Rui Xiao

• Central South University

This study introduced a novel dual fixation method for the pulmonary vasculature and lung tissue in pulmonary hypertension (PH) rats, addressing the limitations of traditional fixation methods that failed to accurately preserve the in vivo status of pulmonary vascular morphology. The modified method involved a dual fixation process, combining indiv...

Nearly complete fuel conversion and high H 2 yield are obtained using Fe 2 O 3 –Al 2 O 3 with a small co-addition of CuO and NiO.

Computing-in-memory (CIM) has emerged as a practical paradigm to bypass the von Neumann bottleneck. However, traditional CIM schemes face challenges due to the nonideal characteristics of nonvolatile memory (NVM). To address this issue, this work provides a resistive random access memory (RRAM)-based CIM macro employing two-transistor–one-RRAM–one-...

Chinese medicine residues (CMRs) are the major waste from pharmaceutical industry with a huge annual output, which could be upcycled into one promising alternative for producing solid carbon materials. However, direct transforming CMRs into engineered biochar needs additional pre-drying treatment, which is one energy-intensive process, mainly owing...

Production of electrical energy in an environmental‐friendly manner is important for meeting the increasing demand of electricity in smart vehicles and energy devices. Benefitted from its moderate working temperatures and high conversion efficiency, proton exchange membrane fuel cell (PEMFC) has received broad attention and commercialized rapidly i...

The special AT-rich sequence-binding (SATB) protein DVE-1 is widely recognized for its pivotal involvement in orchestrating the retrograde mitochondrial unfolded protein response (mitoUPR) in C. elegans. In our study of downstream factors contributing to lifespan extension in sensory ciliary mutants, we find that DVE-1 is crucial for this longevity...

Background Despite recent advances the prognosis of pulmonary hypertension remains poor and warrants novel therapeutic options. Extensive studies, including ours, have revealed that hypoxia-induced pulmonary hypertension is associated with high oxidative stress. Cerium oxide nanozyme or nanoparticles (CeNPs) have displayed catalytic activity mimick...

The intestinal barrier, an indispensable guardian of gastrointestinal health, mediates the intricate exchange between internal and external environments. Anchored by evolutionarily conserved junctional complexes, this barrier meticulously regulates paracellular permeability in essentially all living organisms. Disruptions in intestinal junctional c...

Ammonia, with its high hydrogen storage density of 17.7 wt.% (mass fraction), cleanliness, efficiency, and renewability, presents itself as a promising zero-carbon fuel. However, the traditional Haber–Bosch (H–B) process for ammonia synthesis necessitates high temperature and pressure, resulting in over 420 million tons of carbon dioxide emissions...

BACKGROUND Hyperproliferation of pulmonary arterial smooth muscle cells (PASMCs) and consequent pulmonary vascular remodeling are the crucial pathological features of pulmonary hypertension (PH). Protein methylation has been shown to be critically involved in PASMC proliferation and PH, but the underlying mechanism remains largely unknown. METHODS...

Rising concerns about Bisphenol A (BPA) toxicity have prompted the search for safer alternatives. However, concerns persist regarding the safety of replacements like bisphenol TMC (BPTMC), a rapidly emerging BPA substitute. Utilizing the in vivo model organism Caenorhabditis elegans (C. elegans), whose shared genes mirror human biology, we aim to u...

Mitochondrial stress within the nervous system can trigger non-cell autonomous responses in peripheral tissues. However, the specific neurons involved and their impact on organismal aging and health have remained incompletely understood. Here, we demonstrate that mitochondrial stress in γ-aminobutyric acid-producing (GABAergic) neurons in Caenorhab...

Mitochondrial stress within the nervous system can trigger non-cell autonomous responses in peripheral tissues. However, the specific neurons involved and their impact on organismal aging and health have remained incompletely understood. Here, we demonstrate that mitochondrial stress in γ-aminobutyric acid-producing (GABAergic) neurons in Caenorhab...

Mitochondrial stress within the nervous system can trigger non-cell autonomous responses in peripheral tissues. However, the specific neurons involved and their impact on organismal aging and health have remained incompletely understood. Here, we demonstrate that mitochondrial stress in gamma aminobutyric acid-producing (GABAergic) neurons in Caeno...

With the development of renewable energy technologies, the recovery and utilization of low-grade energy based on hydroelectric effect have drawn much attention owing to its environmental friendliness. Herein, a novel hydroelectric generator utilizing sodium alginate-graphene oxide (SA-GO) fibers is proposed, which is ecofriendly and low-cost. These...

Solid‐state lithium‐ion batteries are widely accepted as the promising next‐generation energy storage technology due to higher energy density and improved safety compared to conventional lithium‐ion batteries with liquid electrolytes. Large‐area solid‐state electrolyte (SSE) films with adequate thickness control, improved ionic conductivity, and go...

Fluidizing cathode particles promotes axial heat transfer and reduces the axial temperature gradient and thermal stress, thus enhancing the stability.

Venous thromboembolism (VTE) is a multifactorial disease, and pulmonary hypertension (PH) is a serious condition characterized by pulmonary vascular remodeling leading with increased pulmonary vascular resistance, ultimately leading to right heart failure and death. Although VTE and PH have distinct primary etiologies, they share some pathophysiolo...

Data transfer between the processing and storage units has become a significant bottleneck in modern von Neumann computing systems for artificial intelligence (AI) tasks. Computing in memory (CIM) has emerged as a promising candidate for lowering latency and power consumption. However, the conventional analog CIM schemes are suffering from reliabil...

Lung cancer patients tend to have strong intratumoral and intertumoral heterogeneity and complex tumor microenvironment, which are major contributors to the efficacy of and drug resistance to immunotherapy. From a new perspective, single-cell techniques offer an innovative way to look at the intricate cellular interactions between tumors and the im...

Ulcerative colitis is a painful inflammatory bowel disease that is frequently comorbid with psychiatric disorders like anxiety and depression. While the exact mechanisms remain unclear, the microbes in our gut, our microbiota, may be part of the connection between the brain and the gut. One of the risk factors for colitis, anxiety, and depression i...

Traditional Chinese medicine (TCM) played an important role in the fight against the COVID-19 virus in the past three years. The production of TCM resulted in huge quantities of traditional Chinese medicine residues (TCMRs) in China. Hydrothermal treatment (HTT) is an appropriate method to convert the TCMRs to hydrochar and liquid phase products. T...

Nitrogen-doped hierarchical porous carbons are considered as important substitutes for noble metal electrocatalysts for the oxygen reduction reaction (ORR) in green-energy devices. Herein, bio-oil, the liquid product of biomass pyrolysis, and urea were used as the carbon and nitrogen source based on a simple MgO template approach. The obtained carb...

Carbon morphology significantly affects the capacitive performance of porous carbons. Biomass-derived porous carbons are usually restricted by inferior capacitive performance owing to their inherently three-dimensional (3D) blocked morphologies. Fabricating two-dimensional (2D) sheet-like morphology is expected to expose more inner space for better...

Heavy-fraction bio-oil (HB) is an underused product of biomass pyrolysis due to its difficulty in direct use or efficient refinery, but it is a potential carbon precursor to prepare porous carbon for energy storage. The fluid HB with structural flexibility and miscibility is desirable to fabricate tailored carbon structure. In this work, we develop...

Computing-in-memory (CIM) accelerators have the characteristics of storage and computing integration, which is becoming an important solution for optimizing the computational performance of large-scale neural networks. The readout system plays a crucial role in the CIM accelerators, with power consumption accounting for a significant proportion and...

Biomass-derived porous carbons are desirable electrode material for supercapacitors, but the blocked carbon morphology leading to the poor accessibility and long diffusion distance hinders the practical application. Exposing the inner carbon space for smooth ion transport is crucial for the enhanced capacitive performance. Herein, porous carbon cag...

Background Although the lack of estrogen receptor β (ERβ) is a risk factor for the development of inflammatory bowel disease (IBD) and psychiatric disorders, the underlying cellular and molecular mechanisms are not fully understood. Herein, we revealed the role of gut microbiota in the development of IBD and related anxiety-like behavior in ERβ-def...

To reduce deforestation and ensure energy security for socioeconomic advancements, Rwanda must find alternatives to wood fuel. Widely developed metasedimentary mudstones gradually became a petroleum survey object due to the progress of petroleum exploration theories and practices in the Mesoproterozoic strata all over the world. In this study, exte...

It is significant to exploit the full potential of CRISPR/Cas based biosensor for non-nucleic-acid targets. Here, we developed a split aptamer regulated CRISPR/Cas12a and gap-enhanced Raman tags based lateral flow biosensor for small-molecule target, 17β-estradiol. In this assay, one split aptamer of 17β-estradiol was designed to complement with crR...

With the economy’s continued and stable growth, China’s political and economic influence in the international community has grown, and more and more friends from all over the world are requesting to learn Chinese and visit China. The growth of information technology and curriculum integration has had a significant impact on TCFL (teaching Chinese a...

The photoelectrochemical reduction of CO2 provides a clean and sustainable route to produce value-added chemicals and fuels using sunlight as the energy source and greenhouse gas CO2 as the feedstock. However, the use of pure CO2 decreases the economic feasibility of the technology. Direct utilization of industrial flue gas is desirable for practic...

Plastic waste remains a global challenge due to the massive amounts being produced without satisfactory treatment technologies for recycling and upcycling. Photocatalytic processes are emerging as green and promising approaches to upcycle plastics into value‐added products under mild conditions using sunlight as the energy source. In this review, t...

The rapid development of artificial intelligence (AI) and Internet of Things (IoT) increase the requirement for edge computing with low power and relatively high processing speed devices. The computing-in-memory (CIM) schemes based on emerging resistive nonvolatile memory (NVM) show great potential in reducing the power consumption for AI computing...

A huge amount of industrial waste will be generated during the industrialization process and their harmless disposal has always been a headache for reducing carbon emissions. In this study, the combustion behaviors and thermal kinetics of four typical industrial polymeric wastes including rubber, leather, plastic and cloth, were systematically stud...

In order to determine the significant role of gas hydrate in seasonal wetland methane emission at the drilling-affected permafrost, the carbon isotopic monthly field monitoring of methane (CH4), as well as carbon dioxide (CO2), emitted from near-surface soil and a gas hydrate drilling well (DK-8) was conducted in the Muli permafrost of the Qinghai-...

The ever-increasing computation complexity of fast-growing Deep Neural Networks (DNNs) has requested new computing paradigms to overcome the memory wall in conventional Von Neumann computing architectures. The emerging Computing-In-Memory (CIM) architecture has been a promising candidate to accelerate neural network computing. However, data movemen...

Abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs) is a critical pathological feature in the pathogenesis of pulmonary arterial hypertension (PAH), but the regulatory mechanisms remain largely unknown. Herein, we demonstrated that interferon regulatory factor 9 (IRF9) accelerated PASMCs proliferation by regulating Prohibitin 1...

The ever-increasing computation complexity of fastgrowing Deep Neural Networks (DNNs) has requested new computing paradigms to overcome the memory wall in conventional Von Neumann computing architectures. The emerging Computing-In-Memory (CIM) architecture has been a promising candidate to accelerate neural network computing. However, data movement...

Astrocytes are integral components of synaptic transmission, and their dysfunction leads to neuropsychiatric disorders such as anxiety and depression. Liver X receptor β (LXRβ) is expressed in astrocytes, and LXRβ global knockout mice shows impaired synaptic formation. In order to define the role of LXRβ in astrocytes, we used a conditional Cre-lox...

Iron is indispensable for normal body functions across species because of its critical roles in red blood cell function and many essential proteins and enzymes required for numerous physiological processes. Regulation of iron homeostasis is an intricate process involving multiple modulators at the systemic, cellular, and molecular levels. Interesti...

Background: Although lack of ERβ is an acknowledged risk factor for the development of inflammatory bowel disease (IBD) and psychiatric disorders, the underlying cellular and molecular mechanisms are not fully understood. Here, we revealed the role of gut microbiota in the development of IBD and related anxiety-like behavior in ERβ deficiency mice....

Converting rice husks into valuable chemicals or advanced materials has attracted significant interests of economic and environmental benefits. In this study, we prepared rice husk-derived porous carbon sheets (PCS) by sustainable and recyclable salt activation. The employed NaCl/KCl salt mixture was not only the template agent for mesopores, but a...

Activation of the CaSR (extracellular calcium-sensing receptor) has been recognized as a critical mediator of hypoxia-induced pulmonary hypertension. Preventive targeting of the early initiating phase as well as downstream events after CaSR activation remains unexplored. As a representative of the G protein-coupled receptor family, CaSR polymerizes...

Bio-oil, the unavoidable liquid product of the thermal conversion of biomass, shows high contents of carbon and aromatic compounds and is a promising carbon precursor. Herein, nitrogen-doped hierarchically porous carbons (NHPCs) as effective catalysts for the electrochemical reduction of oxygen are successfully synthesized from crude bio-oil throug...

Bisphenol A (BPA) is a chemical compound commonly used in the production of plastics for daily lives and industry. As BPA is well known for its adverse health effects, several alternative materials have been developed. This study comprehensively analyzed the toxicity of BPA and its three substitutes including bisphenol S (BPS), bisphenol F (BPF), a...

Lateral flow assay (LFA) is user-friendly diagnostic tools but suffering limitations in poorer sensitivities and specificities especially for double-stranded DNA and single-base mutation quantification. Here, to improve the sensitivity and specificity for the LFA based nucleic acid detection, CRISPR-Cas12a mediated surface enhanced Raman scattering...

The ever-increasing computation complexity of fast-growing Deep Neural Networks (DNNs) has requested new computing paradigms to overcome the memory wall in conventional Von Neumann computing architectures. The emerging Computing-In-Memory (CIM) architecture has been a promising candidate to accelerate neural network computing. However, the data mov...

Transient Receptor Potential Canonical 6 (TRPC6) has been suggested to be involved in synapse function and contribute to hippocampal-dependent cognitive processes. Gene silencing of TRPC6 was performed by injecting adeno-associated virus (AAV) expressing TRPC6-specific shRNA (shRNA-TRPC6) into the hippocampal dentate gyrus (DG). Spatial learning, w...

Stubborn lignin (SL) is the thermochemically stable fragment generated from biomass utilization (e.g., pyrolysis, hydrolysis, fermentation, pulping), which is comparatively difficult to be further depolymerized into value-added bio-products. The cleavage of the stubborn linkages within the structure of SL, such as CC, α-O-4, and 4-O-5 linkages, is...

Transient receptor potential (TRP) channels are expressed in many nonneural tissues where their functions are not well known. Using C. elegans as a model, a new study demonstrated that colonization of the Gram-positive pathogenic bacteria E. faecalis in the intestine causes intestinal distention. Two TRPM channels sense such intestinal distension t...

Biphenyl structure plays an important role in the thermal degradation of woody lignin due to its non-negligible proportion, and its high binding energy of Caryl-Caryl bond leads the lignin fragments not easy to be break into small-molecule products. The in-depth study on the pyrolysis mechanism of biphenyl-containing structures is conducive to solv...

A portable surface-enhanced Raman scattering (SERS)–lateral flow immunoassay (LFIA) detector has been developed for the automatic and highly sensitive detection of West Nile virus (WNV) non-structural protein 1 (NS1) and actual WNV samples. Au@Ag nanoparticles (Au@Ag NPs) labeled with double-layer Raman molecules were used as SERS tags to prepare W...

In this study, two counterexamples of lignin preoxidation-hydroconversion were reported. First, two lignin feedstocks were preoxidized with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in acetonitrile with various dosages (15%, 30%, and 60%). Then, these preoxidized lignins (HELOs and MWLOs) were hydroconverted in supercritical ethanol catalyzed...

Background: The mevalonate pathway generates endogenous cholesterol and intermediates including geranylgeranyl pyrophosphate (GGPP). By reducing GGPP production, statins exert pleiotropic or cholesterol-independent effects. The potential regulation of GGPP homeostasis through dietary intake and the interaction with concomitant statin therapy is unk...

Wetland methane emissions in the permafrost regions of the Qinghai-Tibet Plateau is more sensitive to climate warming and can result in a positive climate feedback. Natural gas hydrate, as a potential methane source, may play a pivotal role in wetland methane emission in the permafrost regions. However, it was lacking of evidence. To determine the...

Temperature is a universal cue and regulates many essential processes ranging from enzymatic reactions to species migration. Due to the profound impact of temperature on physiology and behavior, animals and humans have evolved sophisticated mechanisms to detect temperature changes. Studies from animal models, such as mouse, Drosophila, and C. elega...

As an ancient cellular co-factor ubiquitously present in all domains of life, nearly all iron-sulfur ([Fe-S]) clusters are assembled in the mitochondrion. Although multiple mitochondrion-derived signalings are known to be key players in longevity regulation, whether the mitochondrial [Fe-S] cluster assembly machinery modulates lifespan is previousl...

Co-pyrolysis of lignin and waste plastics, for example polyethylene (PE), has been studied, but related reports are basically on condition optimizations. This study revealed a new perspective on PE-promoted lignin pyrolysis to phenolic monomers with mass transfer and radical explanation. Lignin and PE were first pyrolyzed individually to identify p...

As an ancient cellular co-factor ubiquitously present in all domains of life, nearly all iron-sulfur ([Fe-S]) clusters are assembled in the mitochondrion. Although multiple mitochondria-derived signalings are known to be key players in longevity regulation, whether the mitochondrial [Fe-S] cluster assembly machinery modulates lifespan is previously...

A mass of data transfer between the processing and storage units has been the leading bottleneck in modern Von-Neuman computing systems, especially when used for Artificial Intelligence (AI) tasks. Computing-in-Memory (CIM) has shown great potential to reduce both latency and power consumption. However, the conventional analog CIM schemes are suffe...

All living organisms are subject to the continuously changing environmental stimuli from various sources. Neurosensory systems perceive these cues and elicit appropriate physiological responses. Although sensory perception is traditionally considered as an acute response, recent studies in model organisms have demonstrated that it can also have a l...

Proteotoxic stress is a common challenge for all organisms. Among various mechanisms involved in defending such stress, the evolutionarily conserved unfolded protein responses (UPRs) play a key role across species. Interestingly, UPRs can occur in different subcellular compartments including the endoplasmic reticulum (UPRER), mitochondria (UPRMITO)...

Mitochondrial dysfunction and iron (Fe) dyshomeostasis are invoked among the mechanisms contributing to muscle aging, possibly via a detrimental mitochondrial-iron feed-forward loop. We quantified the labile Fe pool, Fe isotopes, and the expression of mitochondrial Fe handling proteins in muscle biopsies obtained from young and older adults. The ex...

RationaleAutism spectrum disorders (ASDs) are highly prevalent neurodevelopmental disorders characterized by deficits in social communication and interaction, repetitive stereotyped behaviors, and cognitive impairments. Curcumin has been indicated to be neuroprotective against neurological and psychological disorders. However, the role of curcumin...

Aging is the primary risk factor for functional decline; thus, understanding and preventing disability among older adults has emerged as an important public health challenge of the 21st century. The science of gerontology-or geroscience-has the practical purpose of "adding life to the years." The overall goal of geroscience is to increase healthspa...

The effect of self-reactivation on the CO2 capture capacity of the spent calcium based sorbent was investigated in a dual-fixed bed reactor. The sampled sorbents from the dual-fixed bed reactor were sent for XRD, SEM and N2 adsorption analysis to explain the self-reactivation mechanism. The results show that the CaO in the spent sorbent discharged...

Some fungal epithiodiketopiperazine alkaloids display α,β‐polysulfide bridges alongside diverse structural variations. However, the logic of their chemical diversity has rarely been explored. Here, we report the identification of three new (2, 3, 8) and five known (1, 4–7) epithiodiketopiperazines of this subtype from a marine‐derived Penicillium s...

Restless legs syndrome is a sleep‐related sensorimotor neurological disease affecting up to 10% of the population. Genetic analyses have identified Myeloid Ecotropic viral Integration Site 1 (MEIS1), a transcriptional regulator, to be associated with not only the restless legs syndrome but also self‐reported symptoms of insomnia and sleep. This stu...

The rapid development of Artificial Intelligence (AI) and Internet of Things (IoT) increases the requirement for edge computing with low power and relatively high processing speed devices. The Computing-In-Memory(CIM) schemes based on emerging resistive Non-Volatile Memory(NVM) show great potential in reducing the power consumption for AI computing...

Lime mud, a kind of industrial waste that produced in paper mill, was proposed as CO2 sorbent in calcium looping process. The carbonation performance of the lime mud was investigated in a dual‐fixed bed reactor (DFR) and a thermogravimetric analyzer (TGA). The carbonation kinetics of the lime mud in the chemical reaction controlled stage was analyz...

Semiconductor photocatalysis is a promising technology to address both energy and environmental issues. Polymer semiconductors have emerged as a new class of heterogeneous photocatalysts owing to their inherent advantages of low cost, earth abundant nature, facile synthesis, easy functionalization, molecularly tunable optoelectronic properties, and...

Restless Legs Syndrome (RLS) is characterized by an urge to move the legs, usually accompanied by uncomfortable sensations. RLS symptoms generally happen at night and can be relieved by movements. Genetic studies have linked polymorphisms in BTBD9 to a higher risk of RLS. Knockout of BTBD9 homolog in mice (Btbd9) and fly results in RLS-like phenoty...

The effect of calcium sensing receptor (CaSR) on tumor cell proliferation has been studied in several human cancers, and great discrepancies were found in different tumors. However, the role of CaSR in lung adenocarcinomas (LUADs) is not clear. Therefore, we investigated the function of CaSR on regulating the growth of human LUAD and its possible m...

The calcination of oxygen carrier is the essential step prior to its application in chemical looping combustion, which is significantly influenced by calcination conditions. In this study, a natural iron ore was treated under the combined effect of three key calcination parameters (heating rate, temperature, and duration time). The reactivity perfo...

NiFe2O4 exhibits a desirable application prospect in chemical looping process because of the high redox activity and oxygen carrying capacity. However, phase segregation resulting from the outward migration of Fe species in NiFe2O4 was often occurred, which could lead to the serious surface sintering and thus decrease the redox activity of NiFe2O4....

Motor control and learning impairments are common complications in individuals with autism spectrum disorder (ASD). Abnormal cerebellar development during critical phases may disrupt these motor functions and lead to autistic motor dysfunction. However, the underlying mechanisms behind these impairments are not clear. Here, we utilized BTBR T⁺ Itpr...

Restless legs syndrome (RLS) is a neurological disorder characterized by an urge to move and uncomfortable sensations. Genetic studies have identified polymorphisms in up to 19 risk loci, including MEIS1 and BTBD9. Rodents deficient in either homolog show RLS-like phenotypes. However, whether MEIS1 and BTBD9 interact in vivo is unclear. Here, with...