Rumi Ghosh

Rumi Ghosh

PhD

About

21
Publications
3,310
Reads
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479
Citations
Additional affiliations
December 2003 - December 2010
Bharati Vidyapeeth's College of Pharmacy, Navi Mumbai
Position
  • Bharati Vidyapeeth's College of Pharmacy , Navi Mumbai, India
December 2003 - June 2010
University of Mumbai
Position
  • Professor (Assistant)
January 1993 - December 1998
Jadavpur University

Publications

Publications (21)
Article
This article reports synthesis and evaluation of two novel thiazolidinedione ring containing molecules namely (Z)-5-(2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)acetyl)-2-hydroxybenzamide (4) and (Z)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-N-(5-nitrothiazol-2-yl)acetamide (7). The new chemical entities were tested for hypogly...
Article
To study the efficacy of Kumbhajatu in reducing the cholesterol levels and as an antioxidant in hypercholesterolemic rats. Hypercholesterolemia was induced in normal rats by including 2% w/w cholesterol, 1% w/w sodium cholate and 2.5% w/w coconut oil in the normal diet. Powdered form of Kumbhajatu was administered as feed supplement at 250 and 500...
Article
Limnanthemum cristatum (Roxb.) Griseb is described as a hepatoprotective in Indian traditional medicine. However, there are no reports available in the modern medicine regarding its usefulness as a hepatoprotective agent. In the present study the hydroalcoholic extract of the roots of Limnanthemum cristatum (Roxb.) Griseb (LC), at doses 250 and 500...
Article
Full-text available
Phosphodiesterase (PDE) isoenzymes catalyze the inactivation of intracellular mediators of signal transduction such as cAMP and cGMP and thus have pivotal roles in c ellular f unctions. P DE i nhibitors such as theophylline have b een employed as anti-asthmatics since decades and numerous novel selective PDE inhibitors are currently being investiga...
Article
In this study, the antioxidant activity of methanolic extracts of stem bark of Gmelina arborea Roxb. (Verbenaceae) (MEGA) was studied using various in vitro assays. The antioxidant activity of MEGA was evaluated by using the free radical scavenging activity assay (DPPH method), reducing power assay, nitric oxide scavenging activity, hydroxyl radica...
Article
Madhuca longifolia commonly known as the 'Butter nut tree' is used traditionally in the Indian folk medicine for the treatment of diabetes mellitus. The hydroethanolic extract of the leaves of Madhuca longifolia was administered orally to alloxan-induced diabetic rats and investigated for its antidiabetic properties. Administration of 150 mg/kg and...
Article
This study evaluates the antioxidant activities of the hydroalcoholic extract of Abies spectabilis (Family: Pinaceae) in various in vitro models. The hydrogen donating ability of the hydroalcoholic extract of Abies spectabilis was measured in the presence of 2,2- diphenyl-2-picryl-hydrazyl (DPPH) radical. 100 μg/ml of Abies spectabilis and Ascorbic...
Article
Management of acute and chronic pain has always been a key area of clinical research. Enkephalinase inhibitors (EIs) seem to be promising as therapeutic agents having antinociceptive action. They additionally possess anticraving, antidiarrhoeal and antidepressant actions. The antinociceptive action of EIs has been reported for over a decade however...
Article
Full-text available
The antiinflammatory activity of the polyherbal formulation Entox(®) was investigated in rats for acute and sub acute models of inflammation using carrageenan-induced rat paw edema and cotton pellet granuloma methods respectively at a dose of 300 mg/kg and 600 mg/kg administered orally. The formulation in doses of 300 mg/kg and 600 mg/kg showed 51....
Article
In the present study, Livobond was evaluated for its hepatoprotective effects against carbon tetrachloride-induced hepatocellular injury in rats. Hepatotoxicity was induced in male Sprague-Dawley rats by intraperitoneal injection of CCl<sub>4</sub> (1.5 mL kg<sup>-1</sup>) in olive oil (1:1). Livobond at a dose of 500 and 750 mg/kg/day and silymari...
Article
Although a century has passed since initial attempts were made to stimulate the immune system to destroy tumour, the immunotherapy of cancer is still in the early stages. Historically, a variety of specific and nonspecific immunostimulatory strategies have been administered with only modest clinical success. However, recent advances in tumour immun...
Article
Levels of blood glucose, lipid peroxidation, glutathione (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GST) activities and blood selenium levels were determined in streptozotocin (STZ)-induced diabetic mice. The effect of oral administration of sodium selenite was studied on the above parameters. Diabetes caused hyperglycemia (2.8...
Article
The effect of sunlight exposure was studied on the liver function in male Sprague-Dawley rats. The rats were exposed to sunlight daily for a period of 12 weeks. Exposure to 1 and 2 h of intense sunlight daily caused a significant elevation in the activities of the serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and lactat...
Article
Vanadium, as ammonium monovanadate, has been found to stimulate tumour cell proliferation in mice bearing a transplantable ascitic lymphoma. Markers including microsomal cytochrome P-450, UDP-glucuronyltransferase and cytosolic glutathione-S-transferase showed substantial alterations in a dose-responsive manner with vanadium administration when com...
Article
The effect of oral administration of sodium selenite on glucose homoeostasis was studied in male Swiss albino mice 6 weeks after they were made diabetic with streptozotocin. Diabetes caused hyperglycaemia (2.5-fold), a marked decrease (4.5-fold) in liver glycogen, a 4-fold increase in the glucose-6-phosphatase activity and significant decrease in p...
Article
The reduced glutathione (GSH) levels in the hepatic tissues, extent of lipid peroxidation in the liver, kidney and brain, and alterations in the activity of glutathione peroxidase (GPX) in the hepatic tissues were monitored in mice bearing a transplantable ascitic lymphoma. These markers showed substantial alterations during the height of tumour pr...
Article
Vanadium, as ammonium mononium monovanadate, has been found to have anticarcinogenic effect in host mice bearing a transplantable ascitic lymphoma. The potentiating effect of vanadium was supported by biochemical analysis of autopsies relating to markers like microsomal cytochrome P-450, UDP glucuronyl transferase (UDPGT) and cytosolic glutathione-...

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