Ruta Dubakiene

Vilnius University · Faculty of Medicine

Background: MASK-air® is an app whose aim is to reduce the global burden of allergic rhinitis (AR) and asthma. A transfer of innovative practices was performed to disseminate and implement MASK-air® in European regions. The aim of the study was to examine the implementation of the MASK-air® app in Lithuanian adults in order to investigate (i) the...

Airborne allergenic pollen affects a significant part of the population and the information on pollen load is a valuable tool for public health prevention. The messages should be provided in a form easily understandable for the population. The study provides new insight for the categorisation of pollen load by defining thresholds solely from aerobi...

Background The heterogeneity and lack of validation of existing severity scores for food allergic reactions limit standardization of case management and research advances. Objective To develop and validate a severity score for food allergic reactions. Methods Following a multidisciplinary experts consensus it was decided to develop a food allergy...

Background: It is not well-understood why symptom severity varies between patients with peanut allergy (PA). Objective: To gain insight into the clinical profile of subjects with mild-to-moderate and severe PA, and investigate individual and collective predictive accuracy of clinical background and IgE to peanut extract and components for PA severi...

Background: Coexistenceofchildhoodasthma,eczemaandallergicrhinitisishigherthancanbeexpectedbychance,suggestingacommonmechanism.Dataonallergicmultimorbidityfromapan-European,population-basedbirthcohortstudyhasbeenlacking. This study compares the prevalence and early-life risk factors of these diseases in European primary school children. Methods:...

Background The analysis of mobile health (mHealth) data has generated innovative insights into improving allergic rhinitis control, but additive information is needed. A cross-sectional real-world observational study was undertaken in 17 European countries during and outside the estimated pollen season. The aim was to collect novel information incl...

Background: Walnut allergy is common across the globe, but data on the involvement of individual walnut components is scarce. Objectives: To identify geographical differences in walnut component sensitization across Europe, explore co-sensitization and cross-reactivity, and assess associations of clinical and serological determinants with severi...

Background: EAACI guidelines emphasise the importance of patient history in diagnosing food allergy (FA), and the need for studies investigating its value, using standardised allergy-focused questionnaires. Objective: To determine the contribution of reaction characteristics, allergic comorbidities, and demographics, in predicting FA in individu...

Background For adults, prevalence estimates of food sensitization (FS) and food allergy (FA) have been obtained in a standardized manner across Europe. For children, such estimates are lacking. Objectives To determine prevalence of self-reported FA, FS, probable FA (symptoms plus IgE-sensitization), and challenge-confirmed FA in European school-ag...

BACKGROUND The geographical variation and temporal increase in prevalence of food sensitization (FS), suggest environmental influences. OBJECTIVE To investigate how demographics, environment, and infant diet are associated with FS in children and adults, focusing on early-life exposures. METHODS Data on demographics, childhood and adult environme...

Background The prevalence of food allergy (FA) among European school children is poorly defined. Estimates have commonly been based on parent‐reported symptoms. We aimed to estimate the frequency of FA and sensitization against food allergens in primary school children in eight European countries. Methods A follow‐up assessment at age 6‐10 years o...

Background: Hen's egg is one of the commonest causes of food allergy but there are little data on its risk factors. Objective: To assess the risk factors, particularly eczema, for hen's egg allergy in the EuroPrevall birth cohort. Methods: In the pan-European EuroPrevall birth cohort, questionnaires were undertaken at 12 and 24 months or when...

Aims Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurre...

Background: Several studies have suggested an interaction between air pollution and pollen exposure with an impact on allergy symptoms. However, large studies with real-life data are not available. Objectives: In the POLLAR (Impact of Air POLLution in Asthma and Rhinitis) project, we investigated associations between major air pollutants (ozone...

Background: According to the community-based EuroPrevall surveys, prevalence of self-reported food allergy (FA) in adults across Europe ranges from 2% to 37% for any food and 1% to 19% for 24 selected foods. Objective: To determine the prevalence of probable FA (symptoms plus specific IgE-sensitization) and challenge-confirmed FA in European adu...

Background Preschool wheeze is an important problem worldwide. No comparative population-based studies covering different countries have previously been undertaken. Objective To assess the prevalence of early childhood wheeze across Europe and evaluate risk factors focusing on food allergy, breast feeding and smoke exposure. Methods Infants from...

Background Allergic diseases are the most prevalent chronic diseases in the developed countries. It is believed that early allergic sensitization and respiratory viral infections play an important role in the development of allergic diseases and asthma. Methods The current study investigated the correlation between asthma, allergy, and various mar...

Background: Component-resolved diagnosis (CRD) has revealed significant associations between IgE against individual allergens and severity of hazelnut allergy. Less attention has been given to combining them with clinical factors in predicting severity. Aim: To analyze associations between severity and sensitization patterns, patient characteris...

Background: Blinded food challenges are considered the current gold standard for the diagnosis of food allergies. We used data from a pan-European multicentre project to assess differences between study centres, aiming to identify the impact of subjective aspects for the interpretation of oral food challenges. Methods: Nine study centres of the...

The overarching goals of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) are to enable European citizens to lead healthy, active and independent lives while ageing. The EIP on AHA includes 74 Reference Sites. The aim of this study is to transfer innovation from an App developed by the MACVIA-France EIP on AHA reference...

Data S1. Generic forms and SOPs for the assessment of food allergy.

Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases (CRD) as a model. The CRD action plan includes (i) AIRWAYS integrated care pathways (ICPs), (ii) the joint initiative between the...

The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) has proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and consequently synerg...

Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initia...

The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used glob...

Table of contents WORKSHOP 4: Challenging clinical scenarios (CS01–CS06) CS01 Bullous lesions in two children: solitary mastocytoma S. Tolga Yavuz, Ozan Koc, Ali Gungor, Faysal Gok CS02 Multi-System Allergy (MSA) of cystic fibrosis: our institutional experience Jessica Hawley, Christopher O’Brien, Matthew Thomas, Malcolm Brodlie, Louise Michaelis C...

[This corrects the article DOI: 10.1186/s13601-016-0116-9.].

Background The conduct of oral food challenges as the preferred diagnostic standard for food allergy (FA) was harmonized over the last years. However, documentation and interpretation of challenge results, particularly in research settings, are not sufficiently standardized to allow valid comparisons between studies. Our aim was to develop a diagno...

Background Parents and health staff perceive hen's egg allergy (HEA) as a common food allergy in early childhood, but the true incidence is unclear because population-based studies with gold-standard diagnostic criteria are lacking. Objective To establish the incidence and course of challenge-confirmed HEA in children, from birth until the age of 2...

Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and above all patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel Netw...

Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel Ne...

Cows milk allergy (CMA) is one of the most commonly reported childhood food problems. Community-based incidence and prevalence estimates vary widely, due to possible misinterpretations of presumed reactions to milk and differences in study design, particularly diagnostic criteria. Children from the EuroPrevall birth cohort in 9 European countries w...

Hazelnut allergy is birch pollen-driven in Northern/Western Europe and lipid transfer protein-driven in Spain and Italy. Little is known about other regions and other allergens. Establishing a molecular map of hazelnut allergy across Europe. In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization t...

The EuroPrevall project aimed to develop effective management strategies in food allergy through a suite of interconnected studies and a multidisciplinary integrated approach. To address some of the gaps in food allergy diagnosis, allergen risk management and socioeconomic impact, and to complement the EuroPrevall population based surveys, a cross-...

Background We tested the hypothesis that specific molecular sensitization patterns correlate with the clinical data/manifestation in a European peanut allergic population characterized under a common protocol.Methods68 peanut allergic subjects and 82 tolerant controls from 11 European countries were included. Allergy to peanut and lowest symptom-el...

Precautionary labeling is used to warn consumers of the presence of unintended allergens, but the lack of agreed allergen thresholds can result in confusion and risk taking by patients with food allergy. The lack of data on threshold doses below which subjects are unlikely to react is preventing the development of evidence-based allergen management...

The objective of our study was to find out the tendencies of nutrition among pregnant women and to reveal which products, technologically processed or natural foods, were consumed more. 205 women took part in the first Lithuanian newborn cohort, PLANK-K. 62 questionnaires with 198 questions about products consumed during pregnancy were answered. In...

The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch a collaboration to develop multi-sectoral care pathways for chronic respiratory diseases in European countries and regions. AIRWAYS-ICPs has strategic relevance to the European Union Health Strategy and will add value to existing public health knowledge by: 1)...

The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch a collaboration to develop multi-sectoral care pathways for chronic respiratory diseases in European countries and regions. AIRWAYS-ICPs has strategic relevance to the European Union Health Strategy and will add value to existing public health knowledge by: 1)...

Assessing maternal dietary habits across Europe during pregnancy in relation to their national pregnancy recommendations. A collaborative, multi-centre, birth cohort study in nine European countries was conducted as part of European Union funded EuroPrevall project. Standardised baseline questionnaire data included details of food intake, nutrition...

Complaints of 'food allergy' are increasing. Standardized surveys of IgE sensitization to foods are still uncommon and multicountry surveys are rare. We have assessed IgE sensitization to food-associated allergens in different regions of Europe using a common protocol. Participants from general populations aged 20-54 years in eight European centres...

Aim. The aim of this study was to determine foods that cause adverse reactions and ailments to citizens of Vilnius (Lithuania). Methods. Vilnius University was a partner in the EuroPrevall integrated project – “The Prevalence Cost and Basis of Food Allergy in Europe”, which is a EU-funded multi-disciplinary research study. By implementing this proj...

Objectives: In recent decades, the prevalence of allergic diseases, including food allergy, has been increasing. This is becoming an important health problem. Many risk factors of food allergy were identified recently, and many of them still are controversial. The aim of this study was to evaluate the potential risk factors of food allergy in child...

Background: Kiwifruit is a common cause of food allergy. Symptoms range from mild to anaphylactic reactions. Objective: We sought to elucidate geographic differences across Europe regarding clinical patterns and sensitization to kiwifruit allergens. Factors associated with the severity of kiwifruit allergy were identified, and the diagnostic per...

Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has reclassified AR as mild/moderate-severe and intermittent...

The aim of the research was to assess the prevalence and pattern of self-reported adverse reactions to food and food allergies among primary schoolchildren in Vilnius. Material and Methods. Vilnius University was a partner in the EuroPrevall project. A total of 4333 schoolchildren from 13 primary schools participated in the study. Of all 4333 quest...

Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are c...

Cohort studies are of great importance in defining the mechanism responsible for the development of allergy-associated diseases, such as atopic dermatitis, allergic asthma, and allergic rhinoconjunctivitis. Although these disorders share genetic and environmental risk factors, it is still under debate whether they are linked or develop sequentially...

Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are c...

Abstract Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy go...

The aim of research was to assess the prevalence and pattern of self-reported adverse reactions to food and food allergies among primary schoolchildren in Vilnius. Methods. Vilnius University was a partner in EuroPrevall integrated project. Thirteen primary schools out of sixteen participated in the study with total number of 190 classes and 4333 s...

The aim of research was to determine prevalence and pattern of ailments caused by hypersensitivity to food among Vilnius citizens by gender and by different age of children and adults. Methods. Vilnius University was a partner in EuroPrevall integrated project – „The prevalence cost and basis of food allergy in Europe“, which is s a EU-funded multi...

To cite this article: McBride D, Keil T, Grabenhenrich L, Dubakiene R, Drasutiene G, Fiocchi A, Dahdah L, Sprikkelman AB, Schoemaker AA, Roberts G, Grimshaw K, Kowalski ML, Stanczyk-Przyluska A, Sigurdardottir S, Clausen M, Papadopoulos NG, Mitsias D, Rosenfeld L, Reche M, Pascual C, Reich A, Hourihane J, Wahn U, Mills ENC, Mackie A, Beyer K. The E...

To cite this article: Bousquet J, Heinzerling L, Bachert C, Papadopoulos NG, Bousquet PJ, Burney PG, Canonica GW, Carlsen KH, Cox L, Haahtela T, Lodrup Carlsen KC, Price D, Samolinski B, Simons FER, Wickman M, Annesi-Maesano I, Baena-Cagnani CE, Bergmann KC, Bindslev-Jensen C, Casale TB, Chiriac A, Cruz AA, Dubakiene R, Durham SR, Fokkens WJ, Gerth...

The aim of this research was to evaluate the prevalence and pattern of food allergies among primary schoolchildren in Vilnius, Lithuania. Methods. Vilnius University is a partner in EuroPrevall integrated project - ‘‘The prevalence cost and basis of food allergy in Europe’’, which is s a EU-funded multi-disciplinary research study. By implementing...

The aim of this research was to evaluate the prevalence and pattern of food allergies among primary schoolchildren in Vilnius, Lithuania. Methods. Vilnius University was a partner in EuroPrevall integrated project – "The prevalence cost and basis of food allergy in Europe", which is an EU-funded multi-dis-ciplinary research study. By implementing t...

The proposed methodology is designed to function in line with intellectual decision support system (DSS), which is used for managing of the production process. The methodology is designed to function in automatic mode, which uses highly specialized intelligent vocabulary interface. Function process of DSS includes training mode, where standard phon...

Visual pathway assessment is of the main importance for intelligent systems associated with robotic. In this paper we analyze the techniques for signal transmission assessment. Visual information processing analysis is based on kinetic energy exchange in vivo, i.e. experiments are dealing with blood flow indices and retinal layers in human retina....

The aim of research was to determine prevalence of hypersensitivity to food among Vilnius citizens by gender and by different age of children and adults. Methods. Vilnius University was a partner in EuroPrevall integrated project „The prevalence cost and basis of food allergy in Europe“, which is s a EU-funded multi-disciplinary research study. By...

Introduction. Rape and buckwheat are progressively cultured in Lithuania. Pollen of these plants can be present in honeybee products, whereas it is known that pollen can be a potential allergen. Purpose. To explore how often and intensively the pollen of rape, buckwheat and mugwort, as well as monofloral (buckwheat and rape) and polyfloral (spring)...

Allergic diseases are ones of the most frequent disorders of health all over the world, especially in the industrializes countries, and between children and young adults. The causes of these diseases’ and growing prevalence are still little known. Rising of allergies over the last three decades is associated with environmental pollution, genetic pr...

The aim of research was to asses restraints of children with food allergies. Methods. 150 mothers, hospitalized with their children allergic to food in Vilnius university Antakalnis Hospital (The National Centre of Allergology) and in “Pušyno kelias” sanatorium during November, 2008 – February, 2009, were interviewed, using a special questionnaire,...

Food allergies are increasing children disorder all over the world. Due to the fact that children spend most of their time at schools, there is a huge possibility of food allergic reaction happening there. Often the very first allergic re­action happens at school. That’s why it is very important that school staff would be prepared for children with...

Introduction. Rape and buckwheat are progressively cultured in Lithuania. Pollen of these plants can be present in honeybee products, whereas it is known that pollen can be a po-tential allergen. Purpose. To explore how often and intensively the pollen of rape, buckwheat and mugwort, as well as monofloral (buckwheat and rape) and polyfloral (spring...

The relationship between infant feeding patterns and the later development of food allergies has been the focus of much debate and research over the last decade. National recommendations have been made by many countries on how to feed infants to reduce the risk of food allergy but due to the lack of firm evidence the recommendations differ widely....

The true prevalence and risk factors of food allergies in children are not known because estimates were based predominantly on subjective assessments and skin or serum tests of allergic sensitization to food. The diagnostic gold standard, a double-blind placebo-controlled food provocation test, was not performed consistently to confirm suspected al...