Ryan M Calmus

University of Iowa | UI · Department of Neurosurgery

Low-intensity Transcranial Ultrasound Stimulation (TUS) is a promising non-invasive technique for deep-brain stimulation and focal neuromodulation. Research with animal models and computational modelling has raised the possibility that TUS can be biased towards enhancing or suppressing neural function. Here, we first conduct a systematic review of...

The human brain extracts meaning using an extensive neural system for semantic knowledge. Whether broadly distributed systems depend on or can compensate after losing a highly interconnected hub is controversial. We report intracranial recordings from two patients during a speech prediction task, obtained minutes before and after neurosurgical trea...

Understanding how the brain represents and binds complex information distributed over time is a challenging problem, requiring computationally and neurobiologically informed approaches to solve. Human language is a salient example, whereby syntactic knowledge facilitates “movement” and transformation of sequential information into hierarchical ment...

The human brain extracts meaning from the world using an extensive neural system for semantic knowledge. Whether such broadly distributed systems crucially depend on or can compensate for the loss of one of their highly interconnected hubs is controversial. The strongest level of causal evidence for the role of a brain hub is to evaluate its acute...

Background: Animal models of stroke have been criticised as having poor predictive validity, lacking risk factors prevalent in an aging population. This pilot study examined the development of comorbidities in a combined aged and high-fat diet model, and then examined the feasibility of modelling stroke in such rats. Methods: Twelve-month old male...

Understanding how the brain forms representations of structured information distributed in time is a challenging endeavour for the neuroscientific community, requiring computationally and neurobiologically informed approaches. The neural mechanisms for segmenting continuous streams of sensory input and establishing representations of dependencies r...

Understanding the impact of surgical disconnection on neural responses in the human brain has the potential to advance models of normal neurophysiology and its disruption by pathology. We present data from four patients who underwent surgical disconnection of the anterior temporal lobe as part of the procedure to treat intractable epilepsy. In two...

Understanding how the brain binds complex information distributed over time is a challenging problem facing the neuroscientific community, requiring computationally and neurobiologically informed approaches to solve. The combinatorial binding problem is particularly salient in language, whereby human syntactic knowledge supports the encoding and de...

Some first order methods for protein sequence analysis inherently treat each position as independent. We develop a general framework for introducing longer range interactions. We then demonstrate the power of our approach by applying it to secondary structure prediction; under the independence assumption, sequences produced by existing methods can...