Rukiye Sevinç ÖzakarAtaturk University · Department of Pharmaceutical Technology, Faculty of Pharmacy
Rukiye Sevinç Özakar
Doctor of Pharmacy
Pharmaceutical Technology
About
37
Publications
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Introduction
Oral drug delivery systems
Gastroretentive drug delivery systems
Nano drug delivery systems
Publications
Publications (37)
Background: Recent studies have shown that nanoemulsions prepared with essential oils have significant antimicrobial potential against multidrug-resistant pathogens due to increased chemical stability. Nanoemulsion also promotes controlled and sustained release, which increases their bioavailability and efficacy against multidrug-resistant bacteria...
Research has been conducted over time to enhance the utilization of the medicinal benefits of drugs. The focus is on increasing patient compliance and reducing side effects and dosing frequency with low doses of active ingredients. As a result of these studies, new drug delivery systems have emerged. In recent years, colloidal drug delivery systems...
The bioavailability of a drug largely depends on the properties of the drug's dosage form and, therefore, on the design and manufacture of the drug. Drug-food and drug-drug interactions, physiological factors related to the patient, pharmaceutical form of the active substance, and route of administration significantly affect bioavailability. The po...
In recent years, antibiotics have been the ideal drugs for treating infections caused by microorganisms due to their broad-spectrum effects. However, as a result of the unconscious and widespread use of antibiotics, an important disadvantage of current treatments is the emergence of resistant bacteria. With the development of nanotechnology, nano-s...
The oral availability of many drugs is problematic due to the pH of the stomach, enzymes, and first-pass effects through the liver. However, especially geriatric, pediatric, bedridden, or mentally handicapped patients and those with dysphagia have difficulty swallowing or chewing solid dosage forms. Oral Thin Films (OTFs) are one of the new drug de...
Many studies have reported that the widespread use and abuse of antibiotics have led to the emergence of mul-tidrug-resistant bacteria, a significant weakness of current antibiotic therapy. Therefore, the present scenario motivates scientists to develop biocompatible nanoparticles (Nps) that apply better antibacterial effects and biocompatible prop...
Pharmaceutical preparations containing erdosteine, ibuprofen, and pseudoephedrine HCl are among the most prescribed drugs in the treatment of upper respiratory infections. Physicians are obliged to write separately or in combinations of dual since there is no single combined dosage form containing these three active substances at the same time. In...
Nanosuspensions (NS) are one of the new generation drug carrier forms developed to overcome the deficiencies of drugs
with poor water solubility or insolubility and are considered to be one of the most successful approaches to formulate compounds in
recent years. Boron nitride (BN) is insoluble in water and chemically more stable than carbon, it...
Objective: The aim of this preliminary study is to prepare and characterize combined salicylic acid and povidone-iodine-containing nanoemulgels for use in disease models such as wounds and burns in the future. Material and Method: Within the scope of the study, first of all, analytical method validation of salicylic acid was performed. Then, oil so...
Objective: Designing matrix structured controlled release systems using polymers or waxy lipids is a popular option today. Hollowbeads are formulations characterized by the formation of an air-filled cavity inside. In our study, indomethacin was chosen as a model drug. Cetyl alcohol was selected to create the hollowbeads structure, and NaCMC was ch...
Recently, nanoemulsion-based gels have become very popular for dermal drug delivery, overcoming the disadvantages of conventional semi-solid drug forms. The aim of this study is to prepare and characterize nanoemulsion-based hydrogels and organogels containing combined propolis and dexpanthenol, and to compare their stability, antimicrobial, and cy...
Conventional oral drug systems are unable to keep drug concentration within the therapeutic range, and administration of the dosage form several times a day can cause significant fluctuations in plasma drug concentration. Therefore, floating drug delivery systems are being developed. In this study, floating tablets with a model drug (ampicillin sod...
Iodine-based contrast agents have limitations such as rapid clearance, potential renal toxicity, non-specific blood pool distribution, headache, and adverse events. Nowadays, it is quite common to work with nanosized systems in order to eliminate the side effects of contrast agents. This study aims to synthesize a new iodinated contrast agent, prep...
: Iodine-based contrast agents have limitations such as rapid clearance, potential renal toxicity, non-specific blood pool distribution, headache, and adverse events. Nowadays, it is quite common to work with nanosized systems in order to eliminate the side effects of contrast agents. This study aims to synthesize a new iodinated contrast agent, pr...
Daidzein is a water-insoluble phytoestrogenic isoflavone of the Leguminosae family, mainly found in soy and soy-derived foods. Daidzein has a broad spectrum of physiological and pharmacological functions. It has anti-cancer, anti-inflammatory, antioxidant, enzyme inhibitor properties and causes a decrease in low-density lipoprotein levels. Glioblas...
Introduction: Pregabalin (PG) is primarily prescribed for epilepsy, painful diabetic neuropathy, post-herpetic neuralgia, and fibromyalgia. Also, it is used in clinical practice to treat general anxiety disorder due to its anxiolytic properties. Pectin is a water-soluble ionic polysaccharide. As a result of the interaction of pectin with calcium io...
Nanotechnology term is generally used to describe the products, processes, and properties at the nanoscale/microscale that have resulted from the combination of the physical, chemical, and life sciences. Nanomedicine is applying the nanotechnology to medicine that diagnoses, treats, or prevents diseases and improves human health by using nanosized/...
Abstract: Systemic drug delivery via sublingual route arose from the desire to ensure the immediate onset of pharmacological action. Dysphagia (difficulty swallowing) is a common problem for patients of all age groups who have difficulty swallowing oral solid dosage forms. It is especially a problem in the elderly, children, mentally handicapped pe...
Today, treating diseases requires increasing the patient's living standard rather than just applying a
classical treatment protocol. In this study, it was aimed at facilitating drug intake, reduce the dose of the active
substance, reduce the number of daily doses to be taken, reduce or eliminate possible side and/or toxic effects, transport
the act...
Objective: Synthesis and nanosuspension preparation of iodine-based triiodoaniline (TIA) radiocontrast compound, which is not soluble in water, perform their characterization and compare with iopromide and iohexol, which are frequently used in Computed Tomography (CT) imaging. Material and Method: TIA synthesis was obtained using ultrasonic sound w...
The pharmaceutical industry is attempting to discover thin films as a new drug delivery system. Thin films have been described as an alternative approach to conventional dosage forms. They are a versatile platform that provides fast, local, or systemic effects. Additionally, these systems can be easily applied by themselves, especially for dysphagi...
This study was designed to investigate the effects of emulsion formulations of oleuropein isolated from ethanol extract of olive leaf in streptozotocin-diabetic rats. The rats were treated with the administration of the emulsion containing oleuropein at a low (150 mg/kg b.wt.) and high (225 mg/kg b.wt.) dose for 30 days. At the end of the study, bl...
Purpose: To prepare metformin HCl-loaded alginate (AL) and alginate-chitosan (AL-CS) beads for oral application and to evaluate their in vitro characteristics and in vivo activities. Methods: AL and AL-CS beads were prepared using ionotropic gelation. The beads were evaluated for particle size, surface morphology, drug encapsulation efficiency (EE)...