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Citations since 2017
3 Research Items
January 2022 - December 2022
- Visiting Assistant Professor
- As a Visiting Assistant Professor, I taught Behavioral Neuroscience in Spring 2022 and am currently teaching an advanced topics seminar on the Neuroscience of Mood Disorders.
August 2020 - July 2023
- NRSA Postdoctoral Fellow
- As a postdoctoral fellow in Dr. Nick Betley's lab I studied the role of hypothalamic AgRP neurons in prioritizing survival behaviors and ventromedial SF1 neurons in the response to exercise.
August 2014 - August 2020
This review, one of a series of articles, tries to make sense of optogenetics, a recently developed technology that can be used to control the activity of genetically defined neurons with light. Cells are first genetically engineered to express a light-sensitive opsin, which is typically an ion channel, pump, or G protein-coupled receptor. When eng...
Clinical researchers have tracked patients with early life trauma and noted generalized anxiety disorder, unipolar depression, and risk-taking behaviors developing in late adolescence and into early adulthood. Animal models provide an opportunity to investigate the neural and developmental processes that underlie the relationship between early stre...
Survival requires both the ability to persistently pursue goals and the ability to determine when it is time to stop, an adaptive balance of perseverance and disengagement. Neural activity in the lateral habenula (LHb) has been linked to negative valence, but its role in regulating the balance between engaged reward seeking and disengaged behaviora...
Journeys to novel and familiar destinations employ different navigational strategies. The first drive to a new restaurant relies on map-based planning, but after repeated trips the drive is automatic and guided by local environmental cues. Ventral striatal dopamine rises during navigation toward goals and reflects the spatial proximity and value of...
Major depressive disorder can manifest as different combinations of symptoms, ranging from a profound and incapacitating sadness, to a loss of interest in daily life, to an inability to engage in effortful, goal-directed behavior. Recent research has focused on defining the neural circuits that mediate separable features of depression in patients a...
Traditionally, the signaled avoidance (SA) paradigm has been used in an attempt to better understand human phobia. Animal models of this type have been criticized for ineffectively representing phobia. The SA model characterizes phobia as an avoidance behavior by presenting environmental cues, which act as warning signals to an aversive stimulus (i...
Taiep (tremor, ataxia, immobility, epilepsy, paralysis) mutants show a significant increase in myelin thickness from 10 to 30 days of age but then demonstrate a decrease in myelin thickness from 1 to 6 months. The severity of the demyelination in the optic nerve suggests that visual deficits may exist in the taiep mutants. Animals were trained on a...
Currently in our lab, we've been using green retrobeads (Lumiphore) during stereotactic injections to verify coordinates before we inject optogenetic viruses or implant fibers. They work fine but are really too expensive for this purpose since they're intended for retrograde tracing. Does anybody have any recommendations for a cheaper dye with a similar strong florescence (sometimes visible to the naked eye)? Thanks!