Rukiye Sevinç Özakar

Rukiye Sevinç Özakar
Ataturk University · Department of Pharmaceutical Technology, Faculty of Pharmacy

Doctor of Pharmacy
Pharmaceutical Technology

About

31
Publications
2,617
Reads
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52
Citations
Citations since 2017
26 Research Items
52 Citations
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2017201820192020202120222023051015202530
2017201820192020202120222023051015202530

Publications

Publications (31)
Article
Full-text available
Many studies have reported that the widespread use and abuse of antibiotics have led to the emergence of mul-tidrug-resistant bacteria, a significant weakness of current antibiotic therapy. Therefore, the present scenario motivates scientists to develop biocompatible nanoparticles (Nps) that apply better antibacterial effects and biocompatible prop...
Article
Full-text available
Pharmaceutical preparations containing erdosteine, ibuprofen, and pseudoephedrine HCl are among the most prescribed drugs in the treatment of upper respiratory infections. Physicians are obliged to write separately or in combinations of dual since there is no single combined dosage form containing these three active substances at the same time. In...
Article
Full-text available
Nanosuspensions (NS) are one of the new generation drug carrier forms developed to overcome the deficiencies of drugs with poor water solubility or insolubility and are considered to be one of the most successful approaches to formulate compounds in recent years. Boron nitride (BN) is insoluble in water and chemically more stable than carbon, it...
Article
Full-text available
Objective: The aim of this preliminary study is to prepare and characterize combined salicylic acid and povidone-iodine-containing nanoemulgels for use in disease models such as wounds and burns in the future. Material and Method: Within the scope of the study, first of all, analytical method validation of salicylic acid was performed. Then, oil so...
Article
Full-text available
Objective: Designing matrix structured controlled release systems using polymers or waxy lipids is a popular option today. Hollowbeads are formulations characterized by the formation of an air-filled cavity inside. In our study, indomethacin was chosen as a model drug. Cetyl alcohol was selected to create the hollowbeads structure, and NaCMC was ch...
Article
Full-text available
Recently, nanoemulsion-based gels have become very popular for dermal drug delivery, overcoming the disadvantages of conventional semi-solid drug forms. The aim of this study is to prepare and characterize nanoemulsion-based hydrogels and organogels containing combined propolis and dexpanthenol, and to compare their stability, antimicrobial, and cy...
Article
Full-text available
Conventional oral drug systems are unable to keep drug concentration within the therapeutic range, and administration of the dosage form several times a day can cause significant fluctuations in plasma drug concentration. Therefore, floating drug delivery systems are being developed. In this study, floating tablets with a model drug (ampicillin sod...
Article
Full-text available
Iodine-based contrast agents have limitations such as rapid clearance, potential renal toxicity, non-specific blood pool distribution, headache, and adverse events. Nowadays, it is quite common to work with nanosized systems in order to eliminate the side effects of contrast agents. This study aims to synthesize a new iodinated contrast agent, prep...
Article
Full-text available
: Iodine-based contrast agents have limitations such as rapid clearance, potential renal toxicity, non-specific blood pool distribution, headache, and adverse events. Nowadays, it is quite common to work with nanosized systems in order to eliminate the side effects of contrast agents. This study aims to synthesize a new iodinated contrast agent, pr...
Article
Full-text available
Daidzein is a water-insoluble phytoestrogenic isoflavone of the Leguminosae family, mainly found in soy and soy-derived foods. Daidzein has a broad spectrum of physiological and pharmacological functions. It has anti-cancer, anti-inflammatory, antioxidant, enzyme inhibitor properties and causes a decrease in low-density lipoprotein levels. Glioblas...
Article
Full-text available
Introduction: Pregabalin (PG) is primarily prescribed for epilepsy, painful diabetic neuropathy, post-herpetic neuralgia, and fibromyalgia. Also, it is used in clinical practice to treat general anxiety disorder due to its anxiolytic properties. Pectin is a water-soluble ionic polysaccharide. As a result of the interaction of pectin with calcium io...
Presentation
Full-text available
Nanotechnology term is generally used to describe the products, processes, and properties at the nanoscale/microscale that have resulted from the combination of the physical, chemical, and life sciences. Nanomedicine is applying the nanotechnology to medicine that diagnoses, treats, or prevents diseases and improves human health by using nanosized/...
Article
Abstract: Systemic drug delivery via sublingual route arose from the desire to ensure the immediate onset of pharmacological action. Dysphagia (difficulty swallowing) is a common problem for patients of all age groups who have difficulty swallowing oral solid dosage forms. It is especially a problem in the elderly, children, mentally handicapped pe...
Article
Full-text available
Today, treating diseases requires increasing the patient's living standard rather than just applying a classical treatment protocol. In this study, it was aimed at facilitating drug intake, reduce the dose of the active substance, reduce the number of daily doses to be taken, reduce or eliminate possible side and/or toxic effects, transport the act...
Article
Full-text available
Objective: Synthesis and nanosuspension preparation of iodine-based triiodoaniline (TIA) radiocontrast compound, which is not soluble in water, perform their characterization and compare with iopromide and iohexol, which are frequently used in Computed Tomography (CT) imaging. Material and Method: TIA synthesis was obtained using ultrasonic sound w...
Article
Full-text available
The pharmaceutical industry is attempting to discover thin films as a new drug delivery system. Thin films have been described as an alternative approach to conventional dosage forms. They are a versatile platform that provides fast, local, or systemic effects. Additionally, these systems can be easily applied by themselves, especially for dysphagi...
Article
Full-text available
This study was designed to investigate the effects of emulsion formulations of oleuropein isolated from ethanol extract of olive leaf in streptozotocin-diabetic rats. The rats were treated with the administration of the emulsion containing oleuropein at a low (150 mg/kg b.wt.) and high (225 mg/kg b.wt.) dose for 30 days. At the end of the study, bl...
Article
Full-text available
Purpose: To prepare metformin HCl-loaded alginate (AL) and alginate-chitosan (AL-CS) beads for oral application and to evaluate their in vitro characteristics and in vivo activities. Methods: AL and AL-CS beads were prepared using ionotropic gelation. The beads were evaluated for particle size, surface morphology, drug encapsulation efficiency (EE)...

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Projects

Project (1)
Project
To prepare, characterize and determine the cytotoxic properties of different adjuvant candidates from polymeric nanoparticles containing boron and chitosan, determine the immune parameters induced by the selected inactive M. bovis strain in experimental animals with these adjuvants, and develop vaccines.