Ruchit Sood

Ruchit Sood
Leeds Teaching Hospitals NHS Trust · Gastroenterology

MBChB PGCert MD FRCP

About

78
Publications
4,774
Reads
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1,064
Citations
Introduction
Additional affiliations
September 2015 - September 2016
Leeds Teaching Hospitals NHS Trust
Position
  • Advanced Endoscopy Fellow
January 2014 - November 2017
University of Leeds
Position
  • MD student
September 2012 - September 2016
St. James University
Position
  • Gastroenterology Specialist Registrar
Education
February 2006 - November 2008
Royal College Of Physicians Of Edinburgh
Royal College Of Physicians Of Edinburgh
Field of study
September 2000 - June 2005
The University of Sheffield
Field of study
  • Medicine

Publications

Publications (78)
Article
Full-text available
Background: Direct oral anticoagulants are increasingly used for a wide range of indications. However, data are conflicting about the risk of major gastrointestinal bleeding with these drugs. We compared the risk of gastrointestinal bleeding with direct oral anticoagulants, warfarin, and low-molecular-weight heparin. Methods: For this systematic re...
Article
Objectives Many cross-sectional surveys have reported the prevalence of uninvestigated dyspepsia, but there has been no recent systematic review of data from all studies to determine its global prevalence and risk factors. Design MEDLINE, EMBASE and EMBASE Classic were searched (until January 2014) to identify population-based studies that reported...
Article
An acute upper gastrointestinal bleed (AUGIB) often represents a life-threatening event and is recognised universally as a common cause of emergency hospitalisation. Large observational studies have improved our understanding of the disease characteristics and its impact on mortality but despite significant advancement in endoscopic management, mor...
Article
Background and Aims: Azathioprine (AZA) is an established treatment for ulcerative colitis (UC). However, controversy exists regarding its efficacy in inducing and maintaining clinical remission, and long-term data are lacking. We studied the effectiveness of AZA in a large cohort of UC patients treated in a single centre. Methods: All UC patients...
Article
Oesophageal perforations and anastomotic leaks are associated with high morbidity and mortality. Endoscopic vacuum therapy (EVT) is a promising novel treatment that promotes healing and avoids sepsis. There are no data reporting its use in the UK. We report the first British experience of EVT in two elderly frail patients. Two patients were treated...
Article
Full-text available
Background: Conventionally, patients with functional dyspepsia are subgrouped based on upper gastrointestinal symptoms, according to the Rome criteria. However, psychological co-morbidity and extraintestinal symptoms are also relevant to functional gastrointestinal disorders. Aim: To investigate whether it is possible to subgroup people with fun...
Article
Upper gastrointestinal bleeding is a common medical emergency with associated significant morbidity and mortality. There are multiple published national and international guidelines on the management of acute upper gastrointestinal bleeding (AUGIB). However, the 2015 National Confidential Enquiry into Patient Outcome and Death group (NCEPOD) report...
Conference Paper
Full-text available
Introduction: Boerhaave syndrome is an unsual condition associated with an up to 80% mortality rate. Endoscopic vacuum therapy (EVT) is a promising novel treatment for this condition. There are no data reporting its use in the UK. We report the first British experience of EVT in an elderly frail patient. Method: EVT entails the endoscopic insertion...
Conference Paper
Full-text available
Background Duodenal adenomas consist of sporadic and familial adenomatous polyposis (FAP) associated adenomas. Endoscopic mucosal resection (EMR) is the recognised technique when considering endoscopic removal of these lesions, but outcomes from large studies are lacking. Leeds Teaching Hospitals (LTHT) is a large tertiary centre that has a local c...
Conference Paper
Full-text available
Introduction The Gastroenterology department at Leeds Teaching Hospitals is large tertiary referral centre with a catchment area of more than 8 00 000 people. Several issues have been identified that have impacted on the timely provision of an inpatient endoscopy service such as incomplete pre-endoscopy ward checklists, incomplete bowel preparation...
Article
Full-text available
Objectives Patient-reported symptoms correlate poorly with mucosal inflammation. Clinical decision-making may, therefore, not be based on objective evidence of disease activity. We conducted a study to determine factors associated with clinical decision-making in a secondary care inflammatory bowel disease (IBD) population, using a cross-sectional...
Article
Background: Cyclic vomiting syndrome (CVS) is a functional gastrointestinal disorder (FGID) characterized by intermittent episodes of nausea and vomiting. Our aim was to report its prevalence and associated features. Methods: Data concerning demographics, symptoms, and psychiatric comorbidity were collected. Symptoms compatible with CVS were cla...
Conference Paper
Introduction Cyclic vomiting syndrome (CVS) is a functional gastrointestinal disorder (FGID) whose aetiology is poorly understood. It is characterised by acute episodes of vomiting and nausea followed by asymptomatic periods. Average age of symptom onset in adults is 22 years but average age of diagnosis is 31 years. This delay is probably because,...
Conference Paper
Full-text available
Introduction Acute upper gastrointestinal bleeding (AUGIB) is a potentially life threatening condition, resulting in 7.4% all-cause mortality in patients receiving endoscopy in the UK National audit in 2007 [1]. Formal, out-of-hours (OOH) endoscopy rotas for AUGIB are typically delivered by consultant gastroenterologists and have been shown to redu...
Article
en Linked Content This article is linked to Ballou and Lembo, and Sood et al papers. To view these articles visit https://doi.org/10.1111/apt.14002 and https://doi.org/10.1111/apt.13949.
Article
Full-text available
Background: Evaluation of patient-reported symptoms forms the mainstay of disease activity assessment in patients with inflammatory bowel disease (IBD). Despite this, the correlation between symptom reporting and the presence of mucosal inflammation is poor, particularly in Crohn's disease (CD). [1] We conducted a cross-sectional study to determine...
Article
Background: The accuracy of symptom-based diagnostic criteria for irritable bowel syndrome (IBS) is modest. Aims: To derive and validate a new test that utilises latent class analysis. Methods: Symptom, colonoscopy, and histology data were collected from 1981 patients and 360 patients in two cohorts referred to secondary care for investigation of...
Article
Background Inflammatory bowel disease is associated with psychological comorbidity and impaired quality of life. Psychological comorbidity could affect the natural history of inflammatory bowel disease. Psychological therapies might therefore have beneficial effects on disease activity, mood, and quality of life in patients with inflammatory bowel...
Article
en Linked Content This article is linked to Aggio et al paper. To view this article visit https://doi.org/10.1111/apt.13822.
Article
Background: Patient education forms a cornerstone of management of inflammatory bowel disease (IBD). The Internet has opened new avenues for information gathering. Aim: To determine the relationship between different information sources and patient knowledge and anxiety in patients with IBD. Methods: The use of information sources in patients...
Article
Introduction: Optical biopsies of colonic polyps 5 10 mm in size could potentially replace standard histological assessment. WavSTAT version 4 is a novel optical biopsy system designed by Spectrascience Inc, San Diego, California, USA. for prediction of histology based on laser induced autofluorescence spectroscopy. Aims & Methods: The primary aim...
Article
Introduction: Many patients presenting with diarrhoea undergo colonoscopy with random biopsies to rule out microscopic colitis (MC), if the colonoscopy is macroscopically normal. However, the yield of taking biopsies in individuals with diarrhoea is low (1). Accurate predictors of MC could identify at-risk individuals, and avoid the need to take bi...
Article
Introduction: Symptom-based criteria to diagnose irritable bowel syndrome (IBS) positively perform only modestly. Our aim was to assess whether including other items from the clinical history and diagnostic workup improves their performance. Aims & Methods: We collected complete symptom, colonoscopy, and histology data from 318 consecutive, unselec...
Article
To the Editor: We thank Drs Levenstein and Prantera for their insightful comments in response to our recently published manuscript (1,2). Our assertions were that clinical disease activity indices were poor predictors of mucosal inflammation in Crohn’s disease (CD) and only modest predictors of mucosal inflammation in ulcerative colitis, and that t...
Article
Objectives: Symptom-based criteria to diagnose irritable bowel syndrome (IBS) positively perform only modestly. Our aim was to assess whether including other items from the clinical history and limited diagnostic evaluation improves their performance. Methods: We collected complete symptom, colonoscopy, and histology data from 318 consecutive, u...
Article
Symptom-based diagnostic criteria have been criticized for being overly complex and performing modestly in differentiating organic from functional gastrointestinal diseases. The new Rome IV criteria now supersede Rome III. In general, these minor amendments are unlikely to lead to substantial improvement in accuracy and use in routine clinical care...
Article
Introduction WavSTAT version 4 is an optical biopsy system designed for prediction of histology based on laser induced autofluorescence spectroscopy. The primary aim of this study was to demonstrate the accuracy of WavSTAT4 in characterising colorectal polyps <10 mm. The secondary aim was to compare the real time diagnostic performance of WavSTAT4...
Article
Introduction Symptom-based criteria to diagnose irritable bowel syndrome (IBS) positively perform only modestly. Our aim was to assess whether including other items from the clinical history and diagnostic workup improves their performance. Methods We collected complete symptom, colonoscopy, and histology data from 318 consecutive, unselected adul...
Article
Introduction The non-vitamin k antagonist (VKA) oral anticoagulants (NOAC) comprise inhibitors of thrombin and factor Xa. They are being increasingly used in patients requiring long-term anticoagulation due to non-inferiority and relative ease of use when compared to VKA and low molecular weight heparin (LMWH). Prospective randomised studies testin...
Article
Objective: Many patients with diarrhoea undergo colonoscopy. If this is macroscopically normal, random biopsies are obtained to rule out microscopic colitis (MC), but most patients have functional disease. Accurate predictors of MC could avoid the need to take biopsies in a substantial proportion of patients, saving money for the health service. W...
Article
Background & aims: Symptoms compatible with irritable bowel syndrome (IBS) are common in patients with inflammatory bowel disease (IBD), but it is unclear whether this relates to occult IBD activity. We attempted to resolve this issue in a secondary care population by using a cross-sectional study design. Methods: We analyzed Rome III IBS sympto...
Article
Objectives: There is a move toward patient-reported outcome measures as end points in clinical trials of novel therapies for inflammatory bowel disease (IBD). However, the association between patient-reported symptoms and mucosal inflammation, and the influence of psychological factors, remains unclear. We examined this in a secondary care populat...
Article
Full-text available
National Institute for Health and Care Excellence have recommended faecal calprotectin (FC) testing as an option in adults with lower gastrointestinal symptoms for whom specialist investigations are being considered, if cancer is not suspected and it is used to support a diagnosis of inflammatory bowel disease (IBD) or irritable bowel syndrome. Yor...
Article
BACKGROUND: Irritable bowel syndrome (IBS) is a complex, heterogeneous disease which can be challenging to diagnose. No study has identified and assessed the accuracy of all available methods of diagnosing IBS. AIM: To conduct a systematic review of the literature to identify and assess accuracy of symptom-based diagnostic criteria, biomarkers, psy...
Article
Introduction Chromoendoscopy is one of several advanced endoscopic imaging techniques that have emerged in recent years. Chromoenedoscopy can enhance and facilitate mucosal observation of pit patterns in colorectal lesions. In this study we investigated the effectiveness of this technique by exploring the correlation between Kudo score and final hi...
Article
Introduction The Harvey-Bradshaw index (HBI) and simple clinical colitis activity index (SCCAI) are clinical scoring systems used to estimate Crohn’s disease (CD), and ulcerative colitis (UC) activity, respectively. However, whether they are superior to the patient’s own opinion at predicting disease activity, defined by faecal biomarkers of inflam...
Article
Introduction The prevalence of symptoms compatible with irritable bowel syndrome (IBS) in inflammatory bowel disease (IBD) has been previously described.1However, the association between the presence of these symptoms and occult disease activity is less well known, as is the effect of these symptoms on psychological health. We conducted a cross-sec...
Article
IBS is estimated to have a prevalence of up to 20% in Western populations and results in substantial costs to health-care services worldwide, estimated to be US$1 billion per year in the USA. IBS remains difficult to diagnose due to its multifactorial aetiology, heterogeneous nature and overlap of symptoms with organic pathologies, such as coeliac...
Article
Full-text available
Introduction Endoscopic Resection (ER), a technique, first pioneered in Japan for treating early gastric cancers, has gained popularity globally. The delivery of an ER service requires specialist expertise and is therefore limited to a few centres in the UK. Here in Bradford, an ER service was established in 2007, and is delivered by a single opera...
Article
Introduction Azathioprine (AZA) is an established treatment for ulcerative colitis (UC). However, controversy exists regarding its efficacy in inducing and maintaining clinical remission, particularly with the advent of biologics which, unlike AZA, have been tested in large, rigorously designed randomised controlled trials. We studied the effective...
Article
Introduction: Azathioprine (AZA) is an established treatment for ulcerative colitis (UC). However, controversy exists regarding its efficacy in inducing and maintaining clinical remission, particularly with the advent of biologics which, unlike AZA, have been tested in large, rigorously designed randomised controlled trials. We studied the effectiv...
Article
Full-text available
Chronic idiopathic constipation (CIC) and irritable bowel syndrome (IBS) are functional disorders of the lower gastrointestinal tract. Their prevalence in the general population is between 5% and 20%. Both disorders are chronic, with a relapsing and remitting natural history. The medical treatment of both conditions is unsatisfactory at present, an...
Article
Full-text available
Pegylated interferon (Peg-IFN) in combination with ribavirin is the standard of care in the treatment of chronic hepatitis C (HCV). Peg-IFN is known to have a number of side effects but severe respiratory com-plications are uncommon. We report two cases, one of Peg-IFN induced interstitial pneumonitis (IP) and the other of bronchiolitis obliterans...
Article
Full-text available
Hereditary haemochromatosis is an autosomally recessive inherited genetic disorder associated with a defect in the iron regulating hormone hepcidin, causing increased intestinal absorption of iron and subsequent deposition in the liver, pancreas, heart, joints, skin, and gonads. Mutation in the human haemochromatosis protein (HFE) gene is the most...
Article
Dyspepsia is a common presentation but only a small minority of patients have organic pathology. The majority have functional dyspepsia. All physicians should have a framework to manage dyspepsia to avoid over-investigation but to also recognize when it is appropriate to refer patients for further investigations.
Article
A 31 year-old Caucasian lady presented to the gastroenterology clinic with a history of intermittent haematochezia since the age of 2. As a child, she was diagnosed with a prolapsing rectal mucosa resulting from haemorrhoids and was treated with cryotherapy (Fig. 1). is used to be a popular method of treatment for prolapsed rectal mucosa secondary...
Conference Paper
Full-text available
Clostridium difficile associated diarrhoea (CDAD) is one of the commonest hospital acquired infections and accounts for significant and increasing morbidity and mortality in susceptible patients. There is currently no agreement with regard to factors that define an increased risk of mortality. Aims & Methods Data was collected on 125 sequential pat...
Article
Introduction Clostridium difficile associated diarrhoea (CDAD) causes significant morbidity and mortality in susceptible patients. There are no validated risk stratification scores to identify those patients at the greatest risk of death. Methods Data were collected on 125 sequential patients diagnosed with CDAD in our institution between August 20...
Article
INTRODUCTION/OBJECTIVES: In adults, duodenal biopsy is mandatory for diagnosis of coeliac disease. This is usually preceded by serological tests for coeliac specific antibodies - anti-tissue transglutaminase (tTG) and endomysial antibodies (EMA). However, the recent guidelines produced by the European Society for Paediatric Gastroenterology, Hepato...
Article
Full-text available
The intragastric balloon (IGB) has been used for decades as a temporary measure for weight reduction in the morbidly obese. Serious complications related to the device remain rare. We present the case of a 23-year-old Caucasian man who developed signs of bowel obstruction following spontaneous partial deflation of an air filled IGB with subsequent...
Article
Pancreatic cancer is the 10th most common cancer in the UK and the 5th leading cause of cancer death (UK). According to the Office for National Statistics, there were 8085 new cases and 7781 deaths in 2008, highlighting its extremely poor prognosis. The average-size GP practice is likely to see at least one case of pancreatic cancer per year. Curre...
Article
We completed a retrospective analysis of patients with genotype 3 hepatitis C virus (HCV) undergoing therapy in four UK centres with large populations of patients from the Indian subcontinent. Notes on all patients treated with pegylated interferon and ribavirin were reviewed and factors that influenced the response were examined. Six hundred and f...
Article
The prevalence of dyspepsia is 25–40% and it is a common presenting symptom in general practice consultations. Only a small percentage of patients have any organic pathology; the remainder have functional (idiopathic) dyspepsia, which can result in significant morbidity as well as significant costs to the health service when not managed appropriate...
Article
Introduction: Capsule endoscopy is a first line investigative modality for the small bowel. However 15–20% of examinations terminate before the capsule reaches the caecum. The real time viewer (RTV) allows the clinician to view live transmitted images and determine whether or not the capsule has left the stomach. Aims and Methods: To determine if t...

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