Rui Sun

Rui Sun
  • Shanghai University of Finance and Economics

About

25
Publications
4,850
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635
Citations
Introduction
Skills and Expertise
Current institution
Shanghai University of Finance and Economics

Publications

Publications (25)
Article
Full-text available
Islet transplantation is an attractive treatment for type 1 diabetic patients. However, transplanted islets suffered from considerable cell death due to inflammatory reactions and oxidative stress. Ferroptosis is a programmed death characterized by iron-dependent lipid peroxidation, which has been implicated in the islet loss and dysfunction. Our p...
Article
Tumor cells usually display metabolic, genetic, and microenvironment-related alterations, which are beneficial to tumor proliferation, development, and resistance occurrence. Many transporters and enzymes, including ATB0,+, xCT and matrix metalloproteinases (MMPs), are involved in the altered cell metabolism and tumor microenvironment and often abn...
Article
Full-text available
Carbidopa, a peripheral decarboxylase inhibitor used with L-DOPA to treat Parkinson's disease, has attracted significant interest in recent years for its anticancer effect. Increasing evidence reveals that Carbidopa can inhibit cancer cell growth and induce apoptosis through aryl hydrocarbon receptor (AHR) in some cancers. However, the antitumor ef...
Article
Full-text available
Targeted nanocarriers have shown great promise in drug delivery because of optimized drug behavior and improved therapeutic efficacy. How to improve the targeting efficiency of nanocarriers for the maximum possible drug delivery is a critical issue. Here we developed L-carnitine-conjugated nanoparticles targeting the carnitine transporter OCTN2 on...
Article
Full-text available
Osteoarthritis (OA) is a progressive and degenerative disease, which is no longer confined to the elderly. So far, current treatments are limited to symptom relief, and no valid OA disease-modifying drugs are available. Additionally, OA relative joint is challenging for drug delivery, since the drugs experience rapid clearance in joint, showing a p...
Article
An effective steady-state redox balance is maintained in cancer cells, allowing for protection against oxidative stress and thereby enhancing cell proliferation and tumor growth. Disruption of this redox balance would increase cellular content of ROS and potentiate oxidative stress-induced cell death in tumor cells, thus representing an effective s...
Article
Full-text available
Introduction: P-glycoprotein 1 (P-gp) pumps out many foreign/toxic substances out of the cells, including intracellular drugs, causing multidrug resistance (MDR) and chemotherapy failure. It remains quite a challenge to inhibit P-gp to combat MDR and improve cellular bioavailability since it requires efficient inhibitors along with adequate formula...
Article
Full-text available
Introduction: Transporters in the plasma membrane have been exploited successfully for the delivery of drugs in the form of prodrugs and nanoparticles. Organic cation/carnitine transporter 2 (OCTN2, SLC22A5) has emerged as a viable target for drug delivery. OCTN2 is a Na+-dependent high-affinity transporter for L-carnitine and a Na+-independent tr...
Article
Full-text available
The present study aimed to investigate the effect of anlotinib (AL3818) on pharmacokinetics of cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C6, CYP2D1, CYP2D2, and CYP3A1/2) by using five cocktail probe drugs in vivo. After pretreatment for 7 days with anlotinib (treatment group) or saline (control group) by oral administration, probe drugs phenaceti...
Article
Alpinetin, a bioactive flavonoid, has attracted great attention due to its diverse therapeutic effects, namely anti-oxidant, anti-tumor and anti-inflammatory effects with low systemic toxicity. Various determination methods have been developed in quality control and plant chemistry areas. However, quantification and pharmacokinetics of alpinetin in...
Article
In engineering practices, curve fitting is a common method used to evaluate the performance of machines or equipments using the collected data. If the collected data works as a whole and can not be divided into groups, conventional curve fitting methods can be used to perform the task. Researchers have proposed improved methods with higher precisio...
Article
Servo-actuation system is one of the key executing subsystems of the flight control system of an aircraft. With the development of fly-by-wire control systems, redundant servo-actuation systems have been extensively applied. A servo-actuation system has a long life and high reliability, which results in the lack of failure information. In the mean...
Article
In engineering practice, we face a problem of using some collected data to evaluate a kind of machine or equipment. Curve fitting is a common method to solve this problem. Least square method is wildly applied in this procedure. If the source data of curve fitting can be grouped in samples and the distinction of samples obviously express some chara...
Article
In engineering practices, curve fitting is a common method to evaluate the performance of machines or equipments using the collected data. If the collected data works as a whole and can not be divided into groups, conventional curve fitting methods can be used to perform the task. Researchers have proposed some improved methods with higher precisio...
Article
With the rapid growth of electricity grid and the unusually changing of global climate in recent years, the comprehensive analysis of the lightning parameters becomes very important. Sichuan Province started to use Lightning Location System (LLS) in 2003, it has been running for 7 years. The database has accumulated a lot of valuable lightning dete...
Article
Full-text available
Based on ductility exhaustion theory and the generalized energy-based damage parameter, a new viscosity-based life prediction model is introduced to account for the mean strain/stress effects in the low cycle fatigue regime. The loading waveform parameters and cyclic hardening effects are also incorporated within this model. It is assumed that dama...
Conference Paper
A servo-actuation system is one of the key executing subsystems of the flight control system of an aircraft. With the development of the fly-by-wire control systems, the redundant servo-actuation systems have been extensively applied. A servo-actuation system has a long life and high reliability, which results in the lack of experiment information....
Article
Evidence conflict that may cause the counter-intuitive results is one of the most concerns for information fusion by Dempster-Shafer's (D-S) evidence theory. To deal with the issue and manage evidence conflict greatly for the improvement of belief convergence, evidence conflict and belief convergence are investigated based on the analysis of the co...
Article
Reliability prediction involves reliability estimation of equipment or products prior to their production or modification by applying mathematical models and data before empirical data are available. It is an important part of reliability improvement work in the whole lifetime of a system. This paper focuses on the reliability prediction of diesel...
Article
A novel product data management mode, CVPDS (Collaborative Visualization Production Development System), which is based on the cooperative design and visualization technology, is proposed in this paper. It also analyzes and establishes the system frame, discusses the key technology of cooperative visualization development and the implementing manag...
Article
In response to the roller bearing fault of the engineering vehicle, the excellent characteristics of time-frequency of wavelet packet is used to decompose the fault signal. Then we extract the necessary of the fault signals. Finally, we carry out the recognition of fault types using multi-class support vector machine and danamic clustering algorith...
Conference Paper
Condition monitoring and fault diagnosis of bearings are of practical significance in industry. In order to get a feature containing different fault signatures, this paper uses Wavelet Transform (WT), Wavelet Lifting Scheme (WLS) and Empirical Mode Decomposition (EMD), respectively, to decompose signal into different frequency bands. Then, Singular...
Article
Conventional D-S evidence theory has an unavoidable disadvantage in that it will give counter-intuitive result when fusing high conflict information. This paper proposes an improved method to solve this problem. By reassigning weight factors before fusing, the method can give reasonable results especially when the initial weight factors of conflict...
Conference Paper
Propagation of a critical unstable crack under the action of static or varying stresses is determined by the intensity of strain field at tips of the crack. Stress intensity factor (SIF) is an important parameter in fracture mechanics, which is used as a criterion to judge the unstable propagation of a crack and plays an important role in calculati...

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