایی و سلول های جامی شکل آن با استفاده از تکنیکهای هیستولوژی و هیستوشیمیایی میباشد. روش کار: تعداد پنج سر همستر طلایی نر بالغ و سالم با میانگین وزنی 120 گر...

Background Growing evidence indicates that miRs have critical activities in adjusting cellular processes, e.g., cell death, proliferation, and cell-cycle. Introduction This study aimed to provide a concise review of the recent findings regarding tumoral miRs and the cross-talk between miRs and epigenetic factors. Results Like the protein-coding g...

Background: combination treatment was identified as a valuable procedure to decrease breast tumorigenesis. It has been confirmed that microRNAs (miRs) can be considered as a therapeutic agent in breast cancer (BC) combination treatment. Our aim was the examination of potential action and underlying molecular activity of miR-424-5p and miR-142-3p co...

MicroRNAs are important regulators in multiple cellular processes and are closely related to a variety of cancers including breast cancer (BC). Immunotherapy using different methods such as modulating immune check points has been known as an advanced and successful procedure in cancer treatment. Here we investigated the effects of miRNA-138-5p rest...

Combination therapy has been considered as a potential method to overcome the BC chemoresistance. MicroRNAs (miRs) have been suggested as a therapeutic factor in the combination therapy of BC. This project aimed at examining the possible activity and molecular function of miR-424-5p and Taxol combination in the human BC cell line. MDA-MB-231 cells...

Aims MicroRNAs (miRs) play pivotal roles in breast cancer development. The dysregulation of miRs has been associated with PD-L1-mediated immune suppression. This study aimed to examine the effect of transfected miR-383-5p on breast cancer cells and T-cells and its association with clinicopathological features in affected patients. Main methods Ini...

MicroRNAs are endogenous, non‐coding RNAs. Showing both tumor‐suppressive and oncogenic characteristics, miRNAs can regulate important processes in malignancies. This review aimed at highlighting the recent studies on the contribution of miR‐424 to the modulation of carcinogenesis and exploring its probable clinical effectiveness in the diagnosis,...

Multiple sclerosis, as well as toxins such as ethidium bromide, can damage the myelin of neurons. The antioxidant properties of Bacopa monnieri have been reported in previous studies. The aim of this study was to investigate the interaction of Bacopa monnieri and ethidium bromide on spatial memory and lipid peroxidation in the hippocampal formation...

Aims MicroRNAs (miRs) are key modulators of cellular processes such as proliferation, apoptosis, as well as anti-cancer immune responses. Here, we evaluated the role of miR-424-5p in breast cancer (BC) and investigated its effects on T cell-related immune response. Main methods BC tissues and cell lines were prepared and the expression of miR-424-...

Since gastric cancer (GC) is diagnosed at advanced stages, the survival rate is low in affected people. In this regard, investigating the mechanisms underlying GC development, are so critical. MiRNAs, which are small non coding RNAs, as a post transcriptional repressor, regulate expression of target genes by stimulating breakage or transcription su...

Antioxidants are essential in preventing the formation and suppressing the activities of reactive nitrogen and oxygen species. The aim of this study was to review the role of antioxidants in cancer development or prevention. Antioxidants are believed to prevent and treat various types of malignancies. Currently, natural antioxidant compounds have b...

Malathion is one of the commonest type of organophosphate insecticide whose toxicity in human body ismainly considered to result from the induction of oxidative stress. The aim of this study was to investigate theantioxidant effect of Quercetin, a flavonoid compound, on the spatial memory and oxidative stress parameters duringMalathion poisoning in...

Helicobacter pylori (H. pylori) infection performs a key role in gastric tumorigenesis. Long non-coding RNAs (lncRNAs) have demonstrated a great potential to be regarded as effective malignancy biomarkers for various gastrointestinal diseases including gastric cancer (GC). The present review highlighted the relationship between lncRNAs and H. pylor...

n present study, prostate and seminal vesicle gland are investigated to determine their histological structure. Five prostates and seminal vesicles from adult hedgehogs, that had no clinical evidences, were evaluated. The description of the histological characteristics of glands was determined by light microscopy after removal and fixation of tissu...

Helicobacter pylori (H. pylori) infection and the H. pylori-related gastric inflammation can be considered as the most significant promoter of gastric cancer (GC). Recent investigations have evaluated the regulatory function of microRNAs (miRNAs) in H. pylori pathogenesis and H. pylori-related diseases, especially GC. The present study reviewed the...

Authors describe morpho-histology of the alimentary canal in Phasianus colchicus. The wall of the entire alimentary canal was composed of tunicas mucosa, submucosa, muscularis and serosa/adventitia. The esophagus had longitudinal folds in transversal section and a thick non-keratinized stratified squamous epithelium. There were numerous mucous glan...

Background and aims: Alzheimer’s disease (AD) is characterized by loss of memory and an impairment of multiple cognitive functions. One of the factors that play an effective role in the pathogenesis of Alzheimer ’s disease and memory impairment is oxidative stress. Ascorbic acid has high antioxidant activity and is involved in memory and learning....

Background and Aim:Intra-paragigantocellularis lateralis (LPGi) injection of 17β-estradiol produces robust antinociceptive effect on the inflammatory pain in the both male and ovariectomized female rats which is possibly mediated through estrogen receptors of this nucleus. This study aimed to examine the role of estrogen receptors in the pain modul...

Objective(s): Maternal high-fat diet (HFD) consumption has been linked to metabolic disorders and reproductive dysfunctions in offspring. Troxerutin (TRO) has anti-hyperlipidemic, anti-oxidant, and anti-inflammatory effects. This study examined the effects of TRO on apelin-13, its receptors mRNA and ovarian histological changes in the offspring of...

BACKGROUND: Up until now, the effect of thyroid hormones on the male reproductive organ, after puberty, is not well understood. OBJECTIVES: In the present study, the morpho-histometrical effects of thyroid hormone deficiency on the adult-male rat reproductive organs were investigated. MATHODS: Thirty adult male rats were randomly divided into three...

Objective. Reproductive disorders are one of the complications of diabetes mellitus. Since conflicting results have been obtained from different studies, which examined serum levels of cytokines in patients with diabetes, and considering the fact that the origin of cytokines cannot be accurately determined from their serum changes, attempts were ma...

Background: Carbon tetrachloride (CCl4) is an industrial solvent that causes kidney, lung, testicles, brain, and blood diseases. In the present study, we investigated protective effects of Sophora pachycarpa extracts on testicular histopathology damage in rats intoxicated with carbon tetrachloride (CCl4). Methods: In this study, divided into six e...

The proventriculus and gizzard of common pheasant has been studied histologically.

Medicinal plants application in wound healing.

Study of medicinal plants effects on experimental gastric ulcer

Objective: Interleukin-6 (IL-6) is an inflammatory cytokine shown to be a strong factor for growth, proliferation and metastasis with many malignancies. The promoter single nucleotide polymorphism (SNPs) -174G>C (rs1800795) can alter the transcriptional pattern of this gene. The present study was aimed at assessing effects of the IL-6 (rs1800795) S...

Purpose: Fibrates are drugs widely used for the treatment of hyperlipidemic disorders. Previous studies on a novel analogue of clofibrate, called silafibrate, have shown good lipid lowering effects. This study was designed to assess the role of silafibrate as a peroxisome proliferator-activated receptors (PPARs) agonist on sperm health and spermat...

A total of 73 Ablepharus bivittatus specimens (34 males and 39 females) collected from two different localities in Iran (East Azerbaijan and Hamedan Provinces) were examined in terms of pholidotic characters, morphometric measurements and color-pattern features. We performed uni and multivariate analyses on the morphological data (six meristic and...

Mammals Anatomy

Zoology

Background & aim: Nowadays because of difficulty in the supply and injection of insulin and blood sugar reducing drugs and considering the side effects of chemical drugs, researcher’s attention is drawn to using herbal medicines. Liver is one of the organs affected by diabetes in different functional aspects. The purpose of this research was studyi...

Background and Objectives: Carbon tetrachloride (CCl4) causes damage in liver, kidneys, lungs, testis, brain, and blood through generation of free radicals. The purpose of this study was to investigate the protective effects of Sophora pachycarpa root extract on CCl4-induced nephrotoxicity in male rats. Methods: In this experimental study, 36 male...

A total of 73 Ablepharus bivittatus specimens (34 males and 39 females) collected from two different localities in Iran (East Azerbaijan and Hamedan Provinces) were examined in terms of pholidotic characters, morphometric measurements and color-pattern features. We performed uni and multivariate analyses on the morphological data (six meristic and...

Background: Bisphenol A is a xenoestrogen, synthesized in large quantities for the production of polymers (polycarbonates, epoxy resins) and thermal paper, and is widely used in products of everyday use (packaging, containers and bottles). Data concerning the occurrence of BPA in food, water and indoor environments as well as its appearance in tiss...

Background: Carbon tetrachloride (CCl4) is an industrial solvent that causes liver, kidneys, lungs, testis and brain as well as in blood diseases by generating free radicals. Previous studies on the chemical composition of S. pachycarpa have shown the presence of antioxidant compounds such as flavonoids. Objective: In the present study we investig...

Male factor infertility accounts for 40% of infertility cases. Spermatogenetic failure, including azoospermia and oligospermia, is one of the important causes of male infertility. Among different methods, medicinal plants have been used in many Nations to treat male infertility problems. So in this review, we have summarized most of the data dealin...

Male factor infertility accounts for 40% of infertility cases. Spermatogenetic failure, including azoospermia and oligospermia, is one of the important causes of male infertility. Among different methods, medicinal plants have been used in many Nations to treat male infertility problems. So in this review, we have summarized most of the data dealin...

Background and Objectives: Bisphenol A (BPA) is one of the chemical materials, which is used as monomer of epoxy resins and polycarbonate plastics. The present study was performed with the purpose of determining the effect of A on liver enzymes level and liver tissue structure. Methods: In this experimental study 40 male rats were divided into 4 g...

Background and aims: Cyclophosphamide (CP), is a widely used cytotoxic alkylating agent with antitumor and immunosuppressant properties. In spite of its therapeutic importance, a wide range of adverse effects including reproductive toxicity has been demonstrated following CP treatment in humans and experimental animals. This drug has serious side e...

Background and purpose: Follicular atresia is a natural phenomenon throughout growth and development, but in excessive cases it causes disorders in the ovarian function which is the commonest cause of infertility. Outbreak of depression in women is twice as much as men. Electric-shock therapy could be used in the treatment of depression resistant t...

Gastrointestinal parasites are among the most common parasitic infections found in stray cats, which might act potential helminthic parasites to domestic cats. The objective of this study was to determine the prevalence of gastrointestinal parasites in stray cats in the city of Azarshahr, which is located in East Azerbaijan province, Iran. A cross—...

ABSTRACT: This survey reports the prevalence of fasciolosis in slaughtered cattle of Marand abattoir, East azarbayjan Province, Iran. A total of 3000 cattle were randomly sampled and examined after slaughter. The livers of 114 cattle (3.8 %) were positive for fasiolosis. Depending on the degree of pathological lesions, 58 (50.88%), 41 (35.97%), and...

Medicinal plants play a main role in the management of diabetes mellitus especially in expanding countries where resources are few. Rosa canina L. is a medicinal plant largely used in common folk medicine. The aim of present research is studying effects of Rosa canina extract on amounts of serum biochemical factors in diabetic male rats. In this...

Cyclophosphamide (CP) is used as an anticancer drug in chemotherapy. This drug has some side effects including anorexia, nausea, malfunction of sexual glands, azoospermia and oligospermia. The aim of this study was to evaluate the protective role of Heracleum persicum against gametogenesis damages in rats receiving cyclophosphamide. Thirty male Wis...

More than 40,000 species of spiders have been identified in the world. Spider bites is a common problem among people, however few of them are harmful but delay in treatment can cause death. Since the spider bites are risk full to human, they should be taken seriously, especially in endemic areas. Our objective in this review was to study about pois...

Background and Objective: Irregular sexual cycle due of improper hormone secretion is most common cause of infertility. Considering fact that women experience twice the rate of depression as men and electroconvulsive therapy (ECT) is one of used treatment methods, therefore this study was conducted to investigate the effect of electric shock on sec...

Introduction: Ecstasy is an amphetamine derivative, which its use has been consistently increasing over the past years. Ecstasy interacts with the glutamatergic system and it is known that glutamate receptors have a key role in learning and memory. The aim of this study was to investigate the interaction of ecstasy and glutamatergic system on learn...

We examined sexual size dimorphism of the rock-dwelling lizard Darevskia raddei (Boettger, 1892) with the help of 30 specimens that were provided from various sources. Eleven metric and seven meristic features were examined. Seven characters (gulars, length of basal tail, femoral pores, length of head, width of head, length of fore limb and length...

Background: Cornus mas L, an olive-shaped red-colored single-seeded fruit, is used in traditional medicine in different parts of Europe and Asia. Objectives: In the present study, 40 male Wistar rats were randomly divided into five groups, and the effects of 21 days of intraperitoneally (IP) administration of 50, 200 and 400 mg/kg body weight of...

Annual Research & Review in Biology 4(12): …………, 2014 SCIENCEDOMAIN international www.sciencedomain.org Authors' contributions This work was carried out in collaboration between all authors. Authors MD and AK designed the study, performed the statistical analysis, wrote the protocol and wrote the first draft of the manuscript. Authors MD and MBK ma...

Fertility control with medicinal plants has been reported in ancient and modern medical literature. In this research, the effects of methanolic extract of Cornus mas on morphological and functional changes in testes were investigated in male wistar rats. Forty-eight rats divided into 6 groups and methanolic extract of Cornus mas was administered at...

Abstract: In this article we present the effects of waste water of the Sungun copper mine on Darevskia raddei habitat in the Arasbaran protected region, a UNESCO registered biosphere reserve since 1976, and appeal to the Department of Environment of East Azarbaijan province to more consideration on control and precautions regarding the water waste...

Fertility control with medicinal plants has been reported in ancient and modern medical literature. In this research, the effects of methanolic extract of Cornus mas on morphological and functional changes in testes were investigated in male wistar rats. Forty-eight rats divided into 6 groups and methanolic extract of Cornus mas was administered at...

High blood glucose levels increase the ratio of phosphorylated to non-phosphorylated connexin-43 amounts, which leads to the decomposition of the hyperphosphorylated connexin-43. This can cause heart arrhythmia in diabetic patients. Considering the effective role of exercise in diabetic patients, and because there are few studies regarding the effe...

In present study, Prostate and seminal vesicle gland are investigated to determine their histological structure five prostates and seminal vesicles from adult hedgehogs that had no clinical evidences were evaluated. The description of the histological characteristics of glands was determined by light microscopy after removed and fixation of tissue...

The globally-distributed widow spiders are among the venomous and dangerous species of arachnids. Widow spider bites are prevalent in the majority of countries. Since widow spiders had not been previously spotted in the Eastern Azerbaijan Province, we decided to report the cases. This is the report of 4 patients, who had been bitten by widow spider...